Esther
Esther Abramovich Ettinger, Laguna Beach, CA US
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20080262714 | Device, system and method of contact-based routing and guidance - Device, system and method of contact-based routing and guidance; for example, an apparatus including a route guidance information generator adapted to receive a plurality of personal contacts associated respectively with at least one of: a plurality of road-based addresses, or a plurality of latitude and longitude data items; and to generate route guidance information including a reference to at least one of said personal contacts. | 10-23-2008 |
20080262717 | Device, system and method of landmark-based routing and guidance - Device, system and method of landmark-based routing and guidance; for example, an apparatus including a route guidance information generator adapted to generate route guidance information including one or more road-based references and one or more landmark-based references. | 10-23-2008 |
Esther Adi-Japha, Rehovot IL
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20090216146 | Method and System for Processing and Electroencephalograph (Eeg) Signal - The invention provides a method and system for locating an epileptic focus in an individual. In accordance with the method of the invention, an integer N of ictal EEG signals are obtained on the individual and a principal component analysis generating N output signals is executed on the ictal EEG signals. The epileptic focus s then located in a process involving one or more of the N output signals. | 08-27-2009 |
Esther Álvarez Ayuso, Sevilla ES
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20100111821 | GYPSUM STABILISATION METHOD - The invention relates to a method for reducing or eliminating the soluble content of pollutants in gypsum or in compounds containing gypsum, wherein the gypsum or gypsum-containing compound is mixed with additives that contain or can generate aluminium oxide. More specifically, the gypsum originates from gas desulphurisation and the pollutant is fluorine. | 05-06-2010 |
Esther Álvarez Ayuso, Sevilla ES
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20100111821 | GYPSUM STABILISATION METHOD - The invention relates to a method for reducing or eliminating the soluble content of pollutants in gypsum or in compounds containing gypsum, wherein the gypsum or gypsum-containing compound is mixed with additives that contain or can generate aluminium oxide. More specifically, the gypsum originates from gas desulphurisation and the pollutant is fluorine. | 05-06-2010 |
Esther Arranz Plaza, Madrid ES
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20080207573 | COMPOUNDS FOR TREATING VIRAL INFECTIONS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 08-28-2008 |
20090105203 | COMPOUNDS FOR TREATING VIRAL INFECTIONS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 04-23-2009 |
20090149429 | ANTIVIRAL COMPOUNDS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 06-11-2009 |
20110144069 | COMPOUNDS FOR TREATING VIRAL INFECTIONS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 06-16-2011 |
Esther Bachar-Lustig, Rehovot IL
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20110212071 | ANTI THIRD PARTY CENTRAL MEMORY T CELLS, METHODS OF PRODUCING SAME AND USE OF SAME IN TRANSPLANTATION AND DISEASE TREATMENT - An isolated population of cells comprising non-GVHD inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype is provided. The cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation. Methods of generating same, use of same and methods of treatment are also provided. | 09-01-2011 |
20130171108 | USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS FOR ANTI-LEUKEMIA/LYMPHOMA TREATMENT - A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein the cells are either: (i) non-syngeneic with both the subject and the graft; or (ii) non-syngeneic with the graft and syngeneic with the subject, thereby treating the subject. | 07-04-2013 |
20130183322 | IMMUNOSUPPRESSIVE DRUG COMBINATION FOR A STABLE AND LONG TERM ENGRAFTMENT - A method of treating a subject in need of a cell or tissue transplant is disclosed. The method comprising (a) transplanting a non-syngeneic cell or tissue transplant into the subject, wherein the transplant comprises bone marrow or lymphoid cells; and (b) administering to the subject a therapeutically effective amount of an immunosuppressive regimen comprising a Sphingosine 1-Phosphate Receptor Agonist, a B7 molecule inhibitor and a CD2/CD58 pathway inhibitor, thereby treating the subject. | 07-18-2013 |
20140212398 | ANTI THIRD PARTY CENTRAL MEMORY T CELLS, METHODS OF PRODUCING SAME AND USE OF SAME IN TRANSPLANTATION AND DISEASE TREATMENT - A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype. | 07-31-2014 |
20140363437 | COMBINATION THERAPY FOR A STABLE AND LONG TERM ENGRAFTMENT - A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×10 | 12-11-2014 |
20140369974 | COMBINATION THERAPY FOR A STABLE AND LONG TERM ENGRAFTMENT USING SPECIFIC PROTOCOLS FOR T/B CELL DEPLETION - A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The methos comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoetic cells, wherein the T cell depleted immature hematopoetic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject, and wherein the T cell depleted immature hematopoetic cells are obtained by separating the T cells from the immature hematopoetic cells by magnetic cell sorting, and (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per body weight, thereby treating the subject. | 12-18-2014 |
Esther Badosa Romacho, Girona ES
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20100016167 | ANTIMICROBIAL LINEAR PEPTIDES - The present invention relates to novel linear peptides with antimicrobial activity. Said peptides are made up of 11 amino acids, and they have the amino group of the amino acid constituting the N-terminal end in a non-derived form or functionalized with an acetyl group, p-toluene sulphonyl, benzyl or benzoyl. The amino acid constituting the C-terminal end of said peptides is in carboxamide form. The invention describes the synthesis and use of said peptides as antimicrobial agents to combat pathogenic bacteria for plants. The invention also relates to compositions containing said peptides and an auxiliary agent, and to a method for preventing and treating infections and diseases of plants caused by pathogenic bacteria. | 01-21-2010 |
Esther Bataller Leiva, Valterna-Paterna (valencia) ES
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20130035291 | OBTAINMENT OF BIOACTIVE PRODUCTS FROM COCOA HAVING INHIBITORY ACTIVITY AGAINST THE PEP ENZYME AND ANTIOXIDANT AND/OR ANTINEURODEGENERATIVE ACTIVITY - The present invention relates to the production of bioactive products from raw plant matter, namely cocoa extracts. The said products have one or more biopeptides with prolyl endopeptidase (PEP) enzyme inhibitory activity in vitro and/or antioxidant and/or antineurodegenerative capacity in vivo and can be used in dietetics and in the food and pharmaceutical industries. | 02-07-2013 |
Esther Bataller Leiva, Valencia ES
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20100034954 | NUTRITIONALLY SUITABLE COCOA FOR ANIMAL FEED - The invention relates to a method for obtaining fibre-rich cocoa with low carbon hydrate and methylxanthine contents and resulting cocoa powder which is suitable for animal feed. The inventive method includes the following main steps in which: the whole cocoa beans undergo cleaning, deffating, treatment with alpha-amylase, centrifugation, extraction-washing and subsequent centrifugation, separation, drying and grinding. | 02-11-2010 |
