Larson, MA
Brond Larson, Sharon, MA US
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20110093433 | MANAGING METADATA FOR GRAPH-BASED COMPUTATIONS - Determining metadata associated with a graph-based computation includes functionally transforming metadata associated with a first portion of a graph to generate transformed metadata associated with a second portion of the graph; determining a third portion of the graph related to the second portion of the graph; and propagating the transformed metadata from the second portion of the graph to the third portion of the graph. | 04-21-2011 |
20110154051 | SECURING EXECUTION OF COMPUTATIONAL RESOURCES - Controlling access to computational features includes: preparing a computational resource for execution by an execution system that has been provided a primary descriptor containing an identity value and that has associated a feature indicator with the primary descriptor; accessing a secondary descriptor containing the identity value and cryptographically assigned to the computational resource; and granting the computational resource access to a computational feature of the execution system based on the feature indicator. | 06-23-2011 |
20120102029 | MANAGING DATA SET OBJECTS - Managing data set objects for graph-based data processing includes: storing a group of one or more data set objects in a data storage system, the data set objects each representing a respective data set; and generating an association between at least a first data set object in the group and at least a first node of a dataflow graph for processing data in a data processing system, the first node representing a source or sink of data in a flow of data represented by a link in the dataflow graph, and the first data set object including a plurality of modes in which different transformational logic is applied to data processed by the first node. | 04-26-2012 |
20130297562 | MANAGING METADATA FOR GRAPH-BASED COMPUTATIONS - Determining metadata associated with a graph-based computation includes functionally transforming metadata associated with a first portion of a graph to generate transformed metadata associated with a second portion of the graph; determining a third portion of the graph related to the second portion of the graph; and propagating the transformed metadata from the second portion of the graph to the third portion of the graph. | 11-07-2013 |
20140189653 | CONFIGURABLE TESTING OF COMPUTER PROGRAMS - Configurable testing of a computer program includes: storing a set of one or more testing specifications, and attribute information defining one or more attributes of a recognizable portion of the computer program; and processing, using at least one processor, the computer program according to at least a first testing specification associated with the computer program. The processing includes: traversing a representation of the computer program that includes elements that represent recognizable portions of the computer program, and while traversing the representation, recognizing recognizable portions of the computer program, and storing values of attributes, defined by the attribute information, of the recognized portions of the computer program. | 07-03-2014 |
20150160926 | MANAGING INTERFACES FOR SUB-GRAPHS - Combining specifications of dataflow graphs includes receiving: a first dataflow graph specification that specifies two or more components connected by links representing flows of data, and a second dataflow graph specification that specifies at least one component, and at least one sub-graph interface. The sub-graph interface includes at least one flow junction representing a connection between: (1) a flow of data outside the sub-graph interface, and (2) a flow of data inside the sub-graph interface. The method includes processing information including the first dataflow graph specification and the second dataflow graph specification, to generate a combined dataflow graph specification, including: identifying an association between the sub-graph interface and the first dataflow graph specification, for at least a first flow junction, determining a direction associated with transferring a value of a descriptor, and transferring a value of a descriptor according to the determined direction. | 06-11-2015 |
Dale Larson, Waban, MA US
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20090019877 | Systems, Methods and Devices for Frozen Sample Distribution - A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software. | 01-22-2009 |
20120264224 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 10-18-2012 |
20130333399 | Systems, methods, and devices for frozen sample distribution - A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software. | 12-19-2013 |
20140273276 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 09-18-2014 |
20140283536 | Systems, methods, and devices for frozen sample distribution - A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software. | 09-25-2014 |
Dale N. Larson, Waban, MA US
