Harkin
Damien Harkin, Queensland AU
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20100316613 | FEEDER CELL-FREE CULTURE MEDIUM AND SYSTEM - A cell culture medium and system are provided which eliminates or at least reduces the need for feeder cells. The cell culture medium comprises one or more factors that are normally secreted and/or produced by a feeder cell and a synthetic chimeric protein comprising IGF-I and a portion of vitronectin. The cell culture medium is particularly suitable for propagating human embryonic stem cells and keratinocytes. This invention also relates to compositions and methods which utilize the cells cultured in the cell culture medium of the invention. | 12-16-2010 |
Denis Paul Harkin, Dromore GB
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20140031260 | Molecular Diagnostic Test for Cancer - Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. | 01-30-2014 |
20140094379 | Colon Cancer Gene Expression Signatures and Methods of Use - A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful for determining the prognosis of a patient diagnosed with colon cancer, such as stage II colon cancer. The gene signature described herein is also useful for determining effectiveness of surgical resection with or without adjuvant chemotherapy, and determining possibility of cancer recurrence in patients with colon cancer. | 04-03-2014 |
Dennis Paul Harkin, Dromore, County Down GB
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20160002732 | MOLECULAR DIAGNOSTIC TEST FOR CANCER - Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that have an up-regulation or a down-regulation in biomarker expression related to angiogenesis and vascular development. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. | 01-07-2016 |
Dennis Paul Harkin, Dromore GB
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20140051591 | MOLECULAR DIAGNOSTIC TEST FOR CANCER - Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. | 02-20-2014 |
20140342924 | Molecular Diagnostic Test for Cancer - Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen. | 11-20-2014 |
Gerard Francis Harkin, Eindhoven NL
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20090289577 | CONTROL OF BATH WATER COLOR WITH LIGHT - The invention provides a sanitary arrangement with a vessel for a liquid, wherein the vessel further comprises light sources to illuminate the liquid received in the vessel. The illumination colors of the vessel light sources are controllable. The arrangement further comprises a liquid source for a jet of liquid to fill the vessel. The liquid source comprises light sources to illuminate the jet of liquid from the liquid source. The illumination color of these light sources is also controllable. A control unit is provided to control the one or more vessel illumination colors of the vessel light sources. The illumination color of the vessel light sources has a relationship with the illumination color of the light sources of the liquid source. | 11-26-2009 |
James Harkin, County Donegal IE
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20120090605 | MEDICATION DELIVERY DEVICE - A medication delivery device for delivering a medicament by inhalation, said device comprising a housing ( | 04-19-2012 |
James Harkin, Carndonagh IE
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20090313195 | Artificial neural network architecture - An artificial neural network apparatus comprising an array of neural units, each comprising a router, at least one neuron device and at least one synapse unit. The routers of respective neural units communicate with one another using data packets. The synapse units receive and create analogue signals, the routers converting these signals from or into packet form for communication between neural units. The use of routers in this way simplifies the required interconnectivity between neural units in the array and so facilitates the creation of large artificial neural networks. | 12-17-2009 |
James Harkin, Galway IE
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20120019613 | Dynamically Variable Stereo Base for (3D) Panorama Creation on Handheld Device - A technique of generating a stereoscopic panorama image includes panning a portable camera device, and acquiring multiple image frames. Multiple at least partially overlapping image frames are acquired of portions of the scene. The method involves registering the image frames, including determining displacements of the imaging device between acquisitions of image frames. Multiple panorama images are generated including joining image frames of the scene according to spatial relationships and dynamically determining stereoscopic counterpart relationships between the multiple panorama images. The multiple panorama images are processed based on the dynamically determined stereoscopic counterpart relationships to form a stereoscopic panorama image. | 01-26-2012 |
20120019614 | Variable Stereo Base for (3D) Panorama Creation on Handheld Device - A technique of generating a stereoscopic panorama image includes panning a portable camera device, and acquiring multiple image frames. Multiple at least partially overlapping image frames are acquired of portions of the scene. The method involves registering the image frames, including determining displacements of the imaging device between acquisitions of image frames. Multiple panorama images are generated including joining image frames of the scene according to spatial relationships and determining stereoscopic counterpart relationships between the multiple panorama images. The multiple panorama images are processed based on the determined stereoscopic counterpart relationships to form a stereoscopic panorama image. | 01-26-2012 |