20110213122 | OBTAINING COCOA EXTRACTS RICH IN BIOACTIVE PEPTIDES WITH ACE AND PEP ENZYME INHIBITORY ACTIVITY - The present invention relates to obtaining bioactive peptides from plant raw materials, specifically cocoa extracts, by means of enzyme treatment. Said biopeptides have angiotensin converting enzyme (ACE) and prolyl endopeptidase enzyme (PEP) inhibitory activity in vitro and/or antioxidant activity in vivo, being able to be used in the food, dietetic and pharmaceutical industry. | 09-01-2011 |
20130121976 | Lactic Acid Bacteria for Coeliac Disease - The present invention discloses strains of | 05-16-2013 |
Esther Birtalan, Karlsruhe DE
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20120108590 | MELT-EXTRUDED SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT - A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of Formula I, the water-soluble polymeric carrier and the surfactant, to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer or an immune or autoimmune disease. | 05-03-2012 |
Esther Blankenship, Mannheim DE
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20080243567 | SYSTEM AND METHODOLOGY FOR SEQUENTIAL NAVIGATION AND MONITORING IN A BUSINESS PROCESS OR COMPLEX TASK - A method and system to monitor steps in a business process or complex tasks are described. The method may include displaying a graphical step monitor in a graphical user interface of an application, using a plurality of graphical elements indicating statuses of a plurality of steps in a sequence of steps in a process. The method may include receiving update information related to one or more steps of the plurality of steps. The method may also include updating the statuses of the steps for which the update information was received and as indicated by the plurality of graphical elements. Furthermore, the method may include displaying a description region including a further plurality of graphical elements and texts, the texts describing the steps, the statuses of which are indicated by the graphical elements. | 10-02-2008 |
Esther Chávez Amado, San Sebastian ES
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20110266158 | METHOD FOR ELECTROCHEMICALLY COVERING AN INSULATING SUBSTRATE - The present invention relates to a process for obtaining a metal, ceramic or composite coating on the surface of a non-conductive material such as plastic, ceramic or wood which comprises: A) preparing a polypyrrole dispersion in aqueous base paint or in an acid type water-soluble pure resin; B) diluting the dispersion resulting from the previous stage with an alcohol in a factor of 1.5; C) applying the dispersion of the conductive polymer resulting from stage B) on the surface to be coated and drying same; and D) obtaining the metal, ceramic or composite coating by means of an electrolytic process or an electrophoretic deposition. | 11-03-2011 |
Esther Chen, Honolulu, HI US
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20080276402 | WINDSHIELD WIPER WITH SCRUBBER ASSEMBLY - A scrubber assembly ( | 11-13-2008 |
20110119854 | WINDSHIELD WIPER WITH SCRUBBER ASSEMBLY - A scrubber assembly ( | 05-26-2011 |
20110119855 | WINDSHIELD WIPER WITH SCRUBBER ASSEMBLY - A scrubber assembly ( | 05-26-2011 |
Esther Collantes Fernandez, Madrid ES
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20120269823 | VIRULENT ISOLATE OF NEOSPORA CANINUM AND ITS USES - The present invention relates to a new isolate of | 10-25-2012 |
Esther De La Fuente García, Madrid ES
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20100184850 | PHENOLIC EXTRACTS OF ALMOND PEEL CONTAINING PROCYANIDINS, PROPELARGONIDINS, AND PRODELPHINIDINS, AND METHOD FOR PREPARATION THEREOF - The present disclosure concerns phenolic extracts containing procyanidins, propelargonidins and prodelfinidins obtained from peel of the almond [ | 07-22-2010 |
Esther De La Fuente García, Madrid ES
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20100184850 | PHENOLIC EXTRACTS OF ALMOND PEEL CONTAINING PROCYANIDINS, PROPELARGONIDINS, AND PRODELPHINIDINS, AND METHOD FOR PREPARATION THEREOF - The present disclosure concerns phenolic extracts containing procyanidins, propelargonidins and prodelfinidins obtained from peel of the almond [ | 07-22-2010 |
Esther Domínguez Torres, San Cugat Del Valles ES
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20110294659 | PHOTOCATALYTIC MIXTURE FOR THE DEGRADATION OF NITROGEN OXIDES - A first aspect of the invention consists of a photocatalytic mixture designed to obtain degradation of nitrogen oxides through synergic combination of the two compounds: TiO | 12-01-2011 |
Esther Elishaev, Pittsburgh, PA US
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20090029362 | GENE COPY NUMBER PROFILING - The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source. | 01-29-2009 |
Esther Garcia Palomero, Madrid ES
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20090069430 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS - The invention is directed to a compound of formula (I) | 03-12-2009 |
20100041665 | N-PHENYL-PRENYLAMINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS - The present invention is related to a family of N-phenyl-prenylamine derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder. | 02-18-2010 |
20100267827 | PHENYL-PRENYL-ETHER DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS - The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder. | 10-21-2010 |
20110092591 | PHENYL-PRENYL DERIVATIVES, OF MARINE AND SYNTHETIC ORIGIN, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS - The present invention is related to a family of phenyl-prenyl derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the compounds of formula (I) for medical use, particularly for the use for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder, and to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder. | 04-21-2011 |
20110144148 | ACETYLCHOLINESTERASE DUAL INHIBITORS - The invention provides compounds of formula: | 06-16-2011 |
Esther Garcia Palomero, Tres Cantos (madrid) ES
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20100240692 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a treatment neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds. | 09-23-2010 |
20140011835 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or prophylaxis of a neurodegenerative or hematological disease or condition, their use as a medicament, especially for treating a neurodegenerative or hematological disease or condition, and a pharmaceutical composition comprising the compounds. | 01-09-2014 |
Esther García Palomero, Tres Cantos - Madrid ES
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20110306631 | TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER - The present invention relates to a new family of triple substituted phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition or cancer, their use as a medicament, especially for treating a neurodegenerative or haematological disease or condition or cancer, and a pharmaceutical composition comprising the compounds. | 12-15-2011 |
Esther Gelle, Remetschwil CH
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20100016994 | Network Supervision With Control Systems - Supervision of industrial plants can be improved by comparison and analysis of process information and network information. The comparison may be used to provide alarms and operator information for network-related or process device failures. The information may also be used to identify a cause of a failure. A method is described for supervising an industrial control system, including a plant network for supervision, a client/server network for server connection with workstations, and a control network connected to industrial controllers. The method comprises the steps of gathering process information, and gathering network information, and by comparing information provided by data communications network monitoring with process control information and using the result of the comparison to assist in determining a cause of a problem or possible problem in a process controlled of the industrial control system. | 01-21-2010 |
