Weitz, US
Andrew C. Weitz, Pasadena, CA US
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20140087411 | SYSTEM AND METHOD FOR DETERMINING TUMOR INVASIVENESS - A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell. | 03-27-2014 |
Carl Fredric Weitz, Capitola, CA US
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20150235572 | EDUCATIONAL KITS FOR SURFBOARD CONSTRUCTION - Educational and instructive kits for surfboard construction are provided. In accordance with various embodiments of the present teachings, kits for making wooden and fiberglass scale-model surfboards can include blanks, templates, instructions, and/or other materials. A kit in accordance with the present teachings provides an educational tool for developing the skills for, and an understanding of, surfboard construction. As well, a kit of the present teachings can be employed in scale-model prototyping of surfboard designs. | 08-20-2015 |
Craig J. Weitz, Dallas, TX US
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20090263553 | METHOD FOR DEVELOPING A DAIRY PROTEIN CAKE - A method for producing a shelf-stable protein-based pellet that is capable of expansion into a light, crispy snack cake, while providing a good source of protein and calcium. The method, in preferred embodiments, involves making dough from tapioca and potato starches and a milk protein derivative consisting of whey protein isolate, milk protein isolate or calcium caseinate. The mixture is extruded, sliced and dried in a series of dyers. The method produces a shelf-stable pellet having a moisture level of approximately 9-13% by weight which is further processed to produce a puffed dairy protein snack product, having a moisture level typically less than 2%. | 10-22-2009 |
Craig Jordan Weitz, Dallas, TX US
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20140303389 | PALM OIL ENRICHED IN UNSATURATED FATTY ACIDS - A process for producing a food oil containing at least 50% monounsaturated fatty acids from palm oil is disclosed. Fatty acids are released from palm oil glycerides, such as by fat-splitting. The free fatty acids (FFA) are separated to obtain a fraction enriched in unsaturated palm fatty acid. This fraction is subject to a condensation reaction with glycerol to form an oil comprising mainly triglycerides (triacylglycerols). The condensation reaction is catalyzed by an enzyme. | 10-09-2014 |
Davia A. Weitz, Bolton, MA US
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20110305761 | POLYMERSOMES, COLLOIDOSOMES, LIPOSOMES, AND OTHER SPECIES ASSOCIATED WITH FLUIDIC DROPLETS - The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be at least partially biocompatible and/or biodegradable. The vesicles may be formed, according to one aspect, by forming a multiple emulsion comprising a first droplet surrounded by a second droplet, which in turn is surrounded by a third fluid, where the second droplet comprises lipids and/or polymers, and removing fluid from the second droplet, e.g., through evaporation or diffusion, until a vesicle is formed. In certain aspects, the size of the vesicle may be controlled, e.g., through osmolarity, and in certain embodiments, the vesicle may be ruptured through a change in osmolarity. In some cases, the vesicle may contain other species, such as fluorescent molecules, microparticles, pharmaceutical agents, etc., which may be released upon rupture. Yet other aspects of the invention are generally directed to methods of making such vesicles, kits involving such vesicles, or the like. | 12-15-2011 |
David Weitz, Bolton, MA US
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20110116993 | Virus/Nanowire Encapsulation within Polymer Microgels for 2D and 3D Devices for Energy and Electronics - Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices. | 05-19-2011 |
20140151912 | Virus/Nanowire Encapsulation within Polymer Microgels for 2D and 3D Devices for Energy and Electronics - Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices. | 06-05-2014 |
20150024378 | Analysis of DNA-Containing Samples and Resolution of Mixed Contributor DNA Samples - Methods for analyzing DNA-containing samples are provided. The methods can comprise isolating a single genomic equivalent of DNA from the DNA-containing sample to provide a single isolated DNA molecule. The single isolated DNA molecule can be subjected to amplification conditions in the presence of one or more sets of unique molecularly tagged primers to provide one or more amplicons. Any spurious allelic sequences generated during the amplification process are tagged with an identical molecular tag. The methods can also include a step of determining the sequence of the one or more amplicons, in which the majority sequence for each code is selected as the sequence of the single original encapsulated target. The DNA-containing sample can be a forensic sample (e.g., mixed contributor sample), a fetal genetic screening sample, or a biological cell. | 01-22-2015 |
20150079115 | Compositions and Methods for Preventing or Relieving Symptoms of Infections - Food products and/or pharmaceutical preparations including (i) viral neutralizing antibodies or antibody fragments anchored to a probiotic microorganism and (ii) a carrier medium for delivering the viral neutralizing antibodies or antibody fragments anchored to probiotic microorganisms to the gut of a mammal. Also provided are methods of making food products and/or pharmaceutical preparations, which can be used to treat existing viral infections or prevent the spread or transmission of viral infection. | 03-19-2015 |
David Weitz, Cambridge, MA US
