Wolfe, MA
Alicia Peregrin Wolfe, N. Cambridge, MA US
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20120265603 | MOBILE DIGITAL MEDIA DOWNLOAD TRACKING MANAGEMENT UTILIZING STATISTICAL USER FINGERPRINTING TECHNIQUES THROUGH CORRELATION OF WEB-BASED DOWNLOAD USER ACTIONS WITH MOBILE APPLICATION DOWNLOAD USER ACTIONS - A method for tracking downloads to a computer system is disclosed. Digital media content, such as music, games and applications (“apps”) are widely available with the popularity of mobile computing. Suppliers of such digital media content would appreciate it if their works were more widely disseminated and used. Users or customers may receive an incentive to purchase or to download an application. The incentive may be, for example, a free application, rewards points or a virtual currency. In one method, the user downloads digital media content in two stages. In the first stage, the user activates a first web-based link to download the digital media content. In the second stage, after downloading, the user activates a second web-based link to activate the application or other digital media content. The web-based links include user identifiers that are matched for the user to subsequently receive the incentive. | 10-18-2012 |
Edward Wolfe, North Andover, MA US
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20110115498 | Detection and Mitigation of Particle Contaminants in MEMS Devices - Detecting and/or mitigating the presence of particle contaminants in a MEMS device involves including MEMS structures that in normal operation are robust against the presence of particles but which can be made sensitive to that presence during a test mode prior to use, e.g., by switching the impedance of sensitive structures between an exceptionally sensitive condition during test and a normal sensitivity during operation; surrounding sensitive nodes with guard elements that are at the same potential as those nodes during operation, thereby offering protection against bridging particles, but are at a very different potential during test and reveal the particles by their resulting leakage currents; extending the sensitive nodes to interdigitate with or otherwise extend adjacent to the guard structures, which neither contribute to nor detract from the device operation but cover otherwise open areas with detection means during test; and/or converting benign areas in which particles might become trapped undetectably by electric fields during test to field-free regions by extending otherwise non-functional conductive layers so that the particles can then be moved into detection locations by providing some mechanical disturbance. | 05-19-2011 |
20130168675 | Detection and Mitigation of Particle Contaminants in MEMS Devices - Detecting and/or mitigating the presence of particle contaminants in a MEMS device involves including MEMS structures that in normal operation are robust against the presence of particles but which can be made sensitive to that presence during a test mode prior to use, e.g., by switching the impedance of sensitive structures between an exceptionally sensitive condition during test and a normal sensitivity during operation; surrounding sensitive nodes with guard elements that are at the same potential as those nodes during operation, thereby offering protection against bridging particles, but are at a very different potential during test and reveal the particles by their resulting leakage currents; extending the sensitive nodes to interdigitate with or otherwise extend adjacent to the guard structures, which neither contribute to nor detract from the device operation but cover otherwise open areas with detection means during test; and/or converting benign areas in which particles might become trapped undetectably by electric fields during test to field-free regions by extending otherwise non-functional conductive layers so that the particles can then be moved into detection locations by providing some mechanical disturbance. | 07-04-2013 |
Jia Liu Wolfe, Winchester, MA US
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20100055761 | METHODS, COMPOSITIONS, AND KITS FOR THE SELECTIVE ACTIVATION OF PROTOXINS THROUGH COMBINATORAL TARGETING - The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells using a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting moiety and, a modifiable activation moiety which is activated by an activation moiety not naturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population. | 03-04-2010 |
20140113832 | ENGINEERED THIOREDOXIN-LIKE FOLD PROTEINS - The invention features compositions based on thioredoxin-like fold protein domains described as engineered thioredoxin-like fold proteins (ETRXs). These proteins include one or more artificially diversified thioredoxin-like fold protein domains; each domain may be originated from the same or different thioredoxin-like fold protein domains. Features of the invention also include methods for identifying and preparing an enriched composition of target binding, loop-diversified ETRXs with additional sequence variations to improve affinity, stability, selectivity, or solubility. The invention also features compositions of ETRXs substituted with prosthetic groups, polymers, proteins, nucleic acids, carbohydrates, metals, natural or synthetic small molecules and toxins. | 04-24-2014 |
John Thomas Wolfe, Weston, MA US
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20160086171 | Indication of Recurring Transaction for Payment Devices and Credit Cards - A credit card has either a display screen capable of showing either a fully generated transactional credit card number or a partially generated number. In use, a user generates a dynamic “transactional” credit card number associated with his underlying account credit card number. To complete a secure transaction that cannot be copied and used at a later date, the credit card does not display the base credit card number, but instead uses on-card encryption to generate and/or display a transactional cc number that may be may include a portion of the base number or only digits that are generated into the transactional credit card number. The transactional cc number and not the base credit card number are provided to a vendor to complete a transaction. The credit card processing server uses decryption or a reverse lookup table to convert the transactional cc number back to the base cc number. | 03-24-2016 |
