Patent application number | Description | Published |
20110143397 | RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS - The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs. | 06-16-2011 |
20110143436 | COMPOSITIONS AND METHODS FOR REPROGRAMMING EUKARYOTIC CELLS - The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mRNA encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mRNA that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mRNA was introduced, and compositions therefor. For example, the present invention provides mRNA molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells. | 06-16-2011 |
20130189741 | COMPOSITIONS AND METHODS FOR REPROGRAMMING MAMMALIAN CELLS - The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mRNA encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mRNA that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mRNA was introduced, and compositions therefor. For example, the present invention provides mRNA molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells. | 07-25-2013 |
20140315988 | COMPOSITIONS AND METHODS FOR REPROGRAMMING EUKARYOTIC CELLS - The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mRNA encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mRNA that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mRNA was introduced, and compositions therefor. For example, the present invention provides mRNA molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells. | 10-23-2014 |
20140328825 | MAKING AND USING IN VITRO-SYNTHESIZED ssRNA FOR INTRODUCING INTO MAMMALIAN CELLS TO INDUCE A BIOLOGICAL OR BIOCHEMICAL EFFECT - The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides mRNA and methods for reprogramming cells that exhibit a first differentiated state or phenotype to cells that exhibit a second differentiated state or phenotype, such as to reprogram human somatic cells to pluripotent stem cells. | 11-06-2014 |
20150184123 | RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS - The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs. | 07-02-2015 |
20150315572 | RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS - The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs. | 11-05-2015 |
Patent application number | Description | Published |
20140279444 | PEER TO PEER EMAIL BASED FINANCIAL TRANSACTIONS - A method for peer-to-peer e-commerce transaction between a first user and a second user that is facilitated by a payment server is disclosed. The method including receiving a money request from a first user, wherein the money request identifies a second user from which money is requested. The method further including transmitting a money request email message to the second user, wherein the money request email includes a token and receiving a response email message to the money request email message, wherein the response email message includes the token. The method further including determining whether the second user is a member based on the received token and an email address associated with the response email message. | 09-18-2014 |
20140279553 | VENDOR TOKEN GENERATOR - A method for generating tokens for use in an email-based e-commerce transaction between third party vendor and a customer that is facilitated by a payment server is disclosed. The method may comprise generating a token for use with an email checkout, wherein the token comprises a customer name, and customer email address. The processor may generate an email message for at least one recipient, the email message including a mailto hyperlink including the token, wherein the mailto hyperlink generates an email response message addressed to the payment server including the token. The method may comprise receiving a notification from the payment server indicating that the at least one recipient that the email response message was successfully received by the payment server and the email-based e-commerce transaction is successful. | 09-18-2014 |
20150178819 | ALTERNATIVE EMAIL-BASED WEBSITE CHECKOUTS - An e-commerce system and method for facilitating transactions between a customer and a vendor is disclosed. The e-commerce system includes a receiver configured to receive a request for at least one token, the request including the details of at least one transaction for the purchase of at least one product, a processor configured to generate at least one token, a transmitter configured to transmit the at least one token to a customer browser, the customer browser being used to validate the token using at least one iframe, the receiver configured to receive submission in the iframe, the processor configured to decode the token, the processor configured to perform one or more validations, and the processor configured to process the transaction, on a condition that the validations are approved. | 06-25-2015 |
