Patent application number | Description | Published |
20150266438 | COLLISION SENSING AND ENERGY ABSORBING APPARATUS - An apparatus includes an enclosed body defining a chamber therein. The body includes a rearward portion, a forward portion opposite the rearward portion and a first portion extending between the rearward and forward portions. The first portion has a stiffness less than at least one remaining portion of the body. The apparatus further includes at least one pressure sensor coupled to the body and the chamber to detect deformation of the first portion of the body. | 09-24-2015 |
20150298635 | BUMPER COMPONENT WITH EMBEDDED SENSOR - Exemplary methods of making a bumper component are disclosed, along with exemplary bumper assemblies and vehicles. An exemplary method may include providing a first mold portion defining at least in part a front surface, and positioning at least one sensor in the first mold portion. Exemplary methods may further include enclosing the at least one sensor within the first mold portion with a second mold portion. The second mold portion may define at least in part a rear surface. The method may further include forming a body within the first and second mold portions, thereby embedding the at least one sensor between the front and rear surfaces, the body extending between the front and rear surfaces. | 10-22-2015 |
20150336527 | FASTENING AND SENSING APPARATUS - An apparatus includes a body having a fastening portion and a pressure sensor coupled to the body apart from the fastening portion. The pressure sensor has a chamber therein. The body includes a first channel extending therethrough from an outside surface thereof. The first channel is in fluid communication with the chamber. | 11-26-2015 |
20150371092 | LOW-SPEED IMPACT DETECTION SENSOR ARRAY - A vehicle system has a sensor array and a processing device. The sensor array includes a first group of sensors and a second group of sensors. The sensors of the first group are offset relative to the sensors in the second group. The processing device is configured to determine a general shape of an impact object based at least in part on signals received from the sensor array. | 12-24-2015 |
Patent application number | Description | Published |
20110186538 | HOT-FILL CONTAINER HAVING FLAT PANELS - A container may employ an upper portion defining a mouth, a shoulder portion formed with the upper portion and extending away from the upper portion, a bottom portion forming a base, a sidewall extending between and joining the shoulder portion and the bottom portion, and a plurality of smooth surfaced vacuum panels formed in the sidewall, which may be separated by one or more strengthening grooves. The vacuum panels and/or the container in a profile view may form an hourglass shape. The container may also employ a sidewall utilizing three smooth, grooveless, vacuum panels, which may form a triangle in cross-section. The vacuum panels may be concave inward toward a central vertical axis of the container and have an hourglass shape when the container is viewed in a side view. | 08-04-2011 |
20120000921 | PRESSURE RESISTANT VACUUM/LABEL PANEL - A container comprising a finish, a sidewall portion extending from the finish, a base portion extending from the sidewall portion and enclosing the sidewall portion to form a volume therein for retaining a commodity, and a plurality of horizontally disposed rib members disposed in at least one of the sidewall portion and the base portion. The plurality of horizontally disposed rib members is continuously disposed about the sidewall portion or the base portion and, in some embodiments, defines a perimeter length about 3-5% shorter than perimeter lengths of adjacent lands. The plurality of horizontally disposed rib members providing improved structural integrity such that a pre-fill size of the container is approximately equal to a post-filled, cooled size of the container. | 01-05-2012 |
20120187069 | COMPACT SPHERICAL BOTTLE WITH FLAT SIDES - A plastic container with a longitudinal axis includes a neck region with an opening into the container. The container also includes a base region that closes off the container and a sidewall continuously extending from the neck region to the base region. The sidewall includes a rounded portion and at least one panel. The rounded portion lies substantially on an imaginary rounded object that is three dimensional and that is entirely rounded. The panel lies within an imaginary plane that intersects the imaginary rounded object. | 07-26-2012 |
20120205341 | VACUUM PANEL WITH BALANCED VACUUM AND PRESSURE RESPONSE - A container comprising a finish, a sidewall portion extending from the finish, a base portion extending from the sidewall portion and enclosing the sidewall portion to form a volume therein for retaining a commodity, and a panel area disposed in the sidewall portion. The panel area having a belt land portion and a pair of inset portions in mirrored arrangement relative to the belt land portion. | 08-16-2012 |
