Patent application number | Description | Published |
20110100938 | Structurally Ribbed Support Component for Millwork Drying Operations - The present invention is a modular stacking system for continuous stack drying of millwork that is easily transported and takes up a minimal amount of floor space when assembled. The modular stacking system is comprised of modular stabilizing stackable blocks and lightweight cross members which allow the user to create multiple stacking layers. The design of the stackable blocks ensures that the stacking system remains stable even with a large number of layers. | 05-05-2011 |
20120000255 | LOCKABLE ENCLOSURE WITH LOADING CARTRIDGE - A lockable enclosure includes a housing and a loading cartridge assembled with the housing and vertically slidable between a secured position in which a recess of the loading cartridge cannot be accessed through a bottom opening of the housing, and an access position in which at least a portion of the recess extends through at least a portion of the opening, such that a storable item may be withdrawn from the recess. A locking mechanism is assembled with the housing and configured to secure the loading cartridge in the secured position in a locked condition and to release the loading cartridge in an unlocked condition for downward vertical movement from the secured position to the access position. A lock interface assembled with the housing is configured to move the locking mechanism from the locked condition to the unlocked condition in response to proper user manipulation of the lock interface. | 01-05-2012 |
20120305565 | LOCKING MECHANISM - A locking mechanism for a storage container is provided. The locking mechanism is positioned on a center post of the storage container and includes a sled, a handle or knob, a connecting mechanism, a sled arresting mechanism, and a lock. Depending upon the position of the lock, the handle can unlatch the container. When the lock is in the unlocked position, the sled arresting mechanism allows the unlatching of the container. When the lock is in the locked position, the sled arresting mechanism prevents the unlatching of the container. The locking mechanism is resistant to drill attack due to its vertical configuration and positioning of a cover on the center post. | 12-06-2012 |
20150158714 | SYSTEM AND METHOD OF DISPENSING FOOD PRODUCT FROM A PUMP-LESS, REFRIGERATED FOOD DISPENSING SYSTEM - A pump-less, refrigerated food dispensing system including a refrigerated cabinet and a cassette drive system disposed within the refrigerated cabinet. The cassette drive system including at least one cartridge holder, at least one compression assembly operably coupled to the at least one cartridge holder, at least one motor operably coupled to the at least one compression assembly, and at least one switching mechanism operably coupled to the at least one motor. A method for dispensing food from a pump-less refrigerated food dispensing system wherein at least one step includes transferring power from one of the at least two motors to another of the at least two motors when the compression device is at a final predetermined position. | 06-11-2015 |
Patent application number | Description | Published |
20090202493 | MIR-150 FOR THE TREATMENT OF BLOOD DISORDERS - The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively. | 08-13-2009 |
20110280861 | METHOD FOR MIR-125A IN PROMOTING HEMATOPOIETIC STEM CELL SELF RENEWAL AND EXPANSION - Embodiments of the invention relate to methods and compositions for the expansion of hematopoietic stem cell (HSC) self renewal. The microRNA-125a is a master control of HSC self-renewal. Increased expression of mir-125a increased HSC self-renewal by 6-30 folds. Increased expression of mir-125a can be used to expand HSC ex vivo and in vivo. | 11-17-2011 |
20130039895 | MIR-150 FOR THE TREATMENT OF BLOOD DISORDERS - The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively. | 02-14-2013 |
20140050707 | MIR-150 FOR THE TREATMENT OF BLOOD DISORDERS - The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively. | 02-20-2014 |
20140363449 | METHODS, ASSAYS, AND SYSTEMS RELATING TO SAKT - The technology described herein is directed to methods, assays, and systems relating to determining the level of SAKT signaling activity in a sample obtained from a subject as well as methods relating to administering inhibitors and/or agonists of SAKT signaling. | 12-11-2014 |
Patent application number | Description | Published |
20080305085 | Compositions And Methods For Stem Cell Expansion - The present invention features methods and compositions that are useful for promoting stem cell survival and expansion. In addition, the invention also provides compositions and methods for the treatment of neoplasia. | 12-11-2008 |
