Patent application number | Description | Published |
20130202173 | CLASSIFICATION OF BIOLOGICAL TISSUE BY MULTI-MODE DATA REGISTRATION, SEGMENTATION AND CHARACTERIZATION - A method and apparatus for classifying possibly vulnerable plaques from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as vulnerable or stable. | 08-08-2013 |
20140294264 | Quantitatively Characterizing Disease Morphology With Co-Occurring Gland Tensors In Localized Subgraphs - Apparatus, methods, and other embodiments associated with objectively predicting biochemical recurrence with co-occurring gland tensors in localized subgraphs are described. One example apparatus includes a set of logics that associate directional disorder with a risk of failure in a material. A first logic detects a fundamental unit of composition in the material, segments boundaries of the fundamental unit, and calculates a directional tensor for the fundamental unit. A second logic constructs a localized sparsified subgraph whose nodes represent centroids of the fundamental units, defines pairwise spatial relationships between the fundamental units, and constructs a directional co-occurrence matrix based on the spatial relationships. A third logic derives second order statistical features from the co-occurrence matrix, and produces a risk failure score as a function of the second order statistical features. The second order statistical features include the entropy of the directional organization of the fundamental units. | 10-02-2014 |
20140294271 | Image Similarity-Based Finite Element Model Registration - Apparatus, methods, and other embodiments associated with evaluating global deformations and local deformations in a prostate are described. One example apparatus includes logics that evaluate global and local deformations in a prostate and register a pre-External Beam Radiation Treatment (EBRT) three dimensional (3D) magnetic resonance (MR) image with a post-EBRT 3D MR image. An image acquisition logic acquires a pre-EBRT image and a post EBRT image of an organ, item, or volume. An image texture information logic extracts image texture information from the pre-EBRT and post-EBRT images. A finite element model (FEM) transformation logic constructs a FEM of the volume imaged in the pre-EBRT image, deforms the FEM, deforms the pre-EBRT image as a function of the deformed FEM, and maximizes the image texture similarity between the deformed pre-EBRT image and the post-EBRT image. A registration logic registers the pre-EBRT image with the post-EBRT image based on the transformation. | 10-02-2014 |
20140294272 | Discriminatively Weighted Multi-Scale Local Binary Patterns - Apparatus and methods associated with detecting prostate cancer (CaP) in a magnetic resonance (MR) image of a prostate of a CaP patient are described. One example apparatus includes logics that acquire an image of a prostate, learn a weighted vector, detect salient features in the image of the prostate, and generate a heatmap that facilitates detecting CaP. An image acquisition logic acquires a T2 weighted MR image of a prostate. A learning logic learns a weighted vector based on a set of positive LBP descriptors and a set of negative LBP descriptors extracted from the image at multiple scales. A salient feature detection logic detects salient features in the image based on the weighted vector and a pixel-by-pixel weighted Hamming matching of the image. A prediction logic generates a statistical probability heatmap based on the weighted vector and the weighted Hamming matching of the image. | 10-02-2014 |
20140294279 | Quantitatively Characterizing Disease Morphology With Cell Orientation Entropy - Apparatus, methods, and other embodiments associated with objectively predicting biochemical recurrence (BCR) with cell orientation entropy (COrE) are described. One example apparatus includes a set of logics that associate directional disorder with a risk of biochemical recurrence in a tissue. A first logic detects a cell in the tissue, segments boundaries of the cell, and calculates a cell direction for the cell. A second logic constructs a localized sparsified subgraph whose nodes represent centroids of the cells, defines pairwise spatial relationships between the cells, and constructs a directional co-occurrence matrix based on the spatial relationships. A third logic derives second order statistical features from the co-occurrence matrix, and produces a BCR risk score as a function of the second order statistical features. The second order statistical features include the entropy of the directional organization of the cells. | 10-02-2014 |
