Mark Smith
Mark Smith, Ringgold, GA US
Patent application number | Description | Published |
---|---|---|
20110087662 | VISUAL ORGANIZATION OF INFORMATION VIA ASSOCIATED GEOSPATIAL DATA - In a method of organizing information, a plurality of diverse data items is accessed. The diverse data items are related to a physical location. The diverse data items that are accessed comprise at least a non-visual data item and a visual imagery data item, and include geospatial data associated with the individual accessed data items. The diverse data items are parsed by data type and stored in a data store such that the diverse data items are accessible by one or more of the geospatial data associated with the individual data items. Diverse data items related to the physical location are processed to produce an integrated image displayable via a web viewer. The processing occurs in response to receiving a request regarding the physical location. The integrated image comprises an integration of at least two of the stored diverse data items. | 04-14-2011 |
Mark Smith, York GB
Patent application number | Description | Published |
---|---|---|
20100297208 | SCAFFOLD - The present invention relates to scaffolds which can be used as medical devices for guided tissue regeneration and repair, in particular the invention is directed to a scaffold comprising fibres having a mean fibre diameter of between from about 1.2 to 4.0 microns, wherein the fibres comprise a glycolide. The invention further relates to the use of the scaffolds for the selective capture of cell populations for a cell source material. | 11-25-2010 |
20140249513 | TISSUE HARVESTING - The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus. | 09-04-2014 |
20140288534 | TISSUE HARVESTING - The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus. | 09-25-2014 |
Mark Smith, Essex GB
Patent application number | Description | Published |
---|---|---|
20090325172 | Modified nucleotides - The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H. | 12-31-2009 |
20100292452 | Modified nucleotides - The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H. | 11-18-2010 |
Mark Smith, Mill Valley, CA US
Patent application number | Description | Published |
---|---|---|
20100171021 | HOLDER SYSTEMS FOR MOBILE DEVICES - A holder system for mobile devices includes a generally rectangular holder base and a holder configured to secure the mobile device therein. The holder may be removably attachable to the holder base. A retractor mechanism may be attached to the holder base. The holder base includes a pair of spaced cord ports, each cord port receiving a line part of a retractable cord that is engaged to the retractor mechanism. | 07-08-2010 |
Mark Smith, Marion, OH US
Patent application number | Description | Published |
---|---|---|
20100154106 | IMPACT AND/OR VIBRATION ABSORBENT MATERIAL AND PROTECTIVE ARTICLES MAKING USE THEREOF - An impact and/or vibration absorbent material and protective articles making use of said material. An impact and/or vibration absorbent material of the present invention has at least two material layers. The individual layers of the impact and/or vibration absorbent material may be of different materials, or of the same material with the composition of the material of one layer adjusted to be of dissimilar hardness to an adjacent layer. Each material layer preferably contains a number of holes. The holes in one layer are located and arranged to be offset from the holes in an adjacent layer. The combination of material properties and the inclusion and arrangement of holes renders such a material highly impact and/or vibration absorbent. Through use of a protective article of the present invention, the effects of impact and/or vibration forces on a user of the protective article can be minimized. | 06-24-2010 |
Mark Smith, Cleveland, OH US
Patent application number | Description | Published |
---|---|---|
20100113358 | LEPTIN COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE COGNITIVE FUNCTION DISORDERS RESULTING FROM ACCUMULATION OF NEUROFIBRILLARY TANGLES AND AMLYOID BETA - The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles. | 05-06-2010 |
Mark Smith, Wilmington, DE US
Patent application number | Description | Published |
---|---|---|
20100034741 | Imaging agents and methods of imaging alpha7-nicotinic cholinergic receptor - The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the α7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express α7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity. | 02-11-2010 |
Mark Smith, Natrona Heights, PA US
Patent application number | Description | Published |
---|---|---|
