Lim, San Francisco
Daniel A. Lim, San Francisco, CA US
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20150202406 | MICROINJECTION CATHETER - An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter. | 07-23-2015 |
Gary Lim, San Francisco, CA US
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20090004062 | DEVICES FOR IMPROVING THE FLATNESS OF HIGH-DENSITY MICROPLATES - Methods and apparatuses that improve the flatness of the microplates. In some embodiments, a pair of opposing channels that extends along a length of a rigid member is used to retain the microplate on the rigid member and to impart a level of flatness of at least a predetermined value. In some embodiments, one or more rigid framing members each having a channel therein are disposed along the edges of a microplate and impart a level of flatness of at least a predetermined value to the microplate. In some embodiments, a method of flattening the microplate comprises securing the microplate to a rigid member so the microplate has a flatness of at least a predetermined value and maintaining the microplate secured to the rigid member during a subsequent spotting or filling operation. | 01-01-2009 |
20090004064 | Multi-material microplate and method - A microplate assembly for performing an analytical method on an assay, comprising a microplate base structure having a plurality of apertures formed therethrough, and a plurality of well inserts coupled to the microplate base structure adjacent the apertures. Each of the plurality of well inserts has an open top portion and is adapted to receive an assay. The microplate base structure and the plurality of well inserts can comprise different materials. Methods of manufacturing the microplate assembly are also provided. | 01-01-2009 |
20090176661 | WHOLE GENOME EXPRESSION ANALYSIS SYSTEM - A method for simultaneously determining a genetic expression profile for an individual member of a species relative to an entire standard genome for the species. The method can comprise distributing a liquid sample into an array of reaction chambers of a substrate. The array can comprise a primer set and a probe for each polynucleotide target along the entire standard genome. The liquid sample can comprise substantially all genetic material of the member. Each of the reaction chambers can comprise the primer set and the probe for at least one of the polynucleotide targets and a polymerase. The method can further comprise amplifying the liquid sample in the array, detecting a signal emitted by at least one of the probes, and identifying the genetic expression profile in response to the signal. | 07-09-2009 |
20090214811 | Film Preparation for Seal Applicator - A sealing cover roll for use in sealing a microplate comprising an elongated carrier liner having a first surface and a second surface. A plurality of sealing covers are releasably carried on the first surface of the elongated carrier liner. Each of the plurality of sealing covers comprises a base stock and an adhesive. The adhesive is operable to retain the base stock to the elongated carrier liner and permit release of the base stock and the adhesive from the elongated carrier liner. A roll core supports a rolled configuration of the elongated carrier liner such that the first surface of the elongated carrier liner faces toward the roll core when rolled. | 08-27-2009 |
20100298172 | MICROFLUIDIC SIZE-EXCLUSION DEVICES, SYSTEMS, AND METHODS - Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided. | 11-25-2010 |
20110300037 | Multi-Material Microplate and Method - A microplate assembly for performing an analytical method on an assay, comprising a microplate base structure having a plurality of apertures formed therethrough, and a plurality of well inserts coupled to the microplate base structure adjacent the apertures. Each of the plurality of well inserts has an open top portion and is adapted to receive an assay. The microplate base structure and the plurality of well inserts can comprise different materials. Methods of manufacturing the microplate assembly are also provided. | 12-08-2011 |
20110300038 | Devices for Improving the Flatness of High-Density Microplates - The present teachings are methods and apparatuses for improving the flatness of high density microwell plates. The flattening devices impart a level of flatness that is equal to or better than a predetermined value thereby enabling the microwells to be precisely located and easily accessed. | 12-08-2011 |
20110300610 | Thermally Conductive Microplate - Embodiments according to the present teachings of a microplate comprising a main body portion having a first surface and an opposing second surface are disclosed. A plurality of wells are formed in the first surface, each of the plurality of wells being sized to receive an assay therein. A backing is coupled to the opposing second surface of the main body portion. | 12-08-2011 |
20130210674 | WHOLE GENOME EXPRESSION ANALYSIS SYSTEM - A method for simultaneously determining a genetic expression profile for an individual member of a species relative to an entire standard genome for the species. The method can comprise distributing a liquid sample into an array of reaction chambers of a substrate. The array can comprise a primer set and a probe for each polynucleotide target along the entire standard genome. The liquid sample can comprise substantially all genetic material of the member. Each of the reaction chambers can comprise the primer set and the probe for at least one of the polynucleotide targets and a polymerase. The method can further comprise amplifying the liquid sample in the array, detecting a signal emitted by at least one of the probes, and identifying the genetic expression profile in response to the signal. | 08-15-2013 |
20140106364 | Microfluidic Size-Exclusion Devices, Systems, and Methods - Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided. | 04-17-2014 |
20140213487 | Systems and Methods for Biological Analysis - A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens. | 07-31-2014 |
20140242596 | Systems and Methods for Biological Analysis - A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface. | 08-28-2014 |