20150213302 | Automatic Detection Of Mitosis Using Handcrafted And Convolutional Neural Network Features - Methods, apparatus, and other embodiments associated with detecting mitosis in breast cancer pathology images by combining handcrafted (HC) and convolutional neural network (CNN) features in a cascaded architecture are described. One example apparatus includes a set of logics that acquires an image of a region of tissue, partitions the image into candidate patches, generates a first probability that the patch is mitotic using an HC feature set and a second probability that the patch is mitotic using a CNN-learned feature set, and classifies the patch based on the first probability and the second probability. If the first and second probabilities do not agree, the apparatus trains a cascaded classifier on the CNN-learned feature set and the HC feature set, generates a third probability that the patch is mitotic, and classifies the patch based on a weighted average of the first probability, the second probability, and the third probability. | 07-30-2015 |
20150213598 | Spatially Aware Cell Cluster (SPACCL) Graphs - Methods, apparatus, and other embodiments associated with objectively predicting disease aggressiveness using Spatially Aware Cell Cluster (SpACCI) graphs are described. One example apparatus includes a set of logics that acquires an image of a region of tissue, partitions the image into a stromal compartment and an epithelial compartment, identifies cluster nodes within the compartments, constructs a spatially aware stromal sub-graph and a spatially aware epithelial sub-graph based on the cluster nodes and a probabilistic decaying function of the distance between cluster nodes, extracts local features from the sub-graphs, and predicts the aggressiveness of a disease in the region of tissue based on the sub-graphs and the extracted features. Example methods and apparatus may employ a Support Vector Machine classifier to classify super-pixels within the image as stromal super-pixels or epithelial super-pixels. | 07-30-2015 |
20150254417 | Group-Sparse Nonnegative Supervised Canonical Correlation Analysis (GNCCA) - Methods, apparatus, application specific integrated circuits (ASIC)s and other embodiments associated with analyzing a cancerous prostate using group-sparse non-negative canonical correlation analysis (GNCCA) with a variable importance in the projections (VIP) score are described. One example apparatus includes a set of logics that acquires a set of features from a plurality of feature views of a region of tissue demonstrating cancerous pathology, produces a ranked set of discriminative features using GNCCA with the VIP score, optimizes computation of the GNCCA using a vector-block coordinate descent (BCD) approach, and provides a prostate cancer (CaP) grade or a biochemical recurrence (BcR) score based on the set of discriminative features. Embodiments of example apparatus may generate and display the CaP grade, BcR score, or set of discriminative features. | 09-10-2015 |
20150254493 | Tumor Plus Adjacent Benign Signature (TABS) For Quantitative Histomorphometry - Methods, apparatus, and other embodiments associated with predicting prostate cancer (CaP) progression using tumor cell morphology features and benign region graph features are described. One example apparatus includes a set of logics that acquires an image of a region of tissue, detects and segments cells in the image, extracts a set of morphological features from cells in a first region in the image, constructs a graph of a localized cellular network in a second region of the image, extracts a set of graph features from the graph, generates a set of tumor plus adjacent features signature (TABS) features from the sets of graph features and the set of morphological features, and calculates the probability that the image is a progressor or non-progressor based, at least in part, on the set of TABS features. The first region may concern cancerous cells and the second region may concern benign cells. | 09-10-2015 |
20150254494 | Histogram of Hosoya Index (HoH) Features For Quantitative Histomorphometry - Methods, apparatus, and other embodiments associated with classifying a region of cancerous tissue using a Histogram of Hosoya are described. One example apparatus includes a set of logics that acquires an image of a region of tissue demonstrating cancerous pathology, constructs a cell graph of the region of tissue, decomposes the cell graph into a set of subgraphs, computes a Hosoya Index for a subgraph, constructs a Histogram of Hosoya for the image based on the distribution of the subgraphs, and classifies the image based on the Histogram of Hosoya. Embodiments of example apparatus may generate and display the Histogram of Hosoya for the image. A prognosis for the patient may be provided based on the distribution of the histogram. | 09-10-2015 |
