Patent application number | Description | Published |
20100139691 | METHOD FOR THE PLASMA CLEANING OF THE SURFACE OF A MATERIAL COATED WITH AN ORGANIC SUBSTANCE AND THE INSTALLATION FOR CARRYING OUT SAID METHOD - The invention relates to a method of cleaning the surface of a material that is coated with an organic substance. The inventive method is characterized in that it comprises the following steps, consisting in: introducing the material into a treatment chamber, having a pressure of between 10 mbar and 1 bar therein, which is supplied with a gas stream containing at least 90 volume percent of oxygen; and generating a plasma by passing an electric discharge between the surface of the material and a dielectric-covered electrode in order to break down the organic substance under the action of the free radicals O thus produces. The invention also relates to an installation that is used to carry out said method. | 06-10-2010 |
20100139864 | METHOD FOR THE PLASMA CLEANING OF THE SURFACE OF A MATERIAL COATED WITH AN ORGANIC SUBSTANCE AND THE INSTALLATION FOR CARRYING OUT SAID METHOD - The invention relates to a method of cleaning the surface of a material that is coated with an organic substance. The inventive method is characterized in that it comprises the following steps, consisting in: introducing the material into a treatment chamber, having a pressure of between 10 mbar and 1 bar therein, which is supplied with a gas stream containing at least 90 volume percent of oxygen; and generating a plasma by passing an electric discharge between the surface of the material and a dielectric-covered electrode in order to break down the organic substance under the action of the free radicals O thus produces. The invention also relates to an installation that is used to carry out said method. | 06-10-2010 |
20110174333 | PROCESS AND INSTALLATION FOR SURFACE PREPARATION BY DIELECTRIC BARRIER DISCHARGE - A process for surface preparation of a substrate ( | 07-21-2011 |
20110183083 | PROCESS AND INSTALLATION FOR DEPOSITING FILMS ONTO A SUBSTRATE - A process for depositing a film onto a substrate ( | 07-28-2011 |
20110200763 | PROCESS AND INSTALLATION FOR DEPOSITING FILMS SIMULTANEOUSLY ONTO BOTH SIDES OF A SUBSTRATE - A process for the simultaneous deposition of films onto both sides of a substrate ( | 08-18-2011 |
20140230731 | INSTALLATION FOR DEPOSITING FILMS ONTO A SUBSTRATE - An installation, comprising a chamber comprising two ends, a transport unit and a support unit which introduce a two-sided substrate into the chamber, a stabilized high-voltage high-frequency power supply of at least 200 kW, comprising an HF transformer comprising a primary and a secondary circuit connected to terminals, at least two electrodes being connected to the terminals of the secondary circuit, said electrodes being placed on each side of the substrate, at least one dielectric barrier placed between the at least two electrodes; a power supply regulation/control unit placed upstream of the HF transformer that is capable of increasing an active power/reactive power ratio, an introducing unit for introducing at least one reactive substance into the chamber, and an extracting unit for extracting residual substances, wherein an adjustable inductor is placed in the secondary circuit of the transformer in parallel with a circuit comprising the at least two electrodes, and the adjustable inductor enables a phase shift between a voltage generated between the electrodes and a total current delivered by the high-voltage source to be modulated, and the power supply regulation/control unit, placed on the primary circuit of the transformer, and/or a unit for controlling the inductor being capable of generating harmonics extending a time during which a current flows between the electrodes, wherein the installation is suitable for depositing a film onto an inorganic substrate. | 08-21-2014 |
Patent application number | Description | Published |
20130223666 | Hearing Aid Insertion, Positioning and Removal Apparatus and System - An apparatus for insertion, positioning and removal of an in-ear-canal hearing aid, comprising a resilient handle, an elongated support member configured to fit into an ear canal, the support member having a first end that is configured to engage the handle and a second end that includes hearing aid engagement means configured to removably engage an in-ear-canal hearing aid, and an ear canal ingression stop that is configured to limit travel of the support member and, thereby, the in-ear-canal hearing aid when engaged thereto in the ear canal. | 08-29-2013 |
20130266168 | Open Ear Canal Hearing Aid - The invention provides systems and methods for providing hearing aid. An open ear canal hearing aid may be provided in accordance with an embodiment of the invention. The hearing aid may include a part that contains electronic components, a passive amplifier, and a securing mechanism. The securing mechanism may include bristles or balloons. The securing mechanism may have various configurations and be adjustable. | 10-10-2013 |
