Mangold, DE
Alexander Mangold, Ludwigshafen DE
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20100091256 | METHOD AND APPARATUS FOR REPRODUCING A PROGRAMMABLE MASK ON A SUBSTRATE - A pattern, is imaged by means of a programmable mask, on a substrate that has a photosensitive layer, illumination spots being produced on the mask by means of an illumination unit and individual pixels being produced, via an optical unit, forming a grid of pixels on the substrate corresponding to the pattern. Structure edges that are to be reproduced on the substrate are positioned optimally. To this end at least two exposure processes for the photosensitive layer are performed, the illumination spots or exposure points of which are offset from one another. Thereby, spaces in the grid of pixels of the first exposure process, which spaces are proportionate to the number of exposure processes to be effected, are filled with pixels by the subsequent exposure processes. | 04-15-2010 |
20110007322 | METHOD AND ARRANGEMENT FOR DISPLACEMENT - A method and apparatus operable for displacing an image, which is transmitted by electromagnetic radiation, perpendicular to the direction of radiation by use of a rotatably disposed radiation-refracting body, located in the path of an imaging beam, having a refractive index that differs from the surrounding medium with regard to the radiation used. The method allows for precise image displacement. The rotation of the radiation-refracting body causing the displacement is measured, and the change of the optical path length caused by the angular change in a further electromagnetic beam utilized for the measurement is determined by evaluating the superimposition of the radiation reflected by a planar reflecting surface with the incident electromagnetic radiation. Part of the electromagnetic measurement beam, which is reflected on the surface of the radiation-refracting body, strikes a measurement unit, which supplies an electrical signal as a function of the incident position of the electromagnetic radiation. | 01-13-2011 |
Andreas Mangold, Sondheim DE
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20130223780 | ROLLING BEARING CAGE AND ROLLING BEARING - The invention relates to a rolling bearing cage ( | 08-29-2013 |
Artur Mangold, Sulz DE
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20110109118 | FIXATION SYSTEM FOR A FOLDING TOP BIN COVER - A folding top bin cover assembly includes a folding top bin cover and a fixation system. The bin cover is movable to a covered position in which the bin cover covers a folding top bin of a vehicle body. The fixation system acts between the bin cover and a structural element fixable to the vehicle body. The fixation system has a fixing mechanism including a sliding element and an insertion bracket. The sliding element is connected to the bin cover and the insertion bracket is fixedly connected to the structural element. The fixation system adjusts the bin cover at right angles to the longitudinal direction of the vehicle body as the sliding element operates interactively with the insertion bracket while the bin cover is in the covered position. | 05-12-2011 |
Artur Mangold, Sulz-Muhlheim DE
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20140075845 | KINEMATICS FOR A CLOSURE - Apparatus configured to open, close, unlock and lock a flap of a motor vehicle. A drive link of a kinematic drive mechanism is configured to act on a kinematic flap mechanism, in which a deflecting lever of the kinematic actuating mechanism is drivable by an actuator and, during a closing movement, engages in an engagement element of the kinematic flap mechanism or of the flap and, in the process, closes and locks the flap. | 03-20-2014 |
Claus Mangold, Ottilien DE
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20090307977 | DRIVER FOR A WINDOW-RAISING DEVICE - The invention relates to a window lift system of a vehicle door with a first component, wherein the first component is designed for the fixation at a window, wherein the first component can be inserted with the window into a first position in the vehicle door, and with a second component, wherein the second component can be attached to the vehicle door in a detachable manner, wherein the second component is movable from the second position to the first position, and wherein the first component can be connected with the second component in the first position. In other aspects, the invention relates to a method for mounting of the lifter, a first component, and a second component. The invention further relates to a tool for mounting of the lifter. | 12-17-2009 |
Claus Mangold, Helsa St. Ottilien DE
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20080289256 | Window Lift Apparatus, Door Module, Motor Vehicle Door and Method for Installation of a Window Lift Apparatus - The invention concerns a window lift arrangement with | 11-27-2008 |
20090145035 | Window Lift Apparatus, Door Module, Motor Vehicle Door And Method For Installation Of A Window Lift Apparatus - The invention concerns a window lift arrangement with a lifter for a window pane, an door panel, positioning means for positioning the lifter relative to the door panel in an installation position for installation of the window pane, wherein the positioning instruments can assume a first and a second position, wherein the positioning instruments in the first position define the installation position and wherein the positioning instruments in the second position release a movement of the lifter for opening and closing the installed window pane. | 06-11-2009 |