20150254840 | Co-Occurrence of Local Anisotropic Gradient Orientations - Methods, apparatus, and other embodiments associated with distinguishing disease phenotypes using co-occurrence of local anisotropic gradient orientations (CoLIAGe) are described. One example apparatus includes a set of logics that acquires a radiologic image (e.g., MRI image) of a region of tissue demonstrating disease pathology (e.g., cancer), computes a gradient orientation for a pixel in the MRI image, computes a significant orientation for the pixel based on the gradient orientation, constructs a feature vector that captures a discretized entropy distribution for the image based on the significant orientation, and classifies the phenotype of the disease pathology based on the feature vector. Embodiments of example apparatus may generate and display a heatmap of entropy values for the image. Example methods and apparatus may operate substantially in real-time. Example methods and apparatus may operate in two or three dimensions. | 09-10-2015 |
Patent application number | Description | Published |
20100098306 | MALIGNANCY DIAGNOSIS USING CONTENT - BASED IMAGE RETREIVAL OF TISSUE HISTOPATHOLOGY - This invention relates to computer-aided diagnostics using content-based retrieval of histopathological image features. Specifically, the invention relates to the extraction of image features from a histopathological image based on predetermined criteria and their analysis for malignancy determination. | 04-22-2010 |
20100169024 | DEFINING QUANTITATIVE SIGNATURES FOR DIFFERENT GLEASON GRADES OF PROSTATE CANCER USING MAGNETIC RESONANCE SPECTROSCOPY - A method for classifying a possible cancer from a magnetic resonance spectrographic (MRS) dataset includes extracting at least one feature from the MRS dataset as being identified with the possible cancer and embedding the extracted feature into a low dimensional space to form an embedded space. The method then clusters the embedded space into clusters representing a plurality of predetermined classes and spectrally decomposing the clusters to identify substantially significant independent metabolic signatures. The method then classifies the possible cancer as belong to one of at least two cancer classes based on the identified independent metabolic signatures. | 07-01-2010 |
20100177944 | COMBINED FEATURE ENSEMBLE MUTUAL INFORMATION IMAGE REGISTRATION - This invention relates to medical image registration. Specifically, the invention relates to a combined feature ensemble mutual information (COFEMI) for robust inter-modal, inter-protocol image registration. | 07-15-2010 |
20100329529 | COMPUTER ASSISTED DIAGNOSIS (CAD) OF CANCER USING MULTI-FUNCTIONAL, MULTI-MODAL IN-VIVO MAGNETIC RESONANCE SPECTROSCOPY (MRS) AND IMAGING (MRI) - This invention relates to computer-assisted diagnostics and classification of prostate cancer. Specifically, the invention relates to segmentation of the prostate boundary on MRI images, cancer detection using multimodal multi-protocol MR data; and their integration for a computer-aided diagnosis and classification system for prostate cancer. | 12-30-2010 |
20110026798 | SYSTEM AND METHOD FOR AUTOMATED SEGMENTATION, CHARACTERIZATION, AND CLASSIFICATION OF POSSIBLY MALIGNANT LESIONS AND STRATIFICATION OF MALIGNANT TUMORS - A method and apparatus for classifying possibly malignant lesions from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as malignant or benign. The malignant lesions are further classified to separate TN lesions from non-TN lesions. | 02-03-2011 |
20110243417 | SYSTEM AND METHOD FOR ACCURATE AND RAPID IDENTIFICATION OF DISEASED REGIONS ON BIOLOGICAL IMAGES WITH APPLICATIONS TO DISEASE DIAGNOSIS AND PROGNOSIS - The present invention relates to a method and system for detecting biologically relevant structures in a hierarchical fashion, beginning at a low-resolution and proceeding to higher levels of resolution. The present invention also provides probabilistic pairwise Markov models (PPMMs) to classify these relevant structures. The invention is directed to a novel classification approach which weighs the importance of these structures. The present invention also provides a fast, efficient computer-aided detection/diagnosis (CAD) system capable of rapidly processing medical images (i.e. high throughput). The computer-aided detection/diagnosis (CAD) system of the present invention allows for rapid analysis of medical images the improving the ability to effectively detect, diagnose, and treat certain diseases. | 10-06-2011 |
