Patent application number | Description | Published |
20120034318 | DIAGNOSTIC METHOD USING PALB2 - The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient. | 02-09-2012 |
20120115735 | Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene - There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples using SAGE and next-generation sequencing-by-synthesis technologies. We found that pancreatic cancers contain an average of 63 genetic alterations, of which 49 are point mutations, 8 are homozygous deletions, and 6 are amplifications. Further analyses revealed a core set of 12 regulatory processes or pathways that were each genetically altered in 70% to 100% of the samples. The data suggest that dysregulation of this core set of pathways is responsible for the major features of pancreatic tumorigenesis. | 05-10-2012 |
20120135521 | ANTIGENE LOCKS AND THERAPEUTIC USES THEREOF - An oligonucleotide based therapeutic strategy, called anti-gene locks, is described which specifically kills cells based on their genotype. The strategy employs oligonucleotides with arms and a backbone that are complementary to both strands of the gene target. Anti-gene locks bind in vitro in a sequence dependent fashion and inhibit DNA synthesis. In bacterial cells containing an episome target, they cause elimination of the extra-chromosomal DNA structure. When the target is present in the bacterial or human genome, they selectively kill the majority of these cells. | 05-31-2012 |
Patent application number | Description | Published |
20130013552 | Interest-Driven Business Intelligence Systems and Methods of Data Analysis Using Interest-Driven Data Pipelines - Interest-driven Business Intelligence (BI) systems in accordance with embodiments of the invention are illustrated. In one embodiment of the invention, a data processing system includes raw data storage containing raw data, metadata storage containing metadata that describes the raw data, and an interest-driven data pipeline that is automatically compiled to generate reporting data using the raw data, wherein the interest-driven data pipeline is compiled based upon reporting data requirements automatically derived from at least one report specification defined using the metadata. | 01-10-2013 |
20130226860 | Interest-Driven Business Intelligence Systems and Methods of Data Analysis Using Interest-Driven Data Pipelines - Interest-driven Business Intelligence (BI) systems in accordance with embodiments of the invention are illustrated. In one embodiment of the invention, a data processing system includes raw data storage containing raw data, metadata storage containing metadata that describes the raw data, and an interest-driven data pipeline that is automatically compiled to generate reporting data using the raw data, wherein the interest-driven data pipeline is compiled based upon reporting data requirements automatically derived from at least one report specification defined using the metadata. | 08-29-2013 |
20130238551 | Interest-Driven Business Intelligence Systems and Methods of Data Analysis Using Interest-Driven Data Pipelines - Interest-driven Business Intelligence (BI) systems in accordance with embodiments of the invention are illustrated. In one embodiment of the invention, a data processing system includes raw data storage containing raw data, metadata storage containing metadata that describes the raw data, and an interest-driven data pipeline that is automatically compiled to generate reporting data using the raw data, wherein the interest-driven data pipeline is compiled based upon reporting data requirements automatically derived from at least one report specification defined using the metadata. | 09-12-2013 |
20140114970 | Systems and Methods for Interest-Driven Data Visualization Systems Utilized in Interest-Driven Business Intelligence Systems - Systems and methods for interest-driven data visualization systems in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven data visualization system includes a processor, a memory connected configured to store an interest-driven data visualization application, and metadata storage, wherein the interest-driven data visualization application configures the processor to define reporting data requirements, generate data retrieval job data based on the reporting data requirements, transmit the data retrieval job data, receive aggregate data, create at least one piece of reporting data using the received aggregate data and the reporting data requirements, associate visualization metadata with the reporting data describing the visual appearance of the at least one piece of reporting data, and generate a report using the reporting data requirements and the visualization metadata. | 04-24-2014 |
20140114971 | Systems and Methods for Interest-Driven Data Sharing in Interest-Driven Business Intelligence Systems - Systems and methods for interest-driven data sharing in interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven data sharing server system includes a processor, a memory configured to store an interest-driven data sharing application, raw data storage, metadata storage configured to store data description metadata describing the raw data, and report storage configured to store previously generated reports, wherein the interest-driven data sharing application configures the processor to receive a report specification, locate at least one previously generated report stored in the report storage, identify raw data stored in the raw data storage using the data description metadata and at least one of the reporting data requirements, calculate redundant data metadata using the located previously generated reports and the identified raw data, determine modified reporting data requirements, retrieve updated source data, and generate reporting data based on the updated source data. | 04-24-2014 |