20100023303 | Method, Apparatus, and System for Non-Invasive Monitoring of Underground Installations - A system for non-invasive monitoring of an underground installation includes at least one monitoring installation associated with the underground installation; at least one analyzer mechanism configured to measure at least one physical characteristic associated with the at least one monitoring installation and transmit a data set at least partially representative of the at least one measured physical characteristic; and at least one computer having a computer-readable medium having stored thereon instructions, which, when executed by a processor of the computer, causes the processor to implement the instructions. The at least one computer is in communication with an input mechanism and a display unit. The at least one computer includes programming instructions adapted to operate the processor to receive the transmitted data set, and adapted to operate the processor to determine a location of the monitoring installation based at least in part on the transmitted data set. | 01-28-2010 |
Mark Smith, Tarzana, CA US
Patent application number | Description | Published |
---|---|---|
20090260060 | RICH MEDIA COLLABORATION SYSTEM - A user annotates a shared document with text, sound, images, video, an e-mail message, graphics, screen snapshots, web site snapshots to share with others. The document and its annotations are stored in a digital object repository to which other users have access. Within the closed collaboration system, only users who are authenticated may upload digital objects, annotate digital objects and view objects and their annotations. The user sends a message to other users to invite them to view the object and its annotations and to add their own annotations. An annotated object generates an alert for all of the invited users. A remote authentication gateway authenticates users and has a repository for user metadata. Digital object repositories are separate from the authentication gateway, thus providing for disintermediation of the user metadata from the digital object data. The collaboration system may be hosted by a third party on a server computer available over the Internet that displays a web site. A user is not required to have collaboration system software on his or her computer and may annotate any image on the web site for later viewing by other users of the web site. | 10-15-2009 |
Mark Smith, Romeoville, IL US
Patent application number | Description | Published |
---|---|---|
20090014479 | Child resistant closure for a tap - The present invention provides a tap assembly including: (1) a first wall defining a valve chamber having a top surface and a pair of opposed tracks extending axially along an inner surface of the wall, and a fluid outlet; (2) a tap handle mounted to the top surface for rotational movement of the tap handle with respect to the wall, the tap handle having a second wall defining an annular chamber supporting a set of threads; and (3) a generally tubular valve member having a first end and an opposed second end, the first end having a pair of lugs circumferentially spaced from one another, the lugs being positioned within the threads, the second end of the valve member extending into the valve chamber, the valve member is responsive to movement of the tap handle to move from a first position where the fluid outlet is sealed by the second end of the valve member to a second position where the fluid outlet is not sealed by the second end of the valve member and fluid is allowed to flow through the fluid outlet. | 01-15-2009 |
Mark Smith, San Francisco, CA US
Patent application number | Description | Published |
---|---|---|
20090012034 | Non-Nucleoside reverse transcriptase inhibitors - Compounds of formula I, wherein R | 01-08-2009 |
20140341847 | 4'-FLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION - The present disclosure relates to the compound of Formula I: | 11-20-2014 |
20140341848 | 4'-AZIDO, 3'-DEOXY-3'-FLUORO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION - The present disclosure relates to the compound of Formula I: | 11-20-2014 |
20140369959 | 4'-AZIDO, 3'-FLUORO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION - The present invention relates to the use of nucleoside derivatives of formula (I) wherein the symbols are as the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds. | 12-18-2014 |
20150225441 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication - The application discloses nucleoside derivatives of Formula I as inhibitors of Influenza RNA replication. In particular, the application discloses the use of purine and pyrimidine nucleoside derivatives of Formula I as inhibitors of Influenza RNA replication and pharmaceutical compositions containing such compounds. | 08-13-2015 |