Esther Gonzales Cantalapiedra, Madrid ES
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20130029967 | Fused Imidazo [3,2 - D] Pyrazines as P13 Kinase Inhibitors - There is provided compounds of formula (I), wherein A | 01-31-2013 |
Esther Gonzalez Cantalapiedra, Madrid ES
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20110046127 | Imidazopyridazines for Use as Protein Kinase Inhibitors - There is provided compounds of formula (I): wherein Z, M, R | 02-24-2011 |
20130065881 | Tricyclic Compounds for Use as Kinase Inhibitors - There is provided compounds of formula (I), wherein R | 03-14-2013 |
Esther Gonzalez Roncero, Las Palmas ES
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20090318040 | BUOYAGE AND ENVIRONMENTAL MONITORING INSTRUMENT FOR USE ON REGATTA COURSES, COMPRISING AN INFLATABLE PNEUMATIC PLATFORM AND A MODULAR MAST WHICH CAN BE FOLDED AND TRANSPORTED IN A REDUCED-SIZE COMPACT PACKING CONTAINER - The present invention relates to an instrument for marking and environmental monitoring in regatta courses. Incorporated by inflatable pneumatic platform and modular mast, foldable and transportable in compact packing of reduced size. It is intended to simultaneously define the area of conducting such nautical trials, at the same time as the environmental conditions thereof are characterized, in both meteorological and oceanographic terms. The system comprises an inflatable pneumatic float ( | 12-24-2009 |
Esther Gordo Campon, Barcelona ES
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20090099367 | Process for preparing a leukotriene antagonist - Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation. | 04-16-2009 |
Esther Graudens, Paris FR
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20120058992 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease. | 03-08-2012 |
20120283114 | NEW DIAGNOSTIC TOOLS FOR ALZHEIMER DISEASE - The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI and early prodrome of AD, identification of disease sub types, prediction of their response to disease management procedures, drugs and their combinations and for monitoring response for these treatment, including validation of biomarkers for clinical trials. | 11-08-2012 |
Esther Haenni-Bechir, Muelligen CH
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20130069459 | WINDING FOR A ROTATING ELECTRIC MACHINE AND METHOD FOR MANUFACTURING SAME - A winding for a rotating electric machine includes conductive bars having straight parts and end windings and terminal portions of the end windings that are connected together. A protective cap is disposed on at least a portion of each respective connected end winding terminal portion. An electrical insulating material is disposed between each end winding terminal portion and respective protective cap and a seal is inside each protective cap. | 03-21-2013 |
Esther Hietler, Wien AT
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20090299200 | METHOD FOR MONITORING AND COMMUNICATING BIOMEDICAL ELECTROMAGNETIC FIELDS - The present invention provides a system and a method of monitoring and communicating biomedical data to a remote receiver. Specifically, the present invention provides a system and method that can monitor a biomedical-based electromagnetic field, e.g., heart rate variability (HRV) field, emitted from a human user (“sender”), and/or communicate the biomedical-based electromagnetic field to a remote receiver by measuring the biomedical-based electromagnetic field emitted from the sender, creating an electronic signal corresponding to the field and transmitting or broadcast and/or apply the signal to a remote receiver. | 12-03-2009 |
20140145859 | METHOD FOR MONITORING AND COMMUNICATING BIOMEDICAL ELECTROMAGNETIC FIELDS - The present invention provides a system and a method of monitoring and communicating biomedical data to a remote receiver. Specifically, the present invention provides a system and method that can monitor a biomedical-based electromagnetic field, e.g., heart rate variability (HRV) field, emitted from a human user (“sender”), and/or communicate the biomedical-based electromagnetic field to a remote receiver by measuring the biomedical-based electromagnetic field emitted from the sender, creating an electronic signal corresponding to the field and transmitting or broadcast and/or apply the signal to a remote receiver. | 05-29-2014 |
Esther Hinrich, Dalton, NY US
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20120213908 | PEANUT BUTTER WITH AN ORGANIC STABILIZER AND METHOD FOR MANUFACTURE THEREOF - The present invention is directed to a novel organic peanut butter formulation and method for production. The peanut butter includes an organic palm oil stabilizing agent that reduces or prevents separation of oils from the peanut butter during storage. Peanut butter incorporating the palm oil, methods for manufacturing the peanut butter, and foods incorporating the peanut butter are also disclosed. | 08-23-2012 |
Esther Izakovich, Kiryat Bialik IL
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20110275590 | CONJUGATES FOR CANCER THERAPY AND DIAGNOSIS - The present invention relates to conjugates of a drug and an amino acid or an amino acid derivative or analog, pharmaceutical compositions that include the conjugates and methods of use thereof. In particular, the present invention relates to conjugates of anti-proliferative drugs and asparagine and glutamine and analogs thereof as compositions for treatment of cancer, and conjugates of imaging agent carriers and amino acids for the diagnosis of tumors and metastases. | 11-10-2011 |
Esther Kramarsky-Winter, Rehovot IL
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20090176303 | Method and apparatus for propagating benthic marine invertebrates - An apparatus for propagating benthic marine invertebrates in water. The apparatus comprises (a) a culture cell, (b) a sedimentation chamber in fluid connection with the culture cell, and (c) a pump in fluid connection with the culture cell and with the sedimentation chamber capable of pumping water from the sedimentation chamber to the culture cell. Also disclosed is a method for propagating benthic marine invertebrates comprising culturing the invertebrates in a water environment in the apparatus. | 07-09-2009 |
20110179504 | Method For Coral Tissue Cultivation And Propagation - This invention relates to a novel method of culturing coral tissues and polyps in vitro. Coral tissues obtained by the method of the invention may be maintained as heterotypic spheroid tissue balls for a period of at least three months or they may be induced to undergo development into new polyps, a process termed re-morphogenesis. This method can produce genetic clones of model species from single individuals that can be propagated either as undifferentiated tissue calli or as developed polyps. The products of the invention are of value to a number of educational, scientific, and commercial endeavors. Specifically, this method can be used to propagate genetic clones (strains) of a model organism for scientific research, to serve as ‘pro-environmental conservation’ sources of coral stock for educational specimens as well as a rapidly generated inventory for commercial aquarium industry. The method of the invention can produce sustainable test lines of corals that could be used to generate risk assessments for the impact of chemicals/activities on coral reefs, as well as being used as part of a regulatory protocol for testing waste effluent and other discharges. | 07-21-2011 |
Esther Larrea Leoz, Pamplona (navarra) ES