20120205342 | SHOULDER RIB TO DIRECT TOP LOAD FORCE - A container comprising a finish, a sidewall portion having a vacuum panel, a shoulder portion extending between the finish and the sidewall portion, a base portion extending from the sidewall portion and enclosing the sidewall portion to form a volume therein for retaining a commodity, and first inwardly-directed rib extending circumferentially and continuously about the container at an interface between the sidewall portion and the shoulder portion. The first inwardly-directed rib directing top loading forces exerted generally on the finish down the sidewall portion along opposing sides of the vacuum panel. | 08-16-2012 |
20150129537 | PRESSURE RESISTANT VACUUM/LABEL PANEL - A container comprising a finish, a sidewall portion extending from the finish, a base portion extending from the sidewall portion and enclosing the sidewall portion to form a volume therein for retaining a commodity, and a plurality of horizontally disposed rib members disposed in at least one of the sidewall portion and the base portion. The plurality of horizontally disposed rib members is continuously disposed about the sidewall portion or the base portion and, in some embodiments, defines a perimeter length about 3-5% shorter than perimeter lengths of adjacent lands. The plurality of horizontally disposed rib members providing improved structural integrity such that a pre-fill size of the container is approximately equal to a post-filled, cooled size of the container. | 05-14-2015 |
Patent application number | Description | Published |
20080258488 | LOAD-CARRYING BED SYSTEM AND CONSTRUCTION - A load-carrying bed system for attachment to a frame of a vehicle includes a headboard member adapted for securement to a first support component associated with the truck frame and a second separate support component associated with the truck frame. The second support component forms a portion of the frame along a lateral side of the vehicle. A left side wall member is adapted for securement to the second support component. A right side wall member is adapted for securement to the second support component. At least a portion of the headboard member overlaps at least a portion of the left side wall member and at least a portion of the right side wall member. The overlapping portions are secured to both the respective left and right side members and the second support component of the truck frame. | 10-23-2008 |
20080258498 | TRUSS STRUCTURE FOR PICKUP BED AREA - A truss structure for a vehicle having a bed area is provided and includes multiple truss members. The truss structure resides in each sidewall of the bed area. The truss members are made up of either stamped structures or a combination of roll-formed structures and stamped structures. | 10-23-2008 |
20100078968 | VEHICLE BED FRAME ASSEMBLY, SYSTEM AND METHOD - A vehicle frame assembly, system and method includes a vehicle frame assembly having a variable length longitudinal frame component. The longitudinal frame component is formed at a first length when used on a first vehicle type and formed at a second length when used on a second vehicle type. | 04-01-2010 |
20150151795 | VEHICLE BED FRAME ASSEMBLY, SYSTEM AND METHOD - A vehicle frame assembly, system and method includes a vehicle frame assembly having a variable length longitudinal frame component. The longitudinal frame component is formed at a first length when used on a first vehicle type and formed at a second length when used on a second vehicle type. | 06-04-2015 |
Patent application number | Description | Published |
20150073858 | METADATA-DRIVEN AUDIT REPORTING SYSTEM WITH HIERARCHICAL RELATIONSHIPS - A system is provided that reports audit data. The system defines audit metadata that defines a business object of an application module and an attribute of the business object as being auditable. The system further defines business object metadata that defines a hierarchical relationship between the business object and a child business object. The system further generates audit data for the attribute of the business object based on the audit metadata, where the audit data includes a history of modifications to the attribute of the business object. The system further displays the audit data within a user interface. The system further displays the business object and the hierarchical relationship between the business object and the child business object within the user interface based on the business object metadata. | 03-12-2015 |
20150074039 | METADATA-DRIVEN AUDIT REPORTING SYSTEM - A system is provided that reports audit data. The system defines metadata that defines a business object of an application module and an attribute of the business object as being auditable. The system further configures the metadata to enable auditing for the attribute of the business object. The system further generates audit data for the attribute of the business object based on the metadata, where the audit data includes a history of one or more modifications to the attribute of the business object. The system further stores the audit data within a shadow database table based on the metadata. The system further displays the audit data within a user interface. | 03-12-2015 |