Louise Harkin, South Australia AU
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20100088778 | Methods of Treatment, and Diagnosis of Epilepsy by Detecting Mutations in the SCN1A Gene - A method for the diagnosis of an epilepsy syndrome, including SMEI or an SMEI-related syndrome, in a patient comprising testing for an alteration in the SCN1A gene in a sample obtained from the patient; and if an alteration is identified, comparing said alteration to any one of those listed in Table 3, wherein if said alteration is identical to any one of those listed in Table 3, a diagnosis of an epilepsy syndrome, including SMEI or an SMEI-related syndrome, in said patient is made in accordance with the correlation set forth in Table 3. | 04-08-2010 |
Louise Anne Harkin, Northgate AU
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20100136623 | MUTATIONS IN ION CHANNELS - A method of identifying a subject predisposed to a disorder associated with ion channel dysfunction, comprising ascertaining whether at least one of the genes encoding ion channel subunits in said subject has undergone a mutation event such that a cDNA derived from said subject has the sequence set forth in one of SEQ ID NOS: 1-134. | 06-03-2010 |
Louise Anne Harkin, South Australis AU
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20090081724 | Mutations in Ion Channels - A method of identifying a subject predisposed to a disorder associated with ion channel dysfunction, comprising ascertaining whether at least one of the genes encoding ion channel subunits in said subject has undergone a mutation event as set forth in one of SEQ ID Numbers: 1-72. | 03-26-2009 |
Patrick A. Harkin, Beaverton, OR US
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20100053157 | METHODS AND APPARATUS FOR RENDERING OR PREPARING DIGITAL OBJECTS OR PORTIONS THEREOF FOR SUBSEQUENT PROCESSING - Methods and apparatus render images of digital objects or prepare digital objects for subsequent processing. The method includes sorting data representative of positions of at least three vertices of polygons of a digital object, then determining whether the orientation of the vertices of each polygon from a specific reference point differs from the actual, or original, orientation of the vertices. Such a determination may be made by generating an orientation decision variable based on the relative positions of the vertices and calculating a cross product term (CPT) after the vertex data has been sorted. The CPT may also be used in other operations involving the polygon, such as in imparting appearance characteristics to the polygon. The method may be embodied as a computer program that controls the operation of a processor. Accordingly, processors, computers, and systems that render images of digital objects in accordance with the method are also disclosed. | 03-04-2010 |
20110261082 | METHODS AND APPARATUS FOR RENDERING OR PREPARING DIGITAL OBJECTS OR PORTIONS THEREOF FOR SUBSEQUENT PROCESSING - Methods and apparatus render images of digital objects or prepare digital objects for subsequent processing. The method includes sorting data representative of positions of at least three vertices of polygons of a digital object, then determining whether the orientation of the vertices of each polygon from a specific reference point differs from the actual, or original, orientation of the vertices. Such a determination may be made by generating an orientation decision variable based on the relative positions of the vertices and calculating a cross product term (CPT) after the vertex data has been sorted. The CPT may also be used in other operations involving the polygon, such as in imparting appearance characteristics to the polygon. The method may be embodied as a computer program that controls the operation of a processor. Accordingly, processors, computers, and systems that render images of digital objects in accordance with the method are also disclosed. | 10-27-2011 |
Paul Harkin, Belfast GB
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20080268435 | Brca1 Markers - A method of predicting the presence of a non-functional BRCA1 gene in a biological sample, comprises the step of assaying the sample for expression of at least one specific member of the S100 family of genes. The invention also describes a kit for predicting the presence of non-functional BRCA1, comprising means for assaying a sample for expression of at least one specific member of the S100 gene family. A method of detecting a genetic predisposition to cancer is also described, comprising the step of assaying a biological sample for expression of a specific member of the S100 family of genes. Also described is a method of determining a suitable chemotherapeutic agent for an individual. | 10-30-2008 |
Paul Harkin US
