Schindler, US
Adam Schindler, Longview, TX US
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20120094338 | CONTINUOUS PRODUCTION AND EXCRETION OF WAXY PRODUCTS FROM PHOTOSYNTHETIC ORGANISMS - This invention disclosed herein relates generally to production and maintenance of genetically modified organisms that are capable of continuously making and excreting valuable waxy products. | 04-19-2012 |
A. Russell Schindler, Traverse City, MI US
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20080196803 | SECTIONING APPARATUS FOR A PROTECTIVE FORM-FITTING COVER OF AN OBJECT - A sectioning apparatus ( | 08-21-2008 |
Christopher Schindler, Sammamish, WA US
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20090179983 | JOINING USERS TO A CONFERENCING SESSION - Architecture for combining an outbound contact via multiple communications modes and the joining of an invitee to a communications session (e.g., conference call, web conference, etc.) without requiring substantial authentication of the invitee, if at all. The invitee can be automatically connected to the session using the communication method of choice, for example, conference call session or web conferencing session. An invitation can be sent to the invitee through multiple communication channels such as phone, text messaging, SMS, MMS, and email. The architecture facilitates the automatic creation of meeting resources (conference call session or web conferencing session). The meeting (or session) organizer can be treated as an invitee and be contacted by an application to request join in the meeting resource. Moreover, the ability is provided to mix audio/video of meeting resources. The invitee and/or the organizer can have an interactive conversation with the invitee-join application using the communication modes. The invitee-join application can parse and understand invitee responses. | 07-16-2009 |
20090210822 | LOCATING MEETING USERS - The disclosed communications architecture allows meeting organizers to automatically search and find meeting invitees or other target users using all known, discoverable, and available communications channels such as the telephone, text messaging, SMS (short message service), MMS (multimedia messaging service), single-purpose applications (e.g., gadgets), and email, for example, to at least notify the invitees of the meeting. The meeting organizer can initiate the automatic searches for invitees who may have missed the session start, or who may not have responded to participating in the meeting prior to meeting start, for example. Optionally, contacted meeting invitees can be easily joined into a meeting using web conferencing or other conference services (e.g., call) so the meeting can get started. The meeting organizer is then updated on the search request status and any invitee responses. | 08-20-2009 |
20120158864 | CONTEXTUAL CONVERSATION FRAMEWORK - A platform and end user interface are provided as part of a contextual communications framework for enabling developers to add context to conversations before they start or as they occur. The context may be consumed through a communication application user interface or through an application associated with a contextual document or file. The exchanged context and any updates to it may be stored following the conversation such that subsequent continuations of the conversation may be provided with the updated context. | 06-21-2012 |
20120284618 | DOCUMENT BASED CONTEXTUAL COMMUNICATION - A service that is capable of tracking conversations related to documents, surfaces these documents appropriately to users and enables user-friendly notification of new communications associated with the discussed documents while respecting existing user experience, security, and privacy models of the various document and communication modalities. Conversations about particular content are made available within the context of that content through user interface elements that not only provide access to various communication modes, but also present discussion context in summary or detailed versions. | 11-08-2012 |
Daniel Schindler, Newton Upper Falls, MA US
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20110104049 | METHOD OF USING AN ANTI-CD137 ANTIBODY AS AN AGENT FOR RADIOIMMUNOTHERAPY OR RADIOIMMUNODETECTION - The current invention relates to the development and methods of use of a recombinant agonistic antibody anti-human CD137, and glycosylation variants thereof. These antibodies act as anti-cancer agents and/or immune modulators that are effective in shrinking solid tumors or other cancerous indications and preventing their recurrence. The types of cancer for which the contemplated antibody is effective in treating also include leukemia and lymphoma. In a preferred embodiment the recombinant antibodies of the current invention were produced in and purified from the milk of transgenic animals. In another preferred embodiment of the current invention the agonistic anti-CD137 antibodies of the invention can be conjugated to radionuclides for radioimmunodetection or radioimmunotherapeutic purposes, or conjugated to a toxin for enhanced therapeutic treatment of various cancers. | 05-05-2011 |
20120058047 | METHOD OF USING AN ANTI-CD137 ANTIBODY AS AN AGENT FOR RADIOIMMUNOTHERAPY OR RADIOIMMUNODETECTION - The current invention relates to the development and methods of use of a recombinant agonistic antibody anti-human CD137, and glycosylation variants thereof. These antibodies act as anti-cancer agents and/or immune modulators that are effective in shrinking solid tumors or other cancerous indications and preventing their recurrence. The types of cancer for which the contemplated antibody is effective in treating also include leukemia and lymphoma. In a preferred embodiment the recombinant antibodies of the current invention were produced in and purified from the milk of transgenic animals. In another preferred embodiment of the current invention the agonistic anti-CD137 antibodies of the invention can be conjugated to radionuclides for radioimmunodetection or radioimmunotherapeutic purposes, or conjugated to a toxin for enhanced therapeutic treatment of various cancers. | 03-08-2012 |