20150074056 | EXTENSIBLE CUSTOMIZATION MIGRATION VIA PLUGGABLE INTERFACE - A pluggable migration framework can interface with a plurality of repositories that store metadata related to one or more applications. A user can customize the applications to suit the user's business requirements. The user can develop and test the customized applications in a source environment, and the customized features can be stored as metadata in one or more of the plurality of repositories. When the customized application is ready to be used by others, it can be migrated to a target environment. The pluggable migration framework can include an orchestrator that enables the user to export metadata from the plurality of repositories in the source environment, and import the metadata to a plurality of repositories in the target environment, without requiring the user to re-implement the custom features. | 03-12-2015 |
20150074103 | METADATA-DRIVEN AUDIT REPORTING SYSTEM WITH DYNAMICALLY CREATED DISPLAY NAMES - A system is provided that reports audit data. The system retrieves audit data that is stored in database tables, where the audit data includes a history of modifications to data, and where the audit data includes data values. The system further retrieves a display name that is stored in a lookup table, where the display name is associated with a data value of the data values within the lookup table. The system further displays the audit data within a user interface, where the display name is displayed within the user interface. | 03-12-2015 |
20150074747 | METADATA-DRIVEN AUDIT REPORTING SYSTEM THAT APPLIES DATA SECURITY TO AUDIT DATA - A system is provided that reports audit data. The system defines metadata that defines security conditions for a business object. The system further receives a request from a user to retrieve audit data contained within a database table, where the audit data includes a history of modifications to an attribute of the business object. The system further retrieves the audit data from the first database table. The system further applies the security conditions to the audit data based on the metadata. The system further displays the audit data within a user interface when the security conditions are satisfied. | 03-12-2015 |
Patent application number | Description | Published |
20130311747 | Memory Mapping and Translation for Arbitrary Number of Memory Units - A method for address translation in a memory comprising a plurality of memory streaming units (MSUs), wherein n represents the number of MSUs and n is not a power of two, and wherein the memory further comprises a striped region, the method comprising determining an MSU from among the plurality of MSUs having a physical address (PA) in the striped region corresponding to a logical address (LA) comprising performing a modulo n operation on less than all the bits representing the LA; and transmitting the LA to the MSU. | 11-21-2013 |
20140068132 | AUTOMATIC CONSTRUCTION OF DEADLOCK FREE INTERCONNECTS - Systems and methods for automatically building a deadlock free inter-communication network in a multi-core system are described. The example embodiments described herein involve deadlock detection during the mapping of user specified communication pattern amongst blocks of the system. Detected deadlocks are then avoided by re-allocation of channel resources. An example embodiment of the deadlock avoidance scheme is presented on Network-on-chip interconnects for large scale multi-core system-on-chips. | 03-06-2014 |
20140098683 | HETEROGENEOUS CHANNEL CAPACITIES IN AN INTERCONNECT - Systems and methods involving construction of a system interconnect in which different channels have different widths in numbers of bits. Example processes to construct such a heterogeneous channel NoC interconnect are disclosed herein, wherein the channel width may be determined based upon the provided specification of bandwidth and latency between various components of the system. | 04-10-2014 |
20140115218 | ASYMMETRIC MESH NoC TOPOLOGIES - A method of interconnecting blocks of heterogeneous dimensions using a NoC interconnect with sparse mesh topology includes determining a size of a mesh reference grid based on dimensions of the chip, dimensions of the blocks of heterogeneous dimensions, relative placement of the blocks and a number of host ports required for each of the blocks of heterogeneous dimensions, overlaying the blocks of heterogeneous dimensions on the mesh reference grid based on based on a guidance floor plan for placement of the blocks of heterogeneous dimensions, removing ones of a plurality of nodes and corresponding ones of links to the ones of the plurality of nodes which are blocked by the overlaid blocks of heterogeneous dimensions, based on porosity information of the blocks of heterogeneous dimensions, and mapping inter-block communication of the network-on-chip architecture over remaining ones of the nodes and corresponding remaining ones of the links. | 04-24-2014 |
