Patent application number | Description | Published |
20090050538 | Serpentine structures for continuous flow particle separations - An improved technique for particle separation is provided. A serpentine structure is utilized in a continuous fluid flow environment to allow for suitable separation of particles to occur in a manner that does not require external application of forces to initiate the separation. The geometry of the serpentine structure and associated forces generated in connection with fluid flow therein suffice. | 02-26-2009 |
20090114601 | Device and Method for Dynamic Processing in Water Purification - A transformational approach to water treatment is provided that incorporates membrane-free filtration with dynamic processing of the fluid to significantly reduce treatment times, chemical cost, land use, and operational overhead. This approach provides hybrid capabilities of filtration, together with chemical treatment, as the water is transported through various spiral stages. | 05-07-2009 |
20090283452 | METHOD AND APPARATUS FOR SPLITTING FLUID FLOW IN A MEMBRANELESS PARTICLE SEPARATION SYSTEM - A method and system for splitting fluid flow in an outlet of a particle separation device is provided. The system may include static or passive mechanisms or subsystems. These mechanisms could also be modular and interchangeable to provide for preset fluid split divisions of 20:80, 30:70, 40:60, 50:50, . . . etc. In other forms of the presently described embodiments, the system is adjustable and variable. In still another form of the presently described embodiments, the system allows for differential pressure control at the outlets to facilitate the flow of varying size particles or particle bands in the respective channels or paths. | 11-19-2009 |
20090283455 | FLUIDIC STRUCTURES FOR MEMBRANELESS PARTICLE SEPARATION - Fluidic structures for facilitating particle separation in curved or spiral devices are provided. The contemplated systems relate to various fluidic structures, implementations and selected fabrication techniques to realize construction of fluidic separation structures that are of a stacked and/or parallel configuration. These contemplated systems provide for efficient input of fluid to be processed, improved throughput, and, in some variations, adjustable and efficient treatment of output fluid. | 11-19-2009 |
20100072142 | METHOD AND SYSTEM FOR SEEDING WITH MATURE FLOC TO ACCELERATE AGGREGATION IN A WATER TREATMENT PROCESS - A system and method that uses mature floc as seed particles to promote aggregation in a water treatment process is provided. The seed particles do not need to be recovered as they separate out with the waste steam after a spiral separation. One implementation is to prepare the mature floc off-line and inject periodically into the buffer tank, as needed. Another implementation is to tap into the more mature floc downstream and feedback, as needed, to the buffer tank. | 03-25-2010 |
20100314325 | SPIRAL MIXER FOR FLOC CONDITIONING - A system and method for treatment of water. An inlet is operative to receive source water having particles therein. A spiral mixer has a defined spiral channel operative to mix the source water with a coagulant material and an alkalinity material. The spiral mixer is formed to perform in-line coagulation and flocculation processes within the defined spiral channel to form aggregated floc particles. A buffer tank is operative to receive the aggregated floc particles from the spiral mixer. Spiral separator segregates contents of the buffer tank into affluent and waste water that has the aggregated floc particles therein. An outlet is operative to provide a first path for the affluent, and a second path for the waste water having the aggregated floc particles. | 12-16-2010 |
20100314327 | PLATFORM TECHNOLOGY FOR INDUSTRIAL SEPARATIONS - A method and system for treating a fluid stream includes inputting a fluid stream to an input section of the fluid treatment system and receiving the fluid stream via spiral mixer-conditioner. The spiral mixer-conditioner mixes and conditions the input stream. Thereafter the mixed and conditioned fluid stream is input to a spiral separator where the mixed and conditioned fluid stream is separated into at least two fluid streams, a first fluid stream having particulates in the input stream removed, and the second fluid stream having the particulates in the input fluid stream concentrated. | 12-16-2010 |
20120193298 | PLATFORM TECHNOLOGY FOR INDUSTRIAL SEPARATIONS - A method and system for treating a fluid stream includes inputting a fluid stream to an input section of the fluid treatment system and receiving the fluid stream via spiral mixer-conditioner. The spiral mixer-conditioner mixes and conditions the input stream. Thereafter the mixed and conditioned fluid stream is input to a spiral separator where the mixed and conditioned fluid stream is separated into at least two fluid streams, a first fluid stream having particulates in the input stream removed, and the second fluid stream having the particulates in the input fluid stream concentrated. | 08-02-2012 |