20140219488 | Adjustable Securing Mechanism for a Space Access Device - A securing mechanism comprising a plurality of outwardly projecting members having a plurality of contact points that are configured to contact a surface of an opening when disposed on a space access device that is inserted in the opening, the securing mechanism being configured to apply a pressure to a contact surface within the opening less than approximately 10000 kPa. | 08-07-2014 |
20140239634 | Adjustable Securing Mechanism For A Space Access Device - A securing mechanism comprising a plurality of outwardly projecting members having a plurality of contact points that are configured to contact a surface of an opening when disposed on a space access device that is inserted in the opening, the securing mechanism being configured to apply a pressure to a contact surface within the opening less than approximately 10000 kPa. | 08-28-2014 |
20140270300 | Hearing Aid Delivery and Retrieval Platform - An apparatus for insertion, positioning and removal of an in-ear-canal hearing aid, comprising a resilient handle, an elongated support member configured to fit into an ear canal, the support member having a first end that is configured to engage the handle and a second end that includes magnetic engagement means configured to removably engage an in-ear-canal hearing aid, and an ear canal ingression stop that is configured to limit travel of the support member and, thereby, the in-ear-canal hearing aid when engaged thereto in the ear canal. | 09-18-2014 |
20140294213 | Ear Cleaning Apparatus - The invention provides apparatus and methods for cleaning an ear canal. The ear cleaning apparatus includes an elongated support member having an outer surface and first and second ends, and a bristle member that is attached to one end of the support member. The bristle member includes a plurality of flexible elongated members that are configured to contact a surface of an ear canal when the support member/bristle member assembly is inserted into the ear canal. | 10-02-2014 |
20150086054 | Open Ear Canal Hearing Aid - The invention provides systems and methods for providing hearing aid. An open ear canal hearing aid may be provided in accordance with an embodiment of the invention. The hearing aid may include a part that contains electronic components, a passive amplifier, and a securing mechanism. The securing mechanism may include bristles or balloons. The securing mechanism may have various configurations and be adjustable. | 03-26-2015 |
20160029134 | Adjustable Securing Mechanism for a Space Access Device - A securing mechanism comprising a plurality of outwardly projecting members having a plurality of contact points that are configured to contact a surface of an opening when disposed on a space access device that is inserted in the opening, the securing mechanism being configured to apply a pressure to a contact surface within the opening less than approximately 10000 kPa. | 01-28-2016 |
Patent application number | Description | Published |
20110046868 | Aircraft Guidance System for Assisting in Airport Navigation - An aircraft guidance system for assisting in airport navigation includes: at least one airport database comprising topology data of an airport, called airport DB; at least one configuration database comprising aircraft configuration data and the position of a guidance point; a positioning system delivering aircraft kinematic and attitude parameters; at least one computer generating a 2D view of the representation of the airport notably comprising navigation indications and a representation of the aircraft; and at least one display for displaying the representation of the airport. In the system, a first symbol is generated on the display indicating the position of an early guidance point, corresponding to the position of the guidance point at a future time. | 02-24-2011 |
20110246003 | Approach Phase Monitoring System for an Aircraft - The invention relates to a monitoring system dedicated to the landing of an aircraft including means of receiving navigation data, means of receiving a plurality of landing area monitoring information, and display means representing, by various symbols, the landing area and the monitoring information, including means of determining a plurality of successive approach phases constituting the landing procedure and of signalling the current approach phase, means of calculating a plurality of cartographic scale factors of the landing area, and means of selecting monitoring information to be displayed for each approach phase. The display means represent the landing area according to a changing cartographic scale factor and the selected monitoring information by symbols that also change, the cartographic scale factor and the symbols changing automatically according to the current approach phase. | 10-06-2011 |