20150072897 | Systems and Methods for Loading Liquid Samples - A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/−15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action. | 03-12-2015 |
20150080247 | Systems and Methods for Biological Analysis - A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites. | 03-19-2015 |
Hyungwook Lim, San Francisco, CA US
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20100330114 | Use of SIRT1 Activators or Inhibitors to Modulate an Immune Response - The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4 | 12-30-2010 |
20140030295 | Use of Sirt1 Activators or Inhibitors to Modulate an Immune Response - The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4 | 01-30-2014 |
Jack Lim, San Francisco, CA US
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20150375120 | METHODS AND SYSTEMS FOR ADAPTIVE TUNING OF GAME EVENTS - A system, a machine-readable storage medium storing instructions, and a computer-implemented method are described herein for a System Tuner for defining an in-game event requiring accumulation of a pre-defined set of virtual objects in a virtual game (or online game) prior to termination of the in-game event. The System Tuner determines a head-start subset from the pre-defined set of virtual objects for a target player account based on a difference between a reference player skill level for the virtual game and a player skill level of the target player account. The System Tuner determines, based on the player skill level of the target player account and a pre-defined duration of the in-game event, a drop rate for virtual objects remaining in the pre-defined set of virtual objects. The System Tuner sends the head-start subset and the drop rate to a client device associated with the target player account. | 12-31-2015 |
Lee P. Lim, San Francisco, CA US
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20100227909 | COMPOSITIONS COMPRISING MIR34 THERAPEUTIC AGENTS FOR TREATING CANCER - In one aspect, the invention generally relates to compositions comprising miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer. | 09-09-2010 |
20110105583 | METHODS OF USING MIR34 AS A BIOMARKER FOR TP53 FUNCTIONAL STATUS - In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer. | 05-05-2011 |
Melissa Susann Lim, San Francisco, CA US
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20150073289 | SYSTEM AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT - A system and method for sleep disorder diagnosis and treatment are disclosed. A particular embodiment is configured to: generate a first user interface for sleep disorder diagnosis, the first user interface including a plurality of questionnaires for prompting user input on a plurality of queries related to a user's sleep patterns, at least one questionnaire including queries related to the user's potential Obstructive Sleep Apnea (OSA) condition; generate a second user interface for sleep disorder treatment, the second user interface including a plurality of sleep disorder therapies to guide the user through a particular sleep disorder therapy automatically selected for the user based on the user's responses captured and processed by the first user interface, the second user interface being further configured to capture and retain a sleep log, the second user interface being further configured to generate a sleep efficiency assessment; and detect an OSA condition in the user by use of a breathing disturbance metering system in wireless data communication with the first user interface and the second user interface. | 03-12-2015 |
Seung E. Lim, San Francisco, CA US
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20100110025 | CONTROL OF COMPUTER WINDOW SYSTEMS AND APPLICATIONS USING HIGH DIMENSIONAL TOUCHPAD USER INTERFACE - A high dimensional touchpad (HDTP) controls a variety of computer windows systems and applications by detecting a user's finger movement in the left-right, forward-backward, roll, pitch, yaw, and downward pressure directions. One or more of the detected finger movements are then used to control specific computer applications including focusing a user's attention to one of several web pages, gesture recognition, magnification control, 3D-polyhedral menu selection, Internet browsers, navigation applications, games, media players, spreadsheets, and controlling the functions of mobile devices. | 05-06-2010 |
Wendell Lim, San Francisco, CA US
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20140068797 | METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION - The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms. | 03-06-2014 |
Wendell A. Lim, San Francisco, CA US
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20090233364 | Method to Engineer MAPK Signaling Responses Using Synthetic Scaffold Interactions and Scaffold-Mediated Feedback Loops - Synthetic scaffold interactions and scaffold-mediated feedback loops are used to engineer MAPK signaling responses in cells. | 09-17-2009 |
20150368342 | CHIMERIC ANTIGEN RECEPTOR AND METHODS OF USE THEREOF - The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided. | 12-24-2015 |
Yang Lim, San Francisco, CA US
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20090094223 | SYSTEM AND METHOD FOR CLASSIFYING SEARCH QUERIES - A search facility for classifying search queries prior to executing the search queries. The facility can receive a search query from a user and perform one or more of a set of evaluations of the search query to determine likely query classifications. The facility can also decompose the search query into constituent parts and perform one or more of a set of evaluations of the individual constituent parts to determine likely classifications. The facility can then arbitrate amongst the likely query classifications and rank the arbitrated likely query classifications. The ranked arbitrated query classifications can be mapped to data sources and services. The facility can retrieve content from the mapped data sources and services using the user's original search query. Each of the ranked arbitrated query classifications can correspond to a display region that can display content from the mapped one or more data sources and services to the user. | 04-09-2009 |