Kuan, US
Aaron T. Kuan, Cambridge, MA US
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20140262820 | Fabrication of Nanopores In Atomically-Thin Membranes By Ultra-Short Electrical Pulsing - In a method for forming nanopores, two opposing surfaces of a membrane are exposed to an electrically conducting liquid environment. A nanopore nucleation voltage pulse, having a first nucleation pulse amplitude and duration, is applied between the two membrane surfaces, through the liquid environment. After applying the nanopore nucleation voltage pulse, the electrical conductance of the membrane is measured and compared to a first prespecified electrical conductance. Then at least one additional nanopore nucleation voltage pulse is applied between the two membrane surfaces, through the liquid environment, if the measured electrical conductance is no greater than the first prespecified electrical conductance. At least one nanopore diameter tuning voltage pulse, having a tuning pulse voltage amplitude and duration, is applied between the two membrane surfaces, through the liquid environment, if the measured electrical conductance is greater than the first prespecified electrical conductance and no greater than a second prespecified electrical conductance. | 09-18-2014 |
Andrew Kuan, New York, NY US
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20100091960 | INTERACTIVE VOICE RESPONSE SYSTEM AND METHOD WITH COMMON INTERFACE AND INTELLIGENT AGENT MONITORING - A modular interactive voice recognition (“IVR”) overlay system and a method of processing calls. The system provides an application server, a plurality of agent workstations and a graphical user interface (“GUI”) to allow a hybrid approach to processing calls using an automated IVR and live agents. The system and method allow a single agent to process multiple calls simultaneously and is compatible with existing IVR systems and can be implemented as an add-on to existing IVR systems. | 04-15-2010 |
20140079208 | INTERACTIVE VOICE RESPONSE SYSTEM AND METHOD WITH COMMON INTERFACE AND INTELLIGENT AGENT MONITORING - A modular interactive voice recognition (“IVR”) overlay system and a method of processing calls. The system provides an application server, a plurality of agent workstations and a graphical user interface (“GUI”) to allow a hybrid approach to processing calls using an automated IVR and live agents. The system and method allow a single agent to process multiple calls simultaneously and is compatible with existing IVR systems and can be implemented as an add-on to existing IVR systems. | 03-20-2014 |
20140294162 | INTERACTIVE VOICE RESPONSE SYSTEM AND METHOD WITH COMMON INTERFACE AND INTELLIGENT AGENT MONITORING - A modular interactive voice recognition (“IVR”) overlay system and a method of processing calls. The system provides an application server, a plurality of agent workstations and a gaphical user interface (“GUI”) to allow a hybrid approach to processing calls using an automated IVR and live agents. The system and method allow a single agent to process multiple calls simultaneously and is compatible with existing IVR systems and can be implemented as an add-on to existing IVR systems. | 10-02-2014 |
Cara Kuan, Redmond, WA US
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20100094484 | INTEGRATING COMMUNICATION AND SURVEILLANCE - An aircraft control unit has modules for interfacing with various systems of an aircraft to integrate control of the systems. The modules include a communication module configured to be coupled to a communication system of the aircraft and a surveillance module configured to be coupled to a surveillance system of the aircraft. The aircraft control unit also includes a display screen for displaying information and a user interface usable to interact with the modules. Each of the modules is configured to display information on the display screen and to receive user input from the user interface. | 04-15-2010 |
Chia-Yi Kuan, Loveland, OH US
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20100286053 | PLASMINOGEN ACTIVATOR INHIBITOR AMELIORATION OF NEWBORN HYPOXIC ISCHEMIC BRAIN INJURY - Plasminogen activators as potential therapeutic targets in neonatal hypoxia ischemia (HI) brain injury. Use of plasminogen activator inhibitor-1 (PAI-1) to ameliorate HI encephalopathy related disease. Use of PAI-1 as preventive treatment of cerebral palsy (CP). | 11-11-2010 |
Chia-Yi Kuan, Wallingford, CT US
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20120240247 | JNK3 MODULATORS AND METHODS OF USE - The c-Jun NH | 09-20-2012 |
Chien-Tsun Kuan, Cary, NC US
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20090252750 | ANTIBODIES AND IMMUNOTOXINS THAT TARGET HUMAN GLYCOPROTEIN NMB - The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells. | 10-08-2009 |
20090269343 | Dual Specific Immunotoxin for Brain Tumor Therapy - We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a hybridoma and fused to toxin, carrying a C-terminal peptide which increases retention within cells. The binding affinity and specificity of the recombinant bispecific immunotoxin for the EGFRwt and the EGFRvIII proteins was measured. In vitro cytotoxicity was measured. In vivo activity of the recombinant bispecific immunotoxin was evaluated in subcutaneous models and compared to that of an established monospecific immunotoxin. In our preclinical studies, the bispecific recombinant immunotoxin, exhibited significant potential for treating brain tumors. | 10-29-2009 |