20140046033 | ANTIBODIES WITH ENHANCED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY ACTIVITY, METHODS OF THEIR PRODUCTION AND USE - The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease. | 02-13-2014 |
Daniel Schindler, Newton, MA US
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20120322681 | Methods for Preparative In Vitro Cloning - Methods and devices relate to the isolation of nucleic acids of interest from within a population of nucleic acids such as libraries of nucleic acid sequences. | 12-20-2012 |
20130059296 | Compositions and Methods For High Fidelity Assembly of Nucleic Acids - Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end double-stranded nucleic acid fragments having a restriction enzyme recognition sequence at both ends thereof; (2) producing via enzymatic digestion a plurality of cohesive-end double-stranded nucleic acid fragments each having two different and non-complementary overhangs; (3) ligating the plurality of cohesive-end double-stranded nucleic acid fragments with a ligase; and (4) forming a linear arrangement of the plurality of cohesive-end double-stranded nucleic acid fragments, wherein the unique arrangement comprises the target nucleic acid. In certain embodiments, the plurality of blunt-end double-stranded nucleic acid fragments can be provided by: releasing a plurality of oligonucleotides synthesized on a solid support; and synthesizing complementary strands of the plurality of oligonucleotides using a polymerase based reaction. | 03-07-2013 |
20130244884 | Methods for Nucleotide Sequencing and High Fidelity Polynucleotide Synthesis - Methods of obtaining sequence information about target polynucleotide having a predefined sequence are disclosed. The methods include sequencing by ligation and sequencing by polymerase. | 09-19-2013 |
20130296194 | Methods and Devices for Nucleic Acid Synthesis - Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed. | 11-07-2013 |
20130309725 | Methods and Devices for In Situ Nucleic Acid Synthesis - Disclosed are compositions, methods and devices for the in situ synthesis of nucleic acids. In an exemplary embodiment, a support-bound oligonucleotide is elongated by addition of one or more nucleotides by hybridization of a partially double-stranded oligonucleotide, ligation and removal of unwanted nucleotides. | 11-21-2013 |
20140141982 | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning - Methods and compositions relate to the sorting and cloning of high fidelity nucleic acids using high throughput sequencing. Specifically, nucleic acid molecules having the desired predetermined sequence can be sorted from a pool comprising a plurality of nucleic acids having correct and incorrect sequences. | 05-22-2014 |
Daniel J. Schindler, Novelty, OH US
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20140144351 | ADJUSTABLE TRAY ASSEMBLY FOR A FIXTURE, SUCH AS A TRIPOD OR OTHER MULTI-LEGGED DEVICE - A tray assembly adapted to be removably connected to a fixture, e.g. a tripod, ladder, chair, a rigid fixture or other single or multi-legged device, the assembly including a tray adapted to support objects, a securing mechanism for operatively attaching the tray to the fixture and optionally a support leg for maintaining the tray at a desired position in relation to the fixture. Methods for securing a tray assembly to a fixture and using the assembly are disclosed. | 05-29-2014 |
David Schindler, Lecanto, FL US
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20080294202 | Bone Anchor With Locking Cap and Method of Spinal Fixation - A bone anchor ( | 11-27-2008 |
20120253409 | BONE ANCHOR WITH LOCKING CAP AND METHOD OF SPINAL FIXATION - A bone anchor ( | 10-04-2012 |
20140249590 | BONE ANCHOR WITH LOCKING CAP AND METHOD OF SPINAL FIXATION - A bone anchor ( | 09-04-2014 |
David Schindler, Russell, OH US
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20140073994 | EVALUATION OF MOVEMENT DISORDERS - This disclosure relates to a system and method to evaluate movement disorders. A movement data aggregator can combine data from a plurality of sensors into an aggregate movement data describing multi-dimensional movement of a handheld device. A calculator to compute an indication of a movement disorder based on the movement vector data and user input data, the user input data being generated in response to physical interaction between the handheld device and a human machine interface of a computing device/machine that is separate from the handheld device. In some examples, the handheld device can communicate with computing device via a wireless interface. | 03-13-2014 |
David D. Schindler, Chagrin Falls, OH US
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20140163426 | PERFORMANCE TEST FOR EVALUATION OF NEUROLOGICAL FUNCTION - This disclosure relates to a system and method to implement a performance test to help evaluate a patient's neurological and cognitive function. The performance test can be executed by the patient autonomously using a portable computing device, such as a tablet computer or smart phone. The portable computing device can be programmed to execute a set of modules configured to assess motor and cognitive performance, such as a manual function test module, a cognitive processing speed test module, and a movement assessment test module. The set of modules can also include a collection module to aggregate test data from the manual function test module, the cognitive processing speed test module, and the movement assessment test module. | 06-12-2014 |
David D. Schindler, Russell, OH US
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20150094621 | OBJECT RECOGNITION BY TOUCH SCREEN - Devices, systems and methods are described that can facilitate recognition of an engagement between an object and a touch screen in the absence of human contact. Upon the engagement, an electrically conductive path can be established that extends from a surface of the touch screen such that sufficient electrons flow from the touch screen through the electrically conductive path to enable the recognition of the object on the touch screen in the absence of human contact with the object during continued presence of the object on the touch screen. | 04-02-2015 |