20090092625 | PARATHYROID HORMONE RECEPTOR ACTIVATION AND HEMATOPOIETIC PROGENITOR CELL EXPANSION - The invention relates to methods for manipulating hematopoietic progenitor cells and related products In one aspect the invention relates to the use of agents that activate a PTH/PTHrP receptor to enhance the growth and maintenance of hematopoietic progenitor cells in vivo and in vitro, to enhance mobilization of hematopoietic stem cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function. | 04-09-2009 |
20090208467 | P27 AND P21 IN GENE THERAPIES - The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21 | 08-20-2009 |
20090220465 | METHODS AND COMPOSITIONS FOR MODULATION OF STEM CELL AGING - Methods are described for promoting or maintaining self-renewal of a stem cell expressing or expected to express p16 | 09-03-2009 |
20100034832 | METHODS FOR MANIPULATING STEM CELLS - The invention generally features methods and compositions for enhancing stem cell function. In particular, the invention provides therapeutic or prophylactic methods that can increase survival, growth or proliferation during blood and/or stem cell transplant and protect stem cells in settings of injury. | 02-11-2010 |
20100113360 | PARATHYROID HORMONE RECEPTOR ACTIVATION AND STEM AND PROGENITOR CELL EXPANSION - The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells. | 05-06-2010 |
20110224142 | PARATHYROID HORMONE RECEPTOR ACTIVATION AND STEM AND PROGENITOR CELL EXPANSION - The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells. | 09-15-2011 |
20110305675 | METHODS FOR EXPANSION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS - Described herein are methods and compositions for expanding hematopoietic stem and progenitor cells (HSPC) ex vivo and in vivo, and methods and compositions for transplanting HSPCs and treatment of anemia in a human subject. HSPCs are expanded in the presence of an inhibitor of serine threonine kinase 38 (STK38), wherein said inhibitor is preferably an RNAi agent. | 12-15-2011 |
20120201792 | METHODS AND PRODUCTS FOR MANIPULATING HEMATOPOIETIC STEM CELLS - The invention relates to methods for manipulating hematopoietic stem cells and related products. In one aspect the invention relates to the use of stem cell G-protein coupled receptor (SC-GPR) related compositions to identify bone marrow derived hematopoietic stem cells, to enhance mobilization of hematopoietic stem cells, to improve the efficiency of targeting cells to the bone marrow and/or to modulate hematopoietic cell function. | 08-09-2012 |
20120329153 | CAR RECEPTOR AS A MEDIATOR OF MIGRATORY CELL CHEMOTAXIS AND/OR CHEMOKINESIS - This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. Specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. The invention also relates to methods for manipulating io hematopoeitic progenitor cells and related products. In particular the invention includes methods and products for using CaR receptor-related compositions to enhance mobilization of hematopoietic progenitor cells, to improve the efficiency of targeting cells to the bone marrow, and/or to modulate hematopoietic progenitor cell function. | 12-27-2012 |
20130004470 | p27 AND p21 IN GENE THERAPIES - The expansion of a population of stem cells or progenitor cells, or precursors thereof, may be accomplished by disrupting or inhibiting p21 | 01-03-2013 |
20130288969 | PARATHYROID HORMONE RECEPTOR ACTIVATION AND STEM AND PROGENITOR CELL EXPANSION - The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells. | 10-31-2013 |
20130338092 | COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS - This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia. | 12-19-2013 |
20140206624 | TREATMENT OF LEUKEMIA - Compositions and methods for the treatment of leukemia by inhibiting FOXO signaling are described. | 07-24-2014 |
20160030481 | IL-18 INHIBITION FOR PROMOTION OF EARLY HEMATOPOIETIC PROGENITOR EXPANSION - Disclosed herein are methods for enhancing hematopoietic reconstitution of a subject. One method involves administering a therapeutically effective amount of an inhibitor of IL-18 to a recipient subject and also administering hematopoietic stem/progenitor cells to the subject. Another method involves administering an inhibitor of IL-18 to a donor prior to harvest of hematopoietic stem/progenitor cells. Pharmaceutical compositions relating to the methods are also described. | 02-04-2016 |
Patent application number | Description | Published |