20110257873 | ONBOARD ASSISTANCE DEVICE FOR AIDING THE FOLLOWING OF AN AIRPORT ROUTE BY AN AIRCRAFT - A device for aiding the following of an airport route by an aircraft includes: an onboard system of optical sensors; means providing the current position of the aircraft; a database having topological information for the airport; a recognition system providing, on the basis of the video images arising from the system of optical sensors, data characteristics of the airport route portion, making it possible to identify a simple primitive representative of the route portion followed; and a processing computer. The processing computer extracts, from the database, a succession of simple geometric shapes representing the airport route and of the same nature as the primitives arising from the recognition system, compares the succession of shapes with the primitives, and validates or invalidates the route followed by the aircraft as a function of the result of the comparison. | 10-20-2011 |
20120316766 | METHOD FOR CREATION OF A TAXIING ROUTE OVER AN AIRPORT AREA AND ASSOCIATED DEVICE - The general field of the invention is that of the systems and of the methods allowing a taxiing route to be established over an airport area. The method according to the invention comprises the following steps: | 12-13-2012 |
Patent application number | Description | Published |
20080270784 | Display Configuration-Reconfiguration Method For a Set of Display Devices - The invention relates to systems provide with control devices comprising an important number of displaying devices for displaying an important number of parameters according to accurate configurations, as for example, a modern aircraft instrument panel provided with several displays. The inventive method for configuring or reconfiguring the totality of displaying devices consists in inducing said configuration or reconfiguration by an event. Each elementary configuration is substantially obtainable by means of a reconfiguration logic language and an interpreter algorithm, wherein said logic language substantially comprises a reconfiguration domain, properties, transition rules, and preferences and said interpreter algorithm makes it possible to convert each transition rule into a list of elementary reconfiguration. | 10-30-2008 |
20100039295 | GUIDING AND TAXIING ASSISTANCE OPTOELECTRONIC DEVICE FOR AN AIRCRAFT HAVING A DEDICATED SYMBOLOGY - The invention pertains to optoelectronic devices for aiding the guidance and taxiing of aircraft, comprising a so-called head-up collimator allowing the presentation of information in the pilot's visual field. It applies notably to large-size civil aircraft of the Boeing 747 or Airbus A380 type. The optoelectronic device comprises means for calculating a deviation factor for the actual trajectory of said aircraft relative to a theoretical trajectory on said traffic way, means for generating symbols and at least one head-up collimator comprising means for displaying and superimposing said symbols on the outside landscape. The deviation factor is calculated on the basis of an angle (PÂ′G) and that the means for generating symbols generate a symbol representing said deviation factor, so as to be superimposed on said traffic way. | 02-18-2010 |
20100114922 | Method and System for Monitoring an Aircraft Taxiing Phase - The invention relates to the field of monitoring and aid to taxiing of an aircraft at an airport. | 05-06-2010 |
20110046868 | Aircraft Guidance System for Assisting in Airport Navigation - An aircraft guidance system for assisting in airport navigation includes: at least one airport database comprising topology data of an airport, called airport DB; at least one configuration database comprising aircraft configuration data and the position of a guidance point; a positioning system delivering aircraft kinematic and attitude parameters; at least one computer generating a 2D view of the representation of the airport notably comprising navigation indications and a representation of the aircraft; and at least one display for displaying the representation of the airport. In the system, a first symbol is generated on the display indicating the position of an early guidance point, corresponding to the position of the guidance point at a future time. | 02-24-2011 |
20110125400 | Methods of Generating a Connectivity Chart for Elements of an Airport for Assistance in Taxiing and Associated Devices - The method of generating a connectivity chart for elements of an airport that makes use of:
| 05-26-2011 |
20120316766 | METHOD FOR CREATION OF A TAXIING ROUTE OVER AN AIRPORT AREA AND ASSOCIATED DEVICE - The general field of the invention is that of the systems and of the methods allowing a taxiing route to be established over an airport area. The method according to the invention comprises the following steps: | 12-13-2012 |
20130166189 | ON-BOARD SYSTEM TO ASSIST THE TAXIING OF AN AIRCRAFT ON AIRPORT TAXIWAYS - The invention relates to an on-board optoelectronic system to assist the taxiing of an aircraft on the taxiways of an airport, that includes:
| 06-27-2013 |
20140236470 | METHOD FOR DETERMINING AN INSTANTANEOUS OR ANTICIPATED PROBABLE ZONE OF OCCUPANCY OF AN AIRCRAFT IN AN AIRPORT NAVIGATION ZONE - The general field of the invention is that of methods for determining safety zones surrounding an aircraft travelling or taking off from an airport zone, the safety zone being calculated at a determined instant that may be the present instant or the future instant. The method according to the invention comprises at least the following steps:
