Patent application number | Description | Published |
20080305106 | Novel Gene Disruptions, Composition and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. | 12-11-2008 |
20090214563 | TREATMENT FOR ANTIPHOSPHOLIPID-SYNDROME-RELATED PREGNANCY COMPLICATIONS - The present application provides compositions and methods for treating antiphospholipid-syndrome-related pregnancy complications with tissue factor antagonists. | 08-27-2009 |
20110091477 | MODULATORS OF HEPATOCYTE GROWTH FACTOR ACTIVATOR - The invention provides methods and compositions for modulating hepatocyte growth factor activator function. | 04-21-2011 |
20110206704 | Methods and compositions for modulating hepatocyte growth factor activator - The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of hepatocyte growth factor activator function, and the identification and uses of said modulators. | 08-25-2011 |
20110262452 | ANTI-HEPSIN ANTIBODIES AND METHODS USING SAME - The invention provides hepsin antibodies, and compositions comprising and methods of using these antibodies. | 10-27-2011 |
20120195910 | ANTI-PCSK9 ANTIBODIES AND METHODS OF USE - The invention provides anti-PCSK9 antibodies and methods of using the same. | 08-02-2012 |
20120282271 | METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF MACROPHAGE-STIMULATING PROTEIN - The invention provides methods and compositions for modulating hepsin activity and the MSP/Ron pathway, in particular by regulating pro-MSP activation by hepsin. | 11-08-2012 |
20130129743 | ANTI-HtrA1 ANTIBODIES AND METHODS OF USE - The invention provides anti-HtrA1 antibodies and methods of using the same. | 05-23-2013 |
Patent application number | Description | Published |
20090099524 | DEVICE FOR ADMINISTERING A FLUID PRODUCT - A device for administering a substance, e.g. a medicament or a therapeutic agent, at a controllable administration rate, wherein the device includes a housing with a drive receptacle area for a drive unit, a substance receiving region to hold a substance container and an arrangement for hydraulic power transmission, which does not contribute to controlling the administration rate, located between the drive receptacle area and the substance receiving region, whereby the administration rate is controlled exclusively by the drive unit. | 04-16-2009 |
20090198195 | ADMINISTRATION DEVICE COMPRISING A PLUNGER ROD WITH A RETURN LOCK - An administering apparatus including a casing, a reservoir, a piston accommodated in the reservoir such that it can be shifted in an advancing direction, a piston rod which acts on the piston in the advancing direction and forms a first locking mechanism, a second locking mechanism which cannot be moved counter to the advancing direction, a lock element row formed by successively arranged first locking elements, extending in the advancing direction, and formed by one of the locking mechanisms, and a second lock element formed by the other locking mechanism and engaged with the lock element row, wherein it engages with a lock element gap of the lock element row, wherein the second lock element is moved out of engagement by a movement, against an elasticity force, of the piston rod in the advancing direction, but, when engaged, counteracts a movement of the piston rod counter to the advancing direction with a resistance force greater than the elasticity force to prevent the piston rod from moving counter to the advancing direction. In some embodiments, either or both the first and second locking mechanisms form a securing element at one or both ends with respect to the advancing direction, the securing element counteracting a movement of the piston rod counter to the advancing direction with a locking force greater than the resistance force. | 08-06-2009 |
20090240212 | FIXING DEVICE FOR INJECTION NEEDLES - A device for connecting an injection needle to an injection apparatus, wherein the device provides a plurality of possible points of contact in at least two planes, and wherein the points of contact have associated spring forces for acting generally perpendicularly on the injection apparatus. | 09-24-2009 |
20110087186 | DEVICE FOR ADMINISTERING A FLUID PRODUCT - An administering device for a fluid product includes a product receptacle that accommodates the product to be administered, a fluid reservoir for a driving fluid, a driving means, a product chamber, and a fluid connection. The product receptacle includes an opening at a forward end and a product stopper at a rear end. The driving means acts upon the fluid reservoir, the pressure chamber adjoins the product stopper while the fluid connection is located between the fluid reservoir and the pressure chamber, and the driving means acts upon the fluid reservoir in such a way that the pressure chamber is impinged upon by pressure which affects the product stopper and the product is discharged from the product receptacle. | 04-14-2011 |