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20110027224 | USE OF A CYTOKINE FROM THE INTERLEUKIN-6 FAMILY IN THE PREPARATION OF A COMPOSITION FOR COMBINED ADMINISTRATION WITH INTERFERON-ALPHA - The invention relates to the use of at least one cytokine from the IL-6 family −gp130, preferably selected from among IL-11, the leukaemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1, ciliary neurotrophic factor (CNTF), the cardiotrophin-like cytokine (CLC) and combinations thereof or a DNA sequence encoding same, in the preparation of a pharmaceutical composition which is intended for combined administration with at least one IFN-α or a DNA sequence encoding same, for use in the treatment of viral diseases. The invention also relates to a pharmaceutical composition comprising a pharmaceutically-acceptable quantity of at least one cytokin from the IL-6 family −gp130 or a DNA sequence encoding same and a pharmaceutically-acceptable quantity of at least one IFN-α or a DNA sequence encoding same, a pharmaceutical kit and a method for the treatment of viral diseases with the combined administration of the aforementioned cytokines and IFN-α. | 02-03-2011 |
Esther Larrea Leoz, Pamplona(navarra) ES
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20090130055 | Use of a Cytokine From the Interleukin-6 Family In the Preparation of a Composition For Combined Administration With Interferon-Alpha - The invention relates to the use of at least one cytokine from the IL-6 family −gp130, preferably selected from among IL-11, the leukaemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1, ciliary neurotrophic factor (CNTF), the cardiotrophin-like cytokine (CLC) and combinations thereof or a DNA sequence encoding same, in the preparation of a pharmaceutical composition which is intended for combined administration with at least one IFN-α or a DNA sequence encoding same, for use in the treatment of viral diseases. The invention also relates to a pharmaceutical composition comprising a pharmaceutically-acceptable quantity of at least one cytokin from the IL-6 family −gp130 or a DNA sequence encoding same and a pharmaceutically-acceptable quantity of at least one IFN-α or a DNA sequence encoding same, a pharmaceutical kit and a method for the treatment of viral diseases with the combined administration of the aforementioned cytokines and IFN-α. | 05-21-2009 |
Esther Latres, New York, NY US
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20080199479 | Method of treating a muscle-related condition with modified IGF1 polypeptides - A targeting fusion protein comprising a component that comprises a (i) ligand or derivative or fragment thereof that binds a pre-selected target surface protein, such as a receptor, and (ii) an active agent or therapeutic agent(s), and further optionally (iii) a multimerizing component and/or (iv) a signal sequence. In a preferred embodiment, the targeting fusion polypeptide targets muscle and is useful to treat a muscle-related disease or condition, such as muscle atrophy. | 08-21-2008 |
20090292004 | Methods to identify compounds useful for the treatment of proliferative and differentiative disorders - The present invention relates to the discovery and characterization of activity of Fbp1, a substrate-targeting ubiquitin ligase subunit. The invention encompasses interactions between Fbp1 and its substrates, including Fbp5, β-Catenin, and IκBα. The invention also encompasses interactions between the Fbp1 isoform β-Trcp2 and its substrates, including Fbp5, b-Catenin, and IκBα. The present invention relates to screening assays that use Fbp1 and/or β-Trcp2 to identify potential therapeutic agents such as small molecules, compounds or derivatives which modulate Fbp1 and/or β-Trcp2 activity for the treatment of proliferative and differentiative disorders, including infertility, cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention also encompasses methods to diagnose and treat Fbp1-related infertility disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target Fbp1 and its substrates for the treatment of infertility. | 11-26-2009 |
20100212033 | Novel ubiquitin lifases as therapeutic tragets - The present invention relates to the discovery, identification and characterization of nucleotides that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host cell expression systems and proteins encoded by the nucleotides of the present invention. The present invention relates to screening assays that use the novel substrate-targeting subunits to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel ubiquitin ligases which modulate activity of the novel ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative disorders. | 08-19-2010 |
20110293630 | Antibodies to Human GDF8 - The present invention provides isolated human or humanized antibodies or antigen-binding fragments thereof which specifically bind to Growth and Differentiation Factor-8 (GDF8) and block GDF8 activity. The antibodies and antibody fragments of the present invention may be used in therapeutic methods for treating conditions or disorders which are ameliorated or improved by inhibition of GDF8. | 12-01-2011 |
20130122007 | Compositions and Methods for Increasing Muscle Mass and Muscle Strength by Specifically Antagonizing GDF8 and or Activin A - The present invention provides compositions and methods which involve specifically antagonizing GDF8 and Activin A. In certain embodiments, compositions are provided which comprise a GDF8-specific binding protein and an Activin A-specific binding protein. For example, the invention includes compositions comprising an anti-GDF8 antibody and an anti-Activin A antibody. In other embodiments, antigen-binding molecules are provided which comprise a GDF8-specific binding domain and an Activin A-specific binding domain. For example, the invention includes bispecific antibodies that bind GDF8 and Activin A. The compositions of the present invention are useful for the treatment of diseases and conditions characterized by reduced muscle mass or strength, as well as other conditions which are treatable by antagonizing GDF8 and/or Activin A activity. | 05-16-2013 |
20140356369 | ANTIBODIES TO HUMAN GDF8 - The present invention provides isolated human or humanized antibodies or antigen-binding fragments thereof which specifically bind to Growth and Differentiation Factor-8 (GDF8) and block GDF8 activity. The antibodies and antibody fragments of the present invention may be used in therapeutic methods for treating conditions or disorders which are ameliorated or improved by inhibition of GDF8. | 12-04-2014 |
20150037339 | ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF - The present invention provides antibodies that bind to Activin A and methods of using the same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Activin A with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders characterized by decreased muscle mass or strength, such as sarcopenia, cachexia, muscle injury, muscle wasting/atrophy, cancer, fibrosis, and weight loss. The antibodies of the invention are also useful in combination with GDF8 binding proteins for the treatment of diseases and disorders characterized by decreased muscle mass or strength. The antibodies of the invention are also useful for the prevention, treatment, or amelioration of disorders and diseases caused by, promoted by, exacerbated by, and/or aggravated by Activin A, such as renal fibrosis. | 02-05-2015 |
Esther Masih-Khan, Ontario CA
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20090048266 | Effects of Inhibitors of Fgfr3 on Gene Transcription - Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly. | 02-19-2009 |
20120149714 | Effects of Inhibitors of FGFR3 on Gene Transcription - Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly. | 06-14-2012 |
Esther Mayer, Ra'Anana IL
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20090319008 | PROBE DEVICE, SYSTEM AND METHOD FOR PHOTOBIOMODULATION OF TISSUE LINING A BODY CAVITY | 12-24-2009 |