20120106821 | IMAGE-BASED RISK SCORE-A PROGNOSTIC PREDICTOR OF SURVIVAL AND OUTCOME FROM DIGITAL HISTOPATHOLOGY - The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological processes, including but not limited to cancer. Using only a tissue slide samples, a mechanism for digital slide scanning, and a computer, the present invention relates to an image-based CAP system and method which aims to overcome many of the drawbacks associated with prognostic molecular assays (e.g. Oncotype DX) including the high cost associated with the assay, limited laboratory facilities with specialized equipment, and length of time between biopsy and prognostic prediction. | 05-03-2012 |
20120219206 | High-Throughput Biomarker Segmentation Utilizing Hierarchical Normalized Cuts - A method and apparatus for obtaining segmented images of the stained regions may comprise quantifying the extent of the presence of staining of a biomarker in an original image of a sample, which may comprise selecting a domain swatch of data based upon a user specified domain knowledge; clustering the data within the original image by conducting a frequency weighted mean shift of the data within the original image to convergence, forming a hierarchical plurality of layers each having a different data resolution to form a hierarchical data pyramid; segmenting the plurality of mean shifted data images to determine in each mean shifted data image within the hierarchical data pyramid data not excluded as outside of the swatch; mapping the data not excluded as outside the swatch spatially back to the original image to create a final image; and, storing the final image on a storage medium for further analysis. | 08-30-2012 |
20140037172 | ENHANCED MULTI-PROTOCOL ANALYSIS VIA INTELLIGENT SUPERVISED EMBEDDING (EMPRAVISE) FOR MULTIMODAL DATA FUSION - The present invention provides a system and method for analysis of multimodal imaging and non-imaging biomedical data, using a multi-parametric data representation and integration framework. The present invention makes use of (1) dimensionality reduction to account for differing dimensionalities and scale in multimodal biomedical data, and (2) a supervised ensemble of embeddings to accurately capture maximum available class information from the data. | 02-06-2014 |
20140064580 | METHOD AND APPARATUS FOR SEGMENTATION AND REGISTRATION OF LONGITUDINAL IMAGES - The described invention provides systems and methods for detecting and segmenting a lesion from longitudinal, time series, or multi-parametric imaging by utilizing spectral embedding-based active contour (SEAC). In addition, the described invention further provides systems and methods for registering time series data by utilizing reduced-dimension eigenvectors derived from spectral embedding (SE) of feature scenes (SERg). | 03-06-2014 |
20140064581 | BOOSTED CONSENSUS CLASSIFIER FOR LARGE IMAGES USING FIELDS OF VIEW OF VARIOUS SIZES - A system and method for predicting disease outcome by analyzing a large, heterogeneous image by a boosted, multi-field-of-view (FOV) framework, based on image-based features from multi-parametric heterogeneous images, comprises (a) inputting the heterogeneous image; (b) generating a plurality of FOVs at a plurality of fixed FOV sizes, the method for generating the plurality of FOVs at a plurality of fixed FOV sizes comprising dividing simultaneously, via the computing device, the large, heterogeneous image into (i) a plurality of FOVs at a first fixed FOV size from among the plurality of fixed FOV sizes; and (ii) a plurality of FOVs at a second fixed FOV size from among the plurality of fixed FOV sizes; (c) producing simultaneously for the heterogeneous image a combined class decision for: (i) the plurality of FOVs at the first fixed FOV size, and (ii) the plurality of FOV s at the second fixed FOV size. | 03-06-2014 |
20140314286 | Integrated Multivariate Image-Based Method for Disease Outcome Prediction - The described invention provides a system and method for predicting disease outcome using a multi-field-of-view scheme based on image-based features from multi-parametric heterogenous images. | 10-23-2014 |
20150030219 | METHOD AND APPARATUS FOR SHAPE BASED DEFORMABLE SEGMENTATION OF MULTIPLE OVERLAPPING OBJECTS - The present invention provides a system and method for simultaneous variational and adaptive segmentation of single non-overlapping and multiple overlapping/occluded-objects in an image scene. The method according to the present invention synergistically combines shape priors with boundary and region-based active contours in a level set formulation with a watershed scheme for model initialization for identifying and resolving multiple object overlaps in an image scene. The method according to the present invention comprises learning a shape prior for a target object of interest and applying the shape prior into a hybrid active contour model to segment overlapping and non-overlapping objects simultaneously. | 01-29-2015 |