20100047164 | Anti-Tumor Antibodies - Chondroition sulfate proteoglycans represent excellent targets for anti-tumor immunotherapy. Antibodies which target such proteoglycans can be used alone, in combinations, armed with a cytotoxic payload or unarmed. Combinations of such antibodies can target different epitopes of the proteoglycans. Internalization of the antibodies can increase the toxicity of the payloads. Single chain variable regions are especially advantageous for such anti-tumor immunotherapy. | 02-25-2010 |
20100290984 | ANTI-MRP3 ANTIBODIES AND METHODS OF USE - An antibody having an antigen binding region capable of binding an epitope located in an extracellular portion of MRP3 and methods of utilizing same are provided. In particular, the invention provides antibodies targeted at a MRP3 antigen present on cells expressing MRP3 and methods useful in detecting or targeting cells expression the MRP3 antigen, as well as kits, nucleic acids, polypeptides, and cells for providing the antibodies. | 11-18-2010 |
20110229479 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 09-22-2011 |
20120122121 | ANTIBODIES AND IMMUNOTOXINS THAT TARGET HUMAN GLYCOPROTEIN NMB - The invention provides high affinity antibodies suitable for forming Immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells. | 05-17-2012 |
20120189630 | BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES - We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific. These are promising therapeutic agents. | 07-26-2012 |
20120202207 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 08-09-2012 |
20130022598 | Dual Specific Immunotoxin for Brain Tumor Therapy - We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a hybridoma and fused to toxin, carrying a C-terminal peptide which increases retention within cells. The binding affinity and specificity of the recombinant bispecific immunotoxin for the EGFRwt and the EGFRvIII proteins was measured. In vitro cytotoxicity was measured. In vivo activity of the recombinant bispecific immunotoxin was evaluated in subcutaneous models and compared to that of an established monospecific immunotoxin. In our preclinical studies, the bispecific recombinant immunotoxin, exhibited significant potential for treating brain tumors. | 01-24-2013 |
20130245244 | Antibodies and Immunotoxins that Target Human Glycoprotein NMB - The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiforme cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells. The antibodies may be formed in cells transformed with an isolated nucleic acid encoding a polypeptide comprising an antibody heavy chain variable region (“VH”) and an antibody light chain variable region (“VL”). Such nucleic acids are provided. | 09-19-2013 |
20140017266 | ANTI-PODOPLANIN ANTIBODIES AND METHODS OF USE - Recombinant scFv-immunotoxins target tumor cells expressing human podoplanin but not podoplanin-negative or normal cells. The immunotoxins can be used for treatment of malignant glioma patients or any malignant tumor expressing podoplanin. One such immunotoxin comprises a modified | 01-16-2014 |
20140187764 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 07-03-2014 |
20140322248 | Dual Specific Immunotoxin for Brain Tumor Therapy - We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a hybridoma and fused to toxin, carrying a C-terminal peptide which increases retention within cells. The binding affinity and specificity of the recombinant bispecific immunotoxin for the EGFRwt and the EGFRvIII proteins was measured. In vitro cytotoxicity was measured. In vivo activity of the recombinant bispecific immunotoxin was evaluated in subcutaneous models and compared to that of an established monospecific immunotoxin. In our preclinical studies, the bispecific recombinant immunotoxin, exhibited significant potential for treating brain tumors. | 10-30-2014 |
20150132306 | HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES - We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific. These are promising therapeutic agents. | 05-14-2015 |
Chun-Kuang Kuan US
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20150013105 | AIR-WIPING DEVICE OPENING AND CLOSING IN ONE LEVEL PLANE - An air-wiping device for removing particulates, including water, adhering to an elongated member by compressed air is provided. In particular, this invention relates to an air-wiping device that loads said elongated member by opening with a sliding motion in one plane, instead of swinging open in two planes that is commonly to the conventional air-wiping devices embodied in a clamshell configuration, which not only substantially shortens the loading time but also greatly reduces the floor space needed to accommodate said device. | 01-15-2015 |
George Kuan, Chicago, IL US
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20100223604 | MODULE SYSTEM FOR POLYMORPHIC PI-CALCULUS - A method and apparatus is disclosed herein for using a module system for polymorphic π-calculus. In one embodiment, the method comprises receiving a formal specification of a software program; and performing automatic analysis on the formal specification using a module system fitted with processes of the polymorphic π-calculus processes. | 09-02-2010 |
