Armstrong, MA
Christopher Armstrong, Cambridge, MA US
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20090155834 | METHODS FOR IDENTIFYING AGENTS WHICH ALTER HISTONE PROTEIN ACETYLATION, DECREASE AGING OR INCREASE LIFESPAN - Methods of identifying agents which alter the NAD-dependent acetylation status and mono-ADP-ribosylation of nuclear proteins are disclosed. The methods further include identifying agents which alter the life span or aging of a cell or an organism by determining the level of NAD-dependent acetylation and/or ADP ribosylation of a nuclear protein. The invention also relates to a mammalian Sir2 protein which acetylates or deacetylates nuclear proteins in a NAD-dependent manner and has mono-ADP-ribosyltransferase activity. Host cells producing the Sir2 protein and antibodies to the Sir2 protein are also provided. | 06-18-2009 |
Daniel Armstrong, Marblehead, MA US
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20090007614 | SECURE MOUNTING ARRANGEMENTS FOR A LOCK ASSEMBLY - A mountable lock includes a lock body and a retaining member. The lock body is configured to be secured to an external structure by at least one fastening member. The lock body includes a lock interface movable from a locking condition to an unlocking condition in response to proper user manipulation of the lock interface. The retaining member includes a first end receivable in a first opening of the lock body and lockingly engageable with the lock body when the lock interface is in the locking condition, the first end being disengageable from the first opening when the lock interface is in the unlocking condition. The at least one fastening member is accessible through a passageway in the lock body that is blocked when the retaining member is in locking engagement with the lock body, thereby preventing disassembly of the lock body from the external structure. | 01-08-2009 |
Daniel Richard Armstrong, Marblehead, MA US
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20080264883 | Lally Column Sotage Device - The present invention is a clamp storage device which attaches to a lally Column. The invention consists of a Lally Column Clamp which attaches to the Lally Column. Different storage mechanisms can be attached to the lally Column clamp. These storage mechanisms are interchangeable and can include such storage devices as a wire basket retainer, hooks for a bicycle, plastics bins such as those used for recycling and others. The interchangeability of the storages mechanisms is a very unique feature and allows a user great flexibility when using the clamp storage device. | 10-30-2008 |
20090137323 | Toy with memory and USB Ports - A system and method for a toy with memory (flash memory) storage capabilities and a method for the toy to connect to other like toys and to a computer and he internet for online virtual play and simulation. Connection to a computer system allows the user the ability connect to the internet and register the toy allowing the user access to interact with a virtual activities and scenarios including a virtual computer image and animation of the toy connected to a computer which is connected to the Internet. User may also purchase or win a USB (Universal Serial Bus) node or dongle with codes that attach to the USB connection on the toy to allow access to special rooms and events in the virtual world on the website. The status of the game is saved back to the memory storage in the toy. | 05-28-2009 |
20100058561 | Rope Grip Slip-Knot Device - The present invention is a slip-knot grip device which attaches to a rope. The invention consists of a male end cap into which an insert is placed and a female end cap into which an insert is placed with the two end caps being connected by a retaining collar. The inserts have a semi-circle channel on their interior side placed so when the left and right inserts are connected together they form a circle opening through which a rope is placed. The female end cap and the male end cap are turned in opposite directions. This makes the end edges of the combined inserts clasp the rope holding the device in place. | 03-11-2010 |
Dustin D. Armstrong, Everett, MA US
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20100111977 | Methods and compositions for treatment of myotonic dystrophy - In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy. | 05-06-2010 |
20120213760 | METHODS AND COMPOSITIONS FOR TREATMENT OF MYOTUBULAR MYOPATHY USING CHIMERIC POLYPEPTIDES COMPRISING MYOTUBULARIN 1(MTM1) POLYPEPTIDES - The present invention provides chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need. | 08-23-2012 |
20140178377 | METHODS AND COMPOSITIONS FOR TREATMENT OF MYOTONIC DYSTROPHY - In certain embodiments, the present invention provides compositions and methods for treating myotonic dystrophy. | 06-26-2014 |
Dustin D. Armstrong, Quincy, MA US
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20150064181 | ANTISENSE CONJUGATES FOR DECREASING EXPRESSION OF DMPK - The disclosure provides novel conjugates comprising antisense oligonucleotides that hybridize to a DMPK transcript and a 3E10 antibody or binding fragment thereof. Also considered are these conjugates further comprising MBNL1 polypeptides. Methods of treating myotonic dystrophy using these conjugates and kits comprising these conjugates are also considered. Wherein the conjugates are suitable for delivery to muscle cells. | 03-05-2015 |