Patent application number | Description | Published |
20120044817 | Managing Network Bandwidth - A system for managing network bandwidth, according to one embodiment of the present invention comprises a configuration storage module and a call manager. The configuration storage module includes a supported codecs storage, codec lists, administrator settings storage and reservation storage list. The call manager includes an extension module, trunk module, location service engine, settings manager, bandwidth manager and media stream manager. The call manager receives an offer message for a call having one or more media types. The call manager uses information included in the offer message, along with information stored in the configuration storage module, to negotiate a call settings list with one or more other sites for connecting the call, and thereby manage bandwidth for the call. | 02-23-2012 |
20120044931 | Via Site for Managing Network Bandwidth - A system for using one or more via sites to manage network bandwidth, according to one embodiment of the present invention comprises a first call manager at a source site receiving an offer message to connect a call. The offer message includes an endpoint media settings list. The first call manager determines a first filtered media preferences list based on a source media settings list and the endpoint media settings list. The first call manager and transmits an invite message to a second call manager at a first via site. The invite message includes the first filtered media preferences list. The first call manager receives from the second call manager a call settings list that includes a description of the call settings negotiated between the source site, the first via site and a destination site. | 02-23-2012 |
20130155882 | BANDWIDTH UTILIZATION MONITORING FOR A COMMUNICATION SYSTEM - A system to monitor bandwidth can include memory to store session data describing each communication session for at least a portion of a communication system. A bandwidth calculator can access the session data and provide a measure of bandwidth utilization computed based on the accessed session data. | 06-20-2013 |
20140198786 | MANAGING NETWORK BANDWIDTH - A system for using one or more via sites to manage network bandwidth, according to one embodiment of the present invention comprises a first call manager at a source site receiving an offer message to connect a call. The offer message includes an endpoint media settings list. The first call manager determines a first filtered media preferences list based on a source media settings list and the endpoint media settings list. The first call manager and transmits an invite message to a second call manager at a first via site. The invite message includes the first filtered media preferences list. The first call manager receives from the second call manager a call settings list that includes a description of the call settings negotiated between the source site, the first via site and a destination site. | 07-17-2014 |
Patent application number | Description | Published |
20100212920 | INERT GAS FLOODING FIRE SUPPRESSION WITH WATER AUGMENTATION - A method and system are provided for suppressing a fire inside a defined volume within a structure. To suppress a fire, the defined volume is flooded with a flow of inert gas into which a limited amount of water is introduced into the flow of inert gas; the flow of inert gas and the limited amount of water introduced therein being sufficient to establish a fire extinguishing atmosphere within the defined volume having a volumetric oxygen concentration of at least about 14%. A cartridge for storing a limited amount of water has a water outlet in flow communication with a spray nozzle that is in flow communication with a supply of pressurized inert gas. The water storage cartridge has a gas inlet in flow communication with a supply of pressurized inert gas for pressurizing the water storage cartridge to cause water to flow therefrom to the spray nozzle. | 08-26-2010 |
20100294518 | HYBRID INERT GAS FIRE SUPPRESSION SYSTEM - A hybrid fire suppression system includes a supply of pressurized inert gas, a pipe network connected in inert gas flow communication to the inert gas supply, a first inert gas nozzle, a second inert gas nozzle, and a water storage cartridge having an interior volume defining a water reservoir storing a limited amount of water. The water reservoir communicates with the second inert gas spray nozzle. The first inert gas nozzle connects with the first terminus for introducing a flooding flow of inert gas only into a first protected space. The second inert gas nozzle connects with the second terminus for introducing a flooding flow of inert gas and the limited amount of water from the water reservoir into the second protected space. | 11-25-2010 |
