Look
A. Thomas Look, North Reading, MA US
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20100087358 | NOTCH mutations leading to increased receptor signaling - The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients. | 04-08-2010 |
20110054001 | CHK1 SUPPRESSES A CASPASE-2 APOPTOTIC RESPONSE TO DNA DAMAGE THAT BYPASSES P53, BCL-2 AND CASPASE-3 - The invention describes methods that are useful for treating cancer by administering a Chk1 inhibitor which can induce apoptosis in p53-defective cells when combined with a chemotherapy and/or radiotherapy. Methods for screening candidates for a Chk1 inhibitor-based cancer treatment regimen are also described. | 03-03-2011 |
20110166028 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step. | 07-07-2011 |
Douglas Look, Ithaca, NY US
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20140099622 | HIERARCHICAL LEARNING ENVIRONMENT - A design application allows one or more authors to create a learning path associated with a given topic. The learning path includes content curated from various online resources. The design application allows the authors to aggregate the content from the various online resources. The design application allows the author to curate content to include or associate with nodes. The design application also allows the authors to arrange the nodes in a hierarchy. When the learning path is complete, the design application presents the learning path to users. Users access the content within the learning path according to the hierarchy of the nodes. Advantageously, the author is able to present content, which may otherwise be distributed across the internet, within a cohesive learning path. | 04-10-2014 |
Douglas G. Look, Ithaca, NY US
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20090100368 | METHOD AND APPARATUS FOR PROVIDING ACCESS TO AND WORKING WITH ARCHITECTURAL DRAWINGS ON THE INTERNET - A method, apparatus, and article of manufacture provide access to architectural documents in a network based on-line web based system. Servers that are accessible from the Internet maintain persistent multiple architectural documents of different media types. An online user is provided, from the servers via the Internet, a set of basic virtual design tools that have persistent properties and may be copied. The virtual design tools may also be utilized to work with the architectural documents. A workspace is also provided for viewing, accessing, and modifying the architectural documents. | 04-16-2009 |
20130159833 | METHOD AND APPARATUS FOR PROVIDING ACCESS TO AND WORKING WITH ARCHITECTURAL DRAWINGS ON A PERSONAL DIGITAL ASSISTANT - A method, apparatus, and article of manufacture provide access to architectural documents in a network based on-line web based system. Servers that are accessible from the Internet maintain persistent multiple architectural documents of different media types. An online user is provided, from the servers via the Internet, a set of basic virtual design tools that have persistent properties and may be copied. The virtual design tools may also be utilized to work with the architectural documents. A workspace is also provided for viewing, accessing, and modifying the architectural documents. | 06-20-2013 |
Gary Look, Medford, MA US
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20120198351 | Automatically Testing a Web Application That Has Independent Display Trees - An automatic testing application is provided that can simulate a user interaction with a web application. The automatic testing application can determine that the web application has been completely displayed within a graphical user interface of a web browser using a consistent global page state. The automatic testing application can test that the web application has been correctly displayed by verifying a state of a visualization component of the web application using a communication component. Subsequently, the automatic testing application can transmit an event to the web application that can modify the state of the visualization component using the communication component. Once the automatic testing application has determined that the web application has been completely re-displayed, using the consistent global page state, the automatic testing application can test that the web application has been correctly re-displayed by verifying a modified state of the visualization component using the communication component. | 08-02-2012 |
20120293516 | KEYBOARD NAVIGATION AMONG VISUAL ELEMENTS IN A USER INTERFACE - A system navigates among visual elements of a user interface. The system receives a keystroke indicating navigating from a current visual element in a first direction, determines a next visual element that is substantially near the current visual element and in the first direction, and navigates to the next visual element. | 11-22-2012 |
20130038628 | AUTOMATED BOUNDING BOX GENERATION WITHIN THE BOUNDARIES OF ARBITRARY SHAPES - One embodiment is directed to a computer program, embodied on a computer readable medium. The computer program is configured to control a processor to execute instructions. The instructions include sampling a plurality of points that lie within the interior of an arbitrary shape, drawing one or more rectangles from each of the points, gradually increasing the length and width of the rectangles until the rectangles no longer falls within the interior of the arbitrary shape, and assigning the largest of the increased rectangles as the interior bounding box. | 02-14-2013 |