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20090005254 | Compartmentalized Screening by Microfluidic Control - The invention describes a method for the identification of compounds which bind to a target component of a bio-chemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into micro-capsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development. | 01-01-2009 |
20090197248 | VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 08-06-2009 |
20090197772 | Compartmentalised combinatorial chemistry by microfluidic control - The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules. | 08-06-2009 |
20130157872 | IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 06-20-2013 |
20130178368 | IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 07-11-2013 |
20130217601 | IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS - The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention. | 08-22-2013 |
David A. Weitz, Boston, MA US
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20090155563 | Mesoporous Metal Oxide Microspheres and Method for Forming Same - The present disclosure provides a method for forming populations of monodisperse porous silica particles. Also provided are monodisperse populations of porous silica particles, an array of physically connected monodisperse porous silica particles and a microfluidic device for forming populations of monodisperse porous silica particles. | 06-18-2009 |
David A. Weitz, Cambridge, MA US
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20150159224 | ULTRASENSITIVE DETECTION AND CHARACTERIZATION OF CLUSTERED KRAS MUTATIONS USING PEPTIDE NUCLEIC ACID CLAMP PCR IN DROP-BASED MICROFLUIDICS - This disclosure employs the combination of a microfluidics platform and drop-based digital polymerase chain reaction (dPCR) to create a breakthrough technology that enables the detection of CTC genes and the isolation of single CTCs from the blood. In the first method, cDNA molecules from lysed CTCs are amplified in microfluidic drops and detected via fluorescence signal. In the second method, intact single CTCs are encapsulated, and amplification-positive drops are sorted from the remaining cells. To demonstrate the clinical utility of our technology, mutations in the KRAS gene in colorectal cancer are analyzed to study resistance to EGFR-based treatment as a test case. The methods herein present robust techniques for both the diagnosis and treatment of cancers, as well as for the obtainment of a pure CTC sample from billions of other cells in the blood. | 06-11-2015 |
20150217246 | FLUOROCARBON EMULSION STABILIZING SURFACTANTS - Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions. In another embodiment, aqueous droplets are stabilized in a fluorocarbon phase at least in part by the electrostatic attraction of two oppositely charged or polar components, one of which is at least partially soluble in the dispersed phase, the other at least partially soluble in the continuous phase. One component may provide colloidal stability of the emulsion, and the other may prevent the adsorption of biomolecules at the interface between a component and the discontinuous phase. Advantageously, surfactants and surfactant combinations of the invention may provide sufficient stabilization against coalescence of droplets, without interfering with processes that can be carried out inside the droplets. | 08-06-2015 |
Eliot Weitz, San Francisco, CA US
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20100138236 | METHOD, APPARATUS AND SYSTEM FOR COMMUNICATING HEATLHCARE INFORMATION TO AND FROM A PORTABLE, HAND-HELD DEVICE - A method and an apparatus for communicating healthcare information utilize a set of codes to communicate healthcare data in a convenient manner. A set of codes each corresponding to respective healthcare data is generated. The set of codes is stored in a memory associated with a portable terminal. Selection of at least one code corresponding to healthcare data relevant to a patient is detected, where after the selected at least one code is wirelessly transmitted to a recipient. | 06-03-2010 |
G. Rockford Weitz, Boston, MA US
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20110215948 | SYSTEM AND METHOD FOR GENERATING COMMODITY FLOW INFORMATION - This invention provides a global strategic picture of commodity movements generated by tracking ships from satellite and other sources and then combining ship location and movement information with at least one other data set, such as vessel, port, cargo, weather, or market data. Ship positions are integrated with other data, such as vessel, port, cargo, weather, and market information, to create a global strategic picture of commodity flows. A global strategic picture may then be generated by combining (i) ship movements gathered by satellite and other sources, with (ii) vessel, port, cargo, weather, market, and other data from existing sources, and (iii) a time history of these data sets. | 09-08-2011 |
John C. Weitz, Belmont, CA US
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20140244014 | AUDIO AND MUSIC DATA TRANSMISSION MEDIUM AND TRANSMISSION PROTOCOL - A transmission medium and protocol is provided for bi-directional communication between an audio system and a peripheral device. The transmission medium includes a communication medium for communicating data and a communication medium for communicating a clock signal that corresponds to a transmission rate of bits on the other communication media. By transmitting the clock signal on a separate communication medium from the data, clock recovery is avoided. There may be multiple clock domains. By having multiple clock domains, multiple sample rates can be supported. Synchronization information is embedded in the signal by using run length limiting markers between the data for each channel and a synchronization word having more consecutive zero bits than the number of bits for each channel. One or more channels may be dedicated to providing control and status information. | 08-28-2014 |