20150195227 | Email Based E-commerce Using Embedded Forms - A method implemented in an e-commerce system to facilitate transactions between a customer and a vendor using embedded forms. The method includes generating a form for use in an SMTP email campaign; generating at least one token and form information, wherein the token includes at least a type field and amount field, wherein the form information is configured to interact with an email client to automatically render a form with specified input fields; transmitting the token and the form information; receiving customer input details from the email client in an HTTP format; receiving a response email, wherein the response email includes input details requested in the specified input fields and a token; authenticating the response email; decoding the token; and processing a transaction based on the customer input details and the response email. | 07-09-2015 |
Patent application number | Description | Published |
20130069337 | ATV OR UTV DIFFERENTIAL WITH INTEGRATED SENSORS - A vehicle comprising a frame, a seat coupled to the frame, and left and right wheels. Left and right drive shafts transmit power to the left and right wheels, and an input shaft transmits power to the left and right drive shafts. A differential including a housing assembly receives power from the input shaft and divides the power between the left and right drive shafts. A speed sensor is positioned through (e.g., threaded) the housing assembly such that an inner end of the sensor is positioned inside the differential. In one embodiment, the speed sensor includes left and right speed sensors, and the at least two housings comprise a left housing and a right housing. Preferably, both the left speed sensor and the right speed sensor are positioned in one of the left housing and the right housing. | 03-21-2013 |
20130073157 | ENHANCED TORQUE MODEL FOR VEHICLE HAVING A CVT - A vehicle (e.g., an ATV/UTV) comprising a body, at least two wheels supporting the body, a power source providing torque to at least one of the wheels, a torque control system for controlling the torque provided to the wheels. The torque control system has a plurality of slip modes, including a low-slip mode and a high-slip mode. A mode selector is provided for selecting one of the plurality of slip modes, and the torque control system defaults to the low-slip mode on vehicle start up. Preferably, the torque control system further includes a medium-slip mode. In another aspect, the vehicle has a continuously-variable transmission including a drive member and a driven member, and a torque control system for controlling the torque provided to the wheels. The torque control system is programmed to calculate an estimated primary torque factor and an estimated secondary torque factor for modifying as base engine torque. | 03-21-2013 |
20140083793 | ELECTRO-HYDRAULIC POWER STEERING - A hydraulic steering assist assembly is provided for a vehicle with a mechanical steering assembly operable by a user to steer the vehicle. The hydraulic steering assist assembly includes a hydraulic actuator adapted to be coupled to the mechanical steering assembly and has a first side and a second side. A bi-directional hydraulic pump is placed in fluid communication with the first side and the second side of the hydraulic actuator. The hydraulic steering assist assembly further includes a valve in fluid communication with the first side and the second side of the hydraulic actuator, and a control system for controlling the bi-directional hydraulic pump and the valve. The bi-directional hydraulic pump provides a pressurized fluid to the hydraulic actuator, which applies a force on the mechanical steering assembly to assist steering the vehicle. The valve can act as a steering damper. | 03-27-2014 |
Patent application number | Description | Published |
20120246296 | METHOD AND A SYSTEM FOR ANALYSING TRAFFIC ON A WEBSITE INCLUDING MULTIPLE VISITS BY THE VISITORS - A method and a system for analysing traffic on a website are disclosed, the website being arranged on a server. The method comprises the steps of allowing a visitor to perform multiple visits on the website, and monitoring navigations and/or actions performed by the visitor during each visit while accumulating value points in accordance with content viewed by the visitor and actions performed by the visitor, and in accordance with predefined value point settings associated with content of the website, thereby obtaining a value point score for each visit. An origin of the first visit, leading the visitor to the website, is registered and categorised according to type of origin in accordance with two or more predefined categories of origin. An accumulated value point score for the visitor is obtained by adding the obtained value point scores of the first visit and each of the subsequent visit(s). Thereby the website owner obtains information regarding total value generated by the visitor during all visits and regarding what initially lead the visitor to the website. This allows the website owner to evaluate marketing campaigns and to focus and/or improve marketing efforts. | 09-27-2012 |