20140115298 | ASYMMETRIC MESH NoC TOPOLOGIES - A method of interconnecting blocks of heterogeneous dimensions using a NoC interconnect with sparse mesh topology includes determining a size of a mesh reference grid based on dimensions of the chip, dimensions of the blocks of heterogeneous dimensions, relative placement of the blocks and a number of host ports required for each of the blocks of heterogeneous dimensions, overlaying the blocks of heterogeneous dimensions on the mesh reference grid based on based on a guidance floor plan for placement of the blocks of heterogeneous dimensions, removing ones of a plurality of nodes and corresponding ones of links to the ones of the plurality of nodes which are blocked by the overlaid blocks of heterogeneous dimensions, based on porosity information of the blocks of heterogeneous dimensions, and mapping inter-block communication of the network-on-chip architecture over remaining ones of the nodes and corresponding remaining ones of the links. | 04-24-2014 |
20140177473 | HIERARCHICAL ASYMMETRIC MESH WITH VIRTUAL ROUTERS - A network-on-chip configuration includes a first plurality of cores arranged in a two-dimensional mesh; a first plurality of routers, each of the first plurality of routers associated with a corresponding local one of the first plurality of cores, each of the first plurality of routers having a plurality of directional ports configured to provide connections to other ones of the first plurality of routers; a second plurality of cores disposed around a periphery of the two-dimensional mesh arrangement; and a second plurality of routers, each of the second plurality of routers associated with a corresponding local one of the second plurality of cores, and having a directional port configured to provide a connection to a neighboring one of the first plurality of routers. | 06-26-2014 |
20140177648 | TAGGING AND SYNCHRONIZATION FOR FAIRNESS IN NOC INTERCONNECTS - Systems and methods described herein are directed to solutions for NoC interconnects that provide end-to-end uniform- and weighted-fair allocation of resource bandwidths among various contenders. The example implementations are fully distributed and involve tagging the messages with meta-information when the messages are injected in the interconnection network. Example implementations may involve routers using various arbitration phases, and making local arbitration decisions based on the meta-information of incoming messages. The meta-information can be of various types based on the number of router arbitration phases, and the desired level of sophistication. | 06-26-2014 |
20140204735 | AUTOMATIC DEADLOCK DETECTION AND AVOIDANCE IN A SYSTEM INTERCONNECT BY CAPTURING INTERNAL DEPENDENCIES OF IP CORES USING HIGH LEVEL SPECIFICATION - Systems and methods for automatically building a deadlock free inter-communication network in a multi-core system are described. The example implementations described herein involve a high level specification to capture the internal dependencies of various cores, and using it along with the user specified system traffic profile to automatically detect protocol level deadlocks in the system. When all detected deadlock are resolved or no such deadlocks are present, messages in the traffic profile between various cores of the system may be automatically mapped to the interconnect channels and detect network level deadlocks. Detected deadlocks then may be avoided by re-allocation of channel resources. An example implementation of the internal dependency specification and using it for deadlock avoidance scheme is presented on Network-on-chip interconnects for large scale multi-core system-on-chips. | 07-24-2014 |
20140204764 | QOS IN HETEROGENEOUS NOC BY ASSIGNING WEIGHTS TO NOC NODE CHANNELS AND USING WEIGHTED ARBITRATION AT NOC NODES - Systems and methods described herein are directed to solutions for NoC interconnects that provide end-to-end uniform- and weighted-fair allocation of resource bandwidths among various contenders. The example implementations are fully distributed and involve computing weights for various channels in a network on chip (NoC) based on the bandwidth requirements of flows at the channels. Example implementations may involve using the weights to perform weighted arbitration between channels in the NoC to provide quality of service (QoS). The weights may be adjusted dynamically by monitoring the activity of flows at the channels. The newly adjusted weights can be used to perform the weighted arbitrations to avoid unfair bandwidth allocations. | 07-24-2014 |
20140211622 | CREATING MULTIPLE NOC LAYERS FOR ISOLATION OR AVOIDING NOC TRAFFIC CONGESTION - Systems and methods described herein are directed to solutions for Network on Chip (NoC) interconnects that automatically and dynamically determines the number of layers needed in a NoC interconnect system based on the bandwidth requirements of the system traffic flows. The number of layers is dynamically allocated and minimized by performing load balancing of the traffic flows between the channels and routes of different NoC layers as they are mapped. Additional layers may be allocated to provide the additional virtual channels that may be needed for deadlock avoidance and to maintain the isolation properties between various system flows. Layer allocation for additional bandwidth and additional virtual channels (VCs) may be performed in tandem. | 07-31-2014 |