20140258209 | Systems and Methods for Interest-Driven Distributed Data Server Systems - Systems and methods for interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven distributed data server system includes a processor, an interest-driven distributed data server application, aggregate data storage, and a data source directory, wherein the interest-driven distributed data server application configures the processor to obtain reporting data requirements, determine at least one data dimension using the reporting data requirements, identify at least one data source identified that can provide data associated with the data dimension, generate data source job data, transmit the data source job data to at least one data source, and receive job response data, store the received job response data in the aggregate data storage, build reporting data based on the reporting data requirements, and transmit the reporting data. | 09-11-2014 |
Patent application number | Description | Published |
20080288415 | Equity Protection - Systems and methods are illustrated for providing an equity protection product to a borrower of a loan. Aspects of the equity protection product may be implemented using an equity protection agreement. The equity protection product may be used to safeguard a borrower's investment in the event of a housing market downturn. In some examples, once the equity protection is purchased, the borrower's equity can only increase or remain stable (i.e., flat) regardless of market conditions. The payoff amount of the borrower's loan may be reduced to compensate for a change in the market value of the borrower's home. The equity protection product may be provided by a lending institution, bank, or any other comparable entity/person. A trading desk may also be used to hedge against the risk created by the equity protection product. In addition, an appraiser may also be used to evaluate and provide current market values of the relevant property. | 11-20-2008 |
20100293083 | INCOME CURTAILMENT PROTECTION - A method includes enrolling a borrower in income curtailment protection associated with a loan, where the loan requires periodic payments in order for the borrower to avoid defaulting on the loan. If income curtailment has occurred, a determination is made as to what portion of the periodic payment is to be covered on behalf of the borrower. The determined portion of the periodic payment is covered by an entity other than the borrower on behalf of the borrower. | 11-18-2010 |
20100293092 | FORECLOSURE PREVENTION AND PROTECTION - A method for process monitoring is disclosed. A borrower is offered a foreclosure prevention and protection plan associated with a secured loan. A periodic payment is received from the borrower in response to the borrower accepting the foreclosure prevention and protection plan. The foreclosure prevention and protection plan allows for at least a portion of a loan payment for the secured loan to be covered by a foreclosure prevention and protection (FPP) entity on behalf of the borrower in response to a covered event occurring. The foreclosure prevention and protection plan additionally may allow for paying/cancelling the debt's investor in response to loss of the property by the borrower. | 11-18-2010 |
20110178920 | EQUITY PROTECTION - Systems and methods are illustrated for providing an equity protection product to a borrower of a loan. Aspects of the equity protection product may be implemented using an equity protection agreement. The equity protection product may be used to safeguard a borrower's investment in the event of a housing market downturn. In some examples, once the equity protection is purchased, the borrower's equity can only increase or remain stable (i.e., flat) regardless of market conditions. The payoff amount of the borrower's loan may be reduced to compensate for a change in the market value of the borrower's home. The equity protection product may be provided by a lending institution, bank, or any other comparable entity/person. A trading desk may also be used to hedge against the risk created by the equity protection product. In addition, an appraiser may also be used to evaluate and provide current market values of the relevant property. | 07-21-2011 |
20120046973 | Unemployment Insurance Marketing System - Embodiments of the invention include systems, methods, and computer-program products that provide for a unique unemployment insurance marketing system. In one embodiment of the invention, the unemployment insurance marketing system determines selection criteria for the unemployment insurance product. The system then receives data associated with a user, the data received from a financial institution. The system compares the selection criteria with the user data to determine whether the user qualifies to receive an offer. If the user qualifies to receive an offer, the system offers the unemployment insurance to the user. In another embodiment of the invention, the offer is customized to the user's expenses. For example, the offer may be customized based on user's expenses in an online bill payment system. | 02-23-2012 |
20120046974 | Unemployment Insurance Underwriting System - Embodiments of the invention include systems, methods, and computer-program products that provide for a unique unemployment insurance underwriting system. In one embodiment of the invention, the unemployment insurance underwriting system receives a request to enroll in the unemployment insurance from a user. The system then receives data associated with the user from a financial institution. The system then determines the benefits to be paid to the user based, in some cases, on the data received from the financial institution. The system then determines whether the user qualifies to enroll in the unemployment insurance based on the benefits and the user data. In an embodiment of the invention, the unemployment insurance provides benefits for monthly expenses to users that have become involuntarily unemployed. | 02-23-2012 |