20130083056 | INTERACTIVE DISPLAY ELEMENTS IN A VISUALIZATION COMPONENT - One embodiment is directed to a computer program, embodied on a computer readable medium. The computer program is configured to control a processor to execute instructions. The instructions include receiving one or more files as input. The files may each include descriptions of different shapes. The instructions may further include interpreting each of the files as a layer of shapes, converting each of the shapes into an interactive element, layering the converted shapes onto one another to create a custom interactive display, and displaying the custom interactive display. | 04-04-2013 |
Gregory Look, Seattle, WA US
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20140143162 | SYSTEM AND METHOD FOR GATHERING DATA FOR DETECTING FRAUDULENT TRANSACTIONS - A system and method for gathering data for detecting fraudulent transactions includes, in one embodiment, a web page that contains a fraud data gathering script and causes a client device to download a fraud detection applet. The fraud data gathering script causes the client device to collect information from the client device that is usable to identify the client device. The fraud detection applet causes the client device to connect to an identification echo service server to obtain the actual IP address of the client device. The fraud detection data, including the identifying information and the actual IP address, are then sent to a web server and/or a fraud data gathering server for further processing and to determine whether a transaction with the client device is likely to be fraudulent. | 05-22-2014 |
Heather Look, Bloomington, MN US
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20120064874 | MOVIE MODE AND CONTENT AWARDING SYSTEM AND METHOD - A system and method is presented for awarding content to users of mobile devices for attending events, appearing at locations, or viewing audiovisual content. One embodiment also automatically alters the configuration of mobile devices, which is particularly useful in movie theaters. An application on the device recognizes an audible signal provided at the location or in the audiovisual content. The signal can also be used to unlock content. In this way, desired content is available only when the user has attended an event such as an event sponsored by the content creator. The content can relate to the event, and can be synchronized to the event. The signal can also trigger an application or unlock content at a store location. For example, a scavenger hunt can be guided by an application on the mobile device. | 03-15-2012 |
20150205578 | MOVIE MODE AND CONTENT AWARDINGI SYSTEM AND METHOD - A system and method is presented for awarding content to users of mobile devices for attending events, appearing at locations, or viewing audiovisual content. One embodiment also automatically alters the configuration of mobile devices, which is particularly useful in movie theaters. An application on the device recognizes an audible signal provided at the location or in the audiovisual content. The signal can also be used to unlock content. In this way, desired content is available only when the user has attended an event such as an event sponsored by the content creator. The content can relate to the event, and can be synchronized to the event. The signal can also trigger an application or unlock content at a store location. For example, a scavenger hunt can be guided by an application on the mobile device. | 07-23-2015 |
Heather Winter Look, Bloomington, MN US
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20160134755 | SYSTEMS AND METHODS FOR PREDICTIVE PERSONALIZATION AND INTELLIGENT ROUTING - Systems and methods for intelligently routing a member of an organization to a single point-of-contact within an optimized, secure network to address all the member's healthcare needs are described. The disclosed intelligent routing configurations transform and process, in real-time, vast amounts of member data to generate specialized effort scores specific to each member's household. The effort scores, among other things, are used to determine an appropriate tier within the organization to route the member, and its account file containing real-time member and household level data. | 05-12-2016 |
Jee Look, Boyds, MD US
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20150335752 | Temperature Stable Vaccine Formulations - Formulations of vaccine antigen, such as anthrax protective antigen, are provided that are stable after undergoing freeze and thaw conditions. Methods of using the formulations to prepare vaccine are also provided. Vaccines comprising the formulations are useful, for example, to protect against, inhibit or alleviate a disease or infection, such as related to anthrax infection. | 11-26-2015 |
Jee Loon Look, Boyds, MD US
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20120308618 | IC31 NANOPARTICLES - The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL | 12-06-2012 |
20130034580 | NOVEL FORMULATIONS WHICH STABILIZE AND INHIBIT PRECIPITATION OF IMMUNOGENIC COMPOSITIONS - The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like. | 02-07-2013 |
20150216967 | IC31 NANOPARTICLES - The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL | 08-06-2015 |
Jee Loon Look, Gaithersburg, MD US
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20110172393 | NOVEL FORMULATIONS WHICH STABILIZE AND INHIBIT PRECIPITATION OF IMMUNOGENIC COMPOSITIONS - The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like. | 07-14-2011 |
