Patent application number | Description | Published |
20080214614 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE - The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions. | 09-04-2008 |
20090076256 | DEGRADATION-RESISTANT MONONUCLEOSIDE PHOSPHATE COMPOUNDS - The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation-resistant substituent on the terminal phosphate of a polyphosphate mononucleotide. By attaching this degradation-resistant substituent, the stability from degradation matches or exceeds those of certain dinucleotides. The mononucleoside phosphate compounds of the present invention are useful in preventing and treating epithelial tissue diseases or diseases or disorders associated with platelet aggregation. | 03-19-2009 |
20100022517 | OPHTHALMIC FORMULATION OF RHO KINASE INHIBITOR COMPOUND - The present invention relates to an aqueous pharmaceutical formulation comprising at least one inhibitor of Rho-associated protein kinase (ROCK). The aqueous pharmaceutical formulation comprises 0.01-0.4% w/v of ROCK inhibitor(s), a non-ionic surfactant in an amount of 0.01-2% w/v, and a tonicity agent to maintain a tonicity between 220-360 mOsm/kG, at a pH between 6.3 to 7.8, wherein the ROCK inhibitor, the surfactant, and the tonicity agent are compatible in the formulation. The aqueous ophthalmic formulations of this invention have an increased ocular bioavailability and/or aqueous humor concentrations without a concomitant increase in systemic concentrations. The present invention further provides a method of reducing intraocular pressure, particularly a method of treating glaucoma, by administering the aqueous pharmaceutical formulation to a subject. | 01-28-2010 |
20120046275 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE - The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions. | 02-23-2012 |
20130012543 | CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE - The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions. | 01-10-2013 |
Patent application number | Description | Published |
20080228658 | DEAL IDENTIFICATION SYSTEM - A method and system for identifying deals to facilitate travel planning is provided. In one embodiment, a deal identification system identifies deals on travel items and presents those deals to a person in a way that facilitates travel planning and travel shopping. The deal identification system may include an entity attributes service component that provides attributes of entities associated with the items. The deal identification system may also include a historical price service component that provides historical pricing information for the items. The deal identification system may also include a deal component that receives a criterion that defines a deal based on a combination of attributes of entities, historical pricing information, and current pricing information and identifies those items that match the criterion as deals. | 09-18-2008 |
20090063167 | HOTEL RATE ANALYTIC SYSTEM - A hotel deal system provides an observation store with observations that identify a hotel, a stay, a room type, a room rate, and observation date. The hotel deal system receives a request for rate information for a desired hotel for a desired stay. The hotel deal system retrieves current room rate information for the desired hotel for the desired stay. The hotel deal system then analyzes the observations of the observation store to identify a deal rating for the desired hotel for the desired stay at the current room rate. | 03-05-2009 |
20110046989 | SYSTEM AND METHOD OF PROTECTING PRICES - A method and system for protecting prices is provided. The price protection system increases consumer confidence when making purchases by reducing the risk associated with fluctuating prices. The price protection system receives a purchase specification from a consumer. Next, the price protection system determines the risk that the prices of items matching the purchase specification will change and reports a protected price to the consumer that represents the price that the price protection system will protect based on the determined risk for a protection period. Finally, the price protection system receives a request from the consumer to purchase protection of the protected price. | 02-24-2011 |
20120239455 | TRAVEL-RELATED PREDICTION SYSTEM - A method and system is provided for making price-related predictions of items based on training a classifier using historical information including pricing information for the items and labels relating to the price-related information that are generated automatically from the historical information. A prediction system provides price-related predictions for airline tickets. The prediction system collects flight information for flights on a daily basis. The prediction system generates training data to train a classifier to make the price-related predictions using the flight information. After training the classifier, the prediction system then can make the price-related predictions for a trip. | 09-20-2012 |