20120318719 | SERPENTINE STRUCTURES FOR CONTINUOUS FLOW PARTICLE SEPARATIONS - An improved technique for particle separation is provided. A serpentine structure is utilized in a continuous fluid flow environment to allow for suitable separation of particles to occur in a manner that does not require external application of forces to initiate the separation. The geometry of the serpentine structure and associated forces generated in connection with fluid flow therein suffice. | 12-20-2012 |
Patent application number | Description | Published |
20120074074 | SELF-CLEANING SCREEN SYSTEM AND METHOD - A self-cleaning screen system and method removes contaminants from a fluid passed through a screen of the self-cleaning screen system. The self-cleaning screen system includes a cleaning mechanism used to remove contaminants which may have adhered to the screen. The self-cleaning screen system is self-powered by extracting energy from the fluid flow to cause rotation or other movement of either the screen and/or the cleaning mechanism. | 03-29-2012 |
20120152855 | SYSTEMS AND APPARATUS FOR SEAWATER ORGANICS REMOVAL - A non-filtration pre-separation device and method for the removal of algae using the same, comprising a system having a hydrodynamic separator including at least one curved structure for the removal of bio-organisms from seawater, such structure having an inlet in operative connection with a source of raw seawater and a bifurcated outlet operative for passing pre-treated effluent fluid to a downstream filtration system and the removal of waste fluid. Various fluidic structures, implementations and selected fabrication techniques to realize such a device, whether singular or in stacked and/or packed parallel configuration are also provided. | 06-21-2012 |
20140262973 | METHOD AND SYSTEM FOR STACKING AND SEALING HYDRODYNAMIC SEPARATION LAYERS - An assembly for a high output hydrodynamic separation unit includes, in one form, several components or parts. Top and bottom plates serve as caps for and distribute force through layers of separation channels. The compressive forces seal the channels and prevent leakage from the channels. An optional middle plate may also be provided to create smaller subsets of the layers of separation channels. At least one connector is provided to the combination of components to compress the layers of separation channels. In a variation, an optional outer shell may encase the unit to provide support and compress the stack with a unique threaded configuration. | 09-18-2014 |
20140367348 | HDS CHANNEL EXIT DESIGNS FOR IMPROVED SEPARATION EFFICIENCY - Hydrodynamic separation of suspended particles using curved channels offers advantages in many applications, since it is a fast continuous flow technology that can handle neutrally and near neutrally buoyant particles without the need of a physical barrier or the addition of chemical aids. Designs are provided for a flow splitter at the end of the separation channel, to maintain smooth, counter-vortex-free laminar flow and improve particle separation efficiency while reducing clogging and fouling propensities. | 12-18-2014 |
20150175454 | RECYCLING ACTIVATED SLUDGE BY HYDRODYNAMIC SEPERATOR (HDS) TO ENABLE HIGH MLSS BIOREACTOR TO PROCESS HIGH INFLUENT FLOW AND/OR HIGH STRENGTH WASTEWATER - A wastewater treatment plant that employs an activated sludge process and a method of operating the same is described. Wastewater influent is provided to a bioreactor configured to perform activated sludge processing to develop mixed liquor suspended solids (MLSS). The MLSS is passed from the bioreactor to a hydrodynamic separator (HDS) system, where separation operations are performed on the MLSS. The separation operations generate a low concentration MLSS stream and a high concentration MLSS stream. The low concentration MLSS stream is passed from the hydrodynamic separator system via a first output to a clarifier, and the high concentration wastewater stream is passed via a second output back to the bioreactor. The clarifier performs clarification operations on the cleaned wastewater stream and then outputs an effluent flow. | 06-25-2015 |
Patent application number | Description | Published |
20120289196 | COMPACT FORM FACTOR INTEGRATED CIRCUIT CARD AND METHODS - A compact form factor integrated circuit card. In one embodiment, a Subscriber Identity Module (SIM) card is disclosed. In one embodiment, the SIM card has overall dimensions optimized for a particular application; e.g., 12.30 mm (±0.10 mm)×8.80 mm (±0.10 mm)×0.67 mm (+0.03/−0.07). In another embodiment, the SIM card has overall dimensions of 11.90 mm (±0.10 mm)×8.80mm (±0.10mm)×0.70 mm (maximum). Multiple complementary SIM card adapters and methods of use are also disclosed. | 11-15-2012 |
20140106819 | COMPACT FORM FACTOR INTEGRATED CIRCUIT CARD AND METHODS - A compact form factor integrated circuit card. In one embodiment, a Subscriber Identity Module (SIM) card is disclosed. In one embodiment, the SIM card has overall dimensions optimized for a particular application; e.g., 12.30 mm (±0.10 mm)×8.80 mm (0.10 mm)×0.67 mm (+0.03/−0.07). In another embodiment, the SIM card has overall dimensions of 11.90 mm (±0.10 mm)×8.80 mm (±0.10 mm)×0.70 mm (maximum). Multiple complementary SIM card adapters and methods of use are also disclosed. | 04-17-2014 |