| 08-21-2014 |
20140249739 | SYSTEM FOR AIDING THE GUIDANCE OF AN AIRCRAFT TRAVELLING AROUND AN AIRPORT ZONE - The general field of the invention is that of systems for aiding the guidance of a first aircraft travelling around an airport zone. The system according to the invention comprises:
| 09-04-2014 |
20140303815 | METHOD FOR DETERMINING A TAXIING PATH OF AN AIRCRAFT OVER AN AIRPORT AREA - The general field of the invention is that of methods for determining a taxiing path of an aircraft over an airport area. The method is implemented by the avionics system of the aircraft. It comprises the following steps:
| 10-09-2014 |
Patent application number | Description | Published |
20120093725 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 04-19-2012 |
20120183475 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 07-19-2012 |
20140134102 | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies - The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. | 05-15-2014 |
Patent application number | Description | Published |
20120268172 | OSCILLATION DETECTOR - An oscillation detector having an RF oscillator configured to be synchronized with a first frequency and a comparator for distinguishing the synchronized state from the non-synchronized state of the radiofrequency oscillator on the basis of an oscillating signal produced by the radiofrequency oscillator and indicating the presence of oscillations in a frequency band around the first frequency in response to identifying the synchronized state and, in alternation, indicating the absence of oscillations in this frequency band otherwise. | 10-25-2012 |
20120268214 | SYNTHESIZER OF AN OSCILLATING SIGNAL - A synthesizer includes a second frequency-synthesizing stage comprising a radiofrequency oscillator configured to oscillate at a frequency αfo when it is synchronized with a signal s | 10-25-2012 |
20120270515 | DEMODULATOR OF A FREQUENCY-MODULATED ELECTRICAL SIGNAL - A demodulator of an FM signal modulated about a carrier frequency with a modulation frequency has an RF oscillator configured to be synchronized, under identical conditions of operation, with oscillations at first and second frequencies used in the FM signal to encode respective pieces of information. The oscillator has a magnetoresistive device; and a low-pass filter connected to an output electrode of the magnetoresistive device to filter an oscillating signal, generated by the oscillator and to a rendering terminal to provide, as a demodulated electrical signal, the filtered signal, the cut-off frequency f | 10-25-2012 |
Patent application number | Description | Published |
20090092638 | POLYNUCLEOTIDES ALLOWING THE EXPRESSION AND SECRETION OF RECOMBINANT PSEUDO-VIRUS CONTAINING FOREIGN EPITOPES, THEIR PRODUCTION, AND USE - This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells. | 04-09-2009 |
20090093428 | Nucleotide vector, composition containing such vector, and vaccine for immunization against hepatitis - Nucleotide vector composition containing such vector and vaccine for immunization against hepatitis. Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A nucleotide vector composition when administered to even chronic HBV carriers is capable of breaking T cell tolerance to the surface antigens of hepatitis B virus. A vaccine preparation containing said bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers. | 04-09-2009 |
20110027318 | NUCLEOTIDE VECTOR, COMPOSITION CONTAINING SUCH VECTOR, AND VACCINE FOR IMMUNIZATION AGAINST HEPATITIS - Nucleotide vector composition containing such vector and vaccine for immunization against hepatitis. Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A nucleotide vector composition when administered to even chronic HBV carriers is capable of breaking T cell tolerance to the surface antigens of hepatitis B virus. A vaccine preparation containing said bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers. | 02-03-2011 |
20110142878 | POLYNUCLEOTIDES ALLOWING THE EXPRESSION AND SECRETION OF RECOMBINANT PSEUDO-VIRUS CONTAINING FOREIGN EPITOPES, THEIR PRODUCTION, AND USE - This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells. | 06-16-2011 |
20110243986 | POLYNUCLEOTIDES ALLOWING THE EXPRESSION AND SECRETION OF RECOMBINANT PSEUDO-VIRUS CONTAINING FOREIGN EPITOPES, THEIR PRODUCTION, AND USE - This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells. | 10-06-2011 |
Patent application number | Description | Published |
20100015136 | CAMPTOTHECIN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME - The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The compound is more specifically a conjugate of a peptide moiety and a camptothecin, a derivative or analog thereof which provides numerous benefits, including enhancement in terms of aqueous solubility, pharmacokinetics and tissue distribution, enlargement of the therapeutic index, and limitation of the inter-patient metabolic variability, as well as improvement of delivery of the biologically active ingredient to the target cells or tissues. | 01-21-2010 |