20130030507 | PROBE DEVICE, SYSTEM AND METHOD FOR PHOTOBIOMODULATION OF TISSUE LINING A BODY CAVITY - A device is presented for use in treatment of tissues inside a body cavity. The device comprises a probe member having at least a portion thereof carrying a plurality of light sources, at least said portion of the probe member having dimensions and shape suitable for insertion into a certain body cavity and for arranging within the surface thereof a three-dimensional array of said light sources, the light sources being configured and operable to irradiate optical energy outwardly from said probe member. | 01-31-2013 |
Esther Meyer, Nurnberg DE
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20110006525 | Method for Operating a Wind Farm Comprising a Plurality of Wind Turbines - A method and a device for operating a wind farm with a plurality of wind turbines are provided. According to the method, operating parameters of the wind turbines of the wind farm are adjusted according to an optimization goal, the optimization goal being the maximum value of the total output of the wind farm produced from the sum of all individual outputs of the wind turbines. The optimization goal differs from conventional optimization goals where the respective individual outputs of the wind turbines are optimized without taking the overall output into consideration. | 01-13-2011 |
Esther Meyer, Erlangen DE
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20110007956 | SINOGRAM PROCESSING TO REDUCE METAL ARTIFACTS IN COMPUTED TOMOGRAPHY - A method is disclosed for reconstructing image data of an examination object from measurement data, wherein the measurement data was captured as projection data during a relative rotational movement between a radiation source of a computed tomography system and the examination object. In at least one embodiment, a first image is determined from the measurement data and pixel values of the first image are modified, by classifying the pixel values in at least three classes, a class pixel value being assigned to each class, and the pixels of the first image being allocated the respective class pixel value. Projection data is calculated from the thus modified first image. The calculated projection data is used to normalize the measured projection data. Values are modified in the normalized projection data and the thus modified normalized projection data is subjected to a processing that reverses normalization. Finally a second image is determined from the thus processed projection data. | 01-13-2011 |
20130039556 | METHOD, COMPUTING UNIT, CT SYSTEM AND C-ARM SYSTEM FOR REDUCING METAL ARTIFACTS IN CT IMAGE DATASETS - A method is disclosed for reducing metal artifacts in CT image datasets. An embodiment of the method includes reconstructing a first CT image dataset with and a second CT image dataset without metal artifact correction, weighted summation of a high-pass-filtered first and a high-pass-filtered second CT image dataset plus a low-pass-filtered second CT image dataset, wherein the weightings are dependent on the proximity to metal in the CT image datasets. A computing unit, a CT system and a C-arm system designed to execute the method are also disclosed. | 02-14-2013 |
20140300352 | METHOD TO ENTER MAGNETIC RESONANCE DATA INTO A MEMORY ORGANIZED AS k-SPACE, AND MAGNETIC RESONANCE APPARATUS OPERATING ACCORDING TO THE METHOD - In a method to associate k-space lines with echo trains of raw magnetic resonance data, parallel k-space lines orthogonally intersect a plane at respective intersection points. Each echo train has a trajectory length, and the k-space lines are associated with the echo trains such that a sum of trajectory lengths of all echo trains is minimal. The trajectory length TL of an echo train is defined by | 10-09-2014 |
20150022207 | METHOD AND MAGNETIC RESONANCE APPARATUS TO ACQUIRE MR DATA AND TO RECONSTRUCT AN MR IMAGE - In a method to operate a magnetic resonance (MR) system to acquire MR data, an RF excitation pulse is radiated followed by repeated, chronologically sequential implementation of the following steps in order to respectively acquire the MR data of an echo train. A refocusing pulse is radiated, a phase coding gradient is activated, and an additional magnetic field gradient for spatial coding is activated in a direction that is orthogonal to the direction of the phase coding gradient in order to read out the MR data of a k-space line. A k-space line in the k-space center is acquired at a predetermined echo time. A first half of k-space is acquired by entering data into k-space lines of the respective echo train, the data being acquired before the echo time. A second half of k-space is acquired by entering data into k-space lines of the respective echo train, this data having been acquired after the echo time. The k-space lines in the first half of k-space have a first density while the k-space lines in the second half of k-space have a second density that differs from the first density. | 01-22-2015 |
Esther Monlleomas, Barcelona ES
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20120071466 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 - The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by 11-beta-hydroxysteroid dehydrogenase type I (11-beta-HSD1) enzyme-associated disorders, such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive disorders, Alzheimer's disease or neurodegeneration. | 03-22-2012 |
Esther Musgrave-Brown, Great Chesterford GB
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20120122161 | Sorting Asymmetrically Tagged Nucleic Acids by Selective Primer Extension - The present invention provides methods and compositions for amplifying and sorting adapter tagged nucleic acid fragments using selective primer extension. Immortalized pooled polynucleotide samples and method of producing the same are also provided. | 05-17-2012 |
Esther Ochoa-Fernandez, Trondheim NO
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20080226526 | Carbon Dioxide Acceptors - A process for the preparation of a nanoparticulate carbon dioxide acceptor. The acceptor is a mixed metal oxide having at least two metal ions X and Y. The process includes contacting in solution a precursor of an oxide of metal ion X and a precursor of an oxide of metal ion Y; drying said solution to form an amorphous solid; and calcining the amorphous solid to form the acceptor. | 09-18-2008 |
Esther Oliveros, Barbelroth DE
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20090137694 | METHOD OF SURFACE CROSS-LINKING SUPERABSORBENT POLYMER PARTICLES USING ULTRAVIOLET RADIATION - The present invention relates to a method of surface cross-linking superabsorbent polymer particles using UV irradiation. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Radical former molecules are applied on the surface of superabsorbent polymer particles. These superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method of the present invention is able to emit UV radiation of a wavelength between 201 nm and 400 nm. | 05-28-2009 |
20090197985 | METHOD OF SURFACE CROSS-LINKING SUPERABSORBENT POLYMER PARTICLES USING VACUUM ULTRAVIOLET RADIATION - The present invention relates to a method of surface cross-linking superabsorbent polymer particles using UV irradiation. The method is carried out in a so-called drum reactor, which comprises a hollow drum and an irradiation source. The drum has a longitudinal axis and a cross-section. Superabsorbent polymer particles are fed into the drum and are irradiated while they move within the drum, which is rotated around its longitudinal axis. The irradiation source is provided such that the radiation emitted by the irradiation source is able to reach superabsorbent polymer particles within said drum. The irradiation source for use in the method of the present invention is able to emit UV radiation of a wavelength between 100 nm and 200 nm. | 08-06-2009 |
Esther Oliveros, Cepet FR
