Mao, US
Chengjian Mao, Savoy, IL US
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20090291972 | Compositions and Methods Relating to Nuclear Hormone and Steroid Hormone Receptors Including Inhibitors of Estrogen Receptor Alpha-mediated Gene Expression and Inhibition of Breast Cancer - The disclosure herein relates to nuclear hormone receptors including steroid hormone receptors, for example in connection with estrogen, progesterone, and androgen. Embodiments of compositions and methods are disclosed including such relating to compounds, including substituted theophyllines, capable of functioning as inhibitors of estrogen receptor alpha-mediated gene expression and having the ability to modify cancer cells and treat cancer, including breast cancers and resistant breast cancers, particularly those that are resistant to tamoxifen. In embodiments, methods of inhibiting breast cancer cells and resistant breast cancer cells are provided. In embodiments, a useful inhibitor compound includes TPSF/NSC 97998 and other compounds. | 11-26-2009 |
Chiayin Mao, Beaverton, OR US
Chien-Pei Mao, Clive, IA US
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20090065957 | INTEGRATED FUEL INJECTION AND MIXING SYSTEMS FOR FUEL REFORMERS AND METHODS OF USING THE SAME - Systems and methods for injecting and mixing a liquid hydrocarbon fuel to provide a uniform, homogenous fuel vapor mixture for introduction into a fuel reformer for use with a fuel cell are disclosed. Preferably, the system comprises a fuel injector that generates and aspirate a liquid fuel in the presence of an atomizing gas stream; a diverging-converging mixing chamber, into which the atomized fuel and a secondary fluid stream are introduced, to enhance the mixing of the fuel and the added heated gas or steam; and a mixer/swirler, which can be centrally located in the mixing chamber between the upper and lower chambers, to stabilize the fuel vapor mixture further for greater uniformity and homogeneity. More preferably, grooves and/or brazed wires can be provided on the surfaces of the mixing chamber and/or mixer/swirler to channel any accumulated fuel so as to provide sufficient time to evaporate the accumulated fuel. | 03-12-2009 |
20130047620 | CONICAL SWIRLER FOR FUEL INJECTORS AND COMBUSTOR DOMES AND METHODS OF MANUFACTURING THE SAME - A method of manufacturing gas and/or fuel swirlers for fuel injectors and combustor domes and cone-shaped swirlers so manufactured are disclosed. The disclosed conical swirlers feature cut-through slots on a cone-shaped body. The contour and spacing of the slots are configured and arranged to accommodate a wide range of requirements for fluid flow areas and swirl strengths. Preferably, the cone-shaped swirlers can be manufactured by wire EDM processing. More preferably, multiple cone-shaped swirlers can be manufactured simultaneously by nesting wirier blanks in a stack and wire EDM processing the stack as a unit. The cone-shaped pinwheel swirler fits well into various fuel injector heads, enabling the injectors to reduce the frontal surface area and flat area for minimal potential of carbon formation. | 02-28-2013 |
Chungsheng Mao US
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20100098716 | RECOMBINANT HUMAN EPO-FC FUSION PROTEINS WITH PROLONGED HALF-LIFE AND ENHANCED ERYTHROPOIETIC ACTIVITY IN VIVO - A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy. | 04-22-2010 |
20100099145 | RECOMBINANT HUMAN EPO-FC FUSION PROTEINS WITH PROLONGED HALF-LIFE AND ENHANCED ERYTHROPOIETIC ACTIVITY IN VIVO - A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy. | 04-22-2010 |
Guilin Mao, Beachwood, OH US
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20110122896 | HIGH-POWER DIODE END-PUMPED SOLID-STATE UV LASER - A high-power diode end-pumped solid-state UV laser comprises high-power fiber-coupled end pumping laser diodes, a specially designed fundamental laser cavity and multiple high-power high-efficiency harmonic generations. Nonuniform fundamental laser cavity has to be used, i.e. the beam size of the fundamental laser cannot be uniform in the fundamental cavity. Thermal transfer inside the laser crystal and harmonic crystal has to be specially and carefully treated, and special crystal mounts were designed to optimize the thermal contact and maximize the heat transfer. In addition, harmonic crystal mounts were specially designed to minimize the loss and protect the hydroscopic crystals. | 05-26-2011 |
20110188044 | REAL-TIME WIDE-RANGE REFLECTIVE AUTOCORRELATOR - In this invention, multiple pairs of reflective mirror on a high-precision stable rotation stage generate a repetitive wide range delay in a noncolinear intensity autocorrelator. Such autocorrelator is real-time, background-free, dispersion free. It has a continuous long scanning range, from a few femtoseconds to hundreds of picoseconds. | 08-04-2011 |
Guoqiang Mao, Peachtree City, GA US
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20110033617 | Composite Porous Materials and Methods of Making and Using The Same - The invention provides composite porous materials in which a second material is fused to and/or is in the pores and/or is fused directly to some of the pore walls of a porous first material. The invention also provides methods of filtering a fluid using these composite porous materials and methods of manufacturing the composite porous materials. | 02-10-2011 |
20120318139 | Sintered Porous Plastic Liquid Barrier Media and Applications Thereof - This application discloses porous self-sealing media comprising a sintered mixture of an absorbent material and a thermoplastic. The self-sealing media block passage of organic solvents or organic solvents in aqueous mixtures, wherein the organic solvents are at concentrations greater than about 40%. The self-sealing media also block acidic solutions. The self-sealing media are useful in a variety of applications such as a pipette tip filter, in line filter, vent, non-mechanical check valve, safety valve, and suction canister. | 12-20-2012 |
20130203089 | Filtered Adapter for Pipettors - The present invention relates to an adapter containing a filter that can be used with pipetting devices, particularly robotic pipetting devices, to efficiently connect the pipetting device to pipette tips with minimal distortion of the pipette tip. The present invention also relates to a process and a system of using an adapter containing a filter that can be used with pipetting devices, particularly robotic pipetting devices, to assemble the adapter together with an unfiltered pipette tip on the site of application. The adapter and pipette tip are each stackable for saving space at the work station. | 08-08-2013 |
20140017693 | Cards for Sample Storage and Delivery Comprising Sintered Porous Plastic - This application discloses cards comprising sintered porous plastic which may be employed in liquid sample collection, storage, transport and/or delivery to an analytical device. Sintered porous plastic materials provide a unique porous structure, an inert substrate, precise liquid holding capability, are quick drying, and easy to cut and handle. | 01-16-2014 |
20140018701 | Liquid Sampling, Storage, Transfer and Delivery Device - The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand. | 01-16-2014 |
20140188089 | SINTERED POROUS POLYMERIC CAPS AND VENTS FOR COMPONENTS OF MEDICAL DEVICES - The present application provides a device and methods of making and using these devices. The devices comprise porous caps and porous vents made from sintered porous polymeric media comprising plastic particles, elastomeric particles or a combination thereof. These devices are used with medical devices or components thereof to provide ease of use, resistance to infection, sterilization and venting. | 07-03-2014 |
20140205272 | CONDUCTIVE COMPOSITE WICK AND METHOD OF MAKING AND USING THE SAME - This invention relates to a conductive composite wick comprising a porous wicking element coupled a conductive element for releasing vaporizable materials from devices such as an air freshener device or insect control system. | 07-24-2014 |
20140217032 | SINTERED POROUS PLASTIC LIQUID BARRIER MEDIA AND APPLICATIONS THEREOF - This application discloses porous self-sealing media comprising a sintered mixture of an absorbent material and a thermoplastic. The self-sealing media block passage of organic solvents or organic solvents in aqueous mixtures, wherein the organic solvents are at concentrations greater than about 40%. The self-sealing media also block acidic solutions. The self-sealing media are useful in a variety of applications such as a pipette tip filter, in line filter, vent, non-mechanical check valve, safety valve, and suction canister. | 08-07-2014 |