20130080244 | METHOD AND A SYSTEM FOR MANAGING ADVERTISING CAMPAIGNS - In a method and a system for managing advertising campaigns, a plurality of advertising campaigns is launched, and a plurality of visitors is allowed to visit a website. The behavior of the visitors is monitored, a value point score is obtained for each visit, and each visit is designated to an advertising campaign. For each advertising campaign an accumulated value point score and the number of visits designated to the advertising campaign are calculated. The advertising campaigns are compared, including comparing the accumulated value point scores and the number of visits. The comparison may include comparing attributes, elements or themes of the advertising campaigns. Based on the comparison a new advertising campaign is planned. Since the new advertising campaign is designed with consideration to the actual impact of previous advertising campaigns on the generated value, the new advertising campaign is very likely to fulfill specific marketing goals or strategies. | 03-28-2013 |
Patent application number | Description | Published |
20100125663 | SYSTEMS, METHODS, AND DEVICES FOR DETECTING SECURITY VULNERABILITIES IN IP NETWORKS - This invention is a system, method, and apparatus for detecting compromise of IP devices that make up an IP-based network. One embodiment is a method for detecting and alerting on the following conditions: (1) Denial of Service Attack; (2) Unauthorized Usage Attack (for an IP camera, unauthorized person seeing a camera image); and (3) Spoofing Attack (for an IP camera, unauthorized person seeing substitute images). A survey of services running on the IP device, historical benchmark data, and traceroute information may be used to detect a possible Denial of Service Attack. A detailed log analysis and a passive DNS compromise system may be used to detect a possible unauthorized usage. Finally, a fingerprint (a hash of device configuration data) may be used as a private key to detect a possible spoofing attack. The present invention may be used to help mitigate intrusions and vulnerabilities in IP networks. | 05-20-2010 |
20100169975 | SYSTEMS, METHODS, AND DEVICES FOR DETECTING SECURITY VULNERABILITIES IN IP NETWORKS - This invention is a system, method, and apparatus for detecting compromise of IP devices that make up an IP-based network. One embodiment is a method for detecting and alerting on the following conditions: (1) Denial of Service Attack; (2) Unauthorized Usage Attack (for an IP camera, unauthorized person seeing a camera image); and (3) Spoofing Attack (for an IP camera, unauthorized person seeing substitute images). A survey of services running on the IP device, historical benchmark data, and traceroute information may be used to detect a possible Denial of Service Attack. A detailed log analysis and a passive DNS compromise system may be used to detect a possible unauthorized usage. Finally, a fingerprint (a hash of device configuration data) may be used as a private key to detect a possible spoofing attack. The present invention may be used to help mitigate intrusions and vulnerabilities in IP networks. | 07-01-2010 |
Patent application number | Description | Published |
20100027948 | Cable Comprising a Shear Thickening Composition - Shear thickening compositions can function in an energy or communications transmission cable to provide enhanced protection against externally applied forces, e.g., cutting or puncture from a shovel. As a free or bound layer, or when used via impregnation into a substrate used for an internal component or wrap, the shear thickening composition provides protection against mechanical damage that far surpasses conventional technologies. In foamable compositions for cable components, the shear thickening composition provides enhanced integrity of the polymer melt for enhanced foam performance. As a flame retardant component, the shear thickening composition provides an enhanced char formation mechanism for superior flame retardance. | 02-04-2010 |