20150014421 | COMPACT FORM FACTOR INTEGRATED CIRCUIT CARD AND METHODS - A compact form factor integrated circuit card. In one embodiment, a Subscriber Identity Module (SIM) card is disclosed. In one embodiment, the SIM card has overall dimensions optimized for a particular application; e.g., 12.30 mm (±0.10 mm)×8.80 mm (0.10 mm)×0.67 mm (+0.03/−0.07). In another embodiment, the SIM card has overall dimensions of 11.90 mm (±0.10 mm)×8.80 mm (±0.10 mm)×0.70 mm (maximum). Multiple complementary SIM card adapters and methods of use are also disclosed. | 01-15-2015 |
Patent application number | Description | Published |
20130052947 | ELECTRONIC DEVICE WITH SHARED NEAR FIELD COMMUNICATIONS ELEMENT - Electronic devices may be provided with near field communications capabilities. A near field communications antenna may be formed from multiple inductive components. The inductive components may include a speaker coil. One or more switches may be provided in the near field communications antenna to adjust the inductance of the near field communications antenna during different modes of operation. An audio circuit may be used to generate audio signals. A first transmitter may be used to transmit near field hearing aid signals through the near field communications antenna. A second transmitter may be used to transmit near field communications signals to external equipment such as near field communications point of sale equipment. Switching circuitry may be used to selectively couple the audio circuit, the first transmitter, and the second transmitter to the near field communications antenna. | 02-28-2013 |
20130062174 | CAM-ACTION ANTI-ROLL BUTTON - A cam-action anti-rolling mechanism for buttons is described herein. One embodiment may take the form of a button having a body with a slot extending therethrough. The slot has a normal orientation to a direction of motion for the button. The button also includes a cam bar having a first portion extending through the slot and a second portion offset from and parallel to the first portion. The cam bar is coupled in a slip fit manner within the slot to the body and the second portion provides a rotational axis for the cam bar. A fixture coupled to the second portion of the cam bar is provided to allow for rotation of the cam bar. | 03-14-2013 |
20130112536 | SLIDE SWITCH - One embodiment may take the form of a slide switch for electronic devices having a connecting rod and a first joint coupling a first end of the connecting rod to a button. The first joint allows rotation of the connecting rod relative to the button. A second joint couples a second end of the connecting rod to a support structure. The second joint allows the connecting rod to rotate relative to the support structure. The second joint is offset laterally from the button. The button is constrained to move along a straight path between a first resting position and a second resting position. The connecting rod is configured to resist displacement of the button from one of the first or second resting positions until the button passes a threshold displacement distance, at which point the connecting rod snaps the button into the other resting position. | 05-09-2013 |
20130170109 | Mesh Structure Providing Enhanced Acoustic Coupling - A portable electronic device that provides compact configurations for audio elements are disclosed. The audio elements can be drivers (e.g., speakers) or receivers (e.g., microphones). According to one aspect, mesh structures, such as mesh barriers, are formed to facilitate improved acoustic sealing in a space efficient manner. In one embodiment, a mesh barrier for an audio port can be reliably acoustically sealed (or coupled) with an audio chamber and/or outer device housing in a space efficient manner. A mesh barrier can serve to block undesired foreign substances from entry or further entry into an audio port and/or serve as a cosmetic barrier which obscures vision into an audio port. In one embodiment, a portion of a mesh structure can be provided with a substantially planar surface that facilitates improved acoustic sealing. | 07-04-2013 |
20130344352 | Battery Protection Structures - A battery may have a foil battery pack with leads that are coupled to a printed circuit board. Battery protection structures formed from an insulating material such as plastic may be used to protect the foil battery pack. The foil battery pack may have a rectangular shape with front and rear faces surrounded by a rectangular peripheral edge. The battery protection structures may have a ring shape that surrounds the peripheral edge while leaving the front and rear faces exposed to minimize the size of the battery protection structures. An elastomeric material may be used to form the battery protection structures. The elastomeric material may allow the battery protection structures to stretch when the battery pack expands during use. Two shots of plastic may be incorporated into the battery protection structures to provide both puncture resistance and the ability to stretch during use. | 12-26-2013 |
