Patent application number | Description | Published |
20080294188 | Implant Holder and Method of Deploying the Implant - An implant holder for use with a delivery catheter to deploy an implant, such as a filter, in a tubular body part is provided. The holder includes a cartridge body having a lumen extending between two ends and holding a collapsed implant, and an implant image disposed on the cartridge body. The implant image has an axial orientation corresponding to the axial orientation of the implant held in the cartridge body lumen. The axial orientation of the implant image helps to guide a physician in correctly orienting the implant regardless of which access point is used, thereby reducing the chance of deploying the implant in the wrong axial direction. | 11-27-2008 |
20090287242 | Method of Retrieving a Blood Clot Filter - A compact retrievable blood clot filter has a filter section, a releasable lock and an alignment section connected to the filter section. Alignment ribs of the alignment section have releasable upstream ends that are locked to the filter by the releasable lock. The releasable upstream ends of the alignment ribs are capable of being released from the releasable lock so that during retrieval of the filter, the alignment ribs can slide through the endothelial tissue that may have grown around the alignment ribs. | 11-19-2009 |
20090299338 | LOCKING CLAMP - A locking clamp is provided that is used for securing at least one tube. The locking clamp has a first and second end axially opposed end pieces and a plurality of locking members extending between the first and second end pieces. Living hinges connect the first and second end pieces to the locking members and allow selective movement of the locking members between an unlocked position and a locked position. In the locked position, the locking members can extend in overlying partially coextensive relation to each other, and the one set of locking members can be defined in a substantially axially opposed, coplanar parallel relationship to the second set of locking members. The clamp may be used during high pressure applications to secure one tube in relationship to another tube. | 12-03-2009 |
20100185180 | LOCKING CLAMP - A locking clamp is provided that is used for securing at least one tube. The locking clamp has a first and second end axially opposed end pieces and a plurality of locking members extending between the first and second end pieces. Living hinges connect the first and second end pieces to the locking members and allow selective movement of the locking members between an unlocked position and a locked position. In the locked position, the locking members can extend in overlying partially coextensive relation to each other, and the one set of locking members can be defined in a substantially axially opposed, coplanar parallel relationship to the second set of locking members. The clamp may be used during high pressure applications to secure one tube in relationship to another tube. | 07-22-2010 |
20100198252 | Blood Clot Filter - A compact blood clot filter having an alignment section that overlaps with a filter section in an axial direction is provided. The filter section has filter struts that extend radially and longitudinally from a hub. The alignment section has alignment struts in which the downstream end of each alignment strut forms a downstream junction with the downstream end of an adjacent alignment strut while the upstream end of each alignment strut forms an upstream junction with the upstream end of an adjacent alignment strut. | 08-05-2010 |
20110112527 | FLEXIBLE MEDICAL ABLATION DEVICE AND METHOD OF USE - Disclosed herein are methods and devices involving a medical probe placeable into tissue where the probe has a high pushability yet is capable of being conformed to a patient's shape due to use of a removable stiffener and a flexible needle section allowing for placement, imaging, and treatment to be performed without removal of the probe regardless of environmental and physical restrictions related to devices used during the patient's procedure. | 05-12-2011 |
Patent application number | Description | Published |