Jonathan Wolfe, Cambridge, MA US
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20130246102 | METHOD AND APPARATUS FOR PROVIDING LATE RETURN DETECTION OF A SHARED VEHICLE - A method, apparatus and computer program product for providing late return detection of a shared vehicle is presented. A computer system determines an end time of a first reservation of a shared vehicle by a first member of a vehicle sharing service. Then a location of the shared vehicle is determined at a first predetermined time before the end time of the first reservation. Based on the end time of the first reservation and the location of the shared vehicle, a potential late return of the shared vehicle is determined. If the shared vehicle return will be late, then at least one of the first member and a representative of the vehicle sharing service are notified so appropriate actions can be taken. | 09-19-2013 |
Jonathan E. Wolfe, Cambridge, MA US
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20080228533 | MULTI-TIERED FLEET MANAGEMENT CACHE - A method of providing reservation status relating to a group of objects includes providing a database for containing (i) availability data describing availability of at least one of the group of objects, and (ii) reservation data describing allocation of at least one of the group of objects. The availability data and the reservation data are stored in sparse form. The method further includes extracting, from the database, availability data and reservation data corresponding to a predetermined period of time, and combining the extracted availability data and reservation data to form windowed data in a dense format. The method also includes receiving the windowed data and providing the windowed data in a bit-vector view, and sampling the windowed data in the bit-vector view to produce sampled data. The sampled data provides the reservation status as a static view of the windowed data in the bit-vector view. | 09-18-2008 |
Leighton J. Wolfe, Lexington, MA US
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20110202467 | AUTOMATED LOAD CONTROL AND DISPATCH SYSTEM AND METHOD - A group of electronic circuit logic blocks work together to receive a load control event message and respond thereto. A display is generated for a customer that includes (1) a set of plural load control scenarios that can be selected to respond to the load control event message and (2) an amount of reduction associated with selected load control scenarios of the plural load control scenarios that were selected in response to the load control event message. The display may also include a monetary value of the amount of reduction associated with the selected load control scenarios of the plural load control scenarios that were selected in response to the load control event message. An electronic commitment message is sent in response identifying an amount the customer will reduce a load at a time specified in the load control event message. | 08-18-2011 |
Michael S. Wolfe, Newton, MA US
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20100286164 | SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGS AND USES THEREOF - Aspects of the invention relate to substituted aryl propylamino-oxy-analogs and uses thereof. Aspects of the invention relate to compositions that are inhibitors of γ-secretase and uses thereof for treating subjects having, or at risk of developing, Alzheimer's disease. | 11-11-2010 |
20130310384 | Sulfonamide-Containing Compounds - This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of γ-secretase. | 11-21-2013 |
Michael S. Wolfe, West Newton, MA US
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20140243374 | Novel Sulfonamides - This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of γ-secretase. | 08-28-2014 |
Michelle Wolfe, Tyngsboro, MA US
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20100137403 | METHOD FOR ENHANCING COGNITION OR INHIBITING COGNITIVE DECLINE - A method for enhancing cognition or inhibiting cognitive decline in a subject comprises selecting a Ca | 06-03-2010 |
M. Michael Wolfe, Newton Centre, MA US
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20090291883 | COMBINATION OF AN IMMUNOSUPPRESSIVE AGENT AND NONSTEROIDAL ANTI -INFLAMMATORY DRUGS TO TREAT DISEASE - The present invention provides methods and compositions for the treatment and prevention of neoplasia by administering an effective amount of a NSAID in combination with an effective amount of an immunosuppressant agent. In particular, the present invention provides methods and compositions for the treatment and prevention of neoplasia by administering an effective amount of COX-2 inhibitor in combination with an effective amount of an immunosuppressant agent. | 11-26-2009 |
M. Michael Wolfe, Newton, MA US