20130344712 | INTERCONNECTIONS BETWEEN FLEXIBLE AND RIGID COMPONENTS - A low-height connectorless interconnection system includes a first substrate, the first substrate having a first plurality of exposed portions of underlying circuit traces and a second substrate, the second substrate having a second plurality of exposed portions of underlying circuit traces. The system further includes a plurality of conductive formations formed on at least one of the first and second pluralities of exposed portions of underlying circuit traces and a clamping member arranged to join the first and second substrate such that the first and second pluralities of exposed portions of circuit traces are in severable electrical communication. | 12-26-2013 |
20140055915 | COMPLEMENTARY GROUND AND SUPPORT MEMBERS - A ground member of a personal electronic device includes a base and a first deflection arm formed of a portion of the base. The first deflection arm exposes a cutout portion of the base and is bent along a first bend line. The cutout portion is dimensioned to engage with a complementary dimensioned support member and the first deflection arm is configured to deflect and engage with the support member in response to insertion of the support member in the cutout portion. The ground member further includes a second deflection arm extending from the base and bent along a second bend line. | 02-27-2014 |
20140092532 | SYSTEMS AND METHODS FOR SECURING COMPONENTS OF AN ELECTRONIC DEVICE - Systems and methods for securing components of an electronic device are provided. In some embodiments, the electronic device may include a housing having an opening, a cover resting on a portion of the electronic device in a first cover position within the opening, and a lock component configured to move within the housing from a first lock position to a second lock position for securing the cover in the first cover position. | 04-03-2014 |
20140177181 | Electromagnetic Interference Shielding Structures - Electrical components are mounted on a printed circuit in an electronic device housing. Shielding can structures may include a sheet metal shield can layer with a conductive gasket. The printed circuit may have an opening. A screw passes through the opening in the printed circuit and openings in the conductive gasket and sheet metal shield can layer to secure the shielding can structures to the housing. When secured, a lip in the gasket lies between the printed circuit substrate and the housing. The gasket may be formed from conductive elastomeric material. A shield can lid and a flexible printed circuit may be embedded within conductive elastomeric material that provides a thermal conduction path to dissipate heat from electrical components under the lid. Shield can members that are located on opposing sides of a bend in a flexible printed circuit substrate may be coupled by a conductive elastomeric bridging structure. | 06-26-2014 |
20140218874 | Electronic Devices Having Multi-Purpose Cowling Structures And A Compass Mounted On A Flex Circuit - Multi-purpose cowling structures are provided to minimize spacing impact within an electronic device, while maximizing functional utility. In one embodiment, an electromagnetic interference shield may provide one or more anchors for enabling a logic board cowling to apply sufficient downward force to one or more board connectors to prevent inadvertent disconnects. In another embodiment, a cowling can electrically connect the ground plane of a logic board to the ground plane of a housing member and provide a pre-load force to a conductor connection existing on logic board. A compass mounted on a flexible printed circuit board is also provided. Mounting the compass on a flexible printed circuit board enables the compass to be mounted remote from ferrous object that may affect the compass's performance. | 08-07-2014 |
20140323063 | Methods for Manufacturing an Antenna Tuning Element in an Electronic Device - Custom antenna structures may be used to improve antenna performance and to compensate for manufacturing variations in electronic device antennas. An electronic device antenna may include an antenna tuning element and conductive structures formed from portions of a peripheral conductive housing member and other conductive antenna structures. The antenna tuning element may be connected across a gap in the peripheral conductive housing member. The custom antenna structures may be used to couple the antenna tuning element to a fixed custom location on the peripheral conductive housing member to help satisfy design criteria and to compensate for manufacturing variations in the conductive antenna structures that could potentially lead to undesired variations in antenna performance. Custom antenna structures may include springs and custom paths on dielectric supports. | 10-30-2014 |
20140361935 | MODULAR STRUCTURAL AND FUNCTIONAL SUBASSEMBLIES - A housing for a personal electronic device is described herein. The housing may include at least one modular subassembly configured to be arranged within an internal cavity of the housing. The at least one modular subassembly is aligned with a feature external to the housing, is affixed to an interior surface of the internal cavity, and is configured to function both as an antenna and as an internal support member of the housing. | 12-11-2014 |