20130244956 | CAMPTOTHEAN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME - The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The compound is more specifically a conjugate of a peptidic moiety and a camptothecin, a derivative or analog thereof which provides numerous benefits, including enhancement in terms of aqueous solubility, pharmacokinetics and tissue distribution, enlargement of the therapeutic index, and limitation of the inter-patient metabolic variability, as well as improvement of delivery of the biologically active ingredient to the target cells or tissues. | 09-19-2013 |
Patent application number | Description | Published |
20110153901 | VIRTUAL USB KEY FOR BLADE SERVER - A system for sharing data contained on a peripheral device amongst a plurality of blade servers is disclosed. The system includes a memory device for storing the data contained on the peripheral device. The memory device is partitioned into memory areas. Each memory area stores one copy of the data. The system also includes a processor coupled to the memory device for assigning one of the memory areas to each blade server. The system also includes a switch controller coupled to the processor and to the plurality of blade servers for establishing communication between the plurality of blade servers and the plurality of assigned memory areas. | 06-23-2011 |
20120131587 | HARDWARE DEVICE FOR PROCESSING THE TASKS OF AN ALGORITHM IN PARALLEL - A hardware device for concurrently processing a fixed set of predetermined tasks associated with an algorithm which includes a number of processes, some of the processes being dependent on binary decisions, includes a plurality of task units for processing data, making decisions and/or processing data and making decisions, including source task units and destination task units. A task interconnection logic means interconnect the task units for communicating actions from a source task unit to a destination task unit. Each of the task units includes a processor for executing only a particular single task of the fixed set of predetermined tasks associated with the algorithm in response to a received request action, and a status manager for handling the actions from the source task units and building the actions to be sent to the destination task units. | 05-24-2012 |
20120137110 | HARDWARE DEVICE FOR PROCESSING THE TASKS OF AN ALGORITHM IN PARALLEL - A hardware device for concurrently processing a fixed set of predetermined tasks associated with an algorithm which includes a number of processes, some of the processes being dependent on binary decisions, includes a plurality of task units for processing data, making decisions and/or processing data and making decisions, including source task units and destination task units. A task interconnection logic means interconnect the task units for communicating actions from a source task unit to a destination task unit. Each of the task units includes a processor for executing only a particular single task of the fixed set of predetermined tasks associated with the algorithm in response to a received request action, and a status manager for handling the actions from the source task units and building the actions to be sent to the destination task units. | 05-31-2012 |
20120324188 | VIRTUAL USB KEY FOR BLADE SERVER - A method for sharing data contained on a peripheral device amongst a pluratlity of blade servers is disclosed. The method includes storing a copy of data from a peripheral device to a memory device. The memory device is partitioned into at least ‘n’ memory areas, each memory area storing one copy of the data. The method also includes assigning one of the at least ‘n’ memory areas to each of a plurality ‘n’ of servers. The method also includes establishing communication between the plurality of servers and the plurality of assigned memory areas via a switch controller. The switch controller is configured to access the plurality of assigned memory areas via a processor. | 12-20-2012 |
Patent application number | Description | Published |
20130244265 | SECRETION OF RECOMBINANT POLYPEPTIDES IN THE EXTRACELLULAR MEDIUM OF DIATOMS - A transformed diatom includes a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an amino acid sequence including (i) an heterologous signal peptide and (ii) a polypeptide, the heterologous signal peptide leading to the secretion of the polypeptide in the extracellular medium of the transformed diatom; a method for producing a polypeptide which is secreted in the extracellular medium, the method including the steps of (i) culturing a transformed diatom, (ii) harvesting the extracellular medium of the culture and (iii) purifying the secreted polypeptide in the extracellular medium; and use of the transformed diatom for the secretion of a polypeptide in the extracellular medium. | 09-19-2013 |