Edmund S. Schindler, Fairfield, CT US
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20130272940 | On Demand Generation of Ammonia for Small Industrial and Commercial Boilers - A system and method for reducing NOx emissions from a lean burn combustion source is provided. The system includes a blower passing air through a continuous duct having a hot portion and a reaction portion. The hot portion of the duct is positioned in the convective zone of the combustion source to heat the passing air for the reaction portion of the duct. An injector attached to a urea storage container is positioned in the reaction portion of the duct and sprays urea from the storage container into the heated air in the reaction duct for evaporation and decomposition into ammonia gas. The ammonia gas is then supplied to an injection grid in the exhaust duct of the lean burn combustion source upstream of a NOx reduction catalyst. The injection grid supplies the ammonia gas to the exhaust gas in the exhaust duct. | 10-17-2013 |
20150010872 | Hot Surface Igniter With Fuel Assist - A large-scale combustion system has a fuel line having a burner end, a burner at the burner end of the fuel line, a source of fuel flowing through the fuel line to the burner, a hot surface igniter adjacent to the fuel line, a flame holder disposed adjacent to the hot surface igniter, and a source of igniter combustion air. The hot surface igniter is activated to ignite the source of fuel, the ignited fuel leaving the burner, and the hot surface igniter is protected from a heat caused by the ignited fuel. A flame detector detects ignition of the source of fuel and in response to detection of ignition the hot surface igniter is deactivated. | 01-08-2015 |
20150093315 | Tunable AIG for Improved SCR Performance - A system for controlling reagent flow to an exhaust of a lean burn combustion source includes a plurality of decomposition ducts each being connected to at least one injection lance of a reagent injection grid and supplying reagent and hot carrier gas to the injection lance, and at least one metering valve in communication with each of the plurality of decomposition ducts that controls reagent injection rate to the injection lance. A method of controlling a reagent flow to an exhaust of a lean burn combustion source includes providing a reagent injection grid having at least one injection lance, supplying the reagent and hot carrier gas to the reagent injection grid from a plurality of decomposition ducts coupled to the injection grid, and controlling reagent injection rate to the injection grid via at least one metering valve in communication with each of the plurality of decomposition ducts. | 04-02-2015 |
Eric S. Schindler, Beaverton, OR US
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20130212905 | CHANNELED SOLE FOR AN ARTICLE OF FOOTWEAR - A sole structure for an article of footwear is provided. The sole structure extends longitudinally from a back edge to a front edge of the article of footwear and transversely from a medial side to a lateral side of the article of footwear. The sole structure includes an outsole having a ground-contacting layer. A first rib projects upward from the ground-contacting layer. The rib has side walls and an end wall. A channel is defined by the side walls and end wall. The channel opens downward through the ground-contacting layer and has a depth extending above the ground-contacting layer. The rib may have a multi-stage vertical stiffness profile. The sole structure may include a midsole attached to the outsole. An article of footwear having the sole structure attached to an upper is also provided. | 08-22-2013 |
20130340284 | ARTICLE OF FOOTWEAR WITH MULTI-LAYERED SUPPORT ASSEMBLY - An article of footwear including an upper and a sole assembly secured to the upper and including a support assembly having an upper member and a lower member spaced from the upper member. A first layer is positioned beneath and in contact with the upper member and has a wave shaped profile with a plurality of first wave crests and first wave troughs. A second layer is positioned above the lower member and has a wave shaped profile with a plurality of second wave crests and second wave troughs. | 12-26-2013 |
20140026438 | Sole Structure For An Article Of Footwear - A sole structure for an article of footwear includes one or more outsole portions. At least some of these outsole portions include a plurality of alternating upward-facing and downward-facing elongate channels. The channels may have a base and two sidewalls, with adjacent channels sharing a common sidewall. The bases of the downward-facing channels form an upper surface of the outsole portion and the bases of the upward-facing channels form a lower surface of the outsole portion. The sidewalls are arranged at non-perpendicular angles to the upper surface. A first outsole portion has a pressure-versus-strain curve having a local maximum at a “trip point” pressure value and a first strain value and wherein the pressure-versus-strain curve has a change in strain of at least approximately 10% before a second occurrence of the “trip point” pressure value is reached. An article of footwear having the sole structure attached to an upper is also provided. | 01-30-2014 |
20140165304 | Article Of Footwear Incorporating Foam-Filled Elements And Methods for Manufacturing The Foam-Filled Elements - An article of footwear may have an upper and a sole structure secured to the upper. The sole structure has a plurality of support elements, and each of the support elements include a shell and a core. The shell defines an interior void and is formed from a polymer material that extends around substantially all of the void. The core has a shape of the void and is located within the void, with at least a portion of the core being a polymer foam material. The polymer foam material of at least two of the support elements may have different densities. | 06-19-2014 |
20140230282 | ARTICLE OF