20150070219 | HYBRID ANTENNA FOR A PERSONAL ELECTRONIC DEVICE - A housing for a personal electronic device is described herein. The housing may include at least one modular subassembly configured to be arranged within an internal cavity of the housing. The at least one modular subassembly is aligned with a feature external to the housing, is affixed to an interior surface of the internal cavity, and is configured to function both as an antenna and as an internal support member of the housing. A hybrid antenna is also described herein. The hybrid antenna can include first and second flexible members capable of facilitating wireless communication, where the first and second flexible members are affixed to one another via a metal member. | 03-12-2015 |
Patent application number | Description | Published |
20140063769 | Component Mounting Structures with Breakaway Support Tabs - Components may be mounted to printed circuit substrates using solder. A breakaway support tab may be detachably connected to a component and may help prevent the component from shifting or toppling over during reflow operations. The component and breakaway support tab may be formed from sheet metal. The interface that links the component to the breakaway support tab may be perforated or half sheared to allow the breakaway support tab to be easily separated from the component following reflow operations. The breakaway support tab may be fixed in place during reflow operations by mechanically coupling the breakaway support tab to a fixture or by mounting the breakaway support tab to an unused portion of a panel of printed circuit substrates. A breakaway support tab may be mechanically coupled between two components on a printed circuit substrate and may be used to maintain a distance between the components during reflow operations. | 03-06-2014 |
20140070081 | Electronic Device With Light Sensor Alignment Structures - Electronic devices may include light sensors. The light sensors may include alignment features. The light sensors may be optically aligned with an aperture in an opaque structure. The opaque structure may be formed from an opaque material or a transparent material with an opaque coating. The light sensor may be mounted in a support structure that has been optically aligned with the aperture. The light sensor or the support structure may include extended portions that are transparent to ultraviolet light. Ultraviolet light may be transmitted through the extended portions to cure adhesive that attaches the light sensor or the support structure to the opaque structure. The light sensor may be optically aligned with the aperture by viewing the aperture through an opening in the support structure, by viewing the alignment features on the light sensor through the aperture or by gathering alignment data using the light sensor during alignment operations. | 03-13-2014 |
20140071594 | Components Having Breakaway Installation Handles - A component may be molded with an integral breakaway installation handle. The breakaway installation handle may be used to manipulate and maneuver the component during assembly operations and during component mounting operations. A technician may use the breakaway installation handle to mount the component to a fixture while applying adhesive, attaching a mesh, or performing other assembly operations on the component. Following assembly operations, the technician may use the breakaway installation handle to install the component in an electronic device. After installing the component in the electronic device, the technician may bend the breakaway installation handle with respect to the component until the breakaway installation handle breaks off from the component. Components having breakaway installation handles may be formed form an injection molding system in which mold cavities each receive molten plastic from a runner. Plastic that solidifies in each runner may form the breakaway installation handle for each component. | 03-13-2014 |
20140071651 | Insert Molded Cowling Structures - Electronic devices may be provided with electronic components and cowling structures that secure the electronic components. A cowling structure may include a metal portion and an insulating portion that has been insert-molded onto the metal portion. The metal portion and the insert-molded insulating portion may each have an opening that receives a screw. The screws may pass through the respective opening and attach to a substrate. The substrate may be a transparent cover layer for a device display. The cowling structure may press the electronic components against the transparent substrate layer. The device may include an antenna. The insert-molded insulating portion may extend from an edge of the metal portion in the direction of the antenna. The insert-molded insulating portion may prevent one of the screws from forming an electrical connection with the metal portion. | 03-13-2014 |