20140066606 | PRODUCTION OF HIGH MANNOSE GLYCOSYLATED PROTEINS STORED IN THE PLASTID OF MICROALGAE - The present invention concerns a transformed microalga producing a protein harboring a “high mannose” pattern of glycosylation in the plastid of the transformed microalga, wherein 1) the transformed microalga has a Chloroplast Endoplasmic Reticulum (CER); 2) the microalga has been transformed with a nucleic acid sequence operatively linked to a promoter, the nucleic acid sequence encoding an amino acid sequence including (i) an amino-terminal bipartite topogenic signal (BTS) sequence composed of at least a signal peptide followed by a transit peptide; and (ii) The sequence of the protein, 3) the xylosyltransferases and fucosyltransferases of the microalga have not been inactivated; 4) the N-acetylglycosyltransferase I of the microalga has not been inactivated, preferably the N-acetylglycosyltranferases II, III, IV, V and VI, mannosidase II and glycosyltransferases of the microalga have not been inactivated. | 03-06-2014 |
20140154707 | N-GLYCOSYLATION IN TRANSFORMED PHAEODACTYLUM TRICORNUTUM - Transformed | 06-05-2014 |
20150112045 | PRODUCTION OF SECRETED THERAPEUTIC ANTIBODIES IN MICROALGAE - Disclosed is a transformed microalga including a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an amino acid sequence including (i) an heterologous signal peptide; and (ii) a therapeutic antibody, a functional fragment or a derivative thereof, the transformed microalga expressing the therapeutic antibody, functional fragment or derivative thereof secreted in the extracellular media and the microalga being selected among green algae except Volvocales, and among red algae, chromalveolates, and euglenids. Preferably, therapeutic antibody, functional fragment or derivative thereof has an increased antibody-dependant cell-mediated cytotoxicity (ADCC) and a low fucose content. The present invention also relates to a method for producing therapeutic antibody, a functional fragment or a derivative thereof, a functional fragment or a derivative thereof in the extracellular medium, to a therapeutic antibody, a functional fragment or a derivative thereof produced and secreted in the extracellular medium of microalgae. | 04-23-2015 |
Patent application number | Description | Published |
20110186302 | RIGLESS LOW VOLUME PUMP SYSTEM - A deliquification pump for deliquifying a well comprises a fluid end pump adapted to pump a fluid from a wellbore. In addition, the deliquification pump comprises a hydraulic pump adapted to drive the fluid end pump. The hydraulic pump includes a first internal pump chamber and a first pump assembly disposed in the first chamber. The first pump assembly includes a piston having a first end, a second end, and a throughbore extending between the first end and the second end. In addition, the first pump assembly includes a first wobble plate including a planar end face axially adjacent the second end of the piston and a slot extending axially through the first wobble plate. The first wobble plate is adapted to rotate about the central axis relative to the housing to axially reciprocate the piston and cyclically place the throughbore of the piston in fluid communication with the slot. | 08-04-2011 |
20130299181 | Rigless Low Volume Pump System - A deliquification pump for deliquifying a well comprises a fluid end pump adapted to pump a fluid from a wellbore. In addition, the deliquification pump comprises a hydraulic pump adapted to drive the fluid end pump. The hydraulic pump includes a first internal pump chamber and a first pump assembly disposed in the first chamber. The first pump assembly includes a piston having a first end, a second end, and a throughbore extending between the first end and the second end. In addition, the first pump assembly includes a first wobble plate including a planar end face axially adjacent the second end of the piston and a slot extending axially through the first wobble plate. The first wobble plate is adapted to rotate about the central axis relative to the housing to axially reciprocate the piston and cyclically place the throughbore of the piston in fluid communication with the slot. | 11-14-2013 |
20130299182 | Rigless Low Volume Pump System - A deliquification pump for deliquifying a well comprises a fluid end pump adapted to pump a fluid from a wellbore. In addition, the deliquification pump comprises a hydraulic pump adapted to drive the fluid end pump. The hydraulic pump includes a first internal pump chamber and a first pump assembly disposed in the first chamber. The first pump assembly includes a piston having a first end, a second end, and a throughbore extending between the first end and the second end. In addition, the first pump assembly includes a first wobble plate including a planar end face axially adjacent the second end of the piston and a slot extending axially through the first wobble plate. The first wobble plate is adapted to rotate about the central axis relative to the housing to axially reciprocate the piston and cyclically place the throughbore of the piston in fluid communication with the slot. | 11-14-2013 |