20140234891 | Cards for Sample Storage and Delivery Comprising Sintered Porous Plastic - This application discloses cards comprising sintered porous plastic which may be employed in liquid sample collection, storage, transport and/or delivery to an analytical device. Sintered porous plastic materials provide a unique porous structure, an inert substrate, precise liquid holding capability, are quick drying, and easy to cut and handle. | 08-21-2014 |
20140249451 | Liquid Sampling, Storage, Transfer and Delivery Device - The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand. | 09-04-2014 |
20140296805 | HYDROPHOBIC POROUS NON MECHANICAL VALVE FOR MEDICAL SUCTION DEVICE - The present invention provides a porous non mechanical valve which retards or prevents the passage of bodily fluids and is resistant to being occluded or blocked by exposure to the surgical fumes or aerosols encountered during surgical procedures. | 10-02-2014 |
20150030512 | SINTERED POROUS PLASTIC PLUG FOR SEROLOGICAL PIPETTE - The present invention provides sintered porous plastic plugs for use in filtered serological pipettes which facilitate manufacture or assembly of the filtered serological pipettes. In one embodiment, a sintered porous plastic plug of the present invention comprises plastic and a cylindrical body, a first end and a second end, the first end having a cross-sectional area less than the cross-sectional area of the cylindrical body, and the second end having a cross-sectional area less than the cross-sectional area of the cylindrical body. | 01-29-2015 |
20150079614 | Liquid Sampling, Storage, Transfer and Delivery Device - The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand. | 03-19-2015 |
Guoqiano Mao, Smyrna, GA US
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20100081735 | FUNCTIONAL SURFACE COATING - Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein. | 04-01-2010 |
20120288717 | FUNCTIONAL SURFACE COATING - Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein. | 11-15-2012 |
Hai-Quan Mao, Baltimore, MD US
Patent application number | Description | Published |
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20090285892 | METHODS AND SYSTEMS FOR EXPANDING AC133+ CELLS AND DIRECTING DIFFERENTIATION - The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof. | 11-19-2009 |
20110125170 | HYDROGEL-GRAFTED DEGRADABLE NERVE GUIDES - The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides. | 05-26-2011 |
20110305768 | QUICK-DISSOLVING ORAL THIN FILM FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS - This invention describes a quick-dissolving thin film strips comprising bioactive components encapsulated within pH-sensitive polymeric microparticles. The microparticles are embedded within the thin film and provide protection to components encapsulated within. The invention further describes methods to incorporate bioactive components encapsulated within pH-sensitive polymeric microparticles into a quick-dissolving thin film strip while maintaining the bioactivity of the contained therapeutic agents during thin film formation and microencapsulation. | 12-15-2011 |
20120059399 | BIOLOGICAL TISSUE CONNECTION AND REPAIR DEVICES AND METHODS OF USING SAME - The instant invention provides compositions and methods for promoting the repair and/or growth of biological tissue, e.g., tubular biological tissue such as nerves. Specifically, the instant invention provides tissue connection devices and tissue repair devices and methods for using these devices. | 03-08-2012 |
20130296933 | Drug Loaded Microfiber Sutures for Ophthalmic Application - Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. In a preferred embodiment the suture materials are made from a poly(hydroxyl acid) such as poly(l-lactic acid) and a polyalkylene oxide such as poly(ethylene glycol) or a polyalkylene oxide block copolymer. The sutures entrap (e.g., encapsulate) one or more therapeutic, prophylactic or diagnostic agents and provide prolonged release over a period of at least a week, preferably a month. | 11-07-2013 |
20140081297 | BIODEGRADABLE NERVE GUIDES - The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides. | 03-20-2014 |
20140163589 | BIOLOGICAL TISSUE CONNECTION AND REPAIR DEVICES AND METHODS OF USING SAME - The instant invention provides compositions and methods for promoting the repair and/or growth of biological tissue, e.g., tubular biological tissue such as nerves. Specifically, the instant invention provides tissue connection devices and tissue repair devices and methods for using these devices. | 06-12-2014 |
Hanbin Mao, Kent, OH US
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20090296187 | Polymers responsive to radiation pressures - Polymers that undergo a reversible phase change in response to being exposed to a light from a laser having a radiation pressure greater than a threshold level. The phase changeable polymers have the ability to reduce the intensity of the laser and can advantageously scatter laser light incident on the polymers. The on-off response of such polymers is in the microsecond range and the light scattering property is independent of laser wavelength. The polymers can beneficially be incorporated into devices to protect human vision and optical instruments that are vulnerable to lasers at high intensities. Methods for making and using such devices are also disclosed. | 12-03-2009 |
20100099076 | SENSITIVE AND RAPID DETECTION OF VIRAL PARTICLES IN EARLY VIRAL INFECTION BY LASER TWEEZERS - The present system and methods allow for low level detection of as little as single pathogen particles, such as viral or bacterial particles, during the early stage of infection. An optical trapping system, such as laser tweezers, are used to trap a substrate to which an analyte has been bound to detect and record the thermal motion of an antibody-antigen interaction that may occur between an anti-viral antibody-coated microsphere and a viral particle for example. The system may be equipped with a detection system such as a position sensitive photodetector (PSD) to record the thermal motion of a trapped microsphere and particle at a certain frequency. The thermal motion data may be Fourier transformed into a power spectrum, which may be transformed into an output value using a Lorentzian equation. The power spectrum of the trapped microsphere may be recorded before and after binding of the pathogenic particle to determine the presence thereof. | 04-22-2010 |
20130005049 | DEVICES AND METHODS FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS - A device for detecting Single Nucleotide Polymorphism (SNP) and associated methods has been described. The stochastic behavior of a single-molecule probe is utilized to recognize wild type and SNP sequences in a microfluidic platform using a laser-tweezers instrument. The mechanical signal provides substantially noise free sensing with high sensitivity and the selectivity. The method has an inherent capacity to develop as a generic biosensor using other recognition elements such as aptamer for example. | 01-03-2013 |
Hanwen Mao, Annandale, VA US
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20100099076 | SENSITIVE AND RAPID DETECTION OF VIRAL PARTICLES IN EARLY VIRAL INFECTION BY LASER TWEEZERS - The present system and methods allow for low level detection of as little as single pathogen particles, such as viral or bacterial particles, during the early stage of infection. An optical trapping system, such as laser tweezers, are used to trap a substrate to which an analyte has been bound to detect and record the thermal motion of an antibody-antigen interaction that may occur between an anti-viral antibody-coated microsphere and a viral particle for example. The system may be equipped with a detection system such as a position sensitive photodetector (PSD) to record the thermal motion of a trapped microsphere and particle at a certain frequency. The thermal motion data may be Fourier transformed into a power spectrum, which may be transformed into an output value using a Lorentzian equation. The power spectrum of the trapped microsphere may be recorded before and after binding of the pathogenic particle to determine the presence thereof. | 04-22-2010 |
20100183628 | RANDOM HOMOZYGOUS GENE PERTURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR - A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail. | 07-22-2010 |
20140271671 | RANDOM HOMOZYGOUS GENE PERTURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR - A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail. | 09-18-2014 |
Hong Mao, North Andover, MA US
