Patent application number | Description | Published |
20090215699 | Pharmaceutically Active Antiviral Peptides - The inventive peptides were found to have strong antiviral activity against HIV in general and particularly strong drug-resistant HIV activity without exerting any toxic or antiproliferative effects on cells. Consequently, using of the inventive peptides improves the conventional HIV therapy with its toxic side effects. | 08-27-2009 |
20100172881 | USE OF TAILORED RECOMBINASES FOR THE TREATMENT OF RETROVIRAL INFECTIONS - The present invention is directed to a method for preparing an expression vector encoding a tailored recombinase, wherein said tailored recombinase recombines asymmetric target sites within the LTR of proviral DNA of a retrovirus inserted into the genome of a host cell and is useful as means for excising the provirus from the genome of the host cell. The present invention further relates to an in vitro-method of optimising the treatment of a retroviral infection of a subject and to the use of tailored recombinases for the preparation of pharmaceutical compositions for reducing the viral load in a subjected infected by a retrovirus. | 07-08-2010 |
20130164271 | TAILORED RECOMBINASE FOR RECOMBINING ASYMMETRIC TARGET SITES IN A PLURALITY OF RETROVIRUS STRAINS - The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences within the long terminal repeat (LTR) of proviral DNA of a plurality of retrovirus strains inserted into the genome of a host cell, as well as to the obtained expression vector, cells transfected with this, expressed recombinase and pharmaceutical compositions comprising the expression vector, cells and/or recombinase. Pharmaceutical compositions are useful, e.g., in treatment and/or prevention of retrovirus infection. In particular, asymmetric target sequences present in a plurality of HIV strains are disclosed, as well as tailored recombinases capable of combining these sequences (Tre 3.0 and 4.0) and expression vectors encoding them. | 06-27-2013 |
20150104433 | TAILORED RECOMBINASE FOR RECOMBINING ASYMMETRIC TARGET SITES IN A PLURALITY OF RETROVIRUS STRAINS - The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences within the long terminal repeat (LTR) of proviral DNA of a plurality of retrovirus strains inserted into the genome of a host cell, as well as to the obtained expression vector, cells transfected with this, expressed recombinase and pharmaceutical compositions comprising the expression vector, cells and/or recombinase. Pharmaceutical compositions are useful, e.g., in treatment and/or prevention of retrovirus infection. In particular, asymmetric target sequences present in a plurality of HIV strains are disclosed, as well as tailored recombinases capable of combining these sequences (Tre 3.0 and 4.0) and expression vectors encoding them. | 04-16-2015 |
Patent application number | Description | Published |
20130193015 | Fastening System for Sheathing Board - Disclosed is a fastening system that is adapted for securing a sheathing board to an associated framing member. The system includes a feedband for retaining a series of fasteners and a powered drill for sequentially driving the fasteners. The feedband is made from a membrane of a polymeric compound. As the fastener is driven into the sheathing board, a portion of the membrane tears away from the surrounding feedband and becomes seated beneath the fastener. This acts to seal the penetration point and prevent water intrusion and otherwise prevents deterioration of the sheathing board. | 08-01-2013 |
20130295286 | Plastic Coated Composite Building Boards and Method of Making Same - Disclosed are composite building boards and associated manufacturing methods. The composite boards may include, for example, one or more slurry layers with embedded fibrous mats. An exterior plastic coating is mechanically adhered to the underlying slurry layer. The plastic layer chemically bonds and cross-links with polymer additives within the slurry layer. The result is an integrated polymer matrix with greatly improved durability and surface strength. | 11-07-2013 |
20130299059 | Method for Constructing Composite Building Boards Using Dissolvable Films - Disclosed are building board manufacturing techniques that minimize the build-up of slurry on associated forming equipment and also produce panels with enhanced physical properties. The methods involve applying a dissolvable film laminate to one or more fiber mats at the outset of the forming process. In the un-dissolved state, the film acts as a containment envelope for the gypsum slurry and any free floating glass fibers. During subsequent curing, the film is dissolved by vaporized water. In its dissolved state, the film is liquefied and coats the fibers of the underlying mat. This results in a building board with improved physical properties. | 11-14-2013 |
20140373336 | Method For Forming A Seal Between A Fastener And Associated Sheathing Board - Disclosed is a fastening system that is adapted for securing a sheathing board to an associated framing member. The system includes a feedband for retaining a series of fasteners and a powered drill for sequentially driving the fasteners. The feedband is made from a membrane of a polymeric compound. As the fastener is driven into the sheathing board, a portion of the membrane tears away from the surrounding feedband and becomes seated beneath the fastener. This acts to seal the penetration point and prevent water intrusion and otherwise prevents deterioration of the sheathing board. | 12-25-2014 |