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20100120163 | ULTRA-SENSITIVE TEMPERATURE SENSING AND CALORIMETRY - Methods and apparatus for ultra-sensitive temperature sensing and calorimetry. Radiation is directed at a thin electrically conductive film having one or more small apertures. The incident radiation excites surface plasmons on a first surface of the electrically conductive film, and energy associated with the surface plasmons couples to an opposite surface of the electrically conductive film, where surface plasmon-enhanced radiation (SPER) is emitted from the aperture(s). A temperature-sensitive fluid or solid dielectric material is disposed contiguous with at least a portion of the electrically conductive film, such that a temperature change in the dielectric material alters a resonance condition for the SPER. Measureable changes in the SPER due to altered resonance conditions provide for an ultrasensitive temperature sensor that can detect small temperature changes in the dielectric material. The disclosed methods and apparatus may be used for a variety of applications including, but not limited to, nanoscale to microscale calorimetry for pharmaceutical and biotechnology products, combustion sensing, explosive detection, and biotoxin monitoring. | 05-13-2010 |
20140335554 | APPARATUS AND METHODS FOR ALIQUOTTING FROZEN SAMPLES - A method of obtaining an aliquot of a frozen sample contained in a container includes moving a coring device into the sample and then withdrawing it to obtain a frozen sample core. The location from which the core is taken is selected to be at a radial position where the concentration of at least one substance of interest in the frozen sample core is representative of the overall concentration of that substance in the sample notwithstanding any concentration gradients that may exist in the frozen sample. Another method includes taking two different frozen sample cores from the same sample from radial positions selected such that the concentration of one or more substances of interest in the combined sample cores is representative of the overall concentration of said at least one substance in the sample notwithstanding any radial concentration gradients. A robotic system is programmed or hardwired to implement the methods. | 11-13-2014 |
Earl T. Larson, Somerville, MA US
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20100330573 | OPTIMIZED OLIGONUCLEOTIDES AND METHODS OF USING SAME FOR THE DETECTION, ISOLATION, QUANTIFICATION, MONITORING AND SEQUENCING OF BORDETELLA - Described herein are oligonucleotides useful for detecting, isolating, quantitating, monitoring and sequencing | 12-30-2010 |
Erik Larson, Newton Centre, MA US
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20100040844 | SYSTEM AND METHOD FOR COLOR-CHANGING DECORATIVE CONSTRUCTION MATERIALS - A system and method for decorative elements having multiple visual appearances. The decorative elements may present different colors and/or other visual appearance characteristics and yet function as a durable construction material, like a traditional brick, tile or shingle. The decorative elements may receive a mechanical operation that permanently physically alters the decorative element, such as a cutting, sawing, drilling or molding operation, while the decorative element is functional to provide a controllable visual appearance both before and after the physical alteration. The decorative elements may be autonomous in that power needed to change visual appearance states can be gathered by an integrated energy harvesting device, such as a solar cell. A color chip system may be used to select decorative element features. | 02-18-2010 |
Heather Larson, Boston, MA US
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20120289994 | Occlusion Devices and Related Methods of Use - Embodiments of a medical device and related methods of use are provided in the disclosure. The medical device includes an elongate member having a first end and a second end. The elongate member may also include a plurality of radial projections such that each radial projection extends in a spiral configuration along a length of the elongate member. The medical device may be configured to transition between a compressed delivery configuration and an expanded deployed configuration. | 11-15-2012 |
Jonathan Larson, Chelsea, MA US
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20110000560 | Manipulation of Microfluidic Droplets - The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control. | 01-06-2011 |
20140076430 | MANIPULATION OF MICROFLUIDIC DROPLETS - The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control. | 03-20-2014 |
Jonathan W. Larson, Chelsea, MA US
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20100294665 | METHOD AND SYSTEM FOR TRANSFERRING AND/OR CONCENTRATING A SAMPLE - A system for transferring and/or concentrating a sample is provided. The system includes a chamber with a membrane brave positioned within the chamber. An electrode assembly is configured to create an electric field across the membrane to move a charged sample through the chamber such that the sample collects and may concentrate on the membrane. The system may include a plurality of membranes. The system may also include a plurality of microchannels outwardly extending from the channel, where the membrane extends along the plurality of microchannels. Aspects of the invention are also directed to a pipette which may be used to transfer and concentrate a sample on a membrane. Certain embodiments are directed to methods and systems for concentrating a nucleic acid sample. | 11-25-2010 |