Claus Mangold, Helsa DE
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20080202031 | Force Transmission Element, Window Lifter and Motor Vehicle Door with a Window Lifter - The invention relates to a force-transmission element for a window lifter ( | 08-28-2008 |
Dieter Mangold, Maxdorf DE
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20080220539 | Apparatus and Method for Determining an Analyte in a Fluid - The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally microfluidic three-dimensional structure, into which stirring zone a sample of the fluid can be introduced and in which there is a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being configured so as to stir the sample of fluid introduced into the stirring zone and being loaded with at least one reagent which reacts with the analyte. The invention also provides a stirring device which can be operated in a contactless manner and is optionally designed as a microstirrer, the stirring device being loaded with the at least one reagent which reacts with the analyte. | 09-11-2008 |
20090087901 | Analytical Test Element and Method for Blood Analyses - An analytical test element for blood analyses is provided having an application site and a microfluidic channel structure in fluid communication with the application site. The channel structure comprises at least first and second analytical channels for receiving first and second portions of a blood sample applied to the application site. The first analytical channel comprises a first analytical site to determine the total haemoglobin value (Hb) of the blood sample. The second analytical channel comprises a second analytical site to determine a glycohaemoglobin value (HbA1c) of the blood sample. | 04-02-2009 |
20110194980 | Process For Hydrophilizing Surfaces Of Fluidic Components And Systems - A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids. | 08-11-2011 |
Elmar Mangold, Unterschneidheim (zöbinge) DE
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20160105996 | FAN HOLDER FOR A FAN, IN PARTICULAR OF A SWITCH CABINET - A fan holder for a fan includes a frame that has an opening through which a gaseous medium flows during operation. The opening forms an accommodating region that is designed to accommodate various replaceable inserts, in particular a filter insert and a flap device, and has at least one retaining device for fastening the particular insert. | 04-14-2016 |
Elmar Mangold, Zoebingen Unterschneidheim DE
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20100220985 | HEATING DEVICE AND HEAT EXCHANGER - The invention relates to a heating device having a heating arrangement in a housing through which a fluid medium can flow in a longitudinal direction, wherein the at least one heating arrangement comprises at least two grid elements as heat exchanger plates with openings through which the medium flows, the grid planes of which are embodied for the exchange of heat energy between the plate and the fluid medium, at least one heating element, in particular a PTC element, arranged between the grid elements, wherein the at least one heating arrangement is arranged in the housing in such a way that the grid planes of the grid elements are arranged substantially perpendicularly to the longitudinal direction, so that the flow of medium is oriented substantially perpendicularly to the grid planes, wherein the grid elements and the at least one heating element are arranged braced relative to one another by means of at least one tensioning element so that they touch, and wherein the grid elements each have at least one contact region and are arranged in such a way that they absorb the heat energy from the at least one heating element substantially via the contact region. | 09-02-2010 |
Elmar Mangold, Unterschneidheim Zoebingen DE
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20130106566 | BIMETAL CONTROLLER | 05-02-2013 |
Elmar Mangold, Zoebingen DE
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20140290907 | COOLING AND RETAINING BODY FOR HEATING ELEMENTS, HEATING APPLIANCE AND METHOD FOR PRODUCING A COOLING AND RETAINING BODY - A cooling and retaining body for holding heating elements, in particular PTC heating elements, having a heating-element holder, in which the heating elements are mounted. The heating element holder has a plurality of circumferentially distributed accommodating regions, in each of which at least one heating element is arranged, wherein the accommodating regions are formed between an outer part and an inner part, which is arranged in the outer part, and at least the outer part has a polygonal profile with a number of corners connected by sides, wherein the accommodating regions are arranged in the corners of the polygonal profile, and the sides of the polygonal profile are deformed elastically in order to generate a clamping force which acts on the respective heating elements. | 10-02-2014 |