20150059621 | Struvite-K and Syngenite Composition for Use in Building Materials - A composition and process for the manufacture thereof for use in a hybrid building material comprising at least in part Syngenite (K | 03-05-2015 |
20150197034 | Apparatus and Method for Constructing Building Boards Using Low Friction Surfaces - Discloses is an apparatus and method for utilizing air along a building board forming line for the purpose of reducing friction between the board and the underlying forming tables. The device employs a series of air nozzles that are formed within the face of the forming tables. An air source delivers pressurized air to the nozzles. As completed or partially completed boards travel along the forming tables, an air cushion is created to reduce the friction between the board and the underlying table. The pressurized air can also be used to transport the boards and promote the even distribution of slurry during formation. The various components of the present invention, and the manner in which they interrelate, are described in greater detail hereinafter. | 07-16-2015 |
20150197941 | Surface Adhesives for Building Boards - The present disclosure relates to performance enhancing surface coatings for building boards. More particularly, the disclosure relates to the using of building boards employing surface adhesives to eliminate the need for fasteners in holding building boards in place after installation. | 07-16-2015 |
Patent application number | Description | Published |
20090087616 | COATINGS FOR GLASS REINFORCED FACED GYPSUM BOARD - A coating method for gypsum board having a surface gypsum layer in which a polymer additive has been entrained including forming a gypsum board including the polymer additive entrained in a surface layer, application of a preferably acrylic primary coating, curing and drying the gypsum board, passing the gypsum board through a first roll coater wherein a second fluid coating is deposited over the primary layer of the dried, coated gypsum board in which the polymer additive has been entrained, the coating then being dried and cured, wherein the coating material of the primary coating forms a chemical bond with the polymer additive entrained in the surface layer of the gypsum board and the polymer of the primary coating forms a chemical bond with the second fluid coating. A coating material which can form copolymer bonds with the second coating is then deposited on the second coating and then dried and cured, resulting in coated gypsum board having a low surface tension surface that is essentially impermeable to water and vapor or moisture penetration. | 04-02-2009 |
20120308795 | Composite Floor Underlayment With Thermoplastic Coatings - Disclosed is a flooring system consisting of a slab (or base) floor, a floor covering, and a composite underlayment extending between the slab floor and floor covering. The composite underlayment may include, for example, one or more set gypsum layers with embedded fibrous mats. An exterior plastic coating is mechanically adhered to an underlying set gypsum layer. The plastic coating chemically bonds and cross-links with polymer additives within the set gypsum core. The result is an underlayment that is a fully integrated polymer matrix with greatly improved durability and surface strength with only minimal increases in cost or weight. | 12-06-2012 |
20130327461 | System And Method For The Construction Of Bound Fibrous Mats - Disclosed is a system and method for constructing fibrous mats. In accordance with the disclosure, continuous lengths of filament are pre-coated with a liquefied thermoplastic. The pre-coated filaments are then laid down upon a belt to forum a fibrous mat. The filaments can be laid down in continuous lengths or they can be chopped into discontinuous lengths. The filaments are heated after they have been laid down in order to re-liquefy the thermoplastic and facilitate bonding between intersecting fibers. The disclosure further relates to a system and method for incorporating constructed fibrous mats into a composite building board. | 12-12-2013 |
Patent application number | Description | Published |
20110199236 | METHOD AND DEVICE FOR PARKING A MOTOR VEHICLE - A method for turning at least one steerable wheel of a motor vehicle during parking on a longitudinal inclination of a roadway, having the following steps: activating a parking brake of the motor vehicle, ascertaining the inclination angle of the vehicle inclination that is effected by the longitudinal inclination of a roadway, turning the steerable wheel to achieve a wheel angle as a function of at least one specifiable and/or ascertained parameter. It is provided that the setting of the magnitude of the wheel angle take place as a function of at least one surroundings situation of the motor vehicle, ascertained using at least one sensor. Furthermore, a device for turning at least one steerable wheel of a motor vehicle during parking on a longitudinal roadway inclination, particularly for executing the method, which cooperates with a parking brake, an inclination angle sensor and a steering device of the motor vehicle, a surroundings recording device being provided having at least one sensor for recording the immediate surroundings of the motor vehicle. | 08-18-2011 |