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20100229492 | Adjustable structural header beam - A longitudinal length adjustable header made up of a center section and two end sections moveably attached to the center section. The center section has an “L” shaped cross section and at least two longitudinal slots that are adapted to receive bolt means there through. The end sections have a plurality of apertures that align with the slots in the center section and are adapted to receive bolt means there through. The end sections are longitudinally slidable with respect to the center section whereby enabling adjusting the length of the header. | 09-16-2010 |
Paul Harkin, Dromore IE
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20090082218 | 3'-Based sequencing approach for microarray manufacture - Methods are described to derive design sequences for the production of nucleic acid microarrays. The present methods use high throughput 3′ sequencing of transcripts in a tissue sample or diseased state to design probes for nucleic acid microarrays. Also described are nucleic acid microarrays that possess probes directed to the extreme 3′ end of transcripts in a tissue. These microarrays preferably represent alternate polyadenylation sequences that are specific to the tissue from which the transcripts are derived. Also described are methods of using the microarrays directed to the extreme 3′ end of the transcript for evaluating gene expression in a tissue where there are reduced false positive and false negative results. | 03-26-2009 |
Paul Harkin, Belfast IE
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20090221437 | Transcriptome microarray technology and methods of using the same - Arrays containing a transcriptome of a diseased tissue and methods of using the arrays for diagnosis, prognosis, screening, and identification of disease are provided herein. The transcriptome arrays from diseased tissue are useful for diagnosis of a disease by analysis of the genetic profile of a tissue sample specific to a disease state. The genetic profiles are then correlated with data on the effectiveness of specific therapeutic agents. Correlating expression profiles to the effectiveness of therapeutic agents provides a way to screen and select further patients predicted to respond to those therapeutic agents, thereby minimizing needless exposure to ineffective therapy. | 09-03-2009 |
Richard Lee Harkin, Worthing GB
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20150078043 | CONTROLLER FOR A VOLTAGE CONVERTER - In some examples, a control module for a voltage converter may have an input for connection to an AC supply having an operating voltage range. A first detector is provided for detecting the operating voltage range of the AC supply and generating a first control signal to identify the detected operating voltage range. A second detector is also provided for detecting the operating voltage range of the AC supply and generating a second control signal to identify the detected operating voltage range. The control module has one or more switches for selectively enabling and/or disabling a voltage multiplier in response to said first and second control signals. The present disclosure also relates to a method of controlling a voltage converter. | 03-19-2015 |
William James Harkin, Glasgow GB
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20110320369 | PROJECT MANAGEMENT - A method of managing preset and bespoke projects efficiently within a collaborative environment that utilises intranets and or the internet to convey data and messages. In one expression of utility a method of commercialising of proposed intellectual property rights comprising five steps is disclosed. The steps are identifying and protecting intellectual property associated with the invention; developing a prototype product and or end user products based on the intellectual property rights being pursued; identifying and/or developing potential markets for the products; determining a preferred route to market for the products; and, depending on the preferred mute to market, either licensing the invention to 3rd parties and or establishing new companies to bring products to market directly. Also disclosed is a system for implementing the method. The system comprises data storage means including data structures, data processing means in communication with the data storage means, input means and output means. | 12-29-2011 |
20140257936 | PROJECT MANAGEMENT - A method of managing preset and bespoke projects efficiently within a collaborative environment that utilises intranets and or the internet to convey data and messages. In one expression of utility a method of commercialising of proposed intellectual property rights comprising five steps is disclosed. The steps are identifying and protecting intellectual property associated with the invention; developing a prototype product and or end user products based on the intellectual property rights being pursued; identifying and/or developing potential markets for the products; determining a preferred route to market for the products; and, depending on the preferred mute to market, either licensing the invention to 3rd parties and or establishing new companies to bring products to market directly. Also disclosed is a system for implementing the method. The system comprises data storage means including data structures, data processing means in communication with the data storage means, input means and output means. | 09-11-2014 |