20120310208 | DEVICE FOR ADMINISTERING A FLUID PRODUCT - An administering device for a fluid product includes a product receptacle that accommodates the product to be administered, a fluid reservoir for a driving fluid, a driving means, a product chamber, and a fluid connection. The product receptacle includes an opening at a forward end and a product stopper at a rear end. The driving means acts upon the fluid reservoir, the pressure chamber adjoins the product stopper while the fluid connection is located between the fluid reservoir and the pressure chamber, and the driving means acts upon the fluid reservoir in such a way that the pressure chamber is impinged upon by pressure which affects the product stopper and the product is discharged from the product receptacle. | 12-06-2012 |
20120316508 | INJECTION DEVICE COMPRISING A NEEDLE PROTECTING SLEEVE - A device and method for protecting against needle sticks, including a needle protection sleeve for being coupled to an administering device to cover a needle associated with the administering device, wherein the sleeve can be moved against the force of a spring from an extended position to a retracted position and by the force of the spring from the retracted position to the extended position, the spring being carried on the needle protection sleeve. | 12-13-2012 |
20130324937 | ADMINISTERING DEVICE COMPRISING DISPLAY DRUM - A device for administering a product dose, the device including a display drum for displaying a product dose, a housing, a first conveying member moveable relative to the housing in a conveying direction, a second conveying member moveable relative to the housing in and counter to the conveying direction, the second conveying member in a first threaded engagement with the first conveying member while being rotationally movable relative to the housing and the first conveying member and being translationally movable relative to the first conveying member counter to the conveying direction, a metering apparatus by which a product dose can be adjusted and which encompasses the display drum, the display drum being rotationally movable relative to the housing while being translationally movable in and counter to the conveying direction in a second threaded engagement, and a coupling element which interconnects the first conveying member and the display drum in a torsion-resistant manner in a coupling engagement which is releasable by actuating the administering device. | 12-05-2013 |
Patent application number | Description | Published |
20100088836 | TOOTHBRUSH - A toothbrush comprises bristle supporting elements in the head region thereof. The bristle supporting elements are arranged in an elastic manner relative to the neck region and in a bendable and twistable manner relative to one another by a foil-type hard film. Preferably, the foil-type hard film externally extends in a flush fashion around a top opening of the bristle supporting element. | 04-15-2010 |
20100276836 | Transfer System for Multicomponent Injection Molding - The invention relates to a method and a device for producing parts that are made up of more than one component. The first part ( | 11-04-2010 |
20130291320 | TOOTHBRUSH WITH INJECTION-MOULDED BRISTLES AND METHOD AND APPARATUS FOR PRODUCING THE SAME - The brush according to the invention has a bristle carrier, which is produced by injection moulding, and bristles, which are produced from a bristle material likewise by injection moulding. The bristle carrier is provided with at least one distributing channel for the bristle material. The bristles are formed integrally with the bristle material in the distribution channel. | 11-07-2013 |
20140173853 | METHOD FOR PRODUCING A TOOTHBRUSH, AND TOOTHBRUSH - A grip body of a body care article, such as toothbrush, includes a grip part, a neck part and a head part. The grip body includes a first and a second material component of a thermoplastic plastic. The first and the second material component have a common injection point that is arranged outside a mould partition line formed by the mould partition. | 06-26-2014 |
20150135456 | HOUSEHOLD BRUSH OR BODY CARE BRUSH COMPRISING INJECTED BRISTLES, AND INJECTION MOLD FOR MANUFACTURE THEREOF - The household or body care brush has a handle and a bristle arrangement supported thereby. The bristle support and the bristles formed integrally therewith are produced in an injection moulding process. A plurality of injected bristles are arranged in each case such that they stand closely adjacent to one another in a bristle bundle. The bristle bundles on the other hand are arranged with a space between the bundles. The invention further relates to an injection mould that is particularly suited to producing household brushes or body care brushes comprising bristle bundles, the longitudinal directions of which run at an angle to one another or are out of square with one another. | 05-21-2015 |