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20120138531 | PURIFYING DEVICE AND METHOD FOR ELIMINATION OF XENOBIOTICS IN WATER - A purifying device adapted to perform a method of photochemical elimination of xenobiotics present in water. The purifying device comprises a photochemical reactor unit having at least one inlet for contaminated water and one outlet for purified water, it provides a flow path for continuously flowing water from said inlet to said outlet, and is equipped with a radiation source module providing ultraviolet radiation in a wavelength range ranging from 100 to 280 nm. The purifying device further comprises at least one membrane filtration unit designed to perform ultra filtration and connected upstream of said photochemical reactor unit via said inlet and at least one device for supplying air or dioxygen to the water comprised in the photochemical reactor unit. Further, a purification method is provided, using the device of the invention. | 06-07-2012 |
Esther Padilla Lopez, Estella ES
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20100263225 | HOUSEHOLD APPLIANCE COMPRISING A FIRST AIR CONDUIT AND A HEAT PUMP - A household appliance including a housing; a drying chamber to dry wet articles in the drying chamber; and a first air conduit to guide process air drawn into the housing to dry the wet articles. The household appliance also has a heat pump that includes a heat sink to transfer heat into the heat pump; a heat source coupled to the first air conduit to transfer the heat from the heat pump into the process air; and a heat transfer device to transfer the heat from the heat sink to the heat source. A second air conduit is coupled to the heat sink to guide secondary air drawn into the housing. The heat sink transfers the heat from the secondary air into the heat pump. | 10-21-2010 |
20100263226 | WASHING/DRYING DEVICE COMPRISING A MOISTURE DETERMINING DEVICE AND METHOD FOR OPERATING A WASHING/DRYING DEVICE - A laundry drying device having a washing drum; a moisture determining device to determine a moisture content of process air evacuated from the washing drum, wherein the moisture determining device has at least one temperature sensor; and a cooling body to cool the process air, wherein the cooling body has an inlet side, an outlet side, and an inlet for a medium that flows through the cooling body or that is located in the cooling body. A first temperature sensor is arranged behind the inlet of the cooling body; a second temperature sensor is arranged at the outlet side of the cooling body to measure an outlet temperature of the medium; and a third temperature sensor is arranged at the inlet side of the cooling body to measure an inlet temperature of the medium. The medium is the process air or a coolant. | 10-21-2010 |
Esther Palomero, Leganes-Madrid ES
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20100048635 | USE OF COLLISMYCIN AND DERIVATIVES THEREOF AS OXIDATIVE STRESS INHIBITORS - The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease. | 02-25-2010 |
Esther Park, Dublin, CA US
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20090064401 | Toilet Device With Improved Fragrance Delivery - Described is a single function or multi-function device for attachment to the tank of a toilet fixture. The device provides a diffusible air-treatment concentrate for deodorizing or otherwise treating the ambient air surrounding the toilet. At the same time, the multi-function device provides a water-soluble water-treatment concentrate for treating the flush water stored in the toilet tank. The device can have an air moving part with a delay value to increase fragrance delivery. The device can have an air treatment part with a reservoir having fragrance containing particles. The reservoir can have an attachment means so that it can be replaced when the fragrance is used up. The device can deliver a burst of fragranced air during a toilet flush cycle. | 03-12-2009 |
Esther Perea-Borobio, London GB
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20090205657 | Pre-metered dose magazine for dry powder inhaler - A dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway. | 08-20-2009 |
Esther Perez Carrillo, San Nicolas De Los Garza MX
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20110014671 | METHOD FOR OBTAINING BIOETHANOL FROM SORGHUM GRAIN (SORGHUM BICOLOR L. MOENCH), COMPRISING STEPS INVOLVING DECORTICATION AND HYDROLYSIS WITH PROTEASES - The invention relates to an improved method for obtaining bioethanol from | 01-20-2011 |
Esther Pérez David, Madrid ES
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20130069945 | METHOD FOR DISPLAYING THE INFORMATION CONTAINED IN THREE-DIMENSIONAL IMAGES OF THE HEART - This invention describes a method, the starting point of which is a three-dimensional image of the heart. A region of interest is defined on said image. Moreover, the surface which will be represented in the display in the form of a three-dimensional polygon mesh is defined. Each vertex of the mesh is associated with a function which assigns weights to each element in the region of interest. Display parameters are assigned to the vertices using said functions together with the intensity values of the elements in the region of interest. Said parameters are used to generate the interactive display of the surface. One application of the method would be the use thereof to help to characterize the myocardial substrate of ventricular tachycardia in patients with ischemic heart disease and to guide ablation procedures for correcting said tachycardia. | 03-21-2013 |
Esther Perez Herran, Zaragoza ES
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20100129407 | Tuberculosis Vaccine - The present invention relates to an isolated microorganism belonging to the genus | 05-27-2010 |
20130022638 | Tuberculosis Vaccine - The present invention relates to an isolated microorganism belonging to the genus | 01-24-2013 |
Esther Rebollar GonzÁlez, Madrid ES
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20110007308 | METHOD FOR REMOVAL OF WAX FROM POROUS STONES IN HISTORICAL MONUMENTS - Disclosed embodiments include methods for cleaning wax, substantially equivalent impurities, and other contaminants from porous stones in historical monuments and artworks using nondestructive means. According to one embodiment the method for removal of contaminants from porous stones using laser comprises the following method steps: (a) identifying regions of a contaminant on the porous stone monument; (b) characterizing the contaminant on the porous stone monument; (c) exposing the contaminant on the porous stone monument to irradiation from a laser characterized by a wavelength, a pulse length, a repetition rate, and a laser energy fluence determined and optimized for a given contaminant-porous stone system and the laser characteristics; and (d) adaptively evaluating the cleaning results by quantifying the thickness of the remaining contaminant. | 01-13-2011 |
Esther Rebollar GonzÁlez, Madrid ES
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20110007308 | METHOD FOR REMOVAL OF WAX FROM POROUS STONES IN HISTORICAL MONUMENTS - Disclosed embodiments include methods for cleaning wax, substantially equivalent impurities, and other contaminants from porous stones in historical monuments and artworks using nondestructive means. According to one embodiment the method for removal of contaminants from porous stones using laser comprises the following method steps: (a) identifying regions of a contaminant on the porous stone monument; (b) characterizing the contaminant on the porous stone monument; (c) exposing the contaminant on the porous stone monument to irradiation from a laser characterized by a wavelength, a pulse length, a repetition rate, and a laser energy fluence determined and optimized for a given contaminant-porous stone system and the laser characteristics; and (d) adaptively evaluating the cleaning results by quantifying the thickness of the remaining contaminant. | 01-13-2011 |