20130130999 | METHOD OF DETERMINING ACUTE MYELOID LEUKEMIA RESPONSE TO TREATMENT WITH FARNESYLTRANSFERASE INHIBITORS - The disclosed method rapidly identifies with desired accuracy AML patients, including elderly AML patients, likely to respond to treatment with a combination of a farnesyltransferase inhibitor and one or more of etoposide, teniposide, tamoxifen, sorafenib, paclitaxel, temozolomide, topotecan, trastuzumab and cisplatinum. In an embodiment, the improvements include the use of whole blood rather than the customary bone marrow sample, thus making the assay more accurate, rapid, less intrusive, less expensive as well as less painful. The method includes evaluation of a two-gene expression ratio (RASGRP1:APTX), which with a corresponding threshold, provides sufficient accuracy for predicting the response to the combination treatment. In the preferred embodiment the combination treatment combines tipifarnib (R115777, ZARNESTRA®) with etoposide. Further, the elderly AML patients identified as being likely responsive to the combination treatment with tipinifarb and etoposide have a complete recovery rate comparable to the best therapy available for younger patients. | 05-23-2013 |
20160095874 | METHOD OF DETERMINING ACUTE MYELOID LEUKEMIA RESPONSE TO TREATMENT WITH FARNESYLTRANSFERASE INHIBITORS - The disclosed method rapidly identifies with desired accuracy AML patients, including elderly AML patients, likely to respond to treatment with a combination of a farnesyltransferase inhibitor and one or more of etoposide, teniposide, tamoxifen, sorafenib, paclitaxel, temozolomide, topotecan, trastuzumab and cisplatinum. In an embodiment, the improvements include the use of whole blood rather than the customary bone marrow sample, thus making the assay more accurate, rapid, less intrusive, less expensive as well as less painful. The method includes evaluation of a two-gene expression ratio (RASGRP1:APTX), which with a corresponding threshold, provides sufficient accuracy for predicting the response to the combination treatment. In the preferred embodiment the combination treatment combines tipifarnib (R115777, ZARNESTRA®) with etoposide. Further, the elderly AML patients identified as being likely responsive to the combination treatment with tipinifarb and etoposide have a complete recovery rate comparable to the best therapy available for younger patients. | 04-07-2016 |
Patent application number | Description | Published |
20110009288 | METHODS AND REAGENTS FOR THE EARLY DETECTION OF MELANOMA - An assay for identifying early stage malignant melanocyte in biopsy tissues is provided by determining whether differential expression of a particular gene indicative of melanoma exceed a cut-off value. | 01-13-2011 |
20110166030 | Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells - A method for predicting with high specificity from RTPCR detected markers if a patent is likely to respond to docetaxel treatment is disclosed. RTPCR detects the presence of absence of certain mutations due to fusion events. Together, with other protein markers, additional stratification is possible to identify patents suited for docetaxel therapy as opposed to for alternative treatments. | 07-07-2011 |
20110275079 | DIAGNOSTIC BIOMARKERS OF DIABETES - Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility. | 11-10-2011 |
20130059755 | Gene Based Prediction of PSA Recurrence for Clinically Localized Prostate Cancer Patients - Disclosed are methods, devices and kits for determining the likelihood of recurrence of prostate cancer using the expression levels of preferably three-gene classifier. The methods, devices and kits can be used independent of many nomograms currently in use or to improve the overall performance of such nomograms. | 03-07-2013 |
20130217011 | DIAGNOSTIC BIOMARKERS OF DIABETES - Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described kits for the rapid diagnosis of diabetic disease states in patients at a point of care facility. | 08-22-2013 |
Patent application number | Description | Published |
20100024161 | Hold Open Rod - A hold open rod is provided that includes an outer tube, an inner tube, an inner rod, and a friction pad. The inner tube is slidingly disposed within the outer tube and includes a head with an inner bearing surface. The inner rod is slidingly disposed within the inner tube, is secured to one end of the outer tube, and has at least one tapered end portion. The friction pad is captured between the head inner bearing surface and the inner rod. | 02-04-2010 |
20100307872 | Mechanically Dampening Hold Open Road - A hold open rod is provided. The hold open rod includes an outer tube, a lock body connected to the outer tube, an inner tube, slidingly disposed within the outer tube and lock body, the inner tube having an outer surface, and a friction pad captured between the lock body and the outer surface of the inner tube. A method for damping movement of a telescoping rod is also provided. The method includes attaching the locking body to an outer tube, configuring the outer tube and the inner tube to move with respect to each other in a telescoping manner, fitting a damper between an outer diameter of an inner tube and a locking body, and fitting the damper to frictionally engage the outer diameter of the inner tube and the locking body. | 12-09-2010 |