Mark Smith, London CA
Patent application number | Description | Published |
---|---|---|
20080287873 | METHOD AND APPARATUS FOR CONTROLLING OPERATION OF A SYRINGE - A system is provided for controlling operation of a syringe. The system comprises a controller having an interface and at least one input mechanism; and a syringe gun communicably connected to the controller. The syringe gun comprises an elongated body with an open faced barrel cradle and open faced plunger bay for holding a syringe in the body, a plunger cradle moveable within the plunger bay for operating on a plunger of the syringe, and an actuating device for moving the plunger cradle according to a control signal. The controller generates the control signal for controlling the syringe gun. | 11-20-2008 |
Mark Smith, Huby GB
Patent application number | Description | Published |
---|---|---|
20080243028 | TISSUE HARVESTING - The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed. | 10-02-2008 |
20140308742 | Tissue Harvesting - The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed. | 10-16-2014 |
20140309651 | Tissue Harvesting - The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed. | 10-16-2014 |
20140309652 | Tissue Harvesting - The present disclosure relates to a tissue collection apparatus. The tissue collection apparatus comprises a housing defining an inlet and an outlet, a first filter disposed within the housing, a second filter disposed within the housing, the second filter configured to isolate tissue particles of a desired size that pass through the first filter under the application of an aspiration force applied through the housing. A method of harvesting tissue is also disclosed. | 10-16-2014 |
Mark Smith, Huby, NY US
Patent application number | Description | Published |
---|---|---|
20080243029 | TISSUE HARVESTING - The present disclosure relates to a tissue collection apparatus including a housing defining an inlet and an outlet and a tissue scaffold suitable for disposal within the housing, the tissue scaffold configured to be loaded with the tissue under the application of an aspiration force applied through the tissue collection apparatus. | 10-02-2008 |
Mark Smith, Fleet GB
Patent application number | Description | Published |
---|---|---|
20080219472 | Noise suppressor - A method of determining noise in an audio stream, the method comprising: acquiring a plurality of consecutive time frames of the audio stream each comprising samples of the audio stream; generating a discrete frequency spectrum for each frame responsive to the frame samples; partitioning the frequency spectrum of each frame into a plurality of same frequency bands; determining an audio energy for each frequency band in each frame; and determining an estimate of noise energy for each frequency band in a temporally last time frame responsive to a relatively small number of smallest values for the audio energy in the frequency band of the plurality of time frames. | 09-11-2008 |
Mark Smith, Leicester, MA US
Patent application number | Description | Published |
---|---|---|
20110250825 | Tool for removing grout, mortar and the like - A grout removal tool includes a cover shaped to define a substantially enclosed interior cavity and a grinding assembly designed to simultaneously abrade grout from multiple, non-linear tile joints. The grinding assembly includes a motor-driven shaft that is rotatably coupled to the cover by a pair of ball bearings. The grinding assembly additionally includes two or more grinding elements that are axially mounted on the shaft in a spaced apart relationship, each grinding element including at least one disc-shaped grinding wheel. A vacuum attachment is externally mounted on the cover and is in communication with the interior cavity through a plurality of circular openings formed in the cover in direct alignment with the grinding elements. One end of the vacuum attachment is preferably connected to a vacuum device that forcibly withdraws and contains debris created during the grout grinding process. | 10-13-2011 |
Mark Smith, Denver, CO US
Patent application number | Description | Published |
---|---|---|
20110283173 | METHODS AND SYSTEMS FOR DESIGNING PHOTO BOOKS - A method of creating a photo book based on a user-selected, predefined theme is disclosed. During creation of the photo book, design options such as styles, layouts, and design elements are adjusted dynamically based on the selected theme. | 11-17-2011 |
Mark Smith, Plainfield, IL US
Patent application number | Description | Published |
---|---|---|
20120031923 | CLOSURE VALVE ASSEMBLY FOR A CONTAINER - The present invention provides a closure assembly for a container having a housing, a retaining ring and a valve. The closure assembly is useful for attachment to a container to provide flowable, aseptic access to the contents of the container. | 02-09-2012 |
