Thie
Gordon Thie, Hattingen DE
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20110123393 | SURFACE-ACTIVE METAL COMPLEXES ON CARRIER MATERIAL FOR ADSORBING NOXIOUS SUBSTANCES AND METHOD FOR PRODUCTION THEREOF - The present invention relates to complexed metal salts which comprise ligands and at least one complexing agent for chemically binding noxious substances and/or odour-forming substances, the ligands comprising a hydrophobic carbon skeleton with hydrophilic groups. The complexed metal salt formed with the complexing agent is water-soluble and surface-active. Preferred complexing agents are water-soluble acids or salts of at least bifunctional acids, or also ether carboxylic acids. | 05-26-2011 |
Holger Thie, Koln DE
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20140296491 | GENERATING METAL ION BINDING PROTEINS - The present invention provides for a method for generating a metal ion binding protein, the method comprising a) integrating the amino acid sequence DDD into CDR1 of a light chain variable region of an antibody or fragment thereof; and b) combining the sequence of step a) with a heavy chain variable region of an antibody or fragment thereof; and c) isolating the protein. Also provided is the use of metal ion binding proteins generated by the method of the present invention for isolation and purification of proteins and for the reversible labeling of a target molecule. Also provided is a metal ion binding anti-CD8 protein. | 10-02-2014 |
Holger Thie, Bundlesland DE
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20110318757 | RECOMBINANT ANTI-MUC1 ANTIBODIES - Antibodies having a high specificity and high affinity towards the human gene product MUC1, which in specific variants is associated with neoplastic cells, i.e. tumor tissue, to the use of the antibodies for medical purposes, i.e. for tumor treatment, and for analytical purposes, e.g. for tumor diagnosis. Compositions comprising the antibodies, e.g. for use in the analytical processes and analyses, to pharmaceutical compositions comprising the antibodies, and to use of the antibodies in the manufacture of pharmaceutical compositions for tumor treatment or for diagnostic purposes. | 12-29-2011 |
Martijn Ruben Leander Thie, Eelde NL
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20090313342 | Email handling system comprising Meta-data storage - An email handling system comprising an email receiving device for receiving an email having meta-data, the meta-data comprising at least a recipient, a storage device for storing the email wherein, the system further comprises a meta-data extractor for obtaining the meta-data from the email, and a storage handler for storing in a recipient's mailbox the meta-data and a pointer to the email in the storage device. | 12-17-2009 |
Michael Thie, Bestwig DE
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20100104641 | THERAPEUTIC COMPOSITION, AND USE OF A CELL-FREE SUBSTANCE - The invention relates to a therapeutic composition, a method for producing a therapeutic composition, and the use of a cell-free substance, especially a cell-free bone or cartilage matrix. The disclosed therapeutic composition comprises at least a cell-free substance obtained from stimulated stem cells and/or precursor cells. Immunogenic reactions during in vivo therapeutic use are prevented by the fact that the therapeutic composition is free from cells and contains no typically antigenic cell components. The disclosed composition can therefore be universally used for the therapeutic purposes regardless of the origin of the stem cells and/or precursor cells and utilize the natural regenerative potency thereof in a highly efficient manner for replacing tissue, e.g. for a suitable bone and/or cartilage structure. | 04-29-2010 |
Michael Thie, Bonn DE
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20090022693 | METHOD FORISOLATING STEM CELLS FROM CRYOPRESERVED DENTAL TISSUE - The invention relates to a method for isolation of multipotent stem cells from dental tissue in which the stem cells are extracted from a tissue structure and then cultured. The invention also relates to stem cells isolated by means of the method according to the invention as well as bone cells and nerve cells produced by means of the method according to the invention. The invention also relates to a method for producing a bank of stem cells in which the cells are stored by means of the method according to the invention. According to the present invention, the cells of a pad-like soft tissue that can be localized beneath the papilla directly on the apical side of an extracted immature tooth are cryopreserved in the tissue structure such that the tissue structure is disintegrated to extract the stem cells only after thawing. These results show that stem cells/progenitor cells can be isolated even after cryopreservation of the source tissue and these stem cells/progenitor cells respond to osteogenic stimulation. In addition, the response of cells after cryopreservation turns out to be stronger than that without cryopreservation. | 01-22-2009 |
20090162326 | METHOD FOR ISOLATING STEM CELLS AND STEM CELLS DERIVED FROM A PAD-LIKE TISSUE OF TEETH - The invention relates to a method for isolating non-embryonic stem cells from a tissue that is located in immediate vicinity of immature, developing teeth or wisdom teeth. The invention further relates to non-embryonic stem cells derived from said tissue. The method according to the invention utilises a living soft tissue residing underneath the dental papilla 12 in immediate vicinity of the apical side of a developing tooth, which is clearly distinguished from other tooth tissue, such as dental papilla 12 or follicle. The pad-like tissue 16 can only be detected in a defined, specific developmental stage in an early phase of root formation. That is, identifying and separating the pad-like tissue 16 is only possible from the appearance of the bony alveolar fundus to the end of the formation of the root of the tooth. | 06-25-2009 |
20090324555 | Neural Stem Cells - Subject of the invention is a method for generating neural stem cells in vitro, wherein dental progenitor cells are isolated from soft tissue of tooth or wisdom tooth and cultivated until they form primary spheres which are then dissociated into single cells. These single cells are cultivated until they form spheroids and the spheroid-forming cells are separated to obtain neural stem cells. | 12-31-2009 |
William Thie, Sunnyvale, CA US
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20100136788 | THERMAL METHODS FOR CLEANING POST-CMP WAFERS - Methods for cleaning semiconductor wafers following chemical mechanical polishing are provided. An exemplary method exposes a wafer to a thermal treatment in an oxidizing environment followed by a thermal treatment in a reducing environment. The thermal treatment in the oxidizing environment both removes residues and oxidizes exposed copper surfaces to form a cupric oxide layer. The thermal treatment in the reducing environment then reduces the cupric oxide to elemental copper. This leaves the exposed copper clean and in condition for further processing, such as electroless plating. | 06-03-2010 |
William Thie, Fremont, CA US
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20130203256 | CONTROLLED GAS MIXING FOR SMOOTH SIDEWALL RAPID ALTERNATING ETCH PROCESS - A method for etching features in a silicon layer disposed below a mask in a plasma processing chamber a plurality of cycles is provided. A deposition phase forming a deposition on the silicon layer in the plasma processing chamber is provided comprising providing a deposition gas into the plasma processing chamber wherein the deposition gas comprises a halogen containing etchant component and a fluorocarbon deposition component, forming the deposition gas into a plasma, which provides a net deposition on the silicon layer, and stopping the flow of the deposition gas. A silicon etch phase is provided, comprising providing a silicon etch gas into the plasma processing chamber that is different than the deposition gas, forming the silicon etch gas into a plasma to etch the silicon layer, and stopping the flow of the silicon etch gas. | 08-08-2013 |