20130000738 | METHOD AND SYSTEM FOR TRANSFERRING AND/OR CONCENTRATING A SAMPLE - A method of controlling the concentration of a sample flowing through a microchannel is provided. The method includes flowing a sample carrier fluid from a sample carrier channel and into an upstream portion of a microchannel such that the sample carrier fluid flows from the upstream portion and toward a downstream portion of the microchannel, and flowing a sheathing fluid from a sheathing fluid channel and into the upstream portion of the microchannel such that the sheathing fluid flows from the upstream portion and toward the downstream portion of the microchannel, and generally parallel to the sample carrier fluid. The method further includes detecting a concentration of a sample in the sample carrier fluid in the downstream portion of the microchannel, and adjusting a flow rate of at least one of the sample carrier fluid and the sheathing fluid based upon the detected concentration of the sample. | 01-03-2013 |
Jonathan William Larson, Chelsea, MA US
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20110244455 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 10-06-2011 |
20110250597 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 10-13-2011 |
20120219947 | METHODS FOR FORMING MIXED DROPLETS - The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet. | 08-30-2012 |
20130196324 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 08-01-2013 |
20140329239 | DIGITAL ANALYTE ANALYSIS - The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons. | 11-06-2014 |
20150027892 | MANIPULATION OF MICROFLUIDIC DROPLETS - The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control. | 01-29-2015 |
Kent Larson, Boston, MA US
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20160031090 | APPARATUSES, SYSTEMS, AND METHODS FOR TRANSFORMABLE LIVING SPACES - The present disclosure provides apparatuses, methods and systems operable to provide transformable living spaces. The system includes a chassis and a configurable unit movably coupled to the chassis for at least one of translation and rotation with respect to the chassis. The system also includes at least one drivetrain assembly movably coupling the configurable unit to the chassis. The system includes at least one actuator coupled to the configurable unit by the at least one drivetrain assembly. The system also includes at least one robotic controller communicatively coupled to the at least one actuator. | 02-04-2016 |
Martin Larson, Chestnut Hill, MA US
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20110311650 | MULTIPLEXED BIOMARKERS OF INSULIN RESISTANCE - The invention, in some aspects, relates to methods for characterizing glucose-related metabolic disorders. In some aspects, the invention relates to methods and kits useful for diagnosing, classifying, profiling, and treating glucose-related metabolic disorders. In some aspects, the invention relates to methods useful for diagnosing, classifying, profiling, and treating diabetes. | 12-22-2011 |
Noble G. Larson, Arlington, MA US
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20160025478 | Real Time FPGA Resampling for Swept Source Optical Coherence Tomography - Real-time swept source OCT data is most often sampled using a specially cut hardware k-clock. The present invention involves mathematically resampling signals within an FPGA-based data acquisition board based on data sampled from a wide free spectral range reference interferometer. The FPGA can then multiply up the reference clock rate to achieve greater imaging depth. The Nyquist fold-over depth can thus be programmed from a standard reference to an arbitrary depth, much as PLL frequency synthesizer can produce many frequencies from a standard stable reference. The system is also capable of real-time performance. | 01-28-2016 |
Richard C. Larson, Lexington, MA US
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20130138511 | METHODS AND SYSTEMS TO SCHEDULE ONLINE CONTENT DELIVERY - Methods and systems to schedule delivery of items of content selectively to online users are described. In various embodiments, a method of scheduling delivery of multiple items of content selectively to a plurality of online users is disclosed. The method includes determining expected values relating to each user being online during a given time period, and generating an ordered list of the multiple items of content to be selectively delivered to each of the plurality of online users based on the expected values. Other methods and systems are disclosed. | 05-30-2013 |
Roger C. Larson, East Bridgewater, MA US
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20090286432 | Apparatus Having A Buoyant Structure That Resists Rotation - Apparatus includes a buoyant structure having a central vertical axis when floating in water and having at least one feature to reduce a rotation of the buoyant structure about the central vertical axis when floating in the water. The apparatus further includes an electronic camera assembly coupled to the buoyant structure. The electronic camera assembly is configured to generate an electronic image signal. The apparatus further includes a tubular structure coupled to the buoyant structure and configured to remain under the surface of the water. The tubular structure includes a watertight compartment and an electronic circuit assembly disposed within the watertight compartment. The electronic circuit assembly is coupled to receive the electronic image signal and is configured to generate an optical image signal representative of the electronic image signal. The apparatus further includes a fiber optic cable configured to carry the optical image signal. | 11-19-2009 |