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20080238208 | DC-DC switching cell modules for on-board power systems - A DC-DC switching cell module includes a switch, a rectifier, an output filter coupled to the rectifier, and an input port for receiving an external PWM control signal from a controller. The switching cell module is configured to control the switch in response to the external PWM control signal to generate a DC output voltage from a DC input voltage. The switching cell module is configured for attachment to a circuit board as a discrete component. | 10-02-2008 |
20080238393 | Centralized controller and power manager for on-board power systems - A controller for controlling a plurality of DC-DC switching cells each configured to generate an output voltage in response to receiving a PWM control signal from the controller. The controller includes a plurality of output ports for outputting a plurality of PWM control signals, and at least one input port for receiving a plurality of output voltages from the plurality of switching cells. The controller is configured to sample the plurality of output voltages one at a time via a multiplexer and to regulate the output voltages in response to the sampling. | 10-02-2008 |
20110304206 | DC-DC SWITCHING CELL MODULES FOR ON-BOARD POWER SYSTEMS - A DC-DC switching cell module includes a switch, a rectifier, an output filter coupled to the rectifier, and an input port for receiving an external PWM control signal from a controller. The switching cell module is configured to control the switch in response to the external PWM control signal to generate a DC output voltage from a DC input voltage. The switching cell module is configured for attachment to a circuit board as a discrete component. | 12-15-2011 |
Hua Mao, Fayetteville, AR US
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20080287450 | Novel Substituted Tetracyclic Tetahydrofuran, Pyrrolidine And Tetrahydrothiophene Derivatives - This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT | 11-20-2008 |
20090023721 | Novel Substituted Tetracyclic Tetrahydrofuran, Pyrrolidine and Tetrahydrothiophene Derivatives and Their Use as a Medicament - This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT | 01-22-2009 |
20100331325 | NOVEL SUBSTITUTED TETRACYCLIC TETRAHYDROFURAN, PYRROLIDINE AND TETRAHYDROTHIOPHENE DERIVATIVES - This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT | 12-30-2010 |
Hui Mao, Alpharetta, GA US
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20090196831 | NANOSTRUCTURES, METHODS OF SYNTHESIZING THEREOF, AND METHODS OF USE THEREOF - A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an amphiphilic copolymer, wherein the hydrophobic protection structure encapsulates the magnetic iron oxide nanoparticle, and at least one amino-terminal fragment (ATF) peptide or epidermal growth factor receptor (EGFR) antibody conjugated to the amphiphilic copolymer. | 08-06-2009 |
Huina Mao, Bloomington, IN US
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20120158613 | PREDICTING ECONOMIC TRENDS VIA NETWORK COMMUNICATION MOOD TRACKING - A method of investigating public mood from a multi-dimensional model approach and a method to predict economic market trends above chance level based on the multi-dimensional model approach are provided. The text-content of several large-scale collections of daily network communications are analyzed via mood assessment tools, measuring various mood dimensions. A Granger Causality analysis investigated the correlation between daily changes in public mood states via results of the daily mood time series of the mood assessment tools with changes in value of the Dow Jones Industrial Average (“DJIA”) over time. Based on the above investigation, a Self-Organizing Fuzzy Neural Network model was trained to predict next-day DJIA value based on a combination of past DJIA values and public mood state measurements across several specified mood dimensions, such as calm and a combination of calm and happy. | 06-21-2012 |
Jian Mao, Huntington, WV US
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20080201930 | SUPPORT STRUCTURE FOR OPEN MRI AND METHOD AND SYSTEM THEREOF - A multi-layered support structure of an open magnetic resonance imaging (MRI) system, configured to provide high permeability to a magnetic flux from a source of a magnetic field, includes a first multi-layered support structure, a second multi-layered support structure and at least one third support structure, connecting the first multi-layered support structure and the second multi-layered structure. | 08-28-2008 |
Jianfeng Mao, Highlands, CO US
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20090063654 | APPARATUS, SYSTEM, AND METHOD FOR XML BASED DISCONNECTED DATA ACCESS FOR MULTIVALUED/HIERARCHICAL DATABASES - An apparatus, system, and method are disclosed for providing a client with disconnected data access to a non-relational database. A command module requests non-relational XML data from a non-relational database using an XML mapping in response to a non-relational data request. A fill module receives the non-relational XML data from the non-relational database and populates one or more data access sets with the non-relational XML data. A communications module transmits the one or more data access sets to an integration broker in communication with the integration adapter. | 03-05-2009 |
Jianfeng Mao, Highlands Ranch, CO US
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20090064037 | APPARATUS, SYSTEM, AND METHOD FOR XML BASED DISCONNECTED DATA ACCESS FOR MULTIVALUED/HIERARCHICAL DATABASES - An apparatus, system, and method are disclosed for providing a client with disconnected data access to a non-relational database. A command module requests non-relational XML data from a non-relational database using an XML mapping in response to a non-relational data request. A fill module receives the non-relational XML data from the non-relational database and populates one or more data access sets with the non-relational XML data. A communications module transmits the one or more data access sets to an integration broker in communication with the integration adapter. | 03-05-2009 |
Jianfeng Mao, Denver, CO US
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20100287208 | Object-Relational Based Data Access for Nested Relational and Hierarchical Databases - Mechanisms are provided for mapping objects and object-relationships in an object-oriented programming language to a nested relational database. Entity metadata constructs for an object relational mapping framework are obtained, the entity metadata constructs mapping fields in entities of an object model to fields in a data table of the nested relational database and identifying relationships between entities in the object model. A nested relational data model of the nested relational database is obtained, the nested relational data model specifying tables and sub-tables of the nested relational database. Tables and sub-tables of the nested relational database are mapped to a plurality of separate entities of the object model. Data in the nested relational database is accessed using the plurality of separate entities. The mapping is performed without normalizing the data of the tables and sub-tables of the nested relational database to a non-nested representation. | 11-11-2010 |
Jianhua Mao, Columbus, OH US
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20110130289 | BIOCIDE COMPOSITIONS COMPRISING BRANCHED ALKYL POLYGLYCOSIDES - Agrochemical compositions comprising (a) one or more branched alkyl polyglycosides, and (b) one or more biocides are disclosed. The compositions display improved solubility in water, and reduced foam generation. | 06-02-2011 |
20120184470 | Use Of Alk(en)yl Oligoglycosides In Enhanced Oil Recovery Processes - A method of recovering oil from a subterranean formation is suggested, comprising injection into said formation an aqueous composition comprising a surface-active amount of an alkyl or alkenyl oligoglycoside. | 07-19-2012 |
20120241151 | PROCESS FOR MINERAL OIL PRODUCTION USING SURFACTANTS FROM THE CLASS OF THE ALKYL POLYGLUCOSIDES - A process for mineral oil production, in which an aqueous surfactant formulation comprising at least one alkyl polyglucoside is injected into a mineral oil deposit through at least one injection borehole and crude oil is withdrawn from the deposit through at least one production borehole, wherein the formulation does not comprise any alcohols as cosolvents. | 09-27-2012 |
20140249029 | Solid Agricultural Compositions - Suggested are solid agricultural compositions, comprising: (a1) at least one alkoxylated alcohol according to general formula (I) R | 09-04-2014 |
