Firth, GB
Andrew E. Firth, Cambridgeshire GB
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20150190495 | ARTERIVIRUS PROTEIN AND EXPRESSION MECHANISMS - The invention provides the discovery and characterization of a novel arterivirus protein (nsp2TF), whose expression is dependent on −2 ribosomal frameshifting at a site located in the nsp2 coding region. The coding region for the unique TF domain of nsp2TF overlaps the part of ORF1a that encodes the transmembrane region of nsp2 in arteriviruses, including PRRSV, LDV and SHFV. Mutations affecting the expression of nsp2TF impair PRRSV replication and result in a smaller plaque phenotype. Provided herein are arteriviruses that display reduced translation of nsp2TF and/or altered translation of one or more downstream products, arteriviruses in which nsp2TF function is reduced and/or absent, and vaccines comprising said arteriviruses. Also provided herein are diagnostic methods, methods for identifying compounds that inhibit −2 frameshifting, and gene expression tools for eukaryotic systems utilizing −2 frameshifting. | 07-09-2015 |
Charles Basil Firth, Newcastle-Upon-Tyne GB
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20120186421 | Mine Detonating Apparatus - A steerable mine detonation apparatus is adapted to be pushed by a steered vehicle. The apparatus comprises a frame and at least two spaced apart ground engaging members adapted to support the apparatus and adapted to exert a force on mines in the apparatus' path of sufficient to cause detonation thereof. At least one ground engaging member is steerable, and at least one steerable ground engaging member is attached to the frame so as to pivot with respect thereto about a substantially vertical axis and is connected to a steering linkage, the apparatus further comprising a steering mechanism operatively connected to the steering linkage and, in use, to the pushing vehicle. An actuator adapted to vary the configuration of the steering mechanism, is controlled to provide that, in use, the turning radius of at least a part of the innermost ground engaging member is less than or equal to the turning radius of the innermost wheel of the pushing vehicle, and the turning radius of at least a part of the outermost ground engaging member is greater than or equal to the turning radius of the outermost wheel of the pushing vehicle. | 07-26-2012 |
20140157975 | MINE DETONATING APPARATUS - A steerable mine detonation apparatus is adapted to be pushed by a steered vehicle. The apparatus comprises a frame and at least two spaced apart ground engaging members adapted to support the apparatus and adapted to exert a force on mines in the apparatus' path of sufficient to cause detonation thereof. At least one ground engaging member is steerable, and at least one steerable ground engaging member is attached to the frame so as to pivot with respect thereto about a substantially vertical axis and is connected to a steering linkage, the apparatus further comprising a steering mechanism operatively connected to the steering linkage and, in use, to the pushing vehicle. An actuator adapted to vary the configuration of the steering mechanism. | 06-12-2014 |
Daniel Firth, Fife GB
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20130085087 | PYROMELLITAMIDE GELLING AGENTS - A downhole fluid comprises a base fluid, for example a hydrocarbon base fluid, and a pyromellitamide gelling agent. The pyromellitamide gelling agent may have the general formula of: | 04-04-2013 |
20140284059 | AMIDE BRANCHED AROMATIC GELLING AGENTS - A downhole fluid comprises a base fluid, for example a hydrocarbon base fluid, and a gelling agent. The gelling agent has an aromatic core of one or more aromatic rings, the gelling agent having two or more amide branches distributed about the aromatic core, each of the two or more amide branches having one or more organic groups. An example gelling agent is a pyromellitamide gelling agent. The pyromellitamide gelling agent may have the general formula of: | 09-25-2014 |
Daniel Firth, St. Andrews GB
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20140142004 | AMIDE BRANCHED AROMATIC GELLING AGENT ENHANCERS AND BREAKERS - A downhole fluid comprises a base fluid, for example a hydrocarbon base fluid, a gelling agent, and a gel enhancer. The gelling agent has an aromatic core of one or more aromatic rings, the gelling agent having two or more amide branches distributed about the aromatic core, each of the two or more amide branches having one or more organic groups. An example gelling agent is a pyromellitamide gelling agent. A method of making a downhole fluid, the method comprising: combining a base fluid, a gelling agent, and a gel enhancer. A downhole fluid comprising a base fluid, a gelling agent, a breaker, and a gel enhancer. Downhole fluids with such gels and a breaker are also disclosed. | 05-22-2014 |
Graeme Andrew Firth, West Yorkshire GB