20130126561 | CLOSURE VALVE ASSEMBLY FOR A CONTAINER - The present invention provides a closure assembly for a container assembly for a container having a housing with a fluid passage, a retaining ring attached to an inner surface of a wall of the housing and having a sloping centering flange, and a valve positioned in the housing and sealing the fluid passage. | 05-23-2013 |
20140209643 | CLOSURE VALVE ASSEMBLY FOR A CONTAINER - A closure assembly for a container having a housing with a fluid passage, a retaining ring attached to an inner surface of a wall of the housing and having a sloping centering flange, and a valve positioned in the housing and sealing the fluid passage. | 07-31-2014 |
Mark Smith, San Diego, CA US
Patent application number | Description | Published |
---|---|---|
20120060100 | System and method for transferring media content - A system and a method transfer media content. An application may identify rendering devices in a network and/or may register with an events framework for media-related actions. The application may receive information for a media-related action which specifies media content and an action. The application may identify one or more of the rendering devices as capable of rendering the media content and may use a communication to direct the identified rendering device to render the media content. The identified rendering device may render the media content in response to the communication from the application. | 03-08-2012 |
Mark Smith, Nr. Saffron Walden GB
Patent application number | Description | Published |
---|---|---|
20120095201 | MODIFIED NUCLEOTIDES - Provided herein is a method for replacing the allyl group in a compound of formula R—O-allyl, R | 04-19-2012 |
20130197209 | MODIFIED NUCLEOTIDES - The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′) 2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H. | 08-01-2013 |
20160032378 | MODIFIED NUCLEOTIDES - The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H. | 02-04-2016 |
Mark Smith, Larkspur, CA US
Patent application number | Description | Published |
---|---|---|
20120167349 | SYSTEM AND MECHANISMS PROVIDING AN ADJUSTABLE PERCH FOR A WEARER OF A HOLDER BASE WITH DEVICE - A system is described that includes a base adapted to hold a device which is removable therefrom, the system including a retractor mechanism coupled to the base and having a retractable cord wound thereon with both ends extending therefrom through at least one opening as a line part of the retractable cord for access by a wearer of the base, and setting means providing adjustability of a perch position on the wearer for the base. | 07-05-2012 |
20140090209 | SYSTEM, HOLDER, AND TERMINAL STRUCTURE FOR SUPPORTING A MOBILE DEVICE AND EXTERNAL ARTICLES - In a holder system for supporting a mobile device therein, the system includes a base cavity adapted to hold the mobile device, which is removable therefrom, the base cavity having a plurality of slots adapted to receive terminals therein. The plurality of slots is further comprised of a first slot pattern of three slots at an upper end of the base cavity, and a second slot pattern of at least two slots below a midpoint of the base cavity's length. The system includes at least one external article adapted to be coupled to the base cavity via one of the terminals engaged in one of the slots. | 04-03-2014 |
Mark Smith, London GB
Patent application number | Description | Published |
---|---|---|
20120190124 | Reversible Covalent Linkage of Functional Molecules - The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R | 07-26-2012 |
20120190579 | Functionalisation of Solid Substrates - The present invention relates to a product comprising a solid substrate and a moiety of formula (I) linked thereto: wherein X, X′ and R are as defined herein. The product is useful for immobilising target molecules such as molecules of biochemical interest to solid substrates for numerous applications, such as affinity chromatography, ELISA, biotechnological assay techniques and solid phase peptide synthesis. | 07-26-2012 |
20120190814 | Thiol Protecting Group - The present invention relates to the use of a compound comprising a moiety of formula (I) as a reagent for protecting a thiol group in a thiol compound | 07-26-2012 |
20150031861 | Chemical Modification of Antibodies - The present invention relates to antibodies and antibody fragments, one or more of whose native inter-chain disulfide bridges have been replaced with a specific bridging moiety. The bridging moiety can be selectively targeted to inter-chain disulfide bonds within the antibody or antibody fragment, enabling the construction of more homogenously modified products such as antibody-drug conjugates. | 01-29-2015 |