Esther Resendiz, Champaign, IL US
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20110142335 | Image Comparison System and Method - An image comparison system includes a memory unit that stores data representative of target apparel images that depict apparel items. An image processing unit is provided to process a query apparel image to extract data representative of a query apparel item depicted in the query apparel image. The image processing unit determines weighted color and pattern differences between the target apparel images and the query apparel image. | 06-16-2011 |
Esther Rodriquez-Villegas, London GB
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20110137195 | Method and Apparatus for Monitoring Respiratory Activity - A method of monitoring respiratory activity includes obtaining a respiration sound signal. The respiration sound signal is processed to identify a frequency component corresponding to respiration, and an amplitude related parameter of the component is measured. If the measured parameter is in an indeterminate region then a temporal domain related parameter of the identified frequency component is measured. An apparatus for monitoring respiratory activity is also disclosed. | 06-09-2011 |
Esther Rohm, Houston, TX US
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20090067568 | SYSTEM AND METHOD FOR X-RAY BASED ASSESSMENT OF ANEURYSM PULSATION - A method of assessing rupture risk of an aneurysm from time-resolved images includes injecting a contrast enhancing agent into a patient with an aneurysm, using an electrocardiogram (ECG) signal to trigger an image acquisition run, wherein a sequence of 2D X-ray fluoroscopic images is acquired along with a corresponding ECG signal value, rotating a C-arm attaching the X-ray fluoroscopic imaging apparatus during said image acquisition run, wherein the images in said X-ray fluoroscopic image sequence are acquired from a rotating viewpoint, sorting the images in said X-ray fluoroscopic image sequence into time windows of the cardiac cycle based on the ECG signal, and constructing one or more 3-dimensional (3D) angiography image volumes of said aneurysm from said 2D fluoroscopic image sequence. | 03-12-2009 |
Esther Schmitt, Lorrach DE
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20120034650 | Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof - The present invention relates to the provision of a polynucleotide comprising one or more functional fragments of a biosynthetic gene cluster involved in the production of a compound of formula (I) or (I′). The present invention also provides a method of preparing a compound of formula (I) or (I′) or of formula (II) to (VII), (XI) to (XIV) and (XVII) and (XVIII). Moreover, the use of such compound as a pharmaceutical composition is also provided in the present invention. | 02-09-2012 |
20120196790 | CYCLIC DEPSIPEPTIDES - The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase. | 08-02-2012 |
20130172267 | USE OF CYCLIC DEPSIPEPTIDES TO INHIBIT KALLIKREIN 7 - The present application relate to cyclic depsipeptides, or derivatives thereof, having the formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7. | 07-04-2013 |
Esther Schron, Medina, OH US
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20100316439 | MOUNTING SYSTEM - A mounting system with a receiver arrangement with an annular gland nut and an annular receiver bushing. The bushing having an inner passage and an oppositely facing outer surface. The outer bushing surface having at least one receiver-bearing surface shaped to engage a bearing surface of the mounting opening to align the receiver laterally within the opening. The bushing further including a support edge to position the receiver axially within the mounting opening. The annular gland nut having an OD thread configured to threadingly engage an ID thread in the mounting opening and having a contact edge to engage the receiver and force the support edge of the receiver against the bottom ledge of the mounting opening thereby securing the receiver axially in the mounting opening. | 12-16-2010 |
20120076578 | MOUNTING SYSTEM - A mounting system with a receiver arrangement having a double sided configuration, the bushing having an inner passage and an oppositely facing outer surface, the outer bushing surface having at least one receiver bearing surface shaped to engage a bearing surface of the mounting opening to align the receiver laterally within the opening, the bushing being locked or lockable within a mounting opening and further including two locking arrangements for allowing the selectively locking of a shank from either end. | 03-29-2012 |
Esther Shaoul, Nesher IL
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20100111869 | Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostic or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derived therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue - A stinging cell comprising an exogenous polynucleotide capable of expressing a therapeutic, cosmetic or diagnostic agent in the stinging cell is provided. | 05-06-2010 |
Esther Shemenzon, Rehovot IL
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20090006445 | Binding between net technologies and SQL server statements - Methods, systems, and computer code for (i) performance-monitoring a multi-tier application including a .NET tier and a database tier; and (ii) for visually presenting performance-data to a user are disclosed. In some embodiments, a multi-tiered performance data interface, for example, including a .NET tier performance data interface and a database tier performance data interface operatively coupled to the .NET tier performance data interface, is provided. In some embodiments, the .NET tier performance data interface is configured to present .NET stack data and the database performance data interface is configured to present internal database performance data, for example, wait times (e.g. relative magnitudes of different types of wait times). Techniques for matching .NET-tier requests to execute SQL statements with database-tier executions of SQL statements are also disclosed. | 01-01-2009 |
Esther Shmitt, Lorach DE
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20090156472 | Cyclic Depsipeptides - The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase. | 06-18-2009 |
Esther Shohami, Mevasseret Zion IL
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20100099756 | USES OF INCENSOLE, INCENSOLE ACETATE AND DERIVATIVES THEREOF - The described subject matter relates to the use of incensole, incensole acetate, and derivatives thereof, for the treatment, prevention or amelioration of diseases or conditions, including inflammatory-associated conditions; a disease or condition where neuroprotection is required; and a disease or condition selected from depression, anxiety, obsessive compulsive behaviors, deterioration in cognitive function, and deterioration in neurobehavioral function. Pharmaceutical compositions and method of treatment, prevention or amelioration of the above-mentioned diseases or conditions are also provided. | 04-22-2010 |
20100222438 | METHODS COMPOSITIONS AND ARTICLE OF MANUFACTURE FOR MODULATING BONE GROWTH - Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed. | 09-02-2010 |
20120245366 | NOVEL ARYLATED CAMPHENES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF - The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors. | 09-27-2012 |
20130190393 | USES OF INCENSOLE, INCENSOLE ACETATE AND DERIVATIVES THEREOF - The described subject matter relates to the use of incensole, incensole acetate, and derivatives thereof, for the treatment, prevention or amelioration of diseases or conditions, including inflammatory-associated conditions; a disease or condition where neuroprotection is required; and a disease or condition selected from depression, anxiety, obsessive compulsive behaviors, deterioration in cognitive function, and deterioration in neurobehavioral function. Pharmaceutical compositions and method of treatment, prevention or amelioration of the above-mentioned diseases or conditions are also provided. | 07-25-2013 |