20110094772 | METHOD FOR PRODUCING WATER TREE-RESISTANT, TRXLPE-TYPE CABLE SHEATH - TRXLPE-type cable sheaths are prepared by a method in which a solid polymer is mixed with a liquid water tree-resistant agent either by dosing or direct injection. In the dosing method, the solid polymer, e.g., high pressure LDPE, is sprayed or otherwise contacted with the liquid agent, e.g., PEG, the agent is allowed to absorb into the polymer, and the polymer with absorbed agent is then fed to an extrusion apparatus for extrusion over a sheathed or unsheathed wire or optic fiber. In the direct injection method, the solid polymer is first fed to an extrusion apparatus, and the liquid agent is sprayed or otherwise contacted with the polymer before the two are blended with one another through the action of the mixing elements of the apparatus. | 04-28-2011 |
20110100675 | Reduction of Dielectric Losses Through Use of Organoclay in Semiconductor or Insulator Compositions - Organodavs are added to semiconductive compositions to provide a reduction in the dielectric losses of layered composites in which the semiconductive layer contains species which could migrate into the insulation and result in undesirably high dielectric losses, The invention semiconductive compositions provide improved performance in power cable applications. | 05-05-2011 |
20110147041 | Medium Voltage Cable Insulation - Compositions comprising:
| 06-23-2011 |
20130175070 | Coated Conductor with Voltage Stabilized Inner Layer - Disclosed are polymeric compositions with improved breakdown strength. The polymeric compositions contain a polyolefin and a voltage stabilizing agent. The voltage stabilizing agent contains a triazine. The triazine may include a substituent that enables keto-enol tautomerism, which provides the voltage stabilizing agent with additional energy dissipation capacity. The present polymeric compositions exhibit improved breakdown strength when applied as an insulating layer for power cable. | 07-11-2013 |
20130186670 | Polymeric Compositions with Voltage Stabilizer Additive - Disclosed are polymeric compositions with improved breakdown strength. The polymeric compositions contain a polyolefin and a voltage stabilizing agent. The voltage stabilizing agent is a diphenoxybenzene and/or a benzanilide. The present polymeric compositions exhibit improved breakdown strength when applied as an insulating layer for power cable. | 07-25-2013 |
20150299494 | CROSS-LINKABLE POLYMERIC COMPOSITIONS, METHODS FOR MAKING THE SAME, AND ARTICLES MADE THEREFROM - Cross-linkable polymeric compositions comprising an ethylene-based polymer, an organic peroxide, an optional cross-linking coagent, and an antioxidant. Such cross-linkable polymeric compositions are prepared by imbibing at least a portion of the organic peroxide, the optional cross-linking coagent, and the antioxidant into the ethylene-based polymer. Such cross-linkable polymeric compositions can be employed in forming coated conductors. | 10-22-2015 |
Patent application number | Description | Published |
20150203701 | CROSS-LINKABLE POLYMERIC COMPOSITIONS, METHODS FOR MAKING THE SAME, AND ARTICLES MADE THEREFROM - Cross-linkable polymeric compositions comprising an ethylene-based polymer, an organic peroxide, and a polyallyl cross-linking coagent, where the polyallyl cross-linking coagent and the organic peroxide are present in amounts sufficient to provide an allyl-to-active oxygen molar ratio of at least 1.6, based on the allyl content of the polyallyl cross-linking coagent and the active oxygen content of the organic peroxide. Such cross-linkable polymeric compositions can be employed in forming coated conductors. | 07-23-2015 |
20150291823 | ELASTOMER-BASED POLYMERIC COMPOSITIONS HAVING AMORPHOUS SILICA FILLERS - Polymeric compositions suitable for use as insulation materials in electrical applications. Such polymeric compositions comprise an ethylene/α-olefin-based elastomer and a filler, where the filler consists essentially of an amorphous silica. Such polymeric compositions can optionally further comprise an ethylene-based thermoplastic polymer. Also disclosed are coated conductors comprising such polymeric compositions as insulation materials. | 10-15-2015 |
20150299494 | CROSS-LINKABLE POLYMERIC COMPOSITIONS, METHODS FOR MAKING THE SAME, AND ARTICLES MADE THEREFROM - Cross-linkable polymeric compositions comprising an ethylene-based polymer, an organic peroxide, an optional cross-linking coagent, and an antioxidant. Such cross-linkable polymeric compositions are prepared by imbibing at least a portion of the organic peroxide, the optional cross-linking coagent, and the antioxidant into the ethylene-based polymer. Such cross-linkable polymeric compositions can be employed in forming coated conductors. | 10-22-2015 |
20160027550 | COATED CONDUCTOR WITH VOLTAGE-STABILIZED INNER LAYER - Disclosed are polymeric compositions with improved breakdown strength. The polymeric compositions contain a polyolefin and a voltage stabilizing agent, which is selected from one or more of a group of three specific triazine compounds. The present polymeric compositions exhibit improved breakdown strength when applied as an insulating layer for power cable. | 01-28-2016 |