20140299293 | COOLING AND HOLDING DEVICE FOR HEATING-ELEMENTS, HEATER AND METHOD FOR PRODUCING A COOLING AND HOLDING DEVICE - A cooling and holding device for heating-elements, more particularly PTC heating-elements, including a flat housing having at least one heating shaft in which there is at least one heating-element, wherein the heating shaft has opposing shaft walls between which the heating-element is clamped, and at least one side slit that separates the shaft walls such that the distance between the shaft walls can be varied for installation of the heating-element, wherein at least one clamping section outwardly protruding from the flat housing, grips the flat housing, spanning the side slit, and is elastically deformed in the mounted state of the heating-element so as to provide a pressing force of the shaft walls on the heating-element in the assembled state. | 10-09-2014 |
20160042883 | Door Contact Switch, Especially for Switchgear Cabinets - The invention relates to a door contact switch, especially for a switchgear cabinet, having a switching piece, a baseplate and a switch housing accommodating the switching piece, the switch housing being movably mounted relative to the baseplate. | 02-11-2016 |
Florian Mangold, Ismaning DE
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20110172985 | METHOD AND DEVICE FOR DETERMINING REQUIREMENT PARAMETERS OF AT LEAST ONE PHYSICAL HARDWARE UNIT - In a method and a device for determining requirement parameters of at least one physical hardware unit, the operating parameters of simulated, virtual hardware units are varied during the execution of a program flow on the virtual hardware units, for example via an interface device of a simulation device, in such a manner that requirement parameters of the execution of a program flow of at least one physical hardware unit can be identified. A method and a device are used for determining requirement parameters of at least one physical hardware unit. The method and the device are used to determine requirement parameters of software products of hardware components to be used. Requirement parameters are allowed to be identified systematically, using an operating system and eliminates the need for expensive, physical hardware components and for modifications to a physical computer system. | 07-14-2011 |
20110184716 | METHOD AND DEVICE FOR ANALYZING AN EXECUTION OF A PREDETERMINED PROGRAM FLOW ON A PHYSICAL COMPUTER SYSTEM - The functionality of simulated, virtual hardware units is varied during the execution of a program flow on the virtual hardware units, for example via an interface device of a simulation device, in such a manner that the execution behavior changes of a program flow can be identified by using at least one faulty, physical hardware unit. A method and a device are used for analyzing an execution of a predetermined program flow on a physical computer system. The method and the device are used to determine execution behavior changes of software products which changes are due to faulty hardware components. The method and device allow execution behavior changes to be identified systematically, using an operating system and eliminates the need for expensive, physical hardware components and for modifications to a physical computer system. | 07-28-2011 |
Florian Mangold, Munchen DE
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20100088663 | METHOD FOR THE COMPUTER-AIDED DETERMINATION OF THE DEPENDENCIES OF A PLURARITY OF MODULES OF A TECHNICAL SYSTEM, ESPECIALLY OF A SOFTWARE SYSTEM - An embodiment of the present invention discloses a method for the computer-aided determination of the dependencies of a plurality of modules of a technical system, especially of a software system. Every module of the system has a known, first consumption of resources. The first consumption of resources of at least one of the modules is modified according to a predetermined criterion, thereby obtaining a modified system. The modified system is executed. A second consumption of resources is measured for every module of the modified system, the consumption resulting from the modification of the first consumption of resources of the at least one module. An analysis of the second consumption of resources of a respective module and the predetermined criterion is used to determine whether there is a dependency between the respective module and the at least one module that is characterized by the modified consumption of resources. | 04-08-2010 |
20100095275 | METHOD FOR THE COMPUTER-AIDED DETERMINATION OF AN OPTIMIZATION POTENIAL OF A SOFT-WARE SYSTEM - A method is disclosed for the computer-aided determination of the optimization potential of a software system including a plurality of modules that can interact with each other at least to some point during execution of the software system. At least one module to be examined is selected from the plurality of modules, in at least one embodiment, and is examined with respect to the effects of an optimization of the at least one module to be examined on the overall consumption of resources of the software system. A respective consumption of resources of one or more modules not to be examined of the plurality of modules is varied according to at least one predetermined criterion, thereby obtaining a modified software system. The overall consumption of resources of the modified software system is determined taking into consideration the variation of the modules not to be examined. The determined overall consumption of resources of the modified software system is then compared to the overall consumption of resources of the unmodified software system. | 04-15-2010 |