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20080214619 | Business method to treat and/or prevent a gastric acid disorder with a proton pump inhibitor (PPI) and a cholinergic agonist to induce rapid onset of PPI action with or without food - Pharmaceutical proton pump inhibitor (PPI) medications and methods are disclosed for preventing and/or treating gastrointestinal disorders characterized by abnormalities in gastric acid secretion at anytime of the day or night without the need for food effect or to be taken with food. The medications comprise a PPI and a cholinergic agonist for inducing rapid onset of PPI action, for increasing the duration of PPI efficacy and for optimizing clinical PPI effectiveness that may be administered at any time of the day or night without food or on an empty stomach, and possibly on an as-needed or on demand basis. In carrying out the methods, a PPI and cholinergic agonist may be administered together as a single unitary dose in the form of a liquid or solid, or administered together, but separately as either liquids or solids or a combination thereof. Preferably, an oral solid dosage form of the present invention allows for release of a proton pump inhibitor at a pH of about 5 or higher, e.g., pH about 5.5, 6, 6.5 or 7, followed by release of a cholinergic agonist within between about 10 minutes and about 60 minutes, preferably within about 15 minutes and about 30 minutes, after release of the proton pump inhibitor from the dosage form, so that it can be administered at any time of the day or night independent of food or food effect. It is believed that the methods and compositions of the present invention will increase the duration of PPI efficacy by between at least about 5 fold and about 10 fold or even about 20 fold, as compared to the duration of PPI efficacy derived from current PPI dosage forms administered alone and without food or a food effect. Kits comprising a PPI, a cholinergic agonist and optionally an antacid are disclosed, such as kits containing each drug in conventional and commercially available dry or liquid dosage forms for simultaneous or concomitant administration or in dry dosage forms to provide for the easy preparation of a liquid composition from the dry dosage forms. These new medications and methods will simplify the traditional continuous PPI regimen and improve patient compliance. | 09-04-2008 |
Patrick J. Wolfe, Cambridge, MA US
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20100085452 | NEW SPATIO-SPECTRAL SAMPLING PARADIGM FOR IMAGING AND A NOVEL COLOR FILTER ARRAY DESIGN - One aspect of the present invention relates to a new alternative to the Bayer pattern for spatial subsampling in color imaging applications. One aspect of the present invention relates to a new design paradigm for spatio-spectral sampling, which is also described. The proposed scheme offers the potential to significantly reduce hardware complexity in a wide variety of applications, while at the same time improving output color image quality. According to another aspect, it is realized that conventional processing techniques are subject to diminishing returns, and with the exception of the most sophisticated processing techniques generate imperfections perceptible to a practiced eye. According to one aspect, a framework for CFA design in presented. In one embodiment the physical characteristics of the CFA are generated so that the spectral radii of luminance and chrominance channels are maximized. In another embodiment, the CFA designed to subject to the conditions of perfect reconstruction. In one aspect, the physical characteristics of CFA design are constrained to require physically realizable CFA(s). Alternatively, certain physical characteristics can be emphasized to generate easier to manufacture CFA(s). According to another aspect, conventional methods and systems are evaluated, confirming shortcomings regarding aliasing in imaging and bandwidth, against which certain embodiments are benchmarked, showing improved performance under at least some embodiments of proposed designs and methods. According to another aspect, a display device CFA is evaluated in terms of throughput of stimuli as limited by aliasing. It is shown the spectral replicas of the chrominance signals induced by existing CFA patterns are centered around frequencies that are not sufficiently far from the DC, consequently overlapping with the luminance signal spectrum and reducing the throughput of the stimuli. By reinterpreting the interactions between the stimuli, display CFA, and CSF in terms of amplitude modulation, an alternative CFA coding scheme that modulates the chrominance signals to a higher frequency relative to common schemes is provided in some embodiments. | 04-08-2010 |
20100092082 | FRAMEWORK FOR WAVELET-BASED ANALYSIS AND PROCESSING OF COLOR FILTER ARRAY IMAGES WITH APPLICATIONS TO DENOISING AND DEMOSAICING - One aspect of the present invention relates to a new approach to the demosaicing of spatially sampled image data observed through a color filter array. In one embodiment properties of Smith-Barnwell filterbanks may be employed to exploit the correlation of color components in order to reconstruct a sub-sampled image. In other embodiments, the approach is amenable to wavelet-domain denoising prior to demosaicing. One aspect of the present invention relates to a framework for applying existing image denoising algorithms to color filter array data. In addition to yielding new algorithms for denoising and demosaicing, in some embodiments, this framework enables the application of other wavelet-based denoising algorithms directly to the CFA image data. Demosaicing and denoising according to some embodiments of the present invention may perform on a par with the state of the art for far lower computational cost, and provide a versatile, effective, and low-complexity solution to the problem of interpolating color filter array data observed in noise. According to one aspect, a method for processing an image is provided. In one embodiment, image data captured though a color filter array is trans-formed into a series of filterbank subband coefficients, by estimating the filterbank transform for a complete image (which estimation can be shown to be accurate in some embodiments) computation complexity associated with regenerating the complete image can be reduced. In another embodiment, denoising of the CFA image data can occur prior to demosaicing, alternatively denoising can occur in conjunction with demosaicing, or in another alternative, after demosaicing. | 04-15-2010 |
Scot Andrew Wolfe, Winchester, MA US
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20150191744 | CAS9 EFFECTOR-MEDIATED REGULATION OF TRANSCRIPTION, DIFFERENTIATION AND GENE EDITING/LABELING - The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state. | 07-09-2015 |