20150152170 | METHODS FOR INCREASING MUSCLE CONTRACTILITY - The present disclosure provides methods for increasing muscle contractility in a myotubular myopathy subject following administration of fewer than 20 doses of a chimeric polypeptide that has a myotubularin protein and an internalizing moiety. | 06-04-2015 |
20150218540 | METHODS AND COMPOSITIONS FOR TREATMENT OF MYOTUBULAR MYOPATHY USING CHIMERIC POLYPEPTIDES COMPRISING MYOTUBULARIN 1(MTM1) POLYPEPTIDES - The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need. | 08-06-2015 |
20160089451 | METHODS AND COMPOSITIONS FOR TREATMENT OF FORBES-CORI DISEASE - In certain embodiments, the present disclosure provides compositions and methods for treating Forbes-Cori Disease. | 03-31-2016 |
20160108133 | METHODS AND COMPOSITIONS FOR TREATMENT OF POMPE DISEASE - In certain embodiments, the present disclosure provides compositions and methods for treating Pompe disease. | 04-21-2016 |
Dustin Donald Armstrong, Cambridge, MA US
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20100317699 | USE OF HEDGEHOG AGONISTS IN THE TREATMENT OF MUSCULOSKELETAL-RELATED DISORDERS - The invention provides methods for the diagnosis and treatment of musculoskeletal disorders relating to the Hedgehog pathway, including but not limited to muscular dystrophy (e.g., Duchenne Muscular Dystrophy) using agents that agonize Sonic Hedgehog (shh), and thereby, the Hedgehog signaling pathway. Said agonizing agents include, e.g., the compounds of the invention (e.g., a compound of Formula I). The invention also provides methods of screening for agents that are capable of increasing the proliferation of muscle and/or muscle precursor cells. | 12-16-2010 |
Jean F. Armstrong, Groton, MA US
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20080235075 | ENTERPRISE APPLICATION PERFORMANCE MONITORS - Methods, systems, and apparatus, including computer program products, implementing techniques for receiving a first information related to a first transaction associated with a first user session with a multi-tier enterprise application, the first information including performance data that is representative of how well components in at least two tiers of the enterprise application perform in executing the first transaction; and determining based on the first information whether the first transaction is associated with a prioritized aspect of the enterprise application, and if so, taking an action based on the determining. | 09-25-2008 |
Patrick A. Armstrong, Boston, MA US
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20160136094 | Compositions For Treating Acute, Post-Operative, or Chronic Pain and Methods of Using the Same - Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein. | 05-19-2016 |
20160136095 | METHODS FOR TREATING EPILEPSY OR SEIZURE DISORDERS - Provided herein are methods for treating epilepsy or seizure disorders comprising administering a composition to a subject, the composition comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. | 05-19-2016 |
20160136179 | Compositions For Treating Acute, Post-Operative, Or Chronic Pain and Methods of Using the Same - Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein. | 05-19-2016 |
Richard Armstrong, Princeton, MA US
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20090184575 | System Having a Variable Frequency Power Distribution Bus for Driving a Variable Speed Motor - A power distribution system is provided for supplying power to a variable speed motor for rotating a shaft. The system comprises a variable speed prime mover adapted to generate an A/C output having a variable frequency corresponding to the speed of the prime mover, a power switch, a power distribution bus connected to the A/C output of the prime mover and connected, via the switch, to the motor such that the motor's speed is varied relative to the frequency of the A/C output, and a variable frequency drive operatively connected to the A/C output of the prime mover via the bus and effective to provide an alternate A/C output to the motor after the motor is disconnected from the bus. The switch is adapted to disconnect the motor from the bus when the prime mover's speed is equal to or within a predetermined range of the prime mover's speed limit. | 07-23-2009 |
20110254492 | SYSTEM HAVING A VARIABLE FREQUENCY POWER DISTRIBUTION BUS FOR DRIVING A VARIABLE SPEED MOTOR - A system and method for supplying power to a variable speed motor for rotating a shaft may include generating an A/C output having a variable frequency corresponding to speed of a prime mover, where the speed of the prime mover is equal to or greater than a predetermined speed limit. The A/C output of the prime mover may be distributed to the variable speed motor such that the speed of the variable speed motor is varied relative to the frequency of the A/C output. The variable speed motor may be electrically disconnected from the A/C power when the speed of the prime mover being used to drive the variable speed motor is equal to or within a predetermined range of the predetermined speed limit. An alternate A/C output may be distributed to the variable speed motor after the A/C power is electrically disconnected from the variable speed motor. | 10-20-2011 |