20100175046 | METHOD AND DATA PROCESSING SYSTEM FOR COMPUTER-ASSISTED PERFORMANCE ANALYSIS OF A DATA PROCESSING SYSTEM - A method is disclosed for the computer-assisted performance analysis of a data processing system, wherein a program code with a plurality of code parts is running. During the execution of at least one embodiment of the method, one or more parts of the code parts are at least varied once while using a functionality creating a variance in regard to at least one criterion to be evaluated. The data processing system is executed with the varied code part and parts multiple times. A variance of the at least one criterion to be evaluated of the varied code part or parts, or of all code parts of the program code is determined. Finally, a covariance resulting from the variance is subjected to a multivariant analysis. | 07-08-2010 |
Florian Mangold, Raubling DE
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20120278660 | METHOD AND DEVICE FOR TESTING A SYSTEM COMPRISING AT LEAST A PLURALITY OF SOFTWARE UNITS THAT CAN BE EXECUTED SIMULTANEOUSLY - A programmable operating time period of at least one software unit is changed to a settable operating time period. Furthermore, a testing system for validating the system for setting the at least one settable operating time period is provided. Furthermore, the system is tested using the testing system, wherein the testing includes varying the at least one settable operating time period for detecting synchronization errors of the system. Thus, a test of a system including software units for synchronization errors is enabled by the targeted change of operating time period. | 11-01-2012 |
Gerhard Mangold, Wutoschingen DE
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20100190401 | Transparent Planar Material for Architectural Purposes - The invention relates to transparent planar material ( | 07-29-2010 |
Harald Mangold, Lippach DE
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20090062962 | Control Device for an Electronic Domestic Appliance - A control device for an electronic domestic appliance has a control panel of an electrically conducting material and an electronic control system with a mains-connected circuit and a circuit that is galvanically separated from the mains. To protect the electronic control system from electrostatic discharges the control panel is grounded by way of an electrical connection between the control panel and the circuit that is galvanically separated from the mains and also an electrical connection between the galvanically separated circuit and the mains-connected circuit. The latter electrical connection between the galvanically separated circuit and the mains-connected circuit has at least one protection impedance. | 03-05-2009 |
20100013355 | "PUSH BUTTON SWITCH" - A push button switch including a piezoelectric element ( | 01-21-2010 |
Juergen Mangold, Rothhausen DE
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20090068450 | Method and Apparatus for Multi-Cathode PVD Coating and Substrate with PVD Coating - The invention relates to a method for operating a multi-cathode-PVD-coating system. According to the invention, one part of the cathodes operates after the high power impulse cathodic sputtering which is assisted by magnetic fields and the remainder operates after the direct current magnetic field assisted cathodic sputtering. The high power impulse cathodic sputtering which is assisted by magnetic fields is used as a source of multi-ionised metal ions during the ion-assisted in vacuo pre-treatment of substrates, whilst both types of cathodic sputtering are always used simultaneously during coating and whilst both types of cathodes are connected to different materials. | 03-12-2009 |
Matthias Mangold, Eschenlohe DE
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20090298686 | Metallic carrier for catalysts or particle separators and the use of this carrier - A metallic carrier for a catalytic converter or particle separator and the use of a metallic carrier for exhaust gas cleaning of internal combustion engines, especially diesel engines, is provided. The metallic carrier comprises an aluminum alloy having an aluminum content of 75 to 99.5 percent by mass. The metallic carrier helps achieve an advantageous reduction in the mass of the carrier and thermal capacity, as a result of which the light-off temperature is reached more rapidly. The reduction of mass and thermal capacity is not at the expense of a reduction in the catalytic carrier surface. | 12-03-2009 |
Michael Mangold, Grainau DE
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20080309053 | Ski Binding - A ski binding for downhill skiing and cross-country skiing has a plate ( | 12-18-2008 |
20130334795 | BOOT RETAINING UNIT WITH DAMPING - A boot retaining unit of a ski binding or snowboard binding, including at least one boot retaining element, a restoring spring for the boot retaining element, and a damping device for absorbing short, hard impacts, wherein the at least one boot retaining element and the damping device are connected via a translation mechanism, and the translation mechanism translates a deflection of the at least one boot retaining element into a larger deflection of the damping device. | 12-19-2013 |
