Ratnayake
Akhila Ishanka Ratnayake, Kawasaki JP
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20140068192 | PROCESSOR AND CONTROL METHOD OF PROCESSOR - A processor includes a plurality of CPU cores, each having an LI cache memory, that executes processing and issues a request, and an L2 cache memory connected to the plurality of CPU cores, the L2 cache memory is configured, when a request which requests a target data held by none of the L1 cache memories contained in the plurality of CPU cores, is a load request that permits other CPU cores, to make a response to the CPU core having sent the request, with non-exclusive information that indicates that the target data is non-exclusive data, together with the target data; and when the request is a load request that forbids other CPU cores, to make a response to the CPU core having sent the request, with exclusive information that indicates that the target data is exclusive, together with the target data. | 03-06-2014 |
Anokha Ratnayake, Mystic, CT US
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20140134193 | SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION - The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer. | 05-15-2014 |
20160022626 | SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION - The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer. | 01-28-2016 |
Chitra K. Ratnayake, Yorba Linda, CA US
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20090314638 | Methods and Compositions for Capillary Electrophoresis - This invention relates to improved methods and compositions for conducting Capillary Electrophoresis (CE) to separate molecules on the basis of their respective size or charge. | 12-24-2009 |
20110064869 | Coated Capillary Electrophoresis Tubes and System - The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to the inner capillary surface. The capillary tube has an inner surface that is coated with a first polymer layer having a plurality of polymer groups comprising polyethylene imine, designated herein as (CH | 03-17-2011 |
20140305801 | IMPROVED CAPILLARY ELECTROPHORESIS-ELECTROSPRAY IONIZATION-MASS SPECTROMETRY SYSTEM - Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems. | 10-16-2014 |
Chitra Kumari Ratnayake, Yorba Linda, CA US
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20090033002 | METHODS AND APPARATUS FOR IMPROVING THE SENSITIVITY OF CAPILLARY ZONE ELECTROPHORESIS - The present invention relates to novel methods and apparatus for improving the sensitivity of capillary zone electrophoresis (CZE). The invention particularly concerns devices comprising a channel that contains an in-line sol-gel column to concentrate samples being subjected to capillary zone electrophoresis, and the use of such devices to enhance the sensitivity of capillary zone electrophoresis. | 02-05-2009 |
20120267246 | METHODS AND APPARATUS FOR IMPROVING THE SENSITIVITY OF CAPILLARY ZONE ELECTROPHORESIS - The present invention relates to novel methods and apparatus for improving the sensitivity of capillary zone electrophoresis (CZE). The invention particularly concerns devices comprising a channel that contains an in-line sol-gel column to concentrate samples being subjected to capillary zone electrophoresis, and the use of such devices to enhance the sensitivity of capillary zone electrophoresis. | 10-25-2012 |
Jayantha Ratnayake, Bedford GB
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20130095172 | USES FOR AND ARTICLE OF MANUFACTURE INCLUDING HER2 DIMERIZATION INHIBITOR PERTUZUMAB - The present application describes uses for and articles of manufacture including Pertuzumab, a first-in-class HER2 dimerization inhibitor. In particular, the application describes methods for extending progression free survival in a HER2-positive breast cancer patient population; combining two HER2 antibodies to treat HER2-positive cancer without increasing cardiac toxicity; treating early-stage HER2-positive breast cancer; treating HER2-positive cancer by co-administering a mixture of Pertuzumab and Trastuzumab from the same intravenous bag; treating HER2-positive metastatic gastric cancer; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and Vinorelbine; treating HER2-positive breast cancer with Pertuzumab, Trastuzumab and aromatase inhibitor; and treating low HER3 ovarian, primary peritoneal, or fallopian tube cancer. It also describes an article of manufacture comprising a vial with Pertuzumab therein and a package insert providing safety and/or efficacy data thereon; a method of making the article of manufacture; and a method of ensuring safe and effective use of Pertuzumab related thereto. In addition the application describes an intravenous (IV) bag containing a stable mixture of Pertuzumab and Trastuzumab suitable for administration to a cancer patient. | 04-18-2013 |
20150079076 | IDENTIFICATION OF NON-RESPONDERS TO HER2 INHIBITORS - The present invention relates to means and methods for the identification of non-responders to a HER2 inhibitor, whereby one or more mutations in exon 9 of Phosphoinositol-3 kinase (PIK3CA) indicate non-responsiveness. | 03-19-2015 |
Madhawa Ratnayake, Houston, TX US
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20160053577 | PRESSURE DIFFERENTIAL DEVICE WITH CONSTANT PRESSURE DROP - In one aspect, an apparatus for use in a wellbore is disclosed, including: an inlet; an outlet; and a variable flow restriction configured to provide a predetermined constant pressure drop between the inlet and the outlet in response to a range of inlet flow rates. In another aspect, a method for providing a fluid flow within a wellbore is disclosed, including: providing the fluid flow to an inlet; restricting the fluid flow to provide a predetermined constant pressure drop between the inlet and an outlet in response to a range of fluid flow rates; and providing the fluid flow to the wellbore from the outlet. | 02-25-2016 |
Ranjala Ratnayake, Frederick, MD US
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20100286259 | EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER - Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plant | 11-11-2010 |
Ranjala Ratnayake, Gainesville, FL US
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20160051604 | SEAWEED EXTRACTS, UNSATURATED ALDEHYDES, AND METHODS OF TREATMENT - The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof. | 02-25-2016 |
Ruwan Ratnayake, Cambridge, MA US
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20100103999 | PARTIAL RESPONSE DECISION-FEEDBACK EQUALIZATION WITH ADAPTATION BASED ON EDGE SAMPLES | 04-29-2010 |
20140016692 | EDGE BASED PARTIAL RESPONSE EQUALIZATION - A device implements data reception with edge-based partial response decision feedback equalization. In an example embodiment, the device implements a tap weight adapter circuit that sets the tap weights that are used for adjustment of a received data signal. The tap weight adapter circuit sets the tap weights based on previously determined data values and input from an edge analysis of the received data signal using a set of edge samplers. The edge analysis may include adjusting the sampled data signal by the tap weights determined by the tap weight adapter circuit. A clock generation circuit generates an edge clock signal to control the edge sampling performed by the set of edge samplers. The edge clock signal may be generated as a function of the signals of the edge samplers and prior data values determined by the equalizer. | 01-16-2014 |
20150036732 | EDGE BASED PARTIAL RESPONSE EQUALIZATION - A method is disclosed. The method includes sampling a data signal having a voltage value at an expected edge time of the data signal. A first alpha value is generated, and a second alpha value generated in dependence upon the voltage value. The data signal is adjusted by the first alpha value to derive a first adjusted signal. The data signal is adjusted by the second alpha value to derive a second adjusted signal. The first adjusted signal is sampled to output a first data value while the second adjusted signal is sampled to output a second data value. A selection is made between the first data value and the second data value as a function of a prior received data value to determine a received data value. | 02-05-2015 |
Upul Nishantha Ratnayake, Navinna LK
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20120004347 | PROCESS FOR MAKING REINFORCING ELASTOMER-CLAY NANOCOMPOSITES - A process for producing a natural rubber nanocomposite containing exfoliated organically modified montmorillonite and maleic anhydride grafted elastomer in a dispersion of natural rubber and reinforcing filler/inert filler wherein the cured nanocomposite has improved mechanical properties compared to conventional rubber compound containing a mixture of the reinforcing filler, carbon black and the inert filler, CaCO | 01-05-2012 |