Choi, MD
Charles J. Choi, Bethesda, MD US
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20120276549 | Photonic biosensors incorporated into tubing, methods of manufacture and instruments for analyziing the biosensors - Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring. | 11-01-2012 |
20120309080 | Surface Enhanced Raman Spectroscopy Nanodome Biosensors and Methods of Manufacturing the Same - Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring. | 12-06-2012 |
Gil H. Choi, Rockville, MD US
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20100003259 | ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN - The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. | 01-07-2010 |
20100111953 | ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR - The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. | 05-06-2010 |
20100196410 | Streptococcus pneumoniae Antigens and Vaccines - The present invention relates to novel vaccines for the prevention or attenuation of infection by | 08-05-2010 |
20100221287 | Streptococcus pneumoniae Polynucleotides and Sequences - The present invention provides polynucleotide sequences of the genome of | 09-02-2010 |
20110117093 | ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN - The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. | 05-19-2011 |
20110293610 | ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN - The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. | 12-01-2011 |
20120121606 | ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN - The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. | 05-17-2012 |
Hojae Choi, Ellicott City, MD US
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20090093638 | Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions - The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) “paddlewheel complexes, and in particular, dirhodium carboximate and tert-butyl hydroperoxide as catalysts for the reaction. The use of aqueous conditions is particularly advantageous in the allylic oxidation of 7-keto steroids, which could not be effectively oxidized using anhydrous methods, and in extending allylic oxidation to enamides and enol ethers. | 04-09-2009 |
Ki Young Choi, Rockville, MD US
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20140162966 | NANOPARTICLES FOR DELIVERY OF LIGANDS - Disclosed is a nanoparticulate complex comprising an artificial phosphate receptor of formula (I): P-[L-[-N(CH | 06-12-2014 |
Kwangsik Choi, College Park, MD US
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20110101789 | RF POWER HARVESTING CIRCUIT - Provided is an RF power harvesting circuit with improved sensitivity to RF energy. The RF power harvesting device includes an inductor, a first capacitor connected to the inductor, a first MOSFET connected to a first node, and a second MOSFET connected to the first node. The inductor or the first capacitor are connected to the first node. | 05-05-2011 |
Kwong-Kit Choi, Brookeville, MD US
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20110042647 | CORRUGATED-QUANTUM WELL INFRARED PHOTODETECTOR WITH REFLECTIVE SIDEWALL AND METHOD - A quantum well infrared photodetector comprising a tunable voltage source; first and second contacts operatively connected to the tunable voltage source; a substantially-transparent substrate adapted to admit light; first and second layers operatively connected to the first and second contacts; a quantum well layer positioned between the first and second layers; light admitted through the substantially transparent substrate entering at least one of the first and second layers and passing through the quantum well layer; at least one side wall adjacent to at least one of the first and second layers and the quantum well layer; the at least one side wall being substantially non-parallel to the incident light; the at least one sidewall comprising reflective layer which reflects light into the quantum well layer for absorption. A preferred method for improving the reflectivity of a quantum well infrared photodetector comprises forming a first sidewall layer on the sidewalls of the corrugated quantum well infrared photodetector; forming a second sidewall layer on the sidewalls of the corrugated quantum well infrared photodetector; the second sidewall layer being formed of a reflective material and the first sidewall layer operating to electrically isolate the reflective material from at least one of the first and second contact layers; whereby the reflective metal operates to reflect light rays into corrugated quantum well infrared photodetector device and to substantially prevent infrared rays in environment from entering through the sidewalls. | 02-24-2011 |
20120012816 | PHOTODETECTORS USING RESONANCE AND METHOD OF MAKING - An infrared photodetector comprising: a thin contact layer substantially transparent to infrared light; an absorption layer positioned such that light admitted through the substantially transparent thin contact area passes through the absorption layer; the absorption layer being configured to utilize resonance to increase absorption efficiency; at least one reflective side wall adjacent to the absorption layer being substantially non-parallel to the incident light operating to reflect light into the absorption layer for absorption of infrared radiation; and a top contact layer positioned adjacent to the active layer. A method of designing a photodetector comprising selecting a type of material based upon the wavelength range to be detected; determining a configuration geometry; calculating the electromagnetic field distributions using a computer simulated design of the configuration geometry, and determining a quantum efficiency spectrum at the desired wavelength or wavelength range; whereby the effectiveness of the photodetector is simulated prior to fabrication. | 01-19-2012 |