20140217704 | HEEL RETAINER WITH ROLLER-SHAPED SOLE RETAINER - A heel retainer for a ski binding, includes a base plate using which the heel retainer can be fastened to an upper side of a ski or snowboard; a connecting structure connectable to the base plate; and a tensioning device using which a ski boot is tensioned onto the ski. The connecting structure includes first and second connecting structure parts. The first connecting structure part can be moved relative to the second connecting structure part in the transverse release direction when the ski binding is transversely released. The tensioning device includes a sole retainer which, in direct contact with the sole of a ski boot, tensions the ski boot onto the ski or snowboard. The sole retainer is formed as a rolling body exhibiting a rotational axis and is connected to the tensioning device such that the sole retainer can be rotated about its rotational axis. | 08-07-2014 |
Michi Mangold, Grainau DE
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20090218790 | Ski Binding System - Embodiments of the invention relate to a binding ( | 09-03-2009 |
Patrick Mangold, Kirchheim DE
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20100316923 | FUEL CELL SYSTEM - The invention relates to a fuel cell stack ( | 12-16-2010 |
20130004878 | Catalytic Burner for Fuel Cell Exhaust Gas - A catalytic burner includes a catalyst body and a line element for the supply of a gas mixture to the catalyst body. The catalytic burner also includes a transitional region between the line element and the catalyst body. A swirl element is arranged in the flow region upstream of the catalyst body in the direction of flow. | 01-03-2013 |
Peter Mangold, Salem DE
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20110192308 | MISSILE HEAD AND METHOD FOR SEPARATING A SHROUD FROM A FUSELAGE OF A MISSILE - A missile head has a shroud which forms its tip and which can be detached in its totality during flight from the fuselage of the missile. The missile head further has a rear part, which is connected to the fuselage, and a front nose, which can be disconnected from the rear part and forms the tip. A separating device separates the rear part from the fuselage and the nose from the rear part during flight. A physically small shroud can be achieved, and damage to the fuselage of the missile by separation of the shroud can be prevented, if the nose is split into at least two parts and the separating device is prepared to split the nose into these two parts during flight. | 08-11-2011 |
Peter Mangold, Hannover DE
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20140349590 | CHANNEL ESTIMATE PREDICTED FROM SEVERAL PREVIOUS CHANNEL ESTIMATES, FOR PRE-EQUALIZATION - A data transmission method includes transmitting an encoded data signal in form of a data stream of data bursts between a transmitter and a receiver, making a decision as a function of at least one data transmission parameter as to whether an interference treatment o the data signal to be transmitted will be performed in the transmitter or in the reciver, performing the interference treatment in terms of at least on code in the transmitter, and performing ther interference treatment of the data to be transmitted in terms of at least one further code in the reciver. | 11-27-2014 |
Rainer Mangold, Herbrechtingen DE
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20110094919 | ARRANGEMENT OF A PLURALITY OF MOISTENED COSMETIC PADS AND METHOD FOR THE PRODUCTION THEREOF - An arrangement having a plurality of moistened cosmetic pads based on nonwovens which are piled into a closable packaging container in order to distribute to the final consumer and to prevent evaporation. The pads have, on average, a moisture content of at least 200% of the dry weight thereof in the arrangement, the pads have a fiber structure made of staple fibers, are individually moistened and have a homogeneous moisture content such that the difference of the average moisture content of the pads which are arranged in the upper and in the lower quarter of the stack is, at a maximum, 30% of the average moisture content of all of the pads. | 04-28-2011 |
20150144648 | Arrangement of a plurality of moist pads in a packaging container for dispensing to the end user - A plurality of moist pads are arranged in two stacks ( | 05-28-2015 |
Stefan Mangold, Stuttgart DE
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20130200731 | METHOD AND DEVICE FOR DISCHARGING AN INTERMEDIATE CIRCUIT OF A POWER SUPPLY NETWORK - The present invention relates to a method ( | 08-08-2013 |
20140070748 | METHOD AND CONTROL UNIT FOR DETECTING A BLOCKED ELECTRIC MACHINE IN AN ELECTRIC VEHICLE - The invention relates to a method and a control unit, which makes it possible to reliably detect in an electric vehicle whether or not an electric machine is in a blocked state. For this purpose, a current rotational speed of the electric machine ( | 03-13-2014 |
Stefan Mangold, Aachen DE
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20110280253 | NETWORK WITH SEVERAL SUBNETWORKS - The invention relates to a network with several subnetworks, which are organized either decentrally or centrally and can be connected in each case each by bridge terminals, a proxy terminal for a bridge terminal being set up in at least one of the subnetworks, which proxy terminal during an absence (dictated by frequency, time, code, or other factors) of the bridge terminal accepts all data directed to the bridge terminal or to be forwarded thereby, temporarily stores the data, and forwards said data to the bridge terminal when this is present again. | 11-17-2011 |