20110108125 | FLOW SPLITTING DEVICE FOR ANNULAR TWO-PHASE PIPE FLOW - A flow splitting device for use in a two-phase flow distribution network includes a side junction tee having a first conduit and a second conduit opening in flow communication to the first conduit, a flow restriction provided in the first conduit upstream of the opening of the second conduit with the first conduit, and a flow barrier extending into the first conduit at a location in the vicinity of a downstream edge of the opening of the second conduit to the first conduit. The ratio of the liquid phase mass flow to the gas phase mass flow is preserved as the mass flow ratio of liquid to gas to each of the two exit streams is substantially equal to the mass flow ratio of liquid to gas in the two-phase flow received by the flow splitting device. | 05-12-2011 |
20110180276 | FIRE SUPPRESSION SYSTEM WITH IMPROVED TWO-PHASE FLOW DISTRIBUTION - A two-phase liquid/inert gas flow inerting fire suppression system is provided having improved liquid fire suppressant distribution within the inert gas flow. The system includes a flow distribution network having a first pipe interconnected with a second pipe at a flow splitting tee. A liquid flow redistribution device is disposed in the first pipe upstream with respect to fluid flow of the flow splitting tee. | 07-28-2011 |
20110259617 | ATOMIZING NOZZLE FOR A FIRE SUPPRESSION SYSTEM - A nozzle for a fire suppression system has a bonnet and a deflector base. An inlet port extends through the bonnet along the axis of symmetry of the bonnet. The inlet port receives an outlet end of a fire suppression delivery pipe to mount the bonnet to the pipe. The bonnet has a frustoconical surface which extends radially outward and downward from the inlet port. The deflector base is secured to and co-axially aligned with the bonnet at a predetermined distance to create a flow passageway therebetween. The flow passageway imparts a down angle to a suppressant flow discharging from the nozzle to better disperse the suppressant within the fire zone. A discharge port at the circumferential edge of the bonnet and deflector base constricts the suppressant flow to atomize the droplets of liquid suppressant discharged into the fire zone. | 10-27-2011 |
Patent application number | Description | Published |
20160034649 | INTEGRATED HEALTH AND WEALTH ACCOUNT SYSTEM AND METHOD - A computerized method and system for managing a multi-function, integrated account. The account may span multiple legal entities and contain both health and wealth data. The account may contain data pertaining to participants' health insurance, supplemental insurance, and other types of insurance (both health and non-health) and may track payment data, claim data, co-pays, etc. as well as data pertaining to the health of participants. Health data may further comprise information pertaining to participants' weight, body mass index, blood pressure, and fitness level. The multi-function account comprises financial data such as investment data, brokerage data, mortgage data, and savings, debit, and credit account data. Participants are further rewarded for partaking in certain health and financial activities and for performing certain health and financial tasks. Participants may dial a single telephone number or access a single web site in order to access the health and wealth data of the multi-function account. | 02-04-2016 |
20160035243 | PORTABLE HEALTH ACTIVITY TRACKING DEVICE - A portable electronic device that assists in the maintenance of a healthy lifestyle by recording biometric measurement data, confirming completion of healthy activities, and generating graphs from biometric measurement data. The device may comprise a speaker for providing instructions to users as to how the portable device is to be used, results of biometric measurements, counting down the time remaining until a biometric measurement has been obtained, etc. The device may connect to a remote computer of a health care facility, health care provider, or insurance provider. Completion data for health activities is recorded. As the user completes measurements or other health activities such as appointments, the third party may provide a code for the user to record in the device to signal completion of the activity. The device may also be used to record data related to a user's participation in a rewards program. | 02-04-2016 |