Karl K. Weitz, Pasco, WA US
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20090120166 | METHOD AND APPARATUS FOR CONTINUOUS FLUID LEAK MONITORING AND DETECTION IN ANALYTICAL INSTRUMENTS AND INSTRUMENT SYSTEMS - A method and device are disclosed that provide for detection of fluid leaks in analytical instruments and instrument systems. The leak detection device includes a collection tube, a fluid absorbing material, and a circuit that electrically couples to an indicator device. When assembled, the leak detection device detects and monitors for fluid leaks, providing a preselected response in conjunction with the indicator device when contacted by a fluid. | 05-14-2009 |
Lesley A. Weitz, Arlington, VA US
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20120245835 | METHOD AND SYSTEMS FOR DETERMINING REQUIRED INTERVAL MANAGEMENT PERFORMANCE (RIMP) - A method of characterizing an airborne spacing operation is provided. The method includes determining, using a computer, a spacing tolerance based on a performance objective for the spacing operation, determining, using a computer, a minimum state data level and a minimum speed performance level based on the spacing tolerance, determining, using a computer, an airborne functionality required to meet the performance objective, and providing, using a computer, a required interval management performance (RIMP) category for the airborne spacing operation, the RIMP category specifying the spacing tolerance, the minimum state data level, the minimum speed performance level, and the airborne functionality. | 09-27-2012 |
20130231852 | METHODS AND SYSTEMS FOR DETERMINING REQUIRED INTERVAL MANAGEMENT PERFORMANCE (RIMP) - One embodiment provides a method of characterizing an airborne spacing operation. The method includes determining, using a computer, a spacing tolerance based on a performance objective for the airborne spacing operation, determining, using a computer, a minimum state data performance level and a minimum speed performance level based on the spacing tolerance, and providing, using a computer, a required interval management performance (RIMP) category for the airborne spacing operation, the RIMP category specifying the spacing tolerance, the minimum state data performance level, and the minimum speed performance level. | 09-05-2013 |
Robert Weitz, Toms River, NJ US
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20100283363 | READY TO ASSEMBLE MODULAR FURNITURE - A ready to assemble modular article of furniture includes a plurality of panels adapted to be assembled without the use of tools. A plurality of fittings are adapted for securing the plurality of panels in assembled relationship, each of the fittings including a first component and a second component. At least a first one of the panels having a surface supporting at least one of the first components. At least a second one of the panels having a surface supporting at least one of the second components. The first and second panels are arrangeable in transverse relationship with the first and second components in alignment with each other, whereby manipulation of the first component without the use of tools causes the first component to engage the second component thereby securing the first and second panels together in transverse relationship. | 11-11-2010 |
Roland S. Weitz, Bolton, MA US
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20120107601 | SYSTEMS AND METHODS OF TEMPLATING USING PARTICLES SUCH AS COLLOIDAL PARTICLES - The present invention generally relates to systems and methods for using particle templating, e.g., to produce composites, discrete particles, or the like. In some embodiments, the present invention generally relates to the production of particles using the interstitial spaces between templating elements in a template structure. For example, a plurality of templating elements, which can include colloidal particles, may be arranged to form a template structure. The interstices of the templating elements can provide regions in which a fluid may be introduced. The fluid may be hardened (e.g., solidified) in some cases, e.g., to form a composite comprising the templating elements and the interstitial segments. In certain embodiments, the template structure may then be broken down to release the hardened fluid, e.g., as a plurality of discrete particles. | 05-03-2012 |
Stan Weitz, Glenside, PA US
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20110210723 | Method of performing electrostatic discharge testing on a payment card - Methods of performing electrostatic discharge testing on a transaction card are disclosed. A transaction card may be placed on an insulated surface. A grounding probe may be placed at a first location on the transaction card. A discharge probe may be charged to a known voltage level. The discharge probe may then be discharged at a second location on the transaction card. A discharge wave shape may be recorded from the ground probe, and one of a pass condition and a fail condition may be assigned based on at least the value of the known voltage level as compared to a reference voltage level. The first location and the second location may each be selected from a plurality of areas on the transaction card. | 09-01-2011 |
Stanley Weitz, Glenside, PA US