20150061941 | ANTENNA RELATED FEATURES OF A MOBILE PHONE OR COMPUTING DEVICE - Antenna related features of a mobile phone or computing device are disclosed. In one embodiment, wireless control and signal are fed separately through difference types of flexes to optimize performance and cost. In one embodiment, active switching and processing of differing conductive trace lengths are performed on an antenna flex so that antenna performance can be optimized for multiple wireless technologies covering a wide range of wavelengths. In one embodiment, a cantilever arm affixed to a ground screw can provide double grounding in a region with no available screw points due to high z constraint. In one embodiment, a device can provide double feed for antenna through a single screw. In one embodiment, a short pin can be configured to support thinner metal. In one embodiment, a “vibrator bracket/LDS short pin” structure can be used to share a common screw point. | 03-05-2015 |
Patent application number | Description | Published |
20090164319 | DISCOUNT SYSTEM AND METHOD - Discount systems and methods of providing discounts are provided. The discount systems may include an apparatus couplable to an automobile. The apparatus may include indicia thereon relating to an entity desiring to provide a discount upon detection of the apparatus. In some aspects, the apparatus may be a license plate frame. The methods may include providing an apparatus including indicia thereon associated with an entity, coupling the apparatus to an automobile, detecting the presence of the apparatus at a location associated with the entity, and providing a discount for a product or a service associated with the entity after detection of the apparatus. In some aspects, the apparatus may be a license plate frame and the license plate frame may be coupled to an automobile such that the apparatus at least partially surrounds a license plate coupled to the automobile, | 06-25-2009 |
20110170681 | ON HOLD CALL BACK TELEPHONE FEATURE - A telephone system provides an alternative to being kept “on hold”. When placed on hold, *8 or some can be dialed, which allows the party placed on hold to hang up his or her phone without disconnecting the call. To resume the call, the party that placed the call on hold dials any number on his or her phone and the phone of the party that had been placed on hold rings to signify that the call is off hold and can be resumed. When the call back is answered the call is resumed. In a first embodiment, the callback on hold operation is performed in cooperation with a telecommunication company's central office switch. In a second embodiment, dedicated circuitry and microprocessor firmware are added to consumer telephone equipment, performing the callback on hold operation without requiting any specific support from a central office switch. The present invention is disclosed in the environments of telephones, answering machines, combination telephone and answering machines, both corded and cordless telephones (with or without answering machines), cellular telephones, and standalone devices attachable between a telephone and/or answering system and the central office telephone lines. A “hold on hold” indicator lamp may optionally be employed. The indicator lamp circuitry detects brief DTMF tone pairs to signal the operation of a hold LED with a unique cadence indicating of a callback hold, rather than a normal hold condition. | 07-14-2011 |
20110220223 | SANITARY FAUCET HANDLE HAVING MULTIPLE GRASPING REGIONS - A sanitary water faucet handle has multiple levers, or grasping regions. Each lever includes an associated indicator, identifying whether the particular grasping region is intended for use in turning the faucet's water supply on, or off. The indicator may be in the form of indicia applied to a portion of at least one of the levers, a coloration of at least one of the levers, a variation in the relative length of at least one of the levers, or a variation of the height of at least one of the levers relative to a bottom surface of the handle. The handle is attachable to a conventional water valve, permitting the handle to be retrofitted as a replacement handle in existing faucet systems. A supplemental lever or grasping region may be attachable or releasably attachable to a preexisting lever of a faucet system. A powered faucet lever may be provided that reconfigures itself to automatically present one of two separate sets of grasping regions, depending upon whether the associated faucet is activated or deactivated. | 09-15-2011 |
Patent application number | Description | Published |
20110237521 | SPLICE SWITCHING OLIGOMERS FOR TNF SUPERFAMILY RECEPTORS AND THEIR USE IN TREATMENT OF DISEASE - Methods and compositions are disclosed for controlling expression of TNF receptors (TNFR1 and TNFR2) and of other receptors in the TNFR superfamily using compounds that modulate splicing of pre-mRNA encoding these receptors. More specifically these compounds cause the removal of the transmembrane domains of these receptors and produce soluble forms of the receptor which act as an antagonist to reduce TNF-α activity or activity of the relevant ligand. Reducing TNF-α activity provides a method of treating or ameliorating inflammatory diseases or conditions associated with TNF-α activity. Similarly, diseases associated with other ligands can be treated in like manner. In particular, the compounds of the invention are splice-splice switching oligomers (SSOs) which are small molecules that are stable in vivo, hybridize to the RNA in a sequence specific manner and, in conjunction with their target, are not degraded by RNAse H. | 09-29-2011 |