20130317947 | TRAVEL INFORMATION DEPARTURE DATE/DURATION GRID - A method and system for presenting travel information in a way that facilitates identifying travel plans that satisfy objectives is provided. A travel information system collects travel information for the travel items on various observation dates including the current date and presents the travel information to a user in a way that facilitates travel planning and travel shopping. The travel information system stores the travel information in an observation store. To provide travel information that satisfies a search criterion, the travel information system retrieves the travel information that satisfies the search criterion either from flight information of the observation store or from current flight information provided in real time from a source of travel information. The flight information system provides the travel information in various formats to facilitate travel planning. These formats include a fare history graph, an interval grid, a route map, a future fare graph, and/or a departure date/duration grid. | 11-28-2013 |
Patent application number | Description | Published |
20090161163 | Parallel RIP with Preamble Caching - A method and system is provided for splitting a print job into its preamble and at least one chunk. The splitter maintains a collection of RIP node addresses to which chunks of the job currently being split have already been sent. When a new chunk is about to be sent, the splitter checks whether each RIP node address has already received a chunk. If the RIP node has not already received a chunk, the splitter sends the preamble as well as the chunk to an available RIP associated with the RIP node. If, however, the RIP node address has already received a chunk, only the portion of the chunk after the preamble is sent to an available RIP associated with the RIP node and communicate the location of the preamble to the available RIP node. The preamble may contain common content for each job. | 06-25-2009 |
20090324303 | HYBRID SINGLE PASS, MULTI-PASS FULL COLOR PRINTING SYSTEM - A hybrid single pass, multi-pass full color printing system is provided and includes (a) a moveable intermediate transfer belt (ITB) mounted within a machine frame and having a path of movement; (b) a plurality of single pass image output modules mounted along the path of movement, each having imaging devices including an image carrying member and a single developer housing containing a single color developer for forming an image in a single pass on the image carrying member for transfer onto the ITB; and (c) at least one single pass, multi-pass image output module mounted along the path of movement and having imaging devices including an image bearing member and a plural number of selectable developer housings, and each of the selectable developer housings containing a single spot color developer for forming spot color images in single passes and in multiple passes on the image bearing member for transfer onto the ITB. | 12-31-2009 |
20100103440 | IMAGE PATH UTILIZING SUB-SAMPLED CROSS-CHANNEL IMAGE VALUES - A technique for cross-channel correction in real time for digital color printing in which the full resolution value of a selected colorant is combined with low resolution versions of the remaining colorants to provide a basis for correcting the selected colorant based upon the data for the other colorants employed. The pixel values of sub-samples of the remaining colorants are derived from the cell in which the full resolution selected colorant is taken; and, the desired output value is selected from a look-up table established for the known printing process. | 04-29-2010 |
20110194137 | PAGE PARALLEL RIP WITH INTERLEAVED CHUNKS - Systems and methods are described that facilitate distributing a raster image processing task for an input file (e.g., an electronic document) across a plurality of nodes (e.g., computers) in a network. The input file is received at a first node, which becomes the controlling node and splits the pages of the input file into interleaved chunks such that adjacent pages are allocated to different chunks (i.e., no chunk contains adjacent pages in the document). Chunks are then assigned to different nodes for concurrent raster image processing. Once complete, the processed pages are returned to the controller node, which logically orders the pages into their original sequential order, and outputs the logically ordered, raster image processed pages to a printer, where they are printed. | 08-11-2011 |
20110292412 | PAGE PARALLEL RASTER IMAGE PROCESSING - According to an aspect of the disclosure, a printing system is provided comprising a plurality of resources including idle and non-idle resources having a at least one image marking engine. The plurality of resources includes a page parallel RIP system wherein the RIP system supports configurable sized print chunks. The RIP system adaptively adjusts the size of the chunks according to the busyness of receiving RIP nodes. | 12-01-2011 |
Patent application number | Description | Published |