Steffen Mangold, Stodtlen DE
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20150115682 | CARRIER STRUCTURE FOR AN ARMREST OF A VEHICLE - A carrier structure for an armrest for pivotal articulation to a mount in a vehicle includes two carrier arms carrying a support body, wherein the carrier arms are connected at one end to a cross member. The cross member has pins for pivotable support in the mount. The cross member is produced by tube forming, bending and punching of a steel sheet corresponding substantially to the planar projection of the cross member, wherein the pins are formed on the cross member as tube parts. | 04-30-2015 |
Stephanie Mangold, Mainz DE
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20150267079 | SUBSTRATE HAVING A SEMITRANSPARENT COATING - A substrate of glass or glass ceramics having a semitransparent coating is provided. The semitransparent coating has high scratch resistance, good temperature stability, and good adhesion on a sealing layer. The coating material has at least one sol-gel-based matrix, to which colorants are added, and that a polyester-functionalized and/or an epoxy-functionalized silicone resin, such as a polyester-modified silicone resin, is added to the sol-gel-based matrix. | 09-24-2015 |
Stephanie Mangold, Laubenheim DE
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20140335349 | COATED GLASS CERAMIC PLATE - A coated glass ceramic cooking plate is provided, which has a multilayer coating on its lower surface. The multilayer coating includes a metallic layer of an alloy including components chromium, iron, nickel, and silicon. The silicon content of the alloy is at least 2 atomic percent. This metallic layer is covered by a barrier layer in form of an oxide of an alloy including components chromium, iron, nickel, and silicon, also with a silicon content of at least 2 atomic percent. The molar content of oxygen of the barrier layer is greater by at least a factor of 10 than that of the metallic layer. | 11-13-2014 |
Susanne Mangold, München DE
Susanne Mangold, München DE
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20120121600 | PHARMACEUTICAL ANTIBODY COMPOSITIONS WITH RESISTANCE TO SOLUBLE CEA - The present invention relates to pharmaceutical compositions for the treatment of an epithelial tumor in a human, said pharmaceutical composition comprising an IgG1 antibody specifically binding to human CEA, wherein the variable region of said IgG1 antibody comprises at least (i) a CDR-H1 having the amino acid sequence “SYWMH” and a CDR-H2 having the amino acid sequence “FIRNKANGGTTEYAASVKG” and a CDR-H3 having the amino acid sequence “DRGLRFYFDY” or (ii) a CDR-H1 having the amino acid sequence “TYAMH” and a CDR-H2 having the amino acid sequence “LISNDGSNKYYADSVKG” and a CDR-H3 having the amino acid sequence “DRGLRFYFDY”. Furthermore, processes for the production of said pharmaceutical compositions as well as medical/pharmaceutical uses for the IgG1 antibody molecules bearing specificities for the human CEA antigen are disclosed. | 05-17-2012 |
20130273050 | PHARMACEUTICAL COMPOSITIONS WITH RESISTANCE TO SOLUBLE CEA - The present disclosure relates to a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, where the second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7, a pharmaceutical composition comprising the bispecific single chain antibody, and methods for the treatment of an epithelial tumor in a human with the pharmaceutical compositions containing the bispecific single chain antibody. Furthermore, processes for the production of the pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed. | 10-17-2013 |
Susanne Mangold, Munich DE
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20100150918 | CROSS-SPECIES-SPECIFIC BINDING DOMAIN - The present invention relates to a polypeptide comprising a human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide. In a further aspect the invention provides a method for the identification of polypeptides comprising a cross-species specific binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3ε (CD3 epsilon). | 06-17-2010 |
20100183615 | CROSS-SPECIES-SPECIFIC BISPECIFIC BINDERS - The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide. | 07-22-2010 |
20110293619 | CROSS-SPECIES-SPECIFIC PSMAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY - The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain anti-body molecule. | 12-01-2011 |
20120034228 | CROSS-SPECIES-SPECIFIC PSCAxCD3, CD19xCD3, C-METxCD3, ENDOSIALINxCD3, EPCAMxCD3, IGF-1RxCD3 OR FAPALPHAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY - The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an antigen selected from the group consisting of Prostate Stem Cell Antigen (PSCA), B-Lymphocyte antigen CD19 (CD19), hepatocyte growth factor receptor (C-MET), Endosialin, the EGF-like domain 1 of EpCAM, encoded by exon 2, Fibroblast activation protein alpha (FAP alpha) and Insulin-like growth factor I receptor (IGF-IR or IGF-1R). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule. | 02-09-2012 |
20130129730 | CROSS-SPECIES-SPECIFIC PSMAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY - The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule. | 05-23-2013 |