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20110284629 | PAYMENT TERMINAL ESD TEST - Systems and methods for performing test procedures for measuring and defining the sensitivity of payment terminals to ESD (electrostatic discharge) are disclosed. In some embodiments, a plurality of test equipment in a controlled environment are used to measure the peak discharge current (Ip) when a payment device is inserted into a payment terminal during several simulated conditions. Energy levels of the discharge currents are calculated using an energy calculation program. One or more reference current and energy levels are determined. | 11-24-2011 |
20120175420 | SYSTEMS AND METHODS TO DEFINE POSSIBLE ESD RISK - Systems and methods for performing test procedures for measuring and defining the sensitivity of payment devices to ESD (electrostatic discharge) are disclosed. In some embodiments, a plurality of test equipment in a controlled environment are used to measure the peak discharge current (Ip) when a payment device is inserted into a charge/discharge device during several simulated conditions. Energy levels of the discharge currents are calculated using an energy calculation program. One or more reference current and energy levels are determined. | 07-12-2012 |
Stefan D. Weitz, Seattle, WA US
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20080294997 | Contextually Aware Client Application - Techniques and processes for subsidizing network access via content and advertising revenue are described. In one implementation, a user installs a context bar tool on the user's computing device. To access a network (e.g., a wireless network), the user activates the context bar tool and requests access to a network, such as the Internet. A network services provider detects the context bar tool and provides network access to the user. A content and ads service gathers content and advertising and populates a context bar graphic interface that is displayed on the user's device with the content and advertising. Providers of the content and advertising pay for this exposure and thus generate revenue that can be used to offset the cost of providing the network access and other network services. | 11-27-2008 |
Stefan David Weitz, Bellevue, WA US
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20110321129 | DISAMBIGUATING ONLINE IDENTITIES - Described herein are technologies pertaining to disambiguating identities/accounts over a plurality of online services. Public data streams pertaining to accounts of different online services are analyzed, and a determination is made that the accounts are owned by a same user. A searchable profile is generated for the user that comprises data that indicates that the user represented by the profile owns the accounts. The profile is claimable by the user such that the user is enabled to customize contents of the profile. | 12-29-2011 |
20130332592 | DISAMBIGUATING ONLINE IDENTITIES - Described herein are technologies pertaining to disambiguating identities/accounts over a plurality of online services. Public data streams pertaining to accounts of different online services are analyzed, and a determination is made that the accounts are owned by a same user. A searchable profile is generated for the user that comprises data that indicates that the user represented by the profile owns the accounts. The profile is claimable by the user such that the user is enabled to customize contents of the profile. | 12-12-2013 |
Stefan David Weitz, Seattle, WA US
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20110246456 | DYNAMIC RERANKING OF SEARCH RESULTS BASED UPON SOURCE AUTHORITY - Concepts and technologies are described herein for dynamically reranking search results based upon source authority. A search query is received and analyzed. One or more topics are identified in the search query. An authority index is searched to identify authoritative sources for content relating to the identified topic(s). Promoted results corresponding to content generated by the authoritative sources relating to the identified topics are obtained. The promoted results can be presented to an entity requesting the search, or injected into search results. Contribution dimensions associated with the promoted results can be determined, and filters based upon the contribution dimensions can be generated and used by an entity to dynamically manipulate the search results. | 10-06-2011 |
20110246484 | AUTHORITY RANKING - Concepts and technologies are described herein for authority ranking for real time and social search. An authority index configured to store data relating to sources is generated. Data relating to the sources, including an authority value, are generated and stored at the authority index. The authority value may be defined as a function of source, topic, and point of view (“POV”), as well as other data, if desired, and may be determined based upon one or more ranking functions. The ranking functions are determined, and data corresponding to the ranking functions is obtained. Each of the ranking functions may be weighted according to a weighting function, a confidence value or interval, one or more time functions, and/or other methods. The obtained authority value may be used for affecting ranking of search results or for other purposes. | 10-06-2011 |
20120129506 | DESKTOP TO MOBILE DATA AND ACTION TRANSFER - Methods and systems for utilizing tags to transfer data are provided. Digital tags may be presented on a display device of a first computing device such that the tags are selectable by a second computing device. The tags may include tag content that is associated with a target item indicated by a user. The tag content may be identified based on actions performed by the second computing device. Upon selection of the tag by the second computing device, the tag content is communicated to the second computing device. | 05-24-2012 |