20120245816 | METHOD FOR REDUCING THE CLAMPING FORCE APPLIED BY A PARKING BRAKE - In a method for reducing the clamping force applied by a parking brake, which may be generated at least partially by an electromechanical brake device having an electric brake motor and supplemented if necessary by a hydraulic brake device, a signal is generated for actuating the hydraulic brake device for the case that it is not possible for the brake motor to be released for reducing the clamping force. | 09-27-2012 |
20130001027 | Method for operating a parking brake of a vehicle - A method for operating a parking brake of a vehicle, in particular of a motor vehicle, which parking brake operates in the superposition mode, the brake force of the parking brake being applicable by two different force-generating actuators mutually supporting one another in the superposition mode. It is provided that the force-generating, in particular pressure-generating, actuator is activated for support even before the superposition. | 01-03-2013 |
20130056315 | METHOD FOR SETTING THE CLAMPING FORCE EXERTED BY A PARKING BRAKE IN A VEHICLE - In a method for setting the clamping force exerted by a parking brake, for the case in which after the conclusion of a clamping process an event occurs that disturbs the stationary situation of the vehicle, a subsequent clamping process is carried out by actuating an electric brake motor and an additional brake device. | 03-07-2013 |
20130060439 | METHOD FOR SETTING A PARKING BRAKE IN A VEHICLE - In a method for setting a parking brake that has an electromechanical brake device having an electrical brake motor, the release time duration for displacing the electrical brake motor in the release direction is determined from the closing time duration in which the brake motor was previously displaced in the closing direction. | 03-07-2013 |
20130325278 | METHOD FOR SETTING THE ACTUATING FORCE APPLIED BY A PARKING BRAKE - In a method for setting the clamping force applied by a parking brake, which is generated by an electromechanical brake device and additionally by a hydraulic brake device as needed, the hydraulic pressure is ascertained, and the pressure is assigned a pressure reference path which is compared with an actuator path. | 12-05-2013 |
20130333988 | METHOD FOR SETTING THE CLAMPING FORCE EXERTED BY A PARKING BRAKE - In a method for setting the clamping force exerted by a parking brake, which is generated at least partially by an electromechanical braking device and, if needed, in supplementary fashion by a hydraulic braking device, in the provision of the hydraulic clamping force, a boost pressure to be generated in the hydraulic braking device is increased with respect to a switch-off pressure at the switch-off time that corresponds to the hydraulic clamping force. | 12-19-2013 |
20130338895 | METHOD FOR SETTING THE CLAMPING FORCE EXERTED BY A PARKING BRAKE - In a method for setting the clamping force, which is exerted by a parking brake, a portion of which clamping force is at least partially generated by an electromechanical braking device having an electric actuator, and another portion is additionally generated by an additional braking device, as needed, the actual force curve is determined and compared to a characteristic, defined force curve to determine the magnitude of the electromechanical clamping force to be supplied by the electric actuator. If the actual force curve corresponds to the characteristic force curve, then, in addition to the electromechanical clamping force, an additional clamping force of the additional braking device is also taken into account for obtaining the setpoint clamping force. | 12-19-2013 |
20140058642 | METHOD FOR OPERATING A PARKING BRAKE IN A VEHICLE - A method for operating a parking brake having an electromechanical braking device, which includes an electric brake motor, the electromechanical braking device being re-applied in order to generate a clamping force again in the case of a fault of the release process of the electromotive braking device. | 02-27-2014 |
20140172259 | METHOD FOR OPERATING A PARKING BRAKE HAVING AN ELECTROMOTIVELY DRIVEN PARKING BRAKE MECHANISM - A method for operating a parking brake with an electromotively driven parking brake mechanism includes applying the parking brake by the electric motor, switching off the electric motor in the state in which the parking brake is applied, switching on the electric motor after a prespecified time and reapplying the parking brake mechanism in the brake application direction. During the brake reapplication operation, an electrical variable of the electric motor is determined and compared with a reference value. The brake reapplication process is continued or terminated depending on whether the electrical variable, or a variable derived therefrom, is smaller or greater than the reference value. | 06-19-2014 |
20150217737 | Method for Actuating an Automatic Parking Brake - A method for releasing a brake device for an automatic parking brake, a corresponding device, and a control device enable safely releasing the parking brake without stress on components. A method for actuating a parking brake with a brake device having a brake caliper housing with a chamber configured to receive a fluid, a brake piston, a spindle and a spindle nut, includes determining a first hydraulic driver-applied pre-pressure in the chamber during a mechanical application process of the parking brake. The method further includes comparing the first driver-applied pre-pressure to a predetermined pressure threshold value via the control device; and building up a hydraulic support pressure in the chamber in order to unload the spindle when the first driver-applied pre-pressure is above the pressure threshold value. | 08-06-2015 |