Mark Smith, Oakwood Village, OH US
Patent application number | Description | Published |
---|---|---|
20120205293 | MANUFACTURE OF MICROSPHERES USING A HYDROCYCLONE - This disclosure features a system for processing microspheres. A vessel contains a suspension of solidified microspheres comprising polymer and an active agent. A hydrocyclone has a fluid inlet, a first fluid outlet and a second fluid outlet. The fluid inlet is in fluid communication with the vessel and receives the suspension. The second fluid outlet contains a flow of the suspension having concentrated microspheres. The first fluid outlet contains a flow of a relatively large amount of liquid compared to the flow from the second fluid outlet. Also featured is a method of processing the microspheres using the hydrocyclone. | 08-16-2012 |
Mark Smith, Jersey City, NJ US
Patent application number | Description | Published |
---|---|---|
20120230951 | ANTIVIRAL COMPOUNDS - The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection. | 09-13-2012 |
20130102600 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease - The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 04-25-2013 |
20130102601 | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease - The present invention relates to a compound having the general formula II, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 04-25-2013 |
20130317021 | HETEROCYCLIC PYRIMIDINE CARBONIC ACID DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE - The present invention relates to a compound having the general formula (C), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 11-28-2013 |
20130317022 | 7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE - The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 11-28-2013 |
20140038990 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease - The present invention relates to a compound having the general formula (Di), (Dii), or (Diii), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 02-06-2014 |
20140194431 | PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE - The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 07-10-2014 |
20140194432 | NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE - The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 07-10-2014 |
20140194476 | PYRIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELORIATION OR PREVENTION OF A VIRAL DISEASE - The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 07-10-2014 |
20160039818 | NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE - The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, | 02-11-2016 |
Mark Smith, Pagedale, MO US
Patent application number | Description | Published |
---|---|---|
20120251639 | Mole Eliminating Ointment - A topical treatment, and a method for making and using, for eliminating moles comprising, a mixture of natural extracts, where said extracts include garlic, white potatoes, onions and grapefruit. | 10-04-2012 |
Mark Smith, Waunakee, WI US
Patent application number | Description | Published |
---|---|---|
20130086706 | Alfalfa Variety 05N16PY - A novel alfalfa variety designated 05N16PY and seed, plants and plant parts thereof. Methods for producing an alfalfa plant that comprise crossing alfalfa variety 05N16PY with another alfalfa plant. Methods for producing an alfalfa plant containing in its genetic material one or more traits introgressed into 05N16PY through backcross conversion and/or transformation, and to the alfalfa seed, plant and plant part produced thereby. Alfalfa seed, plant or plant part produced by crossing alfalfa variety 05N16PY or a trait conversion of 05N16PY with another alfalfa plant or population. Alfalfa populations derived from alfalfa variety 05N16PY, methods for producing other alfalfa populations derived from alfalfa variety 05N16PY and the alfalfa populations and their parts derived by the use of those methods. | 04-04-2013 |
20130086707 | Alfalfa Variety 06N02PX - A novel alfalfa variety designated 06N02PX and seed, plants and plant parts thereof. Methods for producing an alfalfa plant that comprise crossing alfalfa variety 06N02PX with another alfalfa plant. Methods for producing an alfalfa plant containing in its genetic material one or more traits introgressed into 06N02PX through backcross conversion and/or transformation, and to the alfalfa seed, plant and plant part produced thereby. Alfalfa seed, plant or plant part produced by crossing alfalfa variety 06N02PX or a trait conversion of 06N02PX with another alfalfa plant or population. Alfalfa populations derived from alfalfa variety 06N02PX, methods for producing other alfalfa populations derived from alfalfa variety 06N02PX and the alfalfa populations and their parts derived by the use of those methods. | 04-04-2013 |