Jianhua Mao, West Chester, OH US
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20100331185 | Herbicidal Compositions of Lithium Glyphosate and Adjuvants - Disclosed are herbicidal compositions comprising a lithium salt of glyphosate and one or more surfactants, the surfactant(s) enhancing the herbicidal efficacy of the lithium salt of glyphosate over that of the lithium salt of glyphosate alone. | 12-30-2010 |
20110028679 | Polyamides Prepared From Long-Chain Dicarboxylic Acids and Methods for Making the Polyamides - Polyamides according to formula (I): HO—[OC—(CH | 02-03-2011 |
Jianmin Mao, Winchester, MA US
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20100292236 | 5-Membered Heterocyclic Amides And Related Compounds - 5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies. | 11-18-2010 |
Jingkun Mao, Maricopa, AZ US
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20100127376 | SYSTEM AND METHOD TO PROVIDE RF SHIELDING FOR A MEMS MICROPHONE PACKAGE - A semiconductor package has a substrate. An opening is formed through the substrate. A first RF shield is formed around a perimeter of the opening. A first die is attached to the first surface of the substrate and positioned over the opening. | 05-27-2010 |
Junhua Mao US
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20100073979 | High-voltage-resistant rectifier with standard CMOS transistors - A high-voltage-resistant rectifier with standard CMOS transistors is disclosed in present invention. In a bridge full-wave rectifier comprising four MOS transistors, extra transistors are connected in series between the transistors which endure high voltage and the input to decrease the voltage imposed on the gate of them; moreover, the present invention provides a way to divide voltage imposed between the gate and the source of the said transistors by connecting in series with extra transistors, so it is achieved to implement a high-voltage-resistant rectifier with standard low voltage CMOS transistors without additional process complexity, and decreases manufacture and process costs. | 03-25-2010 |
Junsong Mao, Hanover, NH US
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20120012564 | Plasma Torch with LCD Display with Settings Adjustment and Fault Diagnosis - A portable plasma cutting system includes a power supply and a torch attachable to the power supply. The torch generates a plasma arc for cutting a workpiece. A gas valve is disposed in the system or the torch. The gas valve establishes a gas flow rate or a gas pressure in the torch. A controller is within the system and in communication with the power supply. The controller is capable of automatically manipulating the gas valve to establish the gas flow rate or pressure based upon a predetermined operating condition. A user activated switch is in communication with the controller. The switch has a first setting which causes the controller to automatically establish the gas flow rate or pressure based upon the predetermined operating condition, and a second setting which causes the controller to establish one of a user-determined gas flow rate or a user-determined gas pressure. | 01-19-2012 |
20140069895 | AUTOMATED CARTRIDGE DETECTION FOR A PLASMA ARC CUTTING SYSTEM - The invention features methods and apparatuses for establishing operational settings of a plasma arc cutting system automatically using replaceable cartridges. A replaceable cartridge for use with a plasma arc cutting system includes a housing, a connection mechanism for coupling the housing to a plasma arc torch, an arc constrictor connected to the housing, an arc emitter connected to the housing, and an identification mechanism disposed relative to the housing and configured to communicate information to a reader of the plasma arc cutting system and automatically set at least one operating parameter of the plasma arc cutting system. | 03-13-2014 |
20150027998 | PLASMA ARC CUTTING SYSTEM AND PERSONA SELECTION PROCESS - The invention features methods and apparatuses for establishing operational settings of a plasma arc cutting system. A plasma power supply includes a user selectable control. The user selectable control enables selection of a single cutting persona that establishes at least a current, a gas pressure or gas flow rate, and an operational mode of the plasma arc cutting system. | 01-29-2015 |
Justin Yik Ching Mao, Cambridge, MA US
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20120028969 | BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF - The present invention provides compounds of formula (I); | 02-02-2012 |
Leidong Mao, Athens, GA US
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20120267810 | DEVICES AND METHODS FOR FORMING NON-SPHERICAL PARTICLES - Embodiments of the present disclosure provide for devices, methods for forming non-spherical particles, and the like. | 10-25-2012 |
20130306566 | DEVICES AND METHODS FOR SEPARATING PARTICLES - Embodiments of the present disclosure provide for devices, methods for separating particles, and the like. | 11-21-2013 |
Leng Mao, Latham, NY US
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20100035098 | Using chemical shorting to control electrode corrosion during the startup or shutdown of a fuel cell - A technique that is usable with a fuel cell includes providing a fuel and oxidant mixture to a reactant chamber of the fuel cell to regulate an electrode potential of the fuel cell during startup or shutdown of the fuel cell. | 02-11-2010 |
20130288096 | MODULAR BATTERY - Systems for providing assemblies for containing multi-cell battery systems, and/or multi-cell batteries using such enclosures, are described. A battery case may be partitioned into a battery management portion and a cell portion. Each portion may be configured to accept corresponding battery components in a modular fashion allowing easy installation, removal, and access. The batteries may be configured for convenient handling, storage, and use in a variety of environments. | 10-31-2013 |
Mao Mao, Kirkland, WA US
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20090157326 | Diagnosis and prognosis of breast cancer patients - The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein. | 06-18-2009 |
20110301048 | DIAGNOSIS AND PROGNOSIS OF BREAST CANCER PATIENTS - The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein. | 12-08-2011 |
20120072124 | GENES ASSOCIATED WITH PROGRESSION AND RESPONSE IN CHRONIC MYELOID LEUKEMIA AND USES THEREOF - The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present invention also provides CML target genes, and methods and compositions for treating CML patients by modulating the expression or activity of these CML target genes and/or their encoded proteins. The invention also provides genes that are associated with resistance to imatinib mesylate (Gleevec™) treatment in CML patients, and methods and compositions for determining the responsiveness of a CML patient to imatinib mesylate treatment based on measurements of these genes and/or their encoded proteins. The invention also provides methods and compositions for enhancing the effect of Gleevec™ by modulating the expression or activity of these genes and/or their encoded proteins. | 03-22-2012 |
20130116145 | DIAGNOSIS AND PROGNOSIS OF BREAST CANCER PATIENTS - The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein. | 05-09-2013 |
Mao Mao, Redmond, WA US
Patent application number | Description | Published |
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20090004645 | Methods for Identifying Genes that Mediate a Response of a Living Cell to an Agent - In one aspect, the present invention provides methods for determining whether a gene mediates the response of a living cell to an agent. In another aspect, the present invention provides methods to identify a mammalian subject responsive to a KSP inhibitor. | 01-01-2009 |
20090239214 | Prognosis of breast cancer patients - The present invention relates to sets of genetic markers whose expression is correlated with prognosis of breast cancer in individuals having breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate individuals having a good prognosis, e.g., no reoccurrence or metastasis within five years of initial diagnosis, and individuals having a poor prognosis, e.g., reoccurrence or metastasis within five years of initial diagnosis. The invention relates to methods of prognosis using these markers. The invention also relates to microarrays containing probes to these markers, and to kits containing ready-to-use microarrays and computer software for data analysis using the prognostic and statistical methods disclosed herein. | 09-24-2009 |