20140331027 | ASYMMETRIC MESH NOC TOPOLOGIES - A method of interconnecting blocks of heterogeneous dimensions using a NoC interconnect with sparse mesh topology includes determining a size of a mesh reference grid based on dimensions of the chip, dimensions of the blocks of heterogeneous dimensions, relative placement of the blocks and a number of host ports required for each of the blocks of heterogeneous dimensions, overlaying the blocks of heterogeneous dimensions on the mesh reference grid based on based on a guidance floor plan for placement of the blocks of heterogeneous dimensions, removing ones of a plurality of nodes and corresponding ones of links to the ones of the plurality of nodes which are blocked by the overlaid blocks of heterogeneous dimensions, based on porosity information of the blocks of heterogeneous dimensions, and mapping inter-block communication of the network-on-chip architecture over remaining ones of the nodes and corresponding remaining ones of the links | 11-06-2014 |
20140376569 | MULTIPLE CLOCK DOMAINS IN NOC - Example implementations described herein are directed to a micro-architecture of NoC router clocking which allows for a flexible Globally Asynchronous Locally Synchronous (GALS) implementation. The example implementations allow arbitrary clock domain partitions to be defined across the system. The example implementations further involve allowing the components of the NoC to be configured by the user through a NoC generation system to achieve the desired arbitrary clock domain partitioning. | 12-25-2014 |
20150016257 | IDENTIFICATION OF INTERNAL DEPENDENCIES WITHIN SYSTEM COMPONENTS FOR EVALUATING POTENTIAL PROTOCOL LEVEL DEADLOCKS - Systems and methods for automatically building a deadlock free inter-communication network in a multi-core system are described. The example implementations described herein involve automatically generating internal dependency specification of a system component based on dependencies between incoming/input and outgoing/output interface channels of the component. Dependencies between incoming and outgoing interface channels of the component can be determined by blocking one or more outgoing interface channels and evaluating impact of the blocked outgoing channels on the incoming interface channels. Another implementation described herein involves determining inter-component communication dependencies by measuring impact of a deadlock on the blocked incoming interface channels of one or more components to identify whether a dependency cycle is formed by blocked incoming interface channels. | 01-15-2015 |
20150043575 | SUPPORTING MULTICAST IN NOC INTERCONNECT - Example implementations are directed to more efficiently delivering a multicast message to multiple destination components from a source component. Multicast environment is achieved with transmission of a single message from a source component, which gets replicated in the NoC during routing towards the destination components indicated in the message. Example implementations further relate to an efficient way of implementing multicast in any given NoC topology, wherein one or more multicast trees in the given NoC topology are formed and one of these trees are used for routing a multicast message to its intended destination components mentioned therein. | 02-12-2015 |
20150052309 | COMBINING ASSOCIATIVITY AND CUCKOO HASHING - Addition, search, and performance of other allied activities relating to keys are performed in a hardware hash table. Further, high performance and efficient design may be provided for a hash table applicable to CPU caches and cache coherence directories. Set-associative tables and cuckoo hashing are combined for construction of a directory table of a directory based cache coherence controller. A method may allow configuration of C cuckoo ways, where C is an integer greater than or equal to 2, wherein each cuckoo way C | 02-19-2015 |
Patent application number | Description | Published |
20080235816 | MULTIPLE INDUCIBLE GENE REGULATION SYSTEM - The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes. | 09-25-2008 |
20100275281 | Multiple Inducible Gene Regulation System - The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes. | 10-28-2010 |
20130267023 | Multiple Inducible Gene Regulation System - The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes. | 10-10-2013 |
20130276156 | Multiple Inducible Gene Regulation System - The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes. | 10-17-2013 |
20150067899 | Multiple Inducible Gene Regulation System - The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes. | 03-05-2015 |
Patent application number | Description | Published |