20130239240 | Alfalfa Variety 55Q27 - A novel alfalfa variety designated 55Q27 and seed, plants and plant parts thereof. Methods for producing an alfalfa plant that comprise crossing alfalfa variety 55Q27 with another alfalfa plant. Methods for producing an alfalfa plant containing in its genetic material one or more traits introgressed into 55Q27 through backcross conversion and/or transformation, and to the alfalfa seed, plant and plant part produced thereby. Alfalfa seed, plant or plant part produced by crossing alfalfa variety 55Q27 or a trait conversion of 55Q27 with another alfalfa plant or population. Alfalfa populations derived from alfalfa variety 55Q27, methods for producing other alfalfa populations derived from alfalfa variety 55Q27 and the alfalfa populations and their parts derived by the use of those methods. | 09-12-2013 |
20130239241 | Alfalfa Variety 09N12CY - A novel alfalfa variety designated 09N12CY and seed, plants and plant parts thereof. Methods for producing an alfalfa plant that comprise crossing alfalfa variety 09N12CY with another alfalfa plant. Methods for producing an alfalfa plant containing in its genetic material one or more traits introgressed into 09N12CY through backcross conversion and/or transformation, and to the alfalfa seed, plant and plant part produced thereby. Alfalfa seed, plant or plant part produced by crossing alfalfa variety 09N12CY or a trait conversion of 09N12CY with another alfalfa plant or population. Alfalfa populations derived from alfalfa variety 09N12CY, methods for producing other alfalfa populations derived from alfalfa variety 09N12CY and the alfalfa populations and their parts derived by the use of those methods. | 09-12-2013 |
Mark Smith, Cheltenham GB
Patent application number | Description | Published |
---|---|---|
20130119061 | TAMPER EVIDENT CLOSURE | 05-16-2013 |
20130270272 | CLOSURE - The present disclosure relates to a closure, especially a closure for packages for liquids such as beverages. In particular the invention relates to a closure for containers for carbonated liquids such as soft drinks. The closure comprises an outer shell with a reduced weight and a sealing means which actively compensates the deformation of the outer shell to avoid loss of performance. | 10-17-2013 |
Mark Smith, Morgantown, WV US
Patent application number | Description | Published |
---|---|---|
20130146814 | METHOD OF PREPARING AND UTILIZING A CATALYST SYSTEM FOR AN OXIDATION PROCESS ON A GASEOUS HYDROCARBON STREAM - The disclosure relates to a method of utilizing a catalyst system for an oxidation process on a gaseous hydrocarbon stream with a mitigation of carbon accumulation. The system is comprised of a catalytically active phase deposited onto an oxygen conducting phase, with or without supplemental support. The catalytically active phase has a specified crystal structure where at least one catalytically active metal is a cation within the crystal structure and coordinated with oxygen atoms within the crystal structure. The catalyst system employs an optimum coverage ratio for a given set of oxidation conditions, based on a specified hydrocarbon conversion and a carbon deposition limit. Specific embodiments of the catalyst system are disclosed. | 06-13-2013 |
Mark Smith, Plattsburgh, NY US
Patent application number | Description | Published |
---|---|---|
20140075850 | SURFACE COVERINGS HAVING A PLURALITY OF OVERLAPPING ELEMENTS AND METHODS FOR FORMING SAME - A surface covering includes a frame, an element structure comprising an elongated member and a plurality of elements, and wherein spaced-apart portions of the elongated member being attachable to spaced-apart portions of the frame so that some of the elements are disposed in an overlapping relationship. | 03-20-2014 |
Mark Smith, Chagrin Falls, OH US
Patent application number | Description | Published |
---|---|---|
20140121157 | METHODS FOR TREATING PROGRESSIVE COGNITIVE DISORDERS RELATED TO NEUROFIBRILLARY TANGLES - The described invention provides methods for treating or preventing progression of a progressive cognitive disease, disorder or condition, and methods for improving resilience of cognitive function in a subject in need thereof. | 05-01-2014 |
20150038409 | Leptin Compositions and Methods for Treating Progressive Cognitive Function Disorders Resulting from Accumulation of Neurofibrillary Tangles and Amyloid Beta - The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of Aβ, hyperphosphorylation of tau, or accumulation of neurofibrillary tangles. | 02-05-2015 |
Mark Smith, Skepplanda SE