20130145330 | COMPUTER DESIGNED RESONANT PHOTODETECTORS AND METHOD OF MAKING - A method for designing a photodetector comprising an array of pixels: selecting at a material composition for the photodetector; determining a configuration of at least one pixel in the array of pixels using a computer simulation, each pixel comprising an active region and a diffractive region, and a photodetector/air interface through which light enters, the computer simulation operating to process different configurations of the pixel to determine an optimal configuration for a predetermined wavelength or wavelength range occurring when waves reflected by the diffractive element form a constructive interference pattern inside the active region to thereby increase the quantum efficiency of the photodetector. An infrared photodetector produced by the method. | 06-06-2013 |
Kyu Yong Choi, Rockville, MD US
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20130267408 | Porous Oxide Microparticles and Composites Thereof and Methods of Making and Using Same - Provided are substantially spherical, porous oxide microparticles having a plurality of substantially spherical voids, substantially spherical, porous oxide-organic polymer composite microparticles having a plurality of substantially spherical organic polymer domains. The microparticles can be made using a microdispersive suspension polymerization step to make microparticles having an organic polymer shell and a plurality of discrete substantially spherical organic nanoparticles. The microparticles can be used as polymerization catalyst supports. | 10-10-2013 |
Sean S. Choi, Baltimore, MD US
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20110206734 | HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS - Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof. | 08-25-2011 |
Sean S. Choi, Columbia, MD US
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20140220630 | HYBRID SCFA-HYDROXYL-DERIVATIZED MONOSACCHARIDES, METHODS OF SYNTHESIS, AND METHODS OF TREATING DISORDERS - Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof. | 08-07-2014 |
Wonseon Choi, Chevy Chase, MD US
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20130095053 | REGULATION OF SKIN PIGMENTATION BY NEUREGULIN-1 (NRG-1) - Disclosed herein are compositions and methods of using such compositions to modulate pigmentation and proliferation of a melanocyte, such as to prevent or treat skin disorders, including skin cancer or for use for cosmetic purposes. In one example, a method of modulating pigmentation of a melanocyte includes contacting the melanocyte (such as a human melanocyte) with an agent that modulates neuregulin-1 (NRG-1) activity, such as an agent that increases or decreases NRG-1 activity, thereby modulating pigmentation of the melanocyte. In one particular example, the method of increasing melanocyte pigmentation or proliferation can be used to reduce UV skin damage, including that associated with skin cancer. In another example, the method of decreasing melanocyte pigmentation can be used to treat a skin pigmentation disorder associated with undesired increased skin pigmentation. | 04-18-2013 |
Wookjin Choi, Baltimore, MD US
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20150324979 | METHODS AND APPARATUS FOR INDIVIDUALLY OPTIMIZING UNIFORM CONTRAST ENHANCEMENTS IN COMPUTED TOMOGRAPHY IMAGING - A method is provided for optimizing a contrast injection function for CT imaging. The method includes injecting, with an injector pump, a test bolus of a contrast agent into a subject. The method also includes computing, on a processor, an impulse enhancement function. The method also includes determining, on a processor, a target enhancement function for a region of interest. The method also includes determining, with a processor, a plurality of parameters for a functional form for a contrast injection function in a time domain. The method also includes determining for the contrast injection function a constraint. The method also includes determining, with a processor, particular values for the plurality of parameters, which satisfy the constraint and minimize a difference between a value of an enhancement function and the target enhancement function computed in the time domain at discrete time periods without use of a Fourier transform. | 11-12-2015 |
Young-Tai Choi, Laurel, MD US
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20090084646 | BI-FOLD VALVE-TYPE MAGNETORHEOLOGICAL FLUID ENERGY ABSORBING DEVICE - An energy absorbing device is provided that includes a damper assembly having inner and outer concentric tubes and a piston movable within the inner tube. The damper assembly is configured to form bi-fold valve-type cavities to operatively connect an inner chamber of the inner tube with an outer chamber formed between the inner and outer tubes. A magnetorheological fluid fills the chambers and the bi-fold valve-type cavities. The magnetorheological fluid preferably contains coated magnetic particles at about 10 to 60 percent by volume. Electrical coils adjacent the bi-fold valves are selectively energizable to such that the energy absorbing device provides a tunable damping force, preferably over the entire range of velocities of the piston, especially in automotive applications. | 04-02-2009 |
20090177446 | METHOD OF DESIGNING MAGNETORHEOLOGICAL FLUID ENERGY ABSORBING DEVICE USING HYDROMECHANICAL ANALYSIS - A method of designing a magnetorheological (MR) fluid energy absorbing damper is provided that uses hydromechanical analysis with lumped parameters to allow a determination as to whether a potential damper design will provide predetermined characteristics, such as a desired dynamic force range and maximum piston velocity, with a selected MR fluid and yield stress and preferably meeting predetermined geometric limitations. | 07-09-2009 |
20100332079 | CONSTANT FORCE CONTROL METHODOLOGY FOR SHOCK ABSORPTION - A Constant Force Control methodology and system utilizing integrated sensors and unique control algorithms to determine required applied force to mitigate shock events in an adaptive energy absorption system, typically comprising of a spring and an adjustable energy absorber or damper element. By utilizing an expected acceleration profile and event duration for an anticipated shock event an acceleration amplitude can be determined from a measure impact velocity. From this and a measured payload mass a system controller can determine the force necessary to be applied by the energy absorber in order to stop the payload over the full desired length of the available energy absorber stroke in order to minimize the forces experienced by the payload. | 12-30-2010 |