Patent application number | Description | Published |
20110164803 | METHOD AND APPARATUS FOR DETERMINING MEAN CELL VOLUME OF RED BLOOD CELLS - A method and apparatus for determining a cell volume of a red blood cell is provided. The method includes the steps of: a) depositing a sample into an analysis chamber, the chamber defined by an first panel interior surface, a second panel interior surface, and a known or determinable height, which height is such that at least one red blood cell subject to a sphering agent assumes a partially compressed spherical shape in contact with the interior surfaces; b) imaging the at least one partially compressed spherical red blood cell contacting the interior surfaces, and producing image signals; c) determining a radius of the partially compressed spherical red blood cell from the image signals; and d) determining a volume of the imaged red blood cell using the determined radius. | 07-07-2011 |
20110171067 | GAS SENSITIVE STRUCTURE AND COMPONENT INCLUDING THE SAME - A component of a system configured to monitor one or more gaseous analytes. In one embodiment, the component comprises a conduit and a gas sensitive film. The conduit is formed to enable a flow of gas therethrough. The gas sensitive film is disposed in communication with the flow of gas, and is sensitive to one or more gaseous analytes within the flow of gas. In some instances, the film comprises a dye and a polymer matrix. The dye is sensitive to the one or more gaseous analytes. The polymer matrix carries the dye, is porous, and is formed such that the film has (i) a dynamic range of at least from about 20% to about 90% concentration of the one or more gaseous analytes, and (ii) a response time over at least a portion of the dynamic range of less than about 80 milliseconds. | 07-14-2011 |
20110293480 | SENSOR THAT COMPENSATES FOR DETERIORATION OF A LUMINESCABLE MEDIUM - A sensor that generates an output signal in response to a stimulus, wherein the output signal is generated with a predetermined relationship to one or more properties of the stimulus such that the one or more properties of the stimulus can be determined as a function of the output signal. In one embodiment the sensor comprises a component, a sensor processor, and a transmitter. The component deteriorates, thereby causing predictable fluctuations in the predetermined relationship between the output signal and the one or more properties of the stimulus. The sensor processor provides information related to the deterioration of the component. The transmitter wirelessly transmits the information provided by the processor. | 12-01-2011 |
Patent application number | Description | Published |
20080233116 | Human monoclonal antibodies to CTLA-4 - In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. | 09-25-2008 |
20080233122 | Human monoclonal antibodies to CTLA-4 - In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. | 09-25-2008 |
20120045442 | HUMAN MONOCLONAL ANTIBODIES TO CTLA-4 - In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. | 02-23-2012 |
20120148597 | HUMAN MONOCLONAL ANTIBODIES TO CTLA-4 - In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. | 06-14-2012 |
20140099325 | HUMAN MONOCLONAL ANTIBODIES TO CTLA-4 - In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein. | 04-10-2014 |
Patent application number | Description | Published |
20080205475 | UNSTABLE RESONATOR WITH VARIABLE OUTPUT COUPLING - Through the use of a relatively inexpensive third mirror on a novel folded hybrid unstable resonator configuration, the optimum output coupling for a given laser design can be explored quickly and easily with a minimum of intracavity mirror alignment. No changes in either the radii of curvature of the three cavity optics or their spacing are required for this exploration. In addition to providing techniques for purposefully and systematically introducing mirror edge effects or avoiding edges effects altogether, the invention provides that output beams of different width can be advantageously explored in a relatively simple and straightforward manner. The invention provides that higher geometric magnification cavity designs may be made compatible with low diffraction output coupling in a configuration that uses only three totally reflecting optics. | 08-28-2008 |
20090052010 | Apparatus for providing multiple independently controllable beams from a single laser output beam and delivering the multiple beams via optical fibers - An output beam from a laser is directed into an acousto-optic cell. The acousto-optic cell is driven by RF voltages at four different frequencies. A portion of the laser output beam is diffracted by the acousto-optic cell at four different angles to the laser output beam. This provides four secondary beams. The magnitude of the RF voltages applied to the acousto-optic cell and the power in the laser output beam may be cooperatively varied to provide a predetermined power in each of the secondary beams. The four secondary beams are directed into four beam separating optical fibers connected to four transport optical fibers for transporting the secondary beams to a location remote from the laser. Power in the beams is monitored at the output ends of the four optical fibers for controlling the magnitude of the RF voltages. All four beams are focused into the beam-separating fibers by a single lens. | 02-26-2009 |
20090065697 | Sub-millimeter wave frequency heterodyne detector system - The present invention relates to sub-millimeter wave frequency heterodyne imaging systems. More specifically, the present invention relates to a sub-millimeter wave frequency heterodyne detector system for imaging the magnitude and phase of transmitted power through or reflected power off of mechanically scanned samples at sub-millimeter wave frequencies. | 03-12-2009 |
20090244691 | APPARATUS FOR PROVIDING MULTIPLE TIME-DIVISION MULTIPLEXED INDEPENDENTLY CONTROLLABLE PULSED BEAMS FROM A SINGLE, PULSED LASER OUTPUT-BEAM - An output beam from a laser is directed into an acousto-optic cell. The laser beam includes repeated sequences of two or more pulses. The acousto-optic cell is sequentially driven by RF voltages at two or more frequencies. A portion of the laser output beam is diffracted by the acousto-optic cell at two or more different angles to the laser output beam. This provides two or more secondary beams. One of the secondary beams includes only the first pulses of the sequences; the other includes only the second pulses of the sequences. The duration of the pulses in the laser beam is controlled to control time-averaged power in the secondary beams. | 10-01-2009 |
20150083698 | VIA-HOLE DRILLING IN A PRINTED CIRCUIT BOARD USING A CARBON MONOXIDE LASER - Apparatus for drilling a via-hole in a printed circuit board (PCB) includes a carbon monoxide laser deliver laser radiation pulses. The pulses have a relatively broad wavelength-range, and slow rising and falling edges. The rising and falling edges of the pulses are clipped using and acousto-optic modulator. A dispersion-compensator compensates for dispersion in the clipped pulses introduced by the AOM. Achromatic focusing optics focus the dispersion-compensated, clipped pulses on the PCB for the via-hole drilling. | 03-26-2015 |