20130145579 | CARBON FIBER HOLD OPEN ROD - A hold open rod system is provided. The system may include, a cylindrical bracket having a first portion with a first bore for coupling to an elongate tensile member and a second portion remote from the first portion, having a second bore for coupling to a fastener; and a tubular jacket surrounding the at least a portion of the bracket, the elongate tensile member and at least a portion of the fastener. A method of constructing a hold open rod may be provided. The method may include: attaching a bracket to an end of a composite tube; attaching the composite material to an elongate tension member; operatively connecting a fastener to the elongate tension member; and extending the elongate tension member through at least part of the bracket. | 06-13-2013 |
20130146736 | REINFORCED PLASTIC LOCKING DOGS - A hold open rod may include: an outer tube and an inner tube; a locking mechanism configured to selectively lock the inner tube with the outer tube; a locking groove in an outer surface of the inner tube; a locking dog and an outer housing covering the locking dog and at least part of the locking mechanism, the outer housing defining a cavity to contain the locking dog when the locking dog is in the outer radial position and also having an angled inner wall configured to engage the locking dog to move the locking dog to the inner radial position when the outer housing is moved to a locking position. A method of actuating a locking rod may be provided. | 06-13-2013 |
20130175419 | INTERNAL LOCKING MECHANISM FOR A HOLD OPEN ROD - A hold open rod may include: an inner member; an outer member configured to have the inner member slide in and out of the outer member; a locking mechanism including a portion attached to the outer member and a portion attached to the inner member; a locking plug configured to move axially along an axis of the inner, outer members; a locking dog configured to move radially between a locking position and an unlocking position and a release cable operatively connected to the locking plug and configured to move the locking plug to the unlocking position. A method of actuating a lock mechanism on a hold open rod may also be provided. | 07-11-2013 |
20130206955 | HOLD OPEN ROD VIBRATION DAMPENING SYSTEM AND METHOD - A hold open rod is provided. The hold open rod may include: an outer tube; an inner tube having two ends, at least one end configured to slide within the outer tube; a tube stop located at one end of the inner tube; a groove around the circumference of the tube stop; and a resilient material located in the groove, the resilient material contacting the tube stop and the outer tube. A method of reducing wear on a hold open rod may be provided. The method may include: locating first resilient material between an inner tube and an outer tube; providing a locking mechanism to lock the inner tube with respect to the outer tube; and providing a second resilient material between an isolator and a collar on the locking mechanism. | 08-15-2013 |
Patent application number | Description | Published |
20100087492 | SYSTEMIC TREATMENT OF BLOOD-SUCKING AND BLOOD-CONSUMING PARASITES BY ORAL ADMINISTRATION OF A PARASITICIDAL AGENT - Pharmaceutically acceptable single parasiticidal agent compositions of imidacloprid for oral delivery to mammals to systemically control targeted blood-sucking or blood-consuming parasites, such as fleas, ticks and certain species of helminthes and scabies. | 04-08-2010 |
20130072455 | Methods and Compositions for Treating Ectoparasite Infestation - Compositions and methods for killing ectoparasites on a subject. Compositions containing a fatty acid ester, e.g., isopropyl myristate, effective for killing ectoparasites is described. Also described are compositions containing a fatty acid ester and a siloxane (e.g., decacyclomethicone). The compositions can also contain a mectin and/or a mycin, and S-methoprene. The compositions are useful against a variety of ectoparasites that afflict humans, animals, and plants, e.g., head lice, fleas, body lice, crab lice, scabies, ticks, and plant parasites. | 03-21-2013 |
20140235688 | TREATMENT OF EXTERNAL PARASITES BY ORAL ADMINISTRATION OF PARASITICIDAL AGENTS - Pharmaceutically acceptable compositions of fipronil for oral delivery to mammals and methods for use of the compositions to control external parasites, such as fleas and ticks. | 08-21-2014 |