Min Mao, College Park, MD US
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20090084646 | BI-FOLD VALVE-TYPE MAGNETORHEOLOGICAL FLUID ENERGY ABSORBING DEVICE - An energy absorbing device is provided that includes a damper assembly having inner and outer concentric tubes and a piston movable within the inner tube. The damper assembly is configured to form bi-fold valve-type cavities to operatively connect an inner chamber of the inner tube with an outer chamber formed between the inner and outer tubes. A magnetorheological fluid fills the chambers and the bi-fold valve-type cavities. The magnetorheological fluid preferably contains coated magnetic particles at about 10 to 60 percent by volume. Electrical coils adjacent the bi-fold valves are selectively energizable to such that the energy absorbing device provides a tunable damping force, preferably over the entire range of velocities of the piston, especially in automotive applications. | 04-02-2009 |
20090177446 | METHOD OF DESIGNING MAGNETORHEOLOGICAL FLUID ENERGY ABSORBING DEVICE USING HYDROMECHANICAL ANALYSIS - A method of designing a magnetorheological (MR) fluid energy absorbing damper is provided that uses hydromechanical analysis with lumped parameters to allow a determination as to whether a potential damper design will provide predetermined characteristics, such as a desired dynamic force range and maximum piston velocity, with a selected MR fluid and yield stress and preferably meeting predetermined geometric limitations. | 07-09-2009 |
Ou Mao, Mequon, WI US
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20110274976 | LITHIUM SECONDARY BATTERIES WITH POSITIVE ELECTRODE COMPOSITIONS AND THEIR METHODS OF MANUFACTURING - Positive electrodes for secondary batteries formed with a plurality of substantially aligned flakes within a coating. The flakes can be formed from metal oxide materials and have a number average longest dimension of greater than 100 μm. A variety of metal oxide or metal phosphate materials may be selected such as a group consisting Of LiCoO | 11-10-2011 |
20120235642 | ENERGY SOURCE SYSTEMS HAVING DEVICES WITH DIFFERENTIAL STATES OF CHARGE - A system includes housing having a positive terminal and a negative terminal and one or more energy storage devices disposed therein. One system includes a first energy storage device that operates at a first state of charge level and a second energy storage device that operates at a second state of charge level. The second state of charge level is greater than the first state of charge level. | 09-20-2012 |
20120280435 | ACTIVE MATERIALS FOR LITHIUM-ION BATTERIES - Methods for forming a cathode active material comprise sintering flakes formed from a nickel, manganese, cobalt and lithium-containing slurry to form the cathode material having the formula Li | 11-08-2012 |
20140332731 | Electrode Composition for Battery - Carbon nanotube-based compositions and methods of making an electrode for a battery are disclosed. It is an objective of the instant invention to disclose a composition for an electrode of a battery incorporating three dimensional networks of carbonaceous materials comprising a bi-modal diameter distribution of carbon nanotubes, CNT(A) and CNT(B), graphene, carbon black and, optionally, other forms of carbon-based pastes. | 11-13-2014 |
Ou Mao, Walpole, MA US
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20110143182 | Battery Separator - A battery includes a separator with a trapping layer that traps dissolved metal ions. | 06-16-2011 |
20120034508 | Battery Separator - A battery includes a separator with a trapping layer that traps dissolved metal ions. | 02-09-2012 |
Qinwen Mao, Lowa City, IA US
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20100190243 | siRNA-MEDIATED GENE SILENCING WITH VIRAL VECTORS - The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors. | 07-29-2010 |
20110111491 | RNA INTERFERENCE SUPPRESION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF - The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules. | 05-12-2011 |
Qinwen Mao, Iowa City, IA US
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20080274989 | Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof - The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules. | 11-06-2008 |
20100144026 | siRNA-mediated gene silencing with viral vectors - The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors. | 06-10-2010 |
20110212520 | RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF - The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules. | 09-01-2011 |
20140287492 | RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF - The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules. | 09-25-2014 |
Runsheng Mao, Clinton, NY US
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20090084469 | MATERIALS HAVING INCREASED MOBILITY AFTER HEATING - Materials having increased mobility after heating are disclosed. In one particular exemplary embodiment, the materials may be realized as a material which has reduced apparent molecular weight and/or viscosity and thus increased mobility after a heating process, and which consequently allows material residue to be more easily removed during subsequent cleaning processes. Such a material may be useful in any industrial process which requires heating the material followed by removing material residue. | 04-02-2009 |
Sara Mao, Mica, WA US
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20110041276 | CLEANING ARTICLE - A cleaning and polishing article broadly includes a body fitted for either a left hand or a right hand, and including at least two reversible coverings, each having opposing faces for treating a surface, the reversible coverings being attached to the body to form a plurality of pockets disposed on the body of the cleaning article, the reversible coverings being configured to be individually reversed to an opposing side of the body to expose an opposite side of one of the other reversible coverings for treating the surface. | 02-24-2011 |
Shane Mao, Pittsford, NY US
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20080214421 | CONTACT LENS CARE COMPOSITION - A method of disinfecting, cleaning or packaging a contact lens by contacting the lens with an ophthalmically acceptable lens care composition. The composition comprises a fatty acid monoester and a cationic antimicrobial component. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms, and an aliphatic hydroxyl portion. The invention is also directed to an ophthalmically acceptable lens care composition comprising a fatty acid monoester and a cationic antimicrobial component. | 09-04-2008 |
20100106128 | CONTACT LENS CASES FOR DELIVERY OF OPHTHALMIC AGENTS - Contact lens cases for delivering ophthalmic active agents to contact lenses. A contact lens case includes a container defining a reservoir for soaking a contact lens in a solution, and a lid assembly that may be secured to the container for closing the reservoir. The lid assembly includes a lid and a dispenser pack. The dispenser pack includes one or more compartments containing a treatment unit which may be dispensed from the compartment(s) into the solution. After the contact lens soaks in solution and retains or absorbs a suitable amount of the ophthalmic agent from the treatment unit, the contact lens is inserted in a user's eye for treating the eye. | 04-29-2010 |
20110063568 | CONTACT LENS - A method of making a contact lens involves depositing on a portion of a molding surface of a contact lens mold a colorant composition comprising a pigment, a copolymer of 2-hydroxyethylmethacrylate and N-vinylpyrrolidinone, and a crosslinking monomer. | 03-17-2011 |
Shane S. Mao, Pittsford, NY US
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20090215615 | METHOD OF FORMING SUPPORTED NANOPARTICLE CATALYSTS - A method of forming a supported catalyst, the method comprising forming a colloidal suspension of platinum-iron catalyst nanoparticles in a solvent, depositing at least a portion of the catalyst nanoparticles onto support particles, and removing at least a portion of the iron from the deposited catalyst nanoparticles. | 08-27-2009 |
Shi-Shan Mao, North Wales, PA US
Shuli Mao, Atlanta, GA US
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20090149416 | 2' and 3'-Substituted Cyclobutyl Nucleoside Analogs for the Treatment Viral Infections and Abnormal Cellular Proliferation - Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans. | 06-11-2009 |
20130172313 | Carbapenem Antibacterials with Gram-Negative Activity - The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. | 07-04-2013 |
Shun Mao, Milwaukee, WI US