20090140134 | Hermetically Sealed Packaging and Neutron Shielding for Scintillation-Type Radiation Detectors - A well logging instrument includes a source of high energy neutrons arranged to bombard a formation surrounding the instrument. A scintillator sensitive to gamma radiation resulting from interaction of the high energy neutrons with the formation is disposed in the instrument. A neutron shielding material surrounds the scintillator. A neutron moderator surrounds the neutron shielding material. An amplifier is optically coupled to the scintillator. | 06-04-2009 |
20090150077 | Pulsed X-Ray Signal Processing - Method and system for analyzing electrical pulses contained in a pulse train signal representative of the interaction of x-ray bursts with a nuclear detector configured for subsurface disposal. The pulse train signal is sampled to form a digitized signal. The total energy deposited at the detector during an x-ray burst is determined from the digitized signal, and a count rate of x-ray pulses from the burst is determined. A subsurface parameter is determined using the total energy deposit. | 06-11-2009 |
20120187081 | Method for Optimizing the Spectral Performance of Scintillator Crystals - The invention provides a method for optimizing the spectroscopy performance of a spectroscopy scintillator by surrounding the scintillator by a reflector material, performing a scan or more sectors measuring resolution and light output at three or more axial locations on the crystal, where at least one location is close to the PMT or below the crystal (near the PMT) at least one location is at the end away from the PMT of the scintillator), and adjusting the surface finish of the crystal and/or the reflector to obtain equal light output and optimal resolution over the length and different azimuth of the crystal. | 07-26-2012 |
20130299713 | Multiplier Tube Neutron Detector - A neutron detecting device using a neutron-reactive material as the source of charged particles to feed conventional dynode-based electron multiplier which not gas-filled (i.e., with | 11-14-2013 |
20140319330 | ELPASOLITE SCINTILLATOR-BASED NEUTRON DETECTOR FOR OILFIELD APPLICATIONS - Embodiments described herein are directed to methods and neutron detectors for use in downhole and other oilfield applications. In particular, the neutron detector includes a scintillator formed at least partially from an elpasolite material. In a more specific embodiment, the scintillator is formed from a Cs | 10-30-2014 |
Patent application number | Description | Published |
20110142919 | Cytotoxic T-Lymphocyte-Inducing Immunogens for Prevention, Treatment and Diagnosis of Cancer - The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as ovarian carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against cancer. | 06-16-2011 |
20120141579 | Cytotoxic T Lymphocyte Inducing Immunogens for Prevention Treatment and Diagnosis of Cancer - The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as lung carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against lung and other cancers. | 06-07-2012 |
20140105925 | Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Dengue Virus Infection - Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHR) are significant global public health problems and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive T cell responses. Currently, there are no available tools to assess protective T cell responses during infection or post vaccination. The present invention incorporates immunoproteomics to uncover novel HLA-A2 specific epitopes derived from Dengue Virus (DV)-infected cells. These epitopes are conserved with epitope-specific CTLs cross-reacting against all four DV serotypes. These epitopes have potential as new informational and diagnostic tools to characterize T cell immunity in Dengue virus (DV) infection, and serves as a universal vaccine candidate complementary to current vaccines. | 04-17-2014 |
20140220117 | Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Cancer - The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as pancreatic carcinoma. The invention discloses peptides, polypeptides, and polynucleotides that can be used to stimulate a CTL response against pancreatic and other cancers. | 08-07-2014 |
20140248360 | NANOPARTICLE TUMOUR VACCINES - The present invention provides a vaccine for the prophylactic or therapeutic treatment of a tumour in a mammalian subject, as well as methods of using the vaccine, including in treatment of tumours and in generating a CTL response. The vaccine comprises a plurality of nanoparticles and a pharmaceutically acceptable carrier, salt or diluents. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises an epitopic peptide that is covalently linked to the core via a second linker, said second linker comprising a peptide portion and a non-peptide portion, wherein said peptide portion comprises the sequence X | 09-04-2014 |
