Brik
Andreas Brik, Kronberg DE
Patent application number | Description | Published |
---|---|---|
20150238004 | HEAD FOR AN ORAL CARE IMPLEMENT - A head for an oral care implement has a mounting surface and at least one twisted tuft including a plurality of filaments and having a base mounted on the mounting surface. The twisted tuft has an outer lateral surface, a longitudinal axis, a lower cross-sectional area extending in a plane that is perpendicular to the longitudinal axis and that is arranged at the base, and an upper cross-sectional area extending in a plane that is perpendicular to the longitudinal axis and that is arranged at the twisted tuft's free end. The lower cross-sectional area and the upper cross-sectional area have substantially the same shape and size. The filaments forming the outer lateral surface are substantially straight and inclined with respect to the longitudinal axis in either a clockwise direction or in a counterclockwise direction. The upper cross-sectional area is twisted relative to the lower cross-sectional area. The upper cross-sectional area is not congruent with the lower cross-sectional area when they are orthogonally projected onto each other along the longitudinal axis. | 08-27-2015 |
Ashraf Brik, Be'Er-Sheva IL
Patent application number | Description | Published |
---|---|---|
20130041132 | CHEMICAL PREPARATION OF UBIQUITIN THIOESTERS AND MODIFICATIONS THEREOF - The present invention discloses latent thioester functionalities attached to the C-terminus of a first polypeptide, or a first fragment thereof having a Cys residue at its N-terminus, and a process using this functionality for the preparation of polypeptide thioesters, in particular of ubiquitin thioesters, this process comprising preparing a polypeptide or a fragment thereof, being attached to a latent thioester functionality, which can then be ligated with a second polypeptide fragment, followed by selective activation of the latent thioester functionality group, to provide the requested polypeptide thioester. There are also provided the polypeptides obtained by this method, specific unnatural amino acids useful to be incorporated within the polypeptide thioesters, and kits for preparing them. | 02-14-2013 |
20130060003 | CHEMICAL PREPARATION OF POLYUBIQUITIN CHAINS - The present invention discloses a process for the preparation of a Poly-ubiquitin chain, this process comprising ligating a Ubiquitin thioester Ubm-SR with a Ubiquitin Ubq. Further are disclosed poly-ubiquitin chains prepared according to this process, in particular poly-ubiquitin chains containing at least one unnatural amino acid. | 03-07-2013 |
20130143251 | EXPEDITIOUS SYNTHESIS OF UBIQUITINATED PEPTIDE CONJUGATES - The present invention discloses a process for preparing ubiquinated peptide conjugates comprising a ubiquitin peptide residue UR attached at its C-terminus to a substrate peptide via a native isopeptide bond, this process comprising combining Native Chemical Ligation (NCL) and solid phase peptide synthesis (SPPS). Further are disclosed ubiquinated peptide conjugates containing a native isopeptide bond, as well as various uses thereof. | 06-06-2013 |
Robert Brik, Brookline, MA US
Patent application number | Description | Published |
---|---|---|
20130245647 | LAPAROSCOPIC SUTURING INSTRUMENT WITH MANUAL DRIVE - A suture needle driving instrument comprises a shaft, an end effector, and a handle assembly. The end effector is located at the distal end of the shaft and includes a pair of grasping arms operable to grasp and release a needle. The handle assembly comprises a trigger-operated actuation assembly that is operable to rotate a second grasping arm relative to the shaft. The trigger-operated actuation assembly may include a trigger and a trigger gear assembly that is operable to rotate the second grasping arm. A clutch assembly may also be included to selectively couple a drive shaft associated with the second grasping arm to another shaft. The handle assembly may further include a toggle actuation assembly that is operable to grasp and release a needle with the grasping arms. A locking feature may be included to prevent use of the toggle actuation assembly until trigger-operated actuation assembly has been operated. | 09-19-2013 |
20130245648 | LAPAROSCOPIC SUTURING INSTRUMENT WITH RACK DRIVE - A suture needle driving instrument comprises a shaft, an end effector, and a handle assembly. The end effector is located at the distal end of the shaft and includes a pair of grasping arms having a respective pair of jaws driven by a respective drive shaft. Each pair of jaws is operable to cooperate to grasp and release a suture needle. The handle assembly includes a control assembly that is operable to rotate the drive shafts to transfer the suture needle between the grasping arms. In some versions, the control assembly may include an actuatable rack. The rack may include one or more control features that selectively rotate the drive shafts as the rack is actuated. The rack may further include cam surfaces to selectively restrict the motion of the drive shafts as the rack is actuated. In some versions the rack may actuate vertically. | 09-19-2013 |
Robert Brik, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20150367072 | Portable Drug Mixing and Delivery Device and Associated Methods - A portable auto-injector configured to store a liquid component in a first chamber separately from a dry medication in a second chamber, wherein a first actuation mechanism opens a valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete. | 12-24-2015 |
20150367073 | Portable Drug Mixing and Delivery Device and Associated Methods - A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete. | 12-24-2015 |
Roman Brik, Concord CA
Patent application number | Description | Published |
---|---|---|
20110159955 | FLAT SCREEN GAME TERMINAL - A countertop entertainment terminal includes a terminal housing containing components for a pay to play game terminal including a stereo sound system. The sound system includes a pair of tweeter speakers adjacent an upper edge of the terminal housing and a pair of midrange speakers located on opposite sides of a touchscreen supported by the terminal housing. A sub-woofer speaker is provided within the housing and is open to a side of the housing. In a preferred embodiment the stereo sound system uses subassemblies for each of the tweeter speakers, the midrange speakers and the sub-woofer speaker, simplifying securement within or to the housing. | 06-30-2011 |
Vladimir Alexander Brik, Madison, WI US
Patent application number | Description | Published |
---|---|---|
20100100936 | Secure Wireless Network Using Radiometric Signatures - A network security system for wireless devices derives a fingerprint from the modulation imperfections of the analog circuitry of the wireless transceivers. These fingerprints may be compared to templates obtained when the wireless devices are initially commissioned in a secure setting and used to augment passwords or other security tools in detecting intruders on the network. | 04-22-2010 |