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20120214172 | GRAPHENE-BASED FIELD-EFFECT TRANSISTOR BIOSENSORS - The disclosure provides a field-effect transistor (FET)-based biosensor and uses thereof. In particular, to FET-based biosensors using thermally reduced graphene-based sheets as a conducting channel decorated with nanoparticle-biomolecule conjugates. The present disclosure also relates to FET-based biosensors using metal nitride/graphene hybrid sheets. The disclosure provides a method for detecting a target biomolecule in a sample using the FET-based biosensor described herein. | 08-23-2012 |
Su-Yau Mao, Gaithersburg, MD US
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20090169546 | HIGH AFFINITY ANTIBODIES AGAINST HMGB1 AND METHODS OF USE THEREOF - Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies. | 07-02-2009 |
20100061987 | High Affinity Antibodies Against HMGB1 and Methods Of Use Thereof - Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies. | 03-11-2010 |
20110287023 | High Affinity Antibodies Against HMGB1 and Methods of Use Thereof - Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn's disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies. | 11-24-2011 |
Tiany Mao, Parkville, MD US
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20110256544 | MOLECULES INTERACTING WITH CASL (MICAL) POLYNUCLEOTIDES, POLYPEPTIDES, AND METHODS OF USING THE SAME - The present invention provides MICAL and MICAL-Like polypeptides and polynucleotides. Also provided are methods that for identifying agents that affect axon growth and placement. Furthermore, provided herein are methods for affecting axon growth and placement. | 10-20-2011 |
Tony Mao US
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20090124015 | Modular chemistry analyzer - A chemistry analyzer is disclosed that can include a unitary base with vertical and horizontal supports for constraining subassemblies. The subassemblies include at least a reagent/sample carousel subassembly, a transfer arm subassembly, and a reaction carousel subassembly. A centralized hydraulic system can also be provided behind a user access panel. The analyzer can use machine-readable test specifications coupled with its reagent vessels to define tests that include operations that employ the reagents. The analyzer can also display to the operator a pictorial representation that includes graphical elements that convey levels of usage for the storage vessels, and access icons that are each associated with a color and each lead to a set of screens for different types of operations for the analyzer. | 05-14-2009 |
Tony Mao, Natick, MA US
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20090028727 | Diluter pump for chemistry analyzers - A chemistry analyzer precision pump is disclosed. In one general aspect, it has a pump block that defines a first pump chamber with a fluid port at a first end, an opening for a piston at a second end, and a seal mount located between the opening and the port. A second, smaller, pump chamber also has a fluid port at a first end, an opening for a piston at a second end, and a seal mount located between the opening and the port. A first seal is mounted at the first seal mount and a second seal is mounted at the second seal mount. A first piston is mounted to reciprocate in the first pump chamber, past the first seal, and a second, smaller piston is mounted to reciprocate in the second pump chamber, past the second seal. The first and second pistons and the first and second pump chambers can be conically shaped. | 01-29-2009 |
20130126620 | MODULAR CHEMISTRY ANALYZER - Disclosed in one general aspect is a modular chemistry analysis test unit for a chemistry analyzer that includes one or more vessels for one or more reagents. A machine-readable test specification is coupled with the vessels and identifies a series of test operations that employ the reagents for the vessels. The specification includes one or more reagent quantity specifications that specify a quantity of the reagents to mix with a test sample, and one or more reaction duration specifications that specify a reaction time for the reagents and test sample. | 05-23-2013 |
20130130390 | MODULAR CHEMISTRY ANALYZER - An automated chemistry analysis method is disclosed. In one general aspect, the method includes receiving a modular chemistry analysis test unit that includes one or more vessels for one or more reagents, and a machine-readable test specification coupled with the vessels. The method also includes defining a test that defines a test including a series of operations that employ the reagents for the vessels, and installing the chemistry analysis test unit in a first chemistry analyzer that includes one or more analysis tools and sequencing logic for sequencing instructions to be carried out by the analysis tools. The machine-readable test specification is automatically received from the chemistry analysis test module and stored for access by the sequencing logic to allow the sequencing logic to instruct the analysis tools to carry out the test defined by the test specification. | 05-23-2013 |
20130132882 | MODULAR CHEMISTRY ANALYZER - Disclosed in one general aspect is a method of operating a chemistry analyzer method that includes determining usage levels associated with a plurality of storage vessels that store reagents for use by the analyzer. A pictorial representation that includes a plurality of graphical elements that convey levels of usage for the storage vessels is displayed to the operator. A series of access icons that are each associated with a color and each lead to a set of screens for different types of operations for the analyzer are also displayed, with the screens being color coded to correspond to the color associated with their respective access icons. | 05-23-2013 |
Wei Mao, Palatine, IL US
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20110151917 | METHOD AND APPARATUS FOR BRIDGING CALLS BETWEEN TWO DISPARATE PUSH-TO-TALK SYSTEMS - A PTT bridging gateway between a first PTT system and a second disparate PTT system: receives an invitation to a first client to join a first group call for a first group comprising multiple member clients on the first PTT system, wherein the first client is one of the member clients of the first group; determines that the first client is mapped to a second group comprising multiple member clients on the second PTT system; and initiates a second group call to the multiple member clients on the second PTT system. | 06-23-2011 |
20130115995 | METHOD AND APPARATUS FOR ENSURING CRITICAL RESOURCE ALLOCATION FOR GROUP CALLS MADE IN A PUSH-TO-TALK COMMUNICATION ENVIRONMENT - Critical resource data ( | 05-09-2013 |
20130136036 | METHOD AND APPARATUS FOR MANAGING QUALITY OF SERVICE SETTINGS FOR GROUP COMMUNICATIONS - A centralized quality of service (QoS) entity having a processing device performs a method for managing QoS settings for group communications. The method includes: determining a plurality of active participants of a group communication session; and determining, for each active participant, an individual QoS setting, including a first individual QoS setting for a first active participant. The method further includes modifying the first individual QoS setting based on the individual QoS setting for at least one other active participant, wherein the modified first individual QoS setting is applied to a session leg used by the first active participant during the group communication session. The active participants of the group communication session can be on the same or heterogeneous wireless networks. | 05-30-2013 |
20130272134 | SECURE AD HOC COMMUNICATION SYSTEMS AND METHODS ACROSS HETEROGENEOUS SYSTEMS - A method for rapid peer-to-peer link establishment among a set of mobile devices includes operating a first second device, advertising system attributes in a wireless beacon by the second device, receiving the system attributes from the wireless beacon at the first device, comparing the system attributes to a service needed by the first device, and, if the second device is compatible based on the comparing, establishing a wireless link by the first device to the second device. A system and wireless device for rapid peer-to-peer link establishment among a set of mobile devices are also described. | 10-17-2013 |
Weiwei Mao, Lehigh County, PA US