20150038728 | NOVEL ARYLATED CAMPHENES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF - The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors. | 02-05-2015 |
Esther Sulkin, Ramat IL
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20090043170 | INTERACTIVE SYSTEM AND METHOD FOR NEUROMOTOR FUNCTIONING ASSESSMENT AND TRAINING - The present invention discloses an interactive system for neuromotor functioning assessment and training of a subject, using rhythmic-based techniques. The system may comprise an acquisition unit and an analysis unit connected by communication means. The acquisition unit may comprise measuring devices and may unit enable producing rhythmic aural and/or visual indications and measuring the subject's performing of actions under the produced rhythmus. The actions may be carried out according to predefined exercises using the measuring devices. The analysis unit may include a software application that allows receiving, storing, displaying and analyzing of acquisition data arriving from the acquisition unit. | 02-12-2009 |
Esther Szanton, Rehovot IL
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20090220486 | ANTIBODIES AND USES THEREOF - The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3. | 09-03-2009 |
Esther Tzehoval, Nes-Ziona IL
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20100129410 | Methods and Immunogenic Cell Preparations for Treating Antigen-Associated Diseases - A method of inhibiting growth of, reducing or eliminating a cell population of a subject in need thereof is disclosed. The method comprises (a) thermally, mechanically and/or chemically damaging antigen-bearing cells which comprise at least one antigen characterizing cells of the cell population, with the proviso that the chemically damaging of the antigen-bearing cells is not predominantly effected using one or more antineoplastic agents, thereby generating immunogenic cells; and (b) introducing in the subject a cell aggregate which comprises the immunogenic cells and added antigen-presenting cells, thereby inducing an immune response for inhibiting growth of, reducing or eliminating the cell population of the subject. | 05-27-2010 |
Esther Tzehoval, Rehovot IL
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20100291127 | TUMOR ASSOCIATED ANTIGEN PEPTIDES AND USE OF SAME AS ANTI-TUMOR VACCINES - The present invention relates to tumor associated antigen (TAA) peptides and to use of same, of polynucleotides encoding same and of cells presenting same as anti-tumor vaccines. More particularly, the present invention relates to tumor associated antigen peptides derived from Uroplakin Ia, Ib, II and III, Prostate specific antigen (PSA), Prostate acid phosphatase (PAP) and Prostate specific membrane antigen (PSMA), BA-46 (Lactadherin), Mucin (MUC-1), and Teratocarcinoma-derived growth factor (CRIPTO-1) and the use of same as anti-tumor vaccines to prevent or cure bladder, prostate, breast or other cancers, carcinomas in particular. Most particularly, the present invention relates to tumor associated antigen peptides which are presentable to the immune system by HLA-A2 molecules. | 11-18-2010 |
20140065111 | Affinity Maturated T Cell Receptors And Use Thereof - The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen. | 03-06-2014 |
Esther Vazquez Gomez, Bellaterra ES
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20120148529 | Use of Inclusion Bodies as Therapeutic Agents - The present invention relates to the use of inclusion bodies as vehicles for therapeutic protein delivery. This method is applicable to the delivery of therapeutic proteins to intracellular locations. In addition, the invention also relates to the administration of a cell or a pharmaceutical composition comprising inclusion bodies formed by therapeutic proteins. These inclusion bodies formed by therapeutic proteins could be used for the treatment of different diseases. | 06-14-2012 |
20140308237 | Use of Inclusion Bodies as Therapeutic Agents - The present invention relates to the use of inclusion bodies as vehicles for therapeutic protein delivery. This method is applicable to the delivery of therapeutic proteins to intracellular locations. In addition, the invention also relates to the administration of a cell or a pharmaceutical composition comprising inclusion bodies formed by therapeutic proteins. These inclusion bodies formed by therapeutic proteins could be used for the treatment of different diseases. | 10-16-2014 |
Esther Vázquez Gómez, Bellaterra ES
Patent application number | Description | Published |
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20110268773 | INCLUSION BODIES, BACTERIAL CELLS AND COMPOSITIONS CONTAINING THEM AND USES THEREOF - The present invention relates to an isolated inclusion body comprising a polypeptide, characterised in that such inclusion body is in particulate form. The present invention also refers to a bacterial cell comprising said inclusion body. The present invention additionally refers to a composition comprising said inclusion body and a eukaryotic cell. The present invention moreover refers to a composition comprising said inclusion body and animal or plant tissue. The present invention furthermore refers to the uses of said inclusion body as medicaments and cell-proliferation stimulators and tissue regenerators. | 11-03-2011 |
Esther Zwick-Wallasch, Gauting DE
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20090028851 | Novel Antibodies Directed to the Mammalian Eag1 Ion Channel Protein - The present invention relates to a particularly advantageous antibody, antibody fragment or derivative thereof, which specifically binds to/interacts with at least one epitope of the extracellular or intracellular domain or the mammalian EAG1 ion channel and to nucleic acid molecules encoding the same and to vectors comprising said nucleic acid molecules. The invention additionally relates to methods for the preparation of said antibody, antibody fragments or derivatives thereof and to pharmaceutical compositions comprising the same. Furthermore, the use of said antibody, antibody fragment or derivative thereof and also diagnostic compositions comprising said components are disclosed in the specification. The invention also relates to a method of assessing for the presence of EAG1 expressing cells and for a method of blocking EAG1 function in said cells. The invention further relates to a method of treating diseases with the help or said antibody or antibody fragment or derivative thereof. | 01-29-2009 |
20100330095 | AXL ANTIBODIES - The present invention refers to antibodies, particularly to monoclonal antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity. | 12-30-2010 |
20110110956 | Heparin-Binding Epidermal Growth Factor-like Growth Factor Binding Proteins - Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the biological functions of this growth factor. | 05-12-2011 |
20150056211 | Heparin-Binding Epidermal Growth Factor-like Growth Factor Binding Proteins - Provided herein are antigen binding proteins, e.g., human and/or monoclonal antibodies that have affinity for heparin-binding epidermal growth factor-like growth factor (HB-EGF) and neutralize the biological functions of this growth factor. | 02-26-2015 |
Esther Zwick-Wallasch, Muenchen DE
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20100048684 | EGF RECEPTOR TRANSACTIVATION BY G-PROTEIN-COUPLED RECEPTORS REQUIRES METALLOPROTEINASE CLEAVAGE OF proHB-EGF - The present invention relates to agents and methods for growth-factor receptor activation by modulating the G-protein mediated signal transduction pathway. | 02-25-2010 |