Patent application number | Description | Published |
---|---|---|
20140127399 | Additives for bitumen containing compositions - The present invention relates to a composition comprising bitumen and an alkoxylated amine, to a method for the production of such a composition, and to a method for paving a surface using such a composition. The present invention also relates to an preformulated additive package to be added to bitumen, comprising an alkoxylated amine and an anti-stripping agent. | 05-08-2014 |
Mark Smith, Longmont, CO US
Patent application number | Description | Published |
---|---|---|
20140174835 | Load Suspension and Weighing System for a Dialysis Machine Reservoir - A load suspension and weighing system for a removable reservoir unit of a portable dialysis machine includes a centrally located flexure assembly. The flexure assembly includes magnets and a number of flexure rings which allow for movement of the magnets about a fixed circuit board. Sensors in the circuit board sense changes in the magnetic field as the magnets move in relation to the circuit board. The magnetic field changes produce a voltage output which is used by a processor to generate weight calculations. The top of the flexure assembly is attached to the interior of the dialysis machine. The entirety of the reservoir unit is suspended by a first internal frame that is attached to the bottom of the flexure assembly. Having a single flexure assembly positioned above the reservoir unit provides more accurate weight measurements while also preventing damage to the assembly from water spillage. | 06-26-2014 |
20160069732 | Load Suspension and Weighing System for a Dialysis Machine Reservoir - A load suspension and weighing system for a removable reservoir unit of a portable dialysis machine includes a centrally located flexure assembly. The flexure assembly includes magnets and a number of flexure rings which allow for movement of the magnets about a fixed circuit board. Sensors in the circuit board sense changes in the magnetic field as the magnets move in relation to the circuit board. The magnetic field changes produce a voltage output which is used by a processor to generate weight calculations. The top of the flexure assembly is attached to the interior of the dialysis machine. The entirety of the reservoir unit is suspended by a first internal frame that is attached to the bottom of the flexure assembly. Having a single flexure assembly positioned above the reservoir unit provides more accurate weight measurements while also preventing damage to the assembly from water spillage. | 03-10-2016 |
20160109429 | Modular Reservoir Assembly for a Hemodialysis and Hemofiltration System - The present specification discloses a dialysis system having a reservoir module with a reservoir housing defining an internal space, a surface located within the internal space for supporting a container that contains dialysate, and a conductivity sensor located within the internal space, where the conductivity sensor has a coil, a capacitor in electrical communication with the coil, and an energy source in electrical communication with the circuit. | 04-21-2016 |
Mark Smith, Fairview, TX US
Patent application number | Description | Published |
---|---|---|
20140366091 | CUSTOMIZED INFORMATION SETUP, ACCESS AND SHARING DURING A LIVE CONFERENCE - A user device may access a remote conference management application and setup a conference customized for the user. For example, a number of presentation data files may be received from a user device and a user account may be authenticated which is associated with the user device. The presentation data files may be stored as a unique presentation and a scheduled presentation time may also be setup and stored for execution at a later time, and a notification may be transmitted to the user device to confirm that presentation time. | 12-11-2014 |
20140366098 | CUSTOMIZED INFORMATION SETUP, ACCESS AND SHARING DURING A LIVE CONFERENCE - A user device may access a remote conference management application and setup a conference customized for the user. For example, one method of operation may include transmitting a notification to a user device of an upcoming scheduled meeting time and receiving a confirmation that the scheduled meeting is a valid meeting time. The method may also include receiving at least one instruction from the user device regarding the meeting time, loading a data file sequence stored in a user account, and transmitting the data file sequence to a presentation management device. | 12-11-2014 |
Mark Smith, Troy, MI US
Patent application number | Description | Published |
---|---|---|