Jiun-Yih Kuan, Cambridge, MA US
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20130158444 | Robotic System for Simulating a Wearable Device and Method of Use - A robotic system for simulating a wearable device actuation delivery mechanism and the source removed from the actuation delivery mechanism that is linked to the actuation delivery mechanism by at least one cable. A sensing system detects a physiological feature of the subject and, based on feedback from the sensing system, a control system linked to both the sensing system and the actuation source modulates the actuation source, and thereby modulating actuation of the joint of a subject in response to the physiological future sensed by the sensing system. A method for simulating a wearable robotic system employs the robotic system of the invention to thereby provide a model on which to base design of an ambulatory prosthetic for a subject. | 06-20-2013 |
Juin-Ping Kuan US
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20150013105 | AIR-WIPING DEVICE OPENING AND CLOSING IN ONE LEVEL PLANE - An air-wiping device for removing particulates, including water, adhering to an elongated member by compressed air is provided. In particular, this invention relates to an air-wiping device that loads said elongated member by opening with a sliding motion in one plane, instead of swinging open in two planes that is commonly to the conventional air-wiping devices embodied in a clamshell configuration, which not only substantially shortens the loading time but also greatly reduces the floor space needed to accommodate said device. | 01-15-2015 |
Kah Tiong Kuan, Ballwin, MO US
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20130066098 | Remote Assembly of Targeted Nanoparticles using H-Phosphate ENE/-YNE Hydrophosphonylation Reactions - The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications. | 03-14-2013 |
Nelson Kuan, Brookline, MA US
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20080205025 | Package Having a Plurality of Mounting Orientations - A package apparatus has a base coupled with a lid to form a leadframe package. The package has first and second exterior surfaces with respective first and second contact patterns. The first and second contact patterns are substantially electrically identical to permit the package to be either vertically or horizontally mounted to an underlying apparatus. | 08-28-2008 |
20090230521 | Stress Mitigation in Packaged Microchips - A packaged microchip has a lead frame with a die directly contacting at least a single, contiguous portion of the lead frame. The portion of the lead frame has a top surface forming a concavity and contacting the die. The packaged microchip also has mold material substantially encapsulating part of the top surface of the portion of the lead frame. | 09-17-2009 |
20100013067 | Stress Mitigation in Packaged Microchips - A package apparatus has a base coupled with a lid to form a leadframe package. The package has first and second exterior surfaces with respective first and second contact patterns. The first and second contact patterns are substantially electrically identical to permit the package to be either vertically or horizontally mounted to an underlying apparatus. | 01-21-2010 |
Nelson Kuan, Reston, VA US
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20100258348 | INTERCONNECT AND SYSTEM INCLUDING SAME - An interconnect. The interconnect includes a thermal isolation structure and a layer of conductive material which covers the thermal isolation structure. The thermal isolation structure has a first end, a second end, and a sidewall. | 10-14-2010 |
Wei-Fan Kuan, Newark, DE US
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20150197585 | TAPERED BLOCK COPOLYMER ELECTROLYTES - Copolymers useful as components of polymer electrolytes are provided in which the copolymer comprises at least one block sequence represented by formula (I): | 07-16-2015 |
Yew Cheong Kuan US
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20130264970 | LIGHT EMITTING DIODE (LED) COMPONENTS AND METHODS FOR IMPROVED LIGHT EXTRACTION - Light emitter components with improved light extraction and related methods are disclosed. In one embodiment, the light emitter component can include a submount, at least one light emitting chip disposed over the submount, and a lens disposed over a portion of the light emitting chip. The lens can include an optical element. The optical element can be configured to affect light output from the at least one light emitting chip. | 10-10-2013 |
Yuji Richard Kuan, Plano, TX US
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20120304486 | Drying Silicon Particles and Recovering Solvent - Apparatus to dry milled silicon particles has solvent spray nozzles, solvent drainage, gas inlet, and gas exhaust. This drying can occur, for example, following an acid etch and a deionized water rinse. The drying apparatus is an enclosed system with a lid that contains a solvent feeding tube and exhaust ventilation. This enclosed system design creates an effective low temperature drying system in an inert atmosphere. The apparatus can handle a variety of different particle sizes, inhibits the growth of surface oxides on the particles by using lower temperatures, and allows reuse of solvent. | 12-06-2012 |