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20100314713 | Integrated Circuit Inductors with Reduced Magnetic Coupling - An IC inductor structure is provided which includes a first inductor element formed on a semiconductor substrate and at least a second inductor element formed on the semiconductor substrate proximate the first inductor element. The first inductor element has a first effective magnetic field direction associated therewith, and the second inductor element has a second effective magnetic field direction associated therewith. The first and second inductor elements are oriented relative to one another so as to create a non-zero angle between the first and second effective magnetic field directions. | 12-16-2010 |
Weiwei Mao, Macungie, PA US
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20090177457 | DUTY CYCLE DISTORTION (DCD) JITTER MODELING, CALIBRATION AND GENERATION METHODS - A method and system for modeling and calibrating duty cycle distortion (DCD) of a Serializer and Deserializer (SerDes) device, including first generating a clock DCD signal. Once the clock DCD signal is generated, it is calibrating based upon results obtained from a filtering process of the clock DCD signal. Once the clock DCD signal is calibrated, a data DCD signal is generated and calibrated based upon results obtained from a filtering process of the data DCD signal. | 07-09-2009 |
20090219057 | Systems and methods for determining an out of band signal - Various embodiments of the present invention provide systems and circuits that provide for out of band detection. As one example, an out of band detection circuit is disclosed that includes an input signal, a clock generation circuit, and a sampling circuit. The clock generation circuit receives the input signal and derives therefrom a sampling clock, and the sampling circuit is operable to sample the input signal at a time indicated by the sampling clock. | 09-03-2009 |
Weiying Mao, Decatur, IL US
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20100267095 | ESCHERICHIA COLI STRAINS WHICH OVER-PRODUCE L-THREONINE AND PROCESSES FOR THE PRODUCTION OF L-THREONINE BY FERMENTATION - The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the fermentative production of amino acids such as threonine. | 10-21-2010 |
Wendy L. Mao, Washington, DC US
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20090108237 | X-Ray-Induced Dissociation of H2O and Formation of an O2-H2 Alloy at High Pressure - A novel molecular alloy of O | 04-30-2009 |
Xiaole Mao, State College, PA US
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20090066936 | THREE-DIMENSIONAL (3D) HYDRODYNAMIC FOCUSING USING A MICROFLUIDIC DEVICE - A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-of-plane direction, the out-of-plane direction being normal to a plane including the curved channel. | 03-12-2009 |
20110013287 | Tunable Liquid Gradient Refractive Index Lens Device - A lens device includes a substrate having a channel and a first fluid flow path and a second fluid flow path. The first and second fluid flow paths at least partially in communication with the channel. A light emitting device is positioned adjacent to the channel. At least one first fluid source is in communication with the first fluid path such that a first fluid is moveable along the first fluid path and at least one second fluid source in communication with the second fluid path such that a second fluid is moveable along the second fluid path. The first second fluid paths are configured so the first fluid and second fluid move through the channel to define an adjustable liquid gradient refractive index distribution in the channel. Adjustment of the liquid gradient refractive index distribution permits a change of liquid lens focal distance or an angular adjustment of light emitted by the light emitting device. | 01-20-2011 |
20130021673 | Tunable Liquid Gradient Refractive Index Lens Device - A lens device includes a substrate having a channel and a first fluid flow path and a second fluid flow path. The first and second fluid flow paths at least partially in communication with the channel. A light emitting device is positioned adjacent to the channel. At least one first fluid source is in communication with the first fluid path such that a first fluid is moveable along the first fluid path and at least one second fluid source in communication with the second fluid path such that a second fluid is moveable along the second fluid path. The fluid paths are configured so the first fluid and second fluid move through the channel to define an adjustable liquid gradient refractive index distribution in the channel. Adjustment of the liquid gradient refractive index distribution permits a change of liquid lens focal distance or an angular adjustment of light. | 01-24-2013 |
Xiaole Mao, Mason, OH US
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20120196314 | THREE-DIMENSIONAL (3D) HYDRODYNAMIC FOCUSING USING A MICROFLUIDIC DEVICE - A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-of-plane direction, the out-of-plane direction being normal to a plane including the curved channel. Examples of the invention also include improved flow cytometers. | 08-02-2012 |
20130203008 | Oral Health Detection Device - A handle section for an oral health detection device that is capable of use with both diagnostic and non-diagnostic cleaning sections is disclosed. The handle section includes a motor and a drive shaft having a longitudinal axis; a coupling section at an end of the handle section for coupling a cleaning section thereto; a light source for emitting excitation radiation having a wavelength greater than about 580 nm; an assembly for directing the excitation radiation to the dental region of the mouth; a light sensor for receiving fluorescence radiation having a wavelength greater than about 850 nm reflected from dental deposits; a logic component operable to analyze the fluorescence radiation received by the light sensor; and a controller including a light source activating device that is activated when a diagnostic cleaning section including a coding device is coupled to the coupling section. | 08-08-2013 |
Xiaolin Mao, Tempe, AZ US
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20120147639 | HYBRID SPACE VECTOR PWM SCHEMES FOR INTERLEAVED THREE-PHASE CONVERTERS - Systems and methods for controlling a modular three-phase converter including two or more interleaved, parallel connected Voltage Source Converters (VSCs) utilizing a hybrid Space Vector Pulse Width Modulation (SVM) control scheme are provided. For the hybrid SVM control scheme, six active vectors utilized for SVM define six sectors in a space vector plane. Each sector is divided into two or more regions having corresponding optimal SVM switching sequences. In operation, a revolving reference voltage vector is sampled to provide a reference voltage vector. The SVM controller then identifies one of the regions in one of the sectors that corresponds to an angle and, in some embodiments, a magnitude of the revolving reference voltage vector and applies the corresponding optimal SVM switching sequence to the two or more interleaved, parallel connected VSCs. | 06-14-2012 |
Xuehong Mao, Salt Lake City, UT US
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20090201867 | Method for Allocating Resources in Cell-Edge Bands of OFDMA Networks - A method allocates bandwidth from a radio frequency spectrum in a cellular network including a set of cells. Each cell includes a base station for serving a set of mobile stations in the cell. An area around each base station is partitioned into a center region and an edge region. In each base station, cell-center bandwidth for use by the mobile stations in the center region is reserved according to an inter-cell interference coordination (ICIC) protocol, and cell-edge bandwidth for use by the mobile stations in the edge region is reserved according to the ICIC protocol. The bandwidth can be fixed or adaptive to reduce the signaling overhead. The adaptive bandwidth can be further partitioned into reserved and the free bands. Mobile stations are classified as primary and secondary users, depending on whether they use or are assigned the fixed or adaptive band radio resources. | 08-13-2009 |
20100081441 | Dynamic Radio Frequency Allocation for Base Station Cooperation with Interference Management - A method allocates bandwidth from a radio frequency spectrum in a cellular network including a set of cells. Each cell includes a base station for serving a set of mobile stations in the cell. An area around each base station is partitioned into a center region and a boundary region. In each base station, bandwidth for use in the center region is reserved according to an inter-cell interference coordination (ICIC) protocol, and bandwidth for use in the boundary region is reserved according to the ICIC protocol and a base station cooperation (BSC) protocol. Then, the bandwidth is allocated to mobile stations as the mobile stations communicate with the base station in the center regions and the boundary regions according to the bandwidth reservations. | 04-01-2010 |