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20090299049 | Bicyclic Compounds and Their Use - The present invention provides fluorescent bicyclic compounds of the formula (I); wherein ring A, the broken lines -----, C | 12-03-2009 |
Gregory James Firth, Sheffield GB
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20150202427 | DEVICE FOR AUGMENTING BLOOD FLOW, TISSUE PERFUSION AND FLUID DISTRIBUTION BY NEUROMUSCULAR STIMULATION IN HORSES AND OTHER NON-HUMAN MAMMALS - The invention relates to a method and device for neuromuscular stimulation of one or more muscles, or muscle groups, with one or more beneficial effects selected from increasing arterial, venous and capillary blood flow, increasing flux of interstitial fluid and lymphatic drainage, increasing tissue oxygenation, enhancing heat distribution, enhancing the distribution of pharmaceutical products, and enhancing performance and recovery from exertion in horses. | 07-23-2015 |
Ian Firth, Cambridge GB
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20150264026 | METHOD AND SYSTEM FOR SECURELY TRANSMITTING VOLUMES INTO CLOUD - A first computing device is provided for transmitting one or more volumes via a secured connection. The first computing device includes a controller that is executable by one or more processors and is configured to instruct a cloud computing device to generate a worker virtual machine. The controller is also configured to provide authentication information to facilitate establishing of the secured connection between the controller and the worker virtual machine. The controller is further configured to instruct the cloud computing device to generate one or more target volumes associated with the cloud computing service and to associate the one or more target volumes with the worker virtual machine. The controller is further instructed to provide, irrespective of the content type of the volumes and the size of the volumes, the one or more volumes to the worker virtual machine via the secured connection. | 09-17-2015 |
James Dalton Firth, Farnham, Surrey GB
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20160080804 | MONITORING MEDIA PLAYBACK - A method of monitoring media playback includes outputting media content from a server over a network to a client device, and receiving at the server from the client device, a plurality of beacon signals, each beacon signal having at least one pair of timing data items. A first data item in the pair represents a point in time in the media content and a second data item in the pair represents a time indicated by a real time clock of the client device at which time the part of media content corresponding to the point in time was being played by the client device. The at least one of processed or stored beacon signals are at the server so as to monitor the playback of the media content by the client device. | 03-17-2016 |
James Donald Firth, London GB
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20100298339 | [1,2,4]Triazolo[1,5-a]Pyridine and [1,2,4]Triazolo[1,5-c]Pyrimidine Compounds and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc. | 11-25-2010 |
20140155594 | [1,2,4]Triazolo[1,5-a]Pyridine and [1,2,4]Triazolo[1,5-c]Pyrimidine Compounds and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc. | 06-05-2014 |
20150246915 | [1,2,4]Triazolo[1,5-a]Pyridine and [1,2,4]Triazolo[1,5-c]Pyrimidine Compounds and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc. | 09-03-2015 |
Mark Firth, Buckinghamshire GB
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20090049965 | BOOK TRIMMING APPARATUS - The book trimming apparatus comprises guides ( | 02-26-2009 |
20140130648 | BOOK TRIMMING APPARATUS - The book trimming apparatus includes guides which direct a collated and, optionally, bound book to a fore-edge trimming station. The book trimming apparatus further includes a transfer station and a side-edge trimming station. For both the fore-edge trimming station and the side-edge trimming station in each case the book is orientated so that the edge to be trimmed is arranged substantially parallel to the direction of motion of the book. The automated book trimming apparatus is particularly suited for use in combination with collation and binding stations in in-line book manufacture. | 05-15-2014 |
Mark R. Firth, Halifax GB
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20100114454 | TURBOCHARGED INTERNAL COMBUSTION ENGINE - A control system for controlling the supply of oil to a turbocharger fitted to an internal combustion comprises an oil supply valve ( | 05-06-2010 |
Neil Firth, Cambridgeshire GB
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20090129613 | Acoustic device - An assembly ( | 05-21-2009 |
Paul Firth, Devon GB
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20120106984 | OPTICAL CHIPS AND DEVICES FOR OPTICAL COMMUNICATIONS - Optical devices are disclosed consisting of optical chips (planar lightwave circuits) which have optically symmetric or matching designs and properties and optical components which create asymmetry in the optical devices. The devices find application in detection in coherent and non-coherent optical communications systems. | 05-03-2012 |