Jee Loon Look, Cary, NC US
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20080206281 | Method For Producing Storage Stable Viruses and Immunogenic Compositions Thereof - The invention relates to methods for producing storage stable virus compositions. In certain embodiments, the invention relates to one or more formulations and process steps which result in storage stable virus compositions, wherein the composition is storage stable as a lyophilized solid composition or a frozen liquid composition. | 08-28-2008 |
Kal Look, Oxford GB
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20110024733 | POLYMERISABLE COMPOSITIONS AND ORGANIC LIGHT-EMITTING DEVICES CONTAINING THEM - Compositions of a mixture of a thiol material and a material that contains a reactive unsaturated carbon-carbon bond that can be polymerised to form a charge-transporting or luminescent film are described, as is an organic light-emitting diode (OLED) device comprising at least one such charge-transporting or emissive layer that has been formed by polymerising a thiol material and an ene material. The process for forming such an OLED, including the deposition of a layer of material comprising the polymerisable composition, from solution, exposing said layer to actinic radiation through a mask, and then optionally developing said film to form a photopatterned film, is also disclosed. | 02-03-2011 |
Lena Look, Mantorp SE
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20110139546 | HYDRAULIC SYSTEM FOR DOUBLE STACKER INDUSTRIAL TRUCK - The invention relates to hydraulic system for an double stacker truck comprising a pump for providing hydraulic fluid to the hydraulic system and a first hydraulic lifting cylinder for moving a first load carriage and a second hydraulic lifting cylinder for moving a second load carriage of the truck, the hydraulic lifting system is characterized in a flow divider for dividing the flow of hydraulic fluid between the first and the second hydraulic cylinder and a first directional valve which is arranged open in a first direction for leading hydraulic fluid to the first lifting cylinder or to open in a second direction for leading hydraulic fluid to the second hydraulic cylinder. The invention also relates to a double stacker truck comprising a hydraulic system for moving the load carriages of the truck. | 06-16-2011 |
Maxime P. Look, Amsterdam NL
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20120184455 | Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders - The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment. | 07-19-2012 |
Michael Look, Seattle, WA US
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20150118318 | Methods of Treating Inflammatory and Autoimmune Diseases and Disorders - Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder. The nanolipogel includes a lipid bilayer surrounding a hydrogel core, which may optionally include a host molecule, for example, an absorbent such as a cyclodextrin or ion-exchange resin. In preferred embodiments at least one of active agents is an immunosuppressant. | 04-30-2015 |
Michael Wai-Haung Look, New Haven, CT US
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20120171698 | METHOD AND DEVICE FOR RAPID PARALLEL MICROFLUIDIC MOLECULAR AFFINITY ASSAYS - Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel. | 07-05-2012 |
Michael Wai-Haung Look, Seattle, WA US
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20100081216 | METHOD AND DEVICE FOR RAPID PARALLEL MICROFLUIDIC MOLECULAR AFFINITY ASSAYS - Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel. | 04-01-2010 |
Paul M. Look, Plano, TX US
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20130100349 | Apparatus and Method for Black Bar Detection In Digital TVs and Set-Top Boxes - This invention is a preprocessor apparatus and method algorithm facilitating black bar detection in video frames or fields. The preprocessing marks a sharp discontinuity between pixels a predetermined distance apart on each line. On first detection of this discontinuity the location and pixel value is stored. The location and pixel value is also stored for the last discontinuity in the line. This data enables software to detect top horizontal bars, bottom horizontal bars, left vertical bars and right vertical bars. | 04-25-2013 |
Sally Look, Spicewood, TX US
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20130045253 | ORAL ANTIDEPRESSANT FORMULATION WITH REDUCED EXCIPIENT LOAD - Provided are methods for reducing the excipient load of pharmaceutical formulations containing 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide as the active pharmaceutical ingredient, and compositions related thereto. In particular, provided is a pharmaceutical product comprising 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide and a stabilizer admixed throughout a solid-form unilamellar matrix, wherein the ratio of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide to stabilizer ranges from about 2:3 to about 1:10, and related methods of forming the pharmaceutical product. | 02-21-2013 |
Sally A. Look, Spicewood, TX US