20140302124 | Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of INFLUENZA VIRUS INFECTION - Influenza virus infection and the resulting complications are a significant global public health problem and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Improving humoral immunity to influenza is the target of current conventional influenza vaccines, however, these are generally not cross-protective. On the contrary, cell-mediated immunity generated by primary influenza infection provides substantial protection against serologically distinct viruses due to recognition of cross-reactive T cell epitopes, often from internal viral proteins conserved between viral subtypes. Efforts are underway to develop a universal flu vaccine that would stimulate both the humoral and cellular immune responses leading to long-lived memory. Such a universal vaccine should target conserved influenza virus antibody and T cell epitopes that do not vary from strain to strain. The present invention incorporates immunoproteomics to uncover novel MHC class I specific epitopes derived from influenza-infected cells. These epitopes are conserved with epitope-specific CTLs cross-reacting against various different influenza strains. These epitopes have potential as new informational and diagnostic tools to characterize T cell immunity in influenza infection, and serves as a universal vaccine candidate complementary to current vaccines. | 10-09-2014 |
Patent application number | Description | Published |
20150106869 | METHOD AND SYSTEM FOR DISTRIBUTING SECRETS - Secrets data representing one or more secrets required to access associated resources is provided along with secrets distribution policy data representing one or more secrets distribution factors used to control the distribution of the secrets. When a requesting virtual asset submits secrets request data, virtual asset profile data associated with the requesting virtual asset is obtained. The requesting virtual asset profile data is then analyzed using at least one of the secrets distribution factors to authenticate the requesting virtual asset. The requesting virtual asset profile data is then analyzed using one or more of secrets distribution factors to determine what secrets the requesting virtual asset legitimately needs. Authorized secrets data for the requesting virtual asset representing one or more authorized secrets is then generated. The requesting virtual asset is then provided access to the authorized secrets data. | 04-16-2015 |
20150128295 | METHOD AND SYSTEM FOR VALIDATING A VIRTUAL ASSET - Virtual asset creation data used to create a virtual asset is generated through a virtual asset creation system that includes primary virtual asset data. Secondary authentication data is also generated. When the virtual asset is launched, the secondary authentication data is passed to the virtual asset from the virtual asset creation system. The primary virtual asset data and secondary authentication data from the virtual asset creation system and the virtual asset, and/or one or more other sources associated with the virtual asset, are then sent to a virtual asset validation system through different communication channels. If the primary virtual asset data and secondary authentication data from the two sources match, or have a defined threshold level of similarity, the status of the virtual asset is transformed to the status of validated virtual asset eligible to receive sensitive data. | 05-07-2015 |
20150310221 | METHOD AND APPARATUS TO ROTATE DATA ENCRYPTION KEYS IN DATABASES WITH NO DOWN TIME - A database includes a first instance and a second instance. The first and second instances of the database are encrypted with a first encryption key and have content that is synchronized. Database queries from a user computing device are directed to the first instance of the database. A third instance of the database is created from one of the existing two instances of the database. The third instance is decrypted from the first encryption key and is encrypted with a second encryption key. Database queries from the user computing device are redirected from the first instance of the database to the third instance of the database without interrupting service to the user computing device. The process is repeated by creating additional instances of the database, encrypting the additional instances with new encryption keys, and by redirecting database queries to the additional instances of the database. | 10-29-2015 |
20150319177 | METHOD AND SYSTEM FOR PROVIDING REFERENCE ARCHITECTURE PATTERN-BASED PERMISSIONS MANAGEMENT - Reference architecture pattern role data representing reference architecture pattern roles to be associated with entities taking part in the development, and/or deployment, and/or operation of an application is generated. Reference architecture pattern tier data representing reference architecture pattern tiers used to create, and/or deploy, and/or operate an application using the reference architecture pattern is generated. For each reference architecture pattern role at least one access and/or operational permission is associated with each reference architecture pattern tier. At least one entity is assigned one of the reference architecture pattern roles and for each reference architecture pattern tier, the at least one entity is automatically provided the at least one access and/or operational permission associated with the reference architecture pattern role assigned to the entity. | 11-05-2015 |