20150263483 | Optoelectronic Assembly - The invention relates to an optoelectronic assembly. The optoelectronic assembly comprises one or more optoelectronic components and a housing. The housing comprises an outer wall electrically connected to the one or more optoelectronic elements. The housing is configured to provide an electrical interface between the one or more optoelectronic components and an external electronic device. The electrical connection between the outer wall and the one or more optoelectronic components comprises an electrically conductive element. The electrically conductive element is supported on a dielectric material, such that the dielectric material provides structural support to the electrically conductive element between the one or more optoelectronic components and the outer wall. | 09-17-2015 |
Paul Firth, Nr Totnes GB
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20130016437 | LENSAANM Firth; PaulAACI Nr TotnesAACO GBAAGP Firth; Paul Nr Totnes GB - The invention relates to a lens comprising two or more seating surfaces and an optical axis offset from the centre of the lens such that the optical axis is spaced by a first distance from a first seating surface and by a second distance from a second seating surface. The first and second distances are different so that the lens can be orientated to provide at least two different optical axis heights depending upon which seating surface is chosen to seat the lens. | 01-17-2013 |
Paul Firth, Stoke Gabriel GB
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20120282473 | SURFACE TREATMENTS AND COATINGS - A method of treating a surface for an electronic or optoelectronic component to be bonded with adhesive, and a substrate comprising a ceramic surface for an electronic or optoelectronic component. A coating is applied to the surface that causes a reduction in the surface energy of the surface. | 11-08-2012 |
Paul Firth, Caswell Towcester GB
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20130114629 | ENCLOSURE FOR A LASER PACKAGE - An enclosure for a laser package the enclosure being configured to receive a laser component within the enclosure, and further configured to receive for a driver integrated circuit (IC) ( | 05-09-2013 |
Polly Firth, Oxfordshire GB
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20130001230 | BEVERAGE CAN WITH DISC - A beverage can ( | 01-03-2013 |
Robert Firth, York North Yorkshire GB
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20150174756 | APPARATUS FOR USE WITH POWER TOOLS - The invention relates to apparatus ( | 06-25-2015 |
20160075051 | POWER TOOL - The invention relates to powered cutting apparatus which includes a cutting unit mounted on one or more slide members and provided to perform a cutting action on a workpiece mounted on a base to which the one or more slide members are attacked by support legs. The apparatus includes at least one fence with a contact surface for the workpiece and the fence can be selectively positioned on any of a plurality of guide means provided on the base to aid in the performance of the cutting action. | 03-17-2016 |
Robert Firth, York GB
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20080211154 | Apparatus Including Spring and Method For Tensioning the Same - The invention to which this application relates is to a mechanism for the tensioning of a spring, typically a coil spring ( | 09-04-2008 |
Robert Firth, Pocklington GB
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20100236368 | SAW WITH CIRCULAR BLADE - The invention relates to a powered saw ( | 09-23-2010 |
20140090534 | SAW WITH CIRCULAR BLADE - The invention relates to a powered saw ( | 04-03-2014 |
Robert Firth, North Yorkshire GB
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20100263511 | POWER TOOL CUTTING APPARATUS - The invention relates to apparatus for providing for the powered cutting of a workpiece, typically in the form of a planar or sheet material. The apparatus includes a rotatable blade to cut the workpiece and the blade is mountable such as in a first mode of use to be capable of being held in a fixed position in which the workpiece is moved past the blade, and a second mode of use in which the blade is moved with respect to the workpiece to cut the same. The workpiece is mounted on a base and the blade is mounted with respect to the base via one or more slide members ( | 10-21-2010 |
Steven Firth, London GB
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20110178379 | TISSUE ASSESSMENT - A method of aiding in the diagnosis or prediction of degenerative joint disease in a joint of a patient. The method comprises obtaining a test spectrum of Raman scattered radiation from cartilage tissue in the joint, and analysing the test spectrum, or one or more regions thereof, to assess whether the test spectrum is consistent with the patient having, or subsequently developing, degenerative joint disease in the joint. | 07-21-2011 |