Robert C. Armstrong, Andover, MA US
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20120175683 | Basic Cell Architecture For Structured ASICs - A basic cell circuit architecture having plurality of cells with fixed transistors configurable for the formation of logic devices and single and dual port memory devices within a structured ASIC is provided. Different configurations of ensuing integrated circuits are achieved by forming variable interconnect layers above the fixed structures. The circuit architecture can achieve interconnection of transistors within a single cell or across multiple cells. The interconnection can be configured to form basic logic gates as well as more complex digital and analog subsystems. In addition, each cell contains a layout of transistors that can be variably coupled to achieve a memory device, such as a SRAM device. By having the capability of forming a logic circuit element, a memory device, or both, the circuit architecture is both memory-centric and logic-centric, and more fully adaptable to modern-day SoCs. | 07-12-2012 |
Scott A. Armstrong, Wayland, MA US
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20090324618 | NOVEL SIGNATURE SELF RENEWAL GENE EXPRESSION PROGRAMS - The present invention relates to compounds and methods which are useful in molecular investigations of target genes, as well as their encoded RNAs and protein, belonging to signature self renewal programs in leukemia and/or cancer stem cells. Data herein shows that leukemia stem cells can be generated from committed progenitors without widespread reprogramming of gene expression, and wherein a leukemia self-renewal associated signature is activated in the process. | 12-31-2009 |
Stephen Armstrong, Andover, MA US
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20110072722 | Gasifier ash processing subsystem - A gasifier includes a combustion zone where a gas is introduced and fuel is combusted and at least one sensor for measuring a predetermined condition in the gasifier. A grate subsystem contains the fuel and includes at least one grinding mechanism. A controller is responsive to the at least one sensor and controls the grinding mechanism by activating the grinding mechanism if the predetermined condition exists to reduce the collection of non-fuel products on the grate subsystem. | 03-31-2011 |
Steve Armstrong, Danvers, MA US
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20090248004 | SYSTEMS AND METHODS FOR TREATMENT OF SOFT TISSUE - Methods and systems for treatment of tissue (e.g., the dermal-hypodermal region) with one or more wavelength are disclosed. Electromagnetic radiation devices and methods for lypolysis and/or coagulation of blood and/or treatment of water and/or treatment of skin are disclosed. | 10-01-2009 |
Tom Armstrong, Northbridge, MA US
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20140115152 | MAINTAINING INFORMATION INTEGRITY WHILE MINIMIZING NETWORK UTILIZATION OF ACCUMULATED DATA IN A DISTRIBUTED NETWORK - A method and systems for gathering information regarding usage of a resource from at least one of a plurality of measuring nodes operatively coupled to a controller, wherein the measuring node includes at least one sensor and a node processor operatively coupled to the sensor, and the controller includes a controller processor. The method includes predicting an estimated resource usage value associated with the at least one sensor with the node processor and separately with the controller each using a predictor algorithm and dataset. The method further includes measuring resource usage to which the estimated resource usage value applies with the sensor and calculating a difference between the estimated resource usage value and the measured resource usage with the node processor. If the difference falls outside of a bound the measured resource usage is communicated to the controller. | 04-24-2014 |
Tracey Armstrong, Beverly, MA US
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20080306873 | METHOD AND APPARATUS FOR OBTAINING CONTENT LICENSE RIGHTS VIA A DOCUMENT LINK RESOLVER - A link resolver menu generated by a link resolver server includes a link to a “rights advisor website” containing a program that determines available rights for a resource. When activated, the program uses the resource information in the link to obtain a standard resource identifier and then uses user and context information to access and extract all agreements stored therein that are applicable to the organization to which the user belongs. The resource identifier is then used to determine agreements that are applicable to that resource. An applicable right is selected from each agreement, if available. The rights are then ordered in a tree from the most permissive to the most restrictive. The tree is then traversed from its lowest level upward and the resulting rights are presented to the user. | 12-11-2008 |