Ying Mao, Newark, DE US
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20110245738 | Wearable Cable-Driven Exoskeleton for Functional Arm Training - A device and method for assisting a user to articulate a limb. The device has an upper section, a lower section, and at least one joint between the upper and lower section. The device comprises an exoskeleton with a first cuff coupled to the lower section of the user's limb, a second cuff coupled to the upper section of the user's limb and a third cuff coupled to a portion of the user's body above the upper section of the limb. At least one cable is attached to the first cuff and at least one cable is attached to the second cuff. A series of drivers located remotely from the exoskeleton are attached to cables and are connected to a processor. The processor transmits signals to the drivers to vary the lengths of the cables to guide articulation of the user's limb. | 10-06-2011 |
Yingwei Mao, Arlington, MA US
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20100015130 | DISC-1 PATHWAY ACTIVATORS IN THE CONTROL OF NEUROGENESIS - The invention relates to methods of treating neurological disorders in a subject, by activating a DISC1 pathway. Methods of promoting neurogenesis in adult neural progenitor cells, enhancing nerve generation and treating GSK3 disorders as well as related compositions are also provided. | 01-21-2010 |
20130004517 | DISC-1 PATHWAY ACTIVATORS IN THE CONTROL OF NEUROGENESIS - The invention relates to methods of treating neurological disorders in a subject, by activating a DISC | 01-03-2013 |
Yunyu Mao, Brooklyn, NY US
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20120041202 | Preparation of C-Pyrazine-Methylamines - A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis. | 02-16-2012 |
20120108812 | PROCESS FOR SUBSTITUTED 3-AMINO-5-OXO-4,5-DIHYDRO-[1,2,4]TRIAZINES - Processes including preparation of trans-4-[(3-amino-5-oxo-4,5-dihydro-[1,2,4]triazin-6-ylmethyl)-carbamoyl]-cyclohexanecarboxylic acid methyl ester, and its conversion to trans-4-(4-amino-5-substituted-imidazo[5,1-f][1,2,4]triazin-7-yl)-cyclohexanecarboxylic acid compounds. | 05-03-2012 |
20130261306 | PREPARATION OF C-PYRAZINE-METHYLAMINES - A process for preparing a compound of formula (I) or a salt thereof: (I) wherein R1 is H or optionally substituted aryl or heteroaryl; comprising reacting 2,3-dichloropyrazine with a suitable diaryl imine followed by hydrolysis. | 10-03-2013 |
Zhihong Mao, Redmond, WA US
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20120151381 | DEFINING ACTIONS FOR DATA STREAMS VIA ICONS - Embodiments provide visual programming constructs including icons representing conditions and actions for processing incoming data streams. A user selects icons corresponding to at least one of the conditions and at least one of the actions to define a rule. The selected condition relates to at least one element possibly present in the incoming data stream. Without compilation of the rule, at least one incoming data stream is analyzed based on the condition to detect a presence of the element within the incoming data stream. The action is performed based on the analysis. In some embodiments, formatting of the incoming data streams is altered according to the conditions and actions to personalize the incoming data stream. | 06-14-2012 |
Zhi-Hong Mao, Pittsburgh, PA US
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20080201284 | Computer-Implemented Model of the Central Nervous System - A computer-implemented model of the central nervous system includes at least one of a basal ganglia portion, a cerebral cortex portion coupled to the basal ganglia portion, or a cerebellum portion coupled to the cerebral cortex. Each one of the basal ganglia portion, the cerebral cortex portion, and the cerebellum portion is comprised of respective elements representative of real neuroanatomical structures of a central nervous system and the respective elements are adapted to perform functions representative of real neuroanatomical functions of the central nervous system. At least one of the basal ganglia portion, the cerebral cortex portion, or the cerebellum portion is adapted to control a plant. | 08-21-2008 |
Zhi-Hong Mao, Sewickley, PA US
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20120078381 | HUMAN-MACHINE INTERFACE BASED ON TASK-SPECIFIC TEMPORAL POSTURAL SYNERGIES - A synergy-based human-machine interface that uses low-dimensional command signals to control a high dimensional virtual, robotic or paralyzed human hand is provided. Temporal postural synergies are extracted from angular velocities of finger joints of five healthy subjects when they perform hand movements that are similar to activities of daily living. Extracted Synergies are used in real-time brain control, where a virtual, robotic or paralyzed human hand is controlled to manipulate virtual or real world objects. | 03-29-2012 |
Ziqing Mao, West Lafayette, IN US
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20100071052 | REVERSE PROXY ARCHITECTURE - Aspects of the subject matter described herein relate to a reverse proxy architecture. In aspects, a client that seeks to access a Web document via a proxy sends a request to the reverse proxy. The reverse proxy obtains the Web document from a server indicated by the request and modifies links therein so that if the links are clicked on or otherwise fetched by the client, the communication goes back to the reverse proxy. The reverse proxy may also modify cookies, if needed, so that the cookies refer to a domain or hostname associated with the reverse proxy. | 03-18-2010 |
Zixu Mao, Atlanta, GA US
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20120149645 | COMPOSITIONS AND MODULATION OF MYOCYTE ENHANCER FACTOR 2 (MEF2) - The disclosure relates to mitochondrial myocyte enhancer factor 2 (MEF2), Parkinson's disease, and other related diseases. In certain embodiments, the disclosure relates to analyzing the levels of mitochondrial MEF2 isoforms and/or its mitochondrial target gene ND6 in peripheral blood cells such as white blood cells as an indicator for neuronal mitochondrial MEF2 or ND6 and correlated the level to disease diagnosis, treatment, and prognosis. | 06-14-2012 |
20130065267 | CONJUGATES AND METHODS FOR MEASURING CHAPERONE-MEDIATED AUTOPHAGY - This disclosure relates to methods of detecting chaperone-mediated autophagy. In some embodiments, the disclosure relates to methods of measuring chaperone-mediated autophagy in living cells and in purified lysosomes. In some embodiments, the disclosure relates to methods of detecting, diagnosing, monitoring, and/or treating lysosomal diseases in a subject. | 03-14-2013 |
Zuhua Mao, Issaquah, WA US
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20090069681 | SYSTEM AND METHOD FOR SPATIAL COMPOUNDING USING PHASED ARRAYS - The present invention is directed to a system and method which makes a phased array look like a curved array for purposes of performing spatial compounding calculations. In one embodiment, the phased array is treated as though it were a curved array by creating both a virtual apex and a virtual radius of curvature. Based on this transformation, standard spatial-compounding resampling tables can be used just as they are with curved arrays. In one embodiment, after the data is compounded to form the target image, certain data is removed prior to the actual display. This removed data represents data generated by virtual rays the prior to the physical skin line of the phased array. | 03-12-2009 |
20140336513 | ULTRASONIC IMAGING METHOD AND DEVICE - Method and device for performing ultrasonic imaging on a region of interest are disclosed. The method comprises: emitting a first ultrasonic pulse and receiving a first ultrasonic echo signal; emitting a second ultrasonic pulse and receiving a second ultrasonic echo signal; emitting a third ultrasonic pulse and receiving a third ultrasonic echo signal; extracting echo signal components from the first ultrasonic echo signal, the second ultrasonic echo signal and the third ultrasonic echo signal; and producing an ultrasonic image of the region of interest according to the echo signal component; wherein, amplitude weighting of the third ultrasonic pulse is equal to the sum of amplitude weightings of the first ultrasonic pulse and the second ultrasonic pulse in magnitude. The method processes and modulates the plurality of ultrasonic echo signals, so as to separate nonlinear components and linear components in the ultrasonic echo signals. | 11-13-2014 |