20100225972 | VECTOR HALFTONING IN AN IMAGE PATH UTILIZING SUB-SAMPLED CROSS-CHANNEL IMAGE VALUES - This disclosure provides methods, apparatus and systems to generate vector halftone data for rendering an image on an image output device. According to one aspect, a method generates vector halftone data as a function of contone pixel data for a given colorant at its nominal resolution and contone pixel data for the other colorants at a relatively lower resolution. | 09-09-2010 |
20100290797 | METHODS TO CONTROL APPEARANCE OF GLOSS LEVELS FOR PRINTED TEXT AND IMAGES - A printer configured to adjust gloss appearance of images includes a marking engine configured to render an image on a substrate from input image data; and a controller configured to: (i) correlate a minimum luminance value to be used by the printer based on a gloss selection; (ii) determine a black point compensation function based on the correlated minimum luminance value; and (iii) adjust luminance values for input image data using the determined black point compensation function. A method to adjust gloss appearance of images is also provided. | 11-18-2010 |
20110096330 | MINIMIZING SPECTROPHOTOMETER IMPACT ON SPOT COLOR ACCURACY - Differences between an offline spectrophotometer and an inline spectrophotometer can result in differences between a hardcopy target color and a printed reproduction of that color. The inline spectrophotometer is inside of a printer and configured to measure printer output. As such, the inline spectrophotometer cannot conveniently measure the hardcopy target color. A printing error or an instrument offset can be determined and passed to a color correction module that updates the device dependent color specification associated with the given spot color. This color specification may be stored, for example, in the printer controller, and used when a document subsequently calls for that spot color, thereby providing accurate color reproduction from that particular printer incorporating that particular inline spectrophotometer. | 04-28-2011 |
20110292413 | SYSTEM AND METHOD FOR DETERMINING A BILLING STRUCTURE FOR DOCUMENTS BASED ON MARKING MEDIUM PREDICTIONS - Disclosed is a method for processing raster image data and determining via a reference device (e.g., LUT), an amount of marking medium (toner, ink) to be used for printing a document. Then billing costs based on the amount of medium is determined. In particular, a calibration method may be performed on an apparatus to determine the amounts of medium used for that particular apparatus. The calibration method includes printing pages with test patches for a plurality of colors at a particular dot value (or density), and weighing similar printed test pages so that the amount of medium used to print colors at particular dot values is determined by subtracting a weight of the pages before printing from the weight of the printed test pages. The change in weight (or mass) of the medium is used to populate the reference device for that apparatus. | 12-01-2011 |
20120106835 | HYBRID VECTOR HALFTONE SCREENING AND ERROR DIFFUSION - Vector halftoning and error diffusion are combined to provide a quantization method that yields high quality rendered images while demanding fewer system resources. For instance, the method is tolerant of resolution reductions in secondary or auxiliary channels to the vector halftoning process. Accordingly, these secondary pixel data channels can be sub-sampled and/or bit-depth reduced for transmission bandwidth conservation and/or reduction in data storage requirements. Restoring the resolution of the low resolution channels provides estimated image data to arrange or align with high resolution target channel data for the vector halftoning process. Error from marking decisions generated by the vector halftoning process is diffused to neighboring unprocessed pixels. The method also allows for the use of a small vector halftone threshold array while providing quantized images with fine texture and wide color gamuts. In some embodiments error diffusion is distributed according to vector error diffusion. | 05-03-2012 |
20120274955 | Data architecture for mixed resolution interleaved cross-channel data flow and format - The present application provides a mixed resolution, interleaving-based, cross-channel data flow and data format for a printer image path. The architecture provides pixel data for a colorant of a given writing channel at its nominal (full) resolution, while pixel data for other colorants is provided at lowered resolution. Pixel data for a primary channel at its full resolution is interleaved with data for other secondary channels at lower resolution. Known sub-sampling or compression techniques can be used to lower the resolution of the secondary channels. The data at the different resolutions is generated by the digital front end (DFE), which distributes the data for each writing channel at the time it is needed. Preferably, the low resolution data is sent first to the writer, followed by high resolution data, so that data buffering is minimized. | 11-01-2012 |