Patent application number | Description | Published |
20110090726 | PORTABLE ALTERNATING CURRENT INVERTER HAVING REDUCED IMPEDANCE LOSSES - A portable power supply apparatus is provided having reduced impedance losses. The portable power supply apparatus is comprised of: a portable housing; a battery system residing in the housing; and an inverter circuit residing in the housing. The battery system generates a direct current (DC) voltage having a magnitude greater than or equal to a peak value of a desired alternating current (AC) voltage. The inverter circuit receives the DC voltage directly from the battery system, converts the DC voltage to an AC output voltage and outputs the AC output voltage to one or more outlets exposed on an exterior surface of the portable housing. | 04-21-2011 |
20110203821 | POWER SCREWDRIVER HAVING ROTARY INPUT CONTROL - A power tool includes an output shaft configured to rotate about a longitudinal axis, a motor drivably connected to the output shaft to impart rotary motions thereto, and a rotational motion sensor spatially separated from the output shaft and operable to determine the user-imparted rotational motion of the power tool with respect to the longitudinal axis. A controller is electrically connected to the rotational motion sensor and the motor. The controller determines angular velocity of the power tool about the axis, rotational displacement of the power tool about the axis, and/or a direction of the rotational displacement using input from the rotational motion sensor. The controller then controls the motor according to the angular velocity, the rotational displacement, and/or the direction of the rotational displacement. | 08-25-2011 |
20120160529 | POWER SCREWDRIVER HAVING ROTARY INPUT CONTROL - An improved method is provided for operating a power tool. The method includes: monitoring rotational motion of the power tool about an axis using a rotational motion sensor disposed in the power tool; determining a direction of the rotational motion about the axis; and driving the output member in a direction defined by the detected rotational motion of the tool, where the output member is driven by a motor residing in the power tool. Thus, the output member is drive clockwise when the rotational motion of the tool is clockwise about the axis and the output member is drive counter-clockwise when the rotational motion of the tool is counter-clockwise about the axis. | 06-28-2012 |
20120273242 | TRIGGER PROFILE FOR A POWER TOOL - An improved method is provided for operating a power tool. The method includes receiving an input control variable from an input unit; determining a derivative of the input control variable; selecting one of a plurality of control profiles based on the control input variable and the derivative, each control profile correlating the control input variable of the input unit to a rotational speed at which to drive the output shaft; and driving the output shaft at a rotational speed in accordance with the selected control profile. | 11-01-2012 |
20130008676 | Trigger Profile For A Power Tool - An improved method is provided for operating a power tool. The method includes receiving an input control variable from an input unit; determining a derivative of the input control variable; selecting one of a plurality of control profiles based on the control input variable and the derivative, each control profile correlating the control input variable of the input unit to a rotational speed at which to drive the output shaft; and driving the output shaft at a rotational speed in accordance with the selected control profile. | 01-10-2013 |
20130021783 | LIGHTED POWER TOOL - A power tool includes a tool body having an output member that drives an accessory. An end effector is coupled for rotation with the output member. A light source is disposed on the end effector. A primary coil assembly is configured on the tool body and mounted concentric to the output member. The primary coil assembly includes a primary coil that is electrically connected to a power source of the power tool. A secondary coil assembly is configured on the end effector and mounted concentric to the output member. The secondary coil assembly includes a secondary coil that is electrically connected to the light source. Current flowing through the primary coil creates a magnetic field that causes current to flow through the secondary winding and power the light source. | 01-24-2013 |
20130186659 | TRIGGER PROFILE FOR A POWER TOOL - An improved method is provided for operating a power tool. The method includes receiving an input control variable from an input unit; receiving at least one tool parameter relating to the power tool; determining a derivative of the input control variable; selecting one of a plurality of control profiles based on the control input variable, the derivative of the input control variable, and the tool parameter, each control profile correlating the control input variable of the input unit to a rotational speed at which to drive the output shaft; and driving the output shaft at a rotational speed in accordance with the selected control profile. | 07-25-2013 |
20130186660 | TRIGGER PROFILE FOR A POWER TOOL - An improved method is provided for operating a power tool. The method includes receiving an input control variable from an input unit; determining a second derivative of the input control variable; selecting one of a plurality of control profiles based on the control input variable and the second derivative, each control profile correlating the control input variable of the input unit to a rotational speed at which to drive the output shaft; and driving the output shaft at a rotational speed in accordance with the selected control profile. | 07-25-2013 |