20110269665 | COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY - Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic dystrophy DM1. | 11-03-2011 |
20120142759 | SOLUBLE THF RECEPTORS AND THEIR USE IN TREATMENT OF DISEASE - The present invention relates to splice switching oligonucleotides or splice switching oligomers (SSOs). The preferred SSOs according to the invention target exon 7 of TNFR1 (TNFRSF1A) or TNFR2 (TNFRSF1A) pre-mRNA, typically resulting in the production of TNFR variants which comprise a deletion in part or the entire exon 7 respectfully. SSOs targeting exon 7 are found to result in a soluble form of the TNFR, which has thereputic benefit for treatment of inflammatory diseases. The SSO's are characterized in that they are substantially incapable or incapable of recruiting RNaseH. | 06-07-2012 |
20140057968 | Splice Switching Oligomers for TNF Superfamily Receptors and Their Use in Treatment of Disease - Methods and compositions are disclosed for controlling expression of TNF receptors (TNFR1 and TNFR2) and of other receptors in the TNFR superfamily using compounds that modulate splicing of pre-mRNA encoding these receptors. More specifically these compounds cause the removal of the transmembrane domains of these receptors and produce soluble forms of the receptor which act as an antagonist to reduce TNF-α activity or activity of the relevant ligand. Reducing TNF-α activity provides a method of treating or ameliorating inflammatory diseases or conditions associated with TNF-α activity. Similarly, diseases associated with other ligands can be treated in like manner. In particular, the compounds of the invention are splice-splice switching oligomers (SSOs) which are small molecules that are stable in vivo, hybridize to the RNA in a sequence specific manner and, in conjunction with their target, are not degraded by RNAse H. | 02-27-2014 |
Patent application number | Description | Published |
20090105139 | Soluble HER2 and HER3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease - Soluble epidermal growth factor receptors 2 and 3 (HER2 and HER3) splice variant proteins with HER2 and HER3 antagonist activity and anti-proliferative properties, as well as the corresponding nucleic acids, are provided for treatment of proliferative diseases, in particular cancer. Also provided are compositions and methods for inducing expression of these splice variants, including splice switching oligonucleotides that modulate splicing of pre-mRNA that codes for these receptors. | 04-23-2009 |
20100016215 | COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY - An antisense compound for use in treating myotonic dystrophy DM1 or DM2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating DM1 or DM2 in a mammalian subject are disclosed. The oligonucleotide has 8-30 bases, with at least 8 contiguous bases being complementary to the polyCUG or polyCCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA in DM1 or DM2, respectively. Conjugated to the oligonucleotide is a cell-penetrating peptide having the sequence (RXRR(B/X)R) | 01-21-2010 |
20120058946 | COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY - An antisense compound for use in treating myotonic dystrophy DM1 or DM2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating DM1 or DM2 in a mammalian subject are disclosed. The oligonucleotide has 8-30 bases, with at least 8 contiguous bases being complementary to the polyCUG or polyCCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA in DM1 or DM2, respectively. Conjugated to the oligonucleotide is a cell-penetrating peptide having the sequence (RXRR(B/X)R) | 03-08-2012 |
20140024698 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA - Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin. | 01-23-2014 |
20140024821 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA - Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin. | 01-23-2014 |
20140107013 | COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY - Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic dystrophy DM1. | 04-17-2014 |
20150080311 | COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY - An antisense compound for use in treating myotonic dystrophy DM1 or DM2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating DM1 or DM2 in a mammalian subject are disclosed. The oligonucleotide has 8-30 bases, with at least 8 contiguous bases being complementary to the polyCUG or polyCCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA in DM1 or DM2, respectively. Conjugated to the oligonucleotide is a cell-penetrating peptide having the sequence (RXRR(B/X)R) | 03-19-2015 |
20150141321 | COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY - Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic dystrophy DM1. | 05-21-2015 |