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20110206769 | ORAL ANTIDEPRESSANT FORMULATION WITH REDUCED EXCIPIENT LOAD - Provided are methods for reducing the excipient load of pharmaceutical formulations containing 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide as the active pharmaceutical ingredient, and compositions related thereto. In particular, provided is a pharmaceutical product comprising 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide and a stabilizer admixed throughout a solid-form unilamellar matrix, wherein the ratio of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide to stabilizer ranges from about 2:3 to about 1:10, and related methods of forming the pharmaceutical product. | 08-25-2011 |
Stefan Look, Kleve DE
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20140073381 | Agricultural Harvesting Machine - An agricultural harvesting machine includes a working assembly for processing a crop flow and a discharge accelerator for the processed crop that is designed as a unit to be installed in its entirety into an operating position (P | 03-13-2014 |
Stefan Look, Warendorf DE
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20150327439 | Forage harvester - A forage harvester includes a post-accelerator disposed in an interior of said forage harvester and comprising a conveying fan that rotates about a rotary axle. The post-accelerator is partially enclosed by a housing that is open in sections and that extends in sections into a crop-conveyance path. An extent of the extension into the crop-conveying path is adjusted by displacing the post-accelerator relative to the housing. The forage harvester also includes a wall disposed opposite an open section. The rotary axle includes ends that are mounted in bearing supports disposed on the housing via one end so as to be pivotable about a pivot axle. Each of the bearing supports are connected to an actuator at a free end opposing the one end disposed on the housing. | 11-19-2015 |
Thomas A. Look, North Reading, MA US
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20110110925 | Compositions and Methods for the Treatment and Diagnosis of Cancer - Compositions and methods for the diagnosis and treatment of cancer, particularly T-ALL, are disclosed. | 05-12-2011 |
20130178391 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles, or patterns, with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. It is to be understood and will be appreciated that the same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. Classifying may include stratifying the tumor (and thus stratifying a subject having the tumor), e.g., for a clinical trial. The methods may further comprise selecting a treatment based on the classifying step. The gene expression profiles may also aid in the early identification of patients who may be failing a therapeutic protocol with a gamma secretase inhibitor and thus provide the basis for early intervention. | 07-11-2013 |
Thomas F. Look, Ramsey, MN US
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20130248591 | COMBINED EVENT DRIVER AND FINANCIAL CARD - Combined use transaction cards are disclosed including preferably the functionality of being usable for conducting a financial transaction along with the additional functionality for activation or access to at least one other event. Many types of non-financial events are contemplated such as for access or entry, employee need, student need, and the like. Such cards preferably utilize electronically readable means as may be provided to such cards, such as including magnetic stripes, RFID transponders, OCR text, and one dimensional or two dimensional bar codes. | 09-26-2013 |
20140025518 | FINANCIAL CARD TRANSACTION SECURITY AND PROCESSING METHODS - Methods and systems for a secure financial transaction that can be processed through open loop or closed loop networks using electronically readable or visual data that is preferably provided or integrated into a financial card to determine network selection and card authentication and verification requirements. | 01-23-2014 |
Thomas Finley Look, Ramsey, MN US
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20120221466 | METHOD FOR IMPROVED FINANCIAL TRANSACTIONS - Disclosed are methods and processing techniques for modifying or changing a financial transaction that is being processed, such as for the purchase of goods or services. Methods of the present invention, in particular, relate to methods including the ability to use fixed or variable data, as such data is sent to a financial transaction processor, in order to modify the transaction, and thus changing the financial transaction that is being processed or the method of processing the financial transaction. The modifications that are made to the transaction enhance security to the buyer by disclosing less data during the transaction for others to potentially gain access. | 08-30-2012 |
20130042966 | SECURE DEVICES FOR PERSONAL OR ARTICLE IDENTIFICATION, SUCH AS DRIVER'S LICENSES AND VEHICLE LICENSE PLATES, AND METHODS OF PRODUCING SUCH IMPROVED DEVICES - Methods of personal and article identification and licensing are disclosed. Methods and constructions of cards and plates include driver's license fabrication and production for the purpose of regulating or identifying a driver and assuring their identity and compliance with jurisdictional regulations and license plate fabrication and production for the purpose of regulating or identifying a vehicle and assuring its identity and compliance with jurisdictional regulations. Driver's licenses and license plates are described herein as exemplary embodiments of identification cards and licensing devices that are produced according to certain processes of manufacturing and issuing. | 02-21-2013 |