20150051039 | Planetary Gear Set Module with Limited Slip - A planetary gear set module having planetary gear set and a biasing member. The biasing member may exert a biasing force on a component of the planetary gear set and may permit the component to rotate when sufficient torque is provided to overcome the biasing force. | 02-19-2015 |
Mark Smith, Sunnyvale, CA US
Patent application number | Description | Published |
---|---|---|
20150127905 | Cache Modeling Using Random Sampling and a Timestamp Histogram - A system and method for determining an optimal cache size of a computing system is provided. In some embodiments, the method comprises selecting a portion of an address space of a memory structure of the computing system. A workload of data transactions is monitored to identify a transaction of the workload directed to the portion of the address space. An effect of the transaction on a cache of the computing system is determined, and, based on the determined effect of the transaction, an optimal cache size satisfying a performance target is determined. In one such embodiment the determining of the effect of the transaction on a cache of the computing system includes determining whether the effect would include a cache hit for a first cache size and determining whether the effect would include a cache hit for a second cache size different from the first cache size. | 05-07-2015 |
Mark Smith, Colorado Springs, CO US
Patent application number | Description | Published |
---|---|---|
20150348810 | POROUS BARRIER FOR EVENLY DISTRIBUTED PURGE GAS IN A MICROENVIRONMENT - An improved system and method for purging a microenvironment to desired levels of relative humidity, oxygen, or particulates through the implementation of a purge gas delivery apparatus and method that provides even distribution of the purging gas within the microenvironment. A substrate container has a tower therein with a fluid flow passageway extending the length of the tower. Apertures with porous media between the aperture and fluid flow passageway regulate the volume and pressure of air discharging at each aperture. Alternatively, the tower may be formed of a porous tubular polymeric material. A sleeve may direct the discharge purge gas in the interior. | 12-03-2015 |
Mark Smith, Chattanooga, TN US
Patent application number | Description | Published |
---|---|---|
20160088963 | FOOD TRAY AND LID APPARATUS - A food carrying apparatus with a receptacle and a lid is provided. The receptacle includes a base and a sidewall. The sidewall extends from the base and includes a rim forming an opening into the receptacle. The receptacle further includes at least a pair of slits formed through the sidewall. Each slit is formed on opposing sides of one another on the sidewall. The lid includes a pair of locking tabs. Each of the tabs is formed on opposing sides of one another on the lid. The pair of locking tabs aligns with the pair of slits. To removably attach the lid to the receptacle, the tabs slidably engage the slits and cover the opening. The receptacle and the lid may be made of a paper based material to be used with food and then disposed of. | 03-31-2016 |
Mark Smith, Portland, OR US
Patent application number | Description | Published |
---|---|---|
20160131805 | DEFORMED LENTICULAR MATERIAL GRAPHICS FOR AN ARTICLE OF FOOTWEAR UPPER - The present aspect is directed to lenticular material having both partially deformed lenticules and intact lenticules extending from a substrate. The intact lenticules operate to create an optical effect to enhance background graphical elements placed upon a substrate opposite the intact lenticules. The height of portions of some lenticules are reduced or deformed, thereby disrupting the optical effect. The placement of deformed portions of lenticules is used to create primary graphical elements lacking the optical effect. These primary graphical elements are accentuated by the neighboring intact lenticules, which retain the optical effect regarding the background graphical elements. | 05-12-2016 |
20160135540 | OUTSOLE WITH GRIP REDUCTION EXTENSION MEMBERS - The present invention is directed to an outsole for footwear that reduces grip and enables controlled slippage on a surface during wear. The outsole includes a plurality of low profile tread projections, each tread projection having at least one long, thin, and flexible extension member. An increased width of the extension member where it adjoins the tread projection acts as a pivot point at which the extension member may flex and bend degrees. During wear, the flexible extension members bend over or collapse, becoming sandwiched between the tread projections and a surface. The bent extension members reduce the contact area between the tread projections and a surface, thereby reducing grip and enabling slippage. | 05-19-2016 |