20100119197 | Field Terminable Fiber Optic Connector Assembly - A fiber optic connector assembly includes a connector and a carrier. The connector has a first mating end and a second end and an optical fiber terminated thereto. The fiber defines a first end adjacent the mating end and a second end protruding out of the second end of the fiber optic connector. A carrier having a connector end and an oppositely disposed cable end is engaged with the connector. An alignment structure is disposed on the carrier that includes a first end and a second end and a throughhole extending therebetween, the alignment structure including a cutaway portion extending perpendicularly to and communicating with the throughhole. The optical fiber terminated to the fiber optic connector is positioned within at least a portion of the throughhole with the second end of the optical fiber located within the cutaway portion. A window is disposed within the cutaway portion over the second end of the optic fiber, the window for visually inspecting the alignment of the second end of the fiber with an end of a second fiber entering the cable end of the carrier. A heat activated element that is configured to melt when exposed to a predetermined amount of heat and resolidify when the heat is removed bonds the second optical fiber to the alignment structure. | 05-13-2010 |
20110019963 | Field Terminable Fiber Optic Connector Assembly - A fiber optic connector assembly includes a connector and a carrier. The connector has a first mating end and a second end and a first optical fiber terminated thereto. The fiber defines a first end adjacent the mating end and a second end protruding from the second end of the connector. A polymeric carrier having a connector end and an oppositely disposed cable end is engaged with the connector. The carrier includes a heat activated meltable portion adjacent the cable end. An alignment structure is disposed on the carrier that includes a first end, a second end, and a throughhole. The first end of the alignment structure is for receiving the second end of the first optical fiber and the second end of the alignment structure is for receiving an end of a second optical fiber entering the cable end of the carrier. The heat activated portion of the carrier is configured to melt and assume a flowable condition when exposed to a predetermined amount of heat and resolidify when the heat is removed for bonding the second optical fiber to the carrier after the first fiber is aligned with the second fiber. | 01-27-2011 |
20130343708 | FIELD TERMINABLE FIBER OPTIC CONNECTOR ASSEMBLY - A fiber optic connector assembly includes a connector and a carrier. The connector has a first and second ends and a terminated fiber. The fiber defines a first end adjacent the first end of the connector and a second end protruding out of the second end of the connector. A carrier having a connector end and an opposite cable end is engaged with the connector. An alignment structure on the carrier includes a first end, a second end and a throughhole and also a cutaway extending perpendicularly to and communicating with the throughhole. The fiber is positioned within at least a portion of the throughhole with the second end located within the cutaway. A window is within the cutaway over the second end of the fiber for visually inspecting the alignment of the second end of the fiber with an end of another fiber. | 12-26-2013 |
20140050444 | Field Terminable Fiber Optic Connector Assembly - A fiber optic connector assembly includes a connector and a carrier. The connector has a first mating end and a second end and a first optical fiber terminated thereto. The fiber defines a first end adjacent the mating end and a second end protruding from the second end of the connector. A polymeric carrier having a connector end and an oppositely disposed cable end is engaged with the connector. The carrier includes a heat activated meltable portion adjacent the cable end. An alignment structure is disposed on the carrier that includes a first end, a second end, and a throughhole. The first end of the alignment structure is for receiving the second end of the first optical fiber and the second end of the alignment structure is for receiving an end of a second optical fiber entering the cable end of the carrier. The heat activated portion of the carrier is configured to melt and assume a flowable condition when exposed to a predetermined amount of heat and resolidify when the heat is removed for bonding the second optical fiber to the carrier after the first fiber is aligned with the second fiber. | 02-20-2014 |
20140205240 | HYBRID FIBER/COPPER CONNECTOR SYSTEM AND METHOD - A hybrid fiber/copper connector assembly which permits repair of damaged fibers or copper conductors carried by a hybrid fiber/copper cable without requiring replacement of the entire connector assembly or the cable is disclosed. The hybrid fiber/copper connector assembly disclosed also allows individual hybrid fiber/copper connectors of the assembly to be converted from one gender to a different gender. The hybrid fiber/copper connectors of the assembly include removable keying members mountable to housings of the connectors. The removable keying members allow gender conversion and proper mating and orientation. The hybrid fiber/copper connector assembly also allows the individual connectors of the assembly to be converted from being hybrid fiber/copper connectors to being only fiber connectors or only copper connectors. | 07-24-2014 |