Patent application number | Description | Published |
20120122726 | MARKERS FOR ENDOMETRIAL CANCER - The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals. | 05-17-2012 |
20150337392 | MARKERS FOR ENDOMETRIAL CANCER - The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, SOCS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected and individuals. | 11-26-2015 |
Patent application number | Description | Published |
20110144548 | PATIENT SUPORT WITH IMPROVED CONTROL - A patient support apparatus includes a frame, a patient support surface supported in the frame, and a plurality of functional components associated with the patient support surface or the frame. The apparatus further includes a control system, with a controller, incorporated into the patient support surface or the frame and in operative communication with at least one of the functional components for controlling the component. The control system further includes a touch-screen in communication with the controller for controlling the functional component, which is positioned in the barrier around the patient support surface, and accessible at the exterior or interior surface of the barrier for access by a user. The touch-screen is configured to allow the user to select one or more of the functional components and control a parameter associated with the selected functional component. In addition, an icon is generated at the touch-screen representative of the parameter associated with the selected functional component, and with icon changing in response to the user adjusting the parameter associated with the selected functional component wherein the change in the icon gives the user feedback on the degree of change made by the user to the parameter associated with the selected functional component. | 06-16-2011 |
20150250669 | PATIENT SUPPORT WITH IMPROVED CONTROL - A patient support includes a frame, a patient support surface supported at the frame, a display incorporated into the frame, and a user interface incorporated into the frame. The patient support frame includes a controller incorporated into the frame, which has a plurality of prompts stored therein. The user interface is in communication with the controller and may be used to select a selected prompt from the plurality of prompts stored in the controller. When a prompt is selected, the controller generates a display image or text associated with the selected prompt at the display in response to a passage of time or an input to provide a visual prompt to the user. | 09-10-2015 |
Patent application number | Description | Published |
20140310260 | USING PERSISTENT DATA SAMPLES AND QUERY-TIME STATISTICS FOR QUERY OPTIMIZATION - Techniques for storing and querying graph data in a key-value store are provided. A graph statement (e.g., an RDF graph statement) includes a plurality of values, at least two of which correspond to nodes in a graph. A key is generated based on the graph statement. The key may be generated based on concatenating hash values that are generated based on the plurality of values. The key-value store stores the key. The value that corresponds to the key may be a null or empty value. In response to a graph query (e.g., in SPARQL) that includes one or more query patterns, each of which includes one or more values, a key is generated based on the one or more values and sent to the key-value store, which returns one or more other keys, each of which is a superset of the generated key. | 10-16-2014 |
20140310302 | STORING AND QUERYING GRAPH DATA IN A KEY-VALUE STORE - Techniques for storing and querying graph data in a key-value store are provided. A graph statement (e.g., an RDF graph statement) includes a plurality of values, at least two of which correspond to nodes in a graph. A key is generated based on the graph statement. The key may be generated based on concatenating hash values that are generated based on the plurality of values. The key-value store stores the key. The value that corresponds to the key may be a null or empty value. In response to a graph query (e.g., in SPARQL) that includes one or more query patterns, each of which includes one or more values, a key is generated based on the one or more values and sent to the key-value store, which returns one or more other keys, each of which is a superset of the generated key. | 10-16-2014 |
Patent application number | Description | Published |
20090155449 | MEDICAL DEVICE COATING APPARATUS AND METHODS OF USE - Apparatus and methods are configured to coat a medical device, such as a stent, with a beneficial medicinal agent using one or more liquid feeds and one or more micromist nozzles. In one implementation, an agent coating rig includes a vertical adjustment means, a rotation means, and a traverse adjustment means for moving a medical device along virtually any point on an x or y axis. In additional or alternative implementations, the agent coating rig can further include a secondary horizontal adjustment means that allows adjustment along virtually any point on a z axis. Furthermore, methods and apparatus are provided for distributing the beneficial agent on the medical device, including delivering the beneficial agent efficiently over time. | 06-18-2009 |
20130122183 | MEDICAL DEVICE COATING APPARATUS AND METHODS OF USE - Apparatus and methods are configured to coat a medical device, such as a stent, with a beneficial medicinal agent using one or more liquid feeds and one or more micromist nozzles. In one implementation, an agent coating rig includes a vertical adjustment means, a rotation means, and a traverse adjustment means for moving a medical device along virtually any point on an x or y axis. In additional or alternative implementations, the agent coating rig can further include a secondary horizontal adjustment means that allows adjustment along virtually any point on a z axis. Furthermore, methods and apparatus are provided for distributing the beneficial agent on the medical device, including delivering the beneficial agent efficiently over time. | 05-16-2013 |
Patent application number | Description | Published |
20130241131 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 09-19-2013 |
20130241132 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 09-19-2013 |
20130241133 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 09-19-2013 |
20150265799 | DEVICES AND METHODS FOR TREATING A LUNG - Methods and devices for treating a lung are disclosed. The method may include deploying a catheter into an airway of the lung, and discharging a media into the airway through the catheter. The media may be configured to increase elasticity of lung tissue in the vicinity of the airway or occlude the airway. | 09-24-2015 |
20150272591 | DEVICES AND METHODS FOR MODIFYING A VOLUME OF A CAVITY - Exemplary embodiments of a method for assisting breathing in a lung having damaged tissue are disclosed. The method may include inserting an implant containing a dilatant fluid into a pleural cavity of a patient to reduce an inhalation volume of the lung. Additional embodiments may include an implant configured to apply a force toward a portion of a lung. A controller may be coupled to the implant and configured to sense a biological event and control an amount of outwardly directed force applied by the implant to the lung in response to the biological event. Further, a method may include applying a force to an organ via an implant to expel material from the organ and adjusting the implant so as to transition between a first configuration and a second configuration. The implant may include at least one of an electro-active material and a pressure sensitive material. | 10-01-2015 |
20150273156 | DEVICES FOR SYSTEMIC DRUG DELIVERY AND RELATED METHODS OF USE - A method of treating a disease of the lung may include inserting an implant into the circulatory system. The implant may include an agent configured to be released into the circulatory system over time to deliver the agent to the lungs. The agent may be configured to treat a disease of the lung. | 10-01-2015 |
20160023234 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 01-28-2016 |
Patent application number | Description | Published |
20100075682 | Load Balancing for Capacity Improvement in Mobile Wireless Communication Networks - Technologies for load balancing among neighboring cells of a mobile wireless communication network can reduce traffic congestion and improve network system capacity. Load balancing can be accomplished by adjusting various radio access network parameters. Such adjustments may be made at the cell level or at the neighboring cell level. The adjustments can be applied iteratively in response to various collected operational statistics. The adjustments can adapt cell size and cell shape as well as adapt handover to maximize system resource and hardware utilization. An iterative process of optimization can periodically collect performance statistics and network configuration from a mobile wireless network. The collected information can be periodically analyzed to determine parameter adjustments. Configuring additional capacity from the communication network can prevent or substantially delay the acquisition of additional hardware resources to mitigate system capacity issues. | 03-25-2010 |
20100203881 | Call Quality and Coverage Improvement in Mobile Wireless Communication Networks - Technologies are described herein for improving call quality and coverage of cells within a mobile wireless communication network. Such improvements can be accomplished by adjusting various radio access network parameters. The adjustments may be made at the cell level or at the neighbor level. An iterative process can periodically collect key performance indicator (KPI) statistics from the mobile wireless network. System improvements may derive from one or more rules applied in parallel. Each rule can have a unique combination of minimum or maximum KPI thresholds. System issues may be identified when a cell correlates with one or more of the rules which may then suggest one or more parameter changes to reduce the identified system issue. System capacity policies may be provided as limits to the coverage and call quality triggers. | 08-12-2010 |
20110183704 | Real Time Event-Driven Automation for Energy Management in a Wireless Network - Technologies are described herein for real time event-driven automation of energy management features within a wireless communications network. Resources within a wireless communications network, such as entire base stations or equipment within a base station supporting specific cells, sectors, frequency bands, or services, may be switched on or off in response to events occurring within the communications network. A central controller receives a network interface message corresponding to an event occurring within the communications network. The central controller analyzes the network interface message and, based upon the analysis of the network interface message, generates an action message that includes instructions to take an action on an affected network resource within the communications network. The action message is then transmitted to the appropriate network resource. The action message may cause the affected network resource to implement power management parameters for adjusting the power consumption of the network resource. | 07-28-2011 |
20130060936 | Backup Coverage in a Wireless Network - Concepts and technologies are disclosed herein for identifying backup coverage in wireless networks. An active network resource to be analyzed is identified, and a at least one potential backup network resource is identified. The at least one potential backup network resource is evaluated to determine if the at least one potential backup network resource is available to function as the backup coverage for the active network resource. If the at least one potential backup resource is available to funtion as the backup coverage for the active network resource, a power management parameter associated with the wireless networking environment can be updated. | 03-07-2013 |
20130067093 | Determining Essential Resources in a Wireless Network - Concepts and technologies are disclosed herein for identifying a network resource in a wireless networking environment as essential. A network resource to be tested is identified. The network resource is transitioned to a softbar operation state. In the softbar operation state, use of the network resource is avoided. If access data indicates substantial use of the network resource, the network resource can be identified as essential. | 03-14-2013 |
Patent application number | Description | Published |
20100279937 | Method of Inhibiting Angiogenesis, Tumorigenesis and Cathepsin Activity - Insulin-like growth factor binding proteins (IGFBPs) and variants thereof, including IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, IGFBP-6 and the C-terminal fragments thereof, inhibit angiogenesis, tumorigenesis and cathepsin activity, particularly cathepsin B activity. | 11-04-2010 |
20120045391 | Formulations Targeting IGFBP7 for Diagnosis and Therapy of Cancer - The invention relates to antibodies or fragments thereof specific for insulin-like growth factor binding protein-7 (IGFBP7). A method of raising anti-IGFBP7 single domain antibodies is also disclosed and specific antibody clones are described, along with their binding characteristics. The anti-IGFBP7 antibodies may be useful as diagnostic tools for detecting neoplastic diseases involving tumor angiogenesis, and a variety of other angiogenesis associated diseases. | 02-23-2012 |
20130090717 | NON-WOVEN MAT AND METHOD OF PRODUCING SAME - A mat having a highly uniform porosity distribution is produced by consolidating 15 or more layers of melt blown webs (or the like) having different orientations. Control over the porosity is provided by using webs that exhibit a narrow, unimodal distribution of fiber diameters over the bulk of its distribution, such as in the top 80%. A compliance of the mats can be chosen by selecting a number and orientation of the webs. It is thus possible to produce mats that are good candidates for vascular grafts, for example. The uniformity of the porosity within the range of 6 μm to 30 μm permits seeding of the vascular graft with endothelial and smooth muscle cells. The mats have the demonstrated ability to retain, and support growth of, smooth muscle cells and endothelial cells. | 04-11-2013 |
20160082083 | METHOD OF INHIBITING ANGIOGENESIS, TUMORIGENESIS AND CATHEPSIN ACTIVITY - Insulin-like growth factor binding proteins (IGFBPs) and variants thereof, including IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, IGFBP-8 and the C-terminal fragments thereof, inhibit angiogenesis, tumorigenesis and cathepsin activity, particularly cathepsin B activity. | 03-24-2016 |
Patent application number | Description | Published |
20150203928 | PROCESS FOR DRY RECYCLING AND PROCESSING OF STEEL SLAG - The present invention relates to a process for recycling and processing steel slag, comprising the removal of the metal fractions of the slag in an innovative separation system and through the metal-free material, to produce granules of ore and steel shot, sealing block, apparent blocks, building blocks, interlocking floors in all models, caissons, guides, masonry mortar, adhesive mortar, floor on floor mortar, pumpable mortars, grouts, colored grouts, flexible grouts, epoxy grouts, epoxy masses, replacing natural minor aggregates, as the sand and crushing stone by steel slag in their proper particle size and especially the replacement of 100% of the conventional cement produced by a steel slag cement, applying additives from 0.1% to 30% of additives, depending on the application of each product. The invention belongs to the recycling area, specifically the recycling of steel slag. | 07-23-2015 |
Patent application number | Description | Published |
20100280056 | IDENTIFICATION OF SUBJECTS LIKELY TO BENEFIT FROM STATIN THERAPY - Methods are provided herein to determine if a subject is a candidate for treatment with an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). The method includes determining the presence of at least one polymorphism in the HMGCR gene in a sample from a subject. The presence of at least one polymorphism indicates that the subject is a candidate for treatment with a statin, for example to decrease risk of or treat cancer, cardiovascular disease, diabetes, obesity, inflammatory disease, or auto-immune disease. | 11-04-2010 |
20120225793 | METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS - Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject. | 09-06-2012 |
Patent application number | Description | Published |
20100143077 | SPINNING PROCESS FOR METALLIC PACKAGES FORMING WITH PRE-FLAP FORMING AND SPINNING EQUIPMENT FOR METALLIC PACKAGES FORMING WITH PRE-FLAP FORMING - It is understood as being preferably intended for the manufacture of cans through spinning, molding the can bodies ( | 06-10-2010 |
20130055785 | THERMOFORMING EQUIPMENT FOR THE FORMATION OF METALLIC PACKAGES WITH PRE-FLAP FORMATION - It is understood as being preferably intended for the manufacture of cans through spinning, molding the can bodies in the most varied shapes, also enabling the attainment of deep necking or die-necking in the can bodies; it may be used for the several purposes, from food and beverage cans, to chemicals and others, and they may be manufactured in several materials such as tin foil, chromed sheet and black plate, using the spinning process molding the can bodies, being able to be used in several types of cans, from those which use metallic, plastic or mixed lids (compound plastic+metallic), clamped such as those using metallic, plastic or mixed (compound plastic+metallic) lid system and unclamped, provided with sealing gaskets and vacuum closure. | 03-07-2013 |
20130078056 | EXPANSION PROCESS FOR CONFORMATION OF TWO PARTS METAL PACKS, AND EXPANSION PROCESS EQUIPMENT FOR CONFORMATION OF TWO PARTS METAL PACKS - The present invention relates to the manufacture of two-piece cans, comprising body and cover, with the most varied shapes of bodies, enabling expansion by means of various processes through the specific tooling, that expands the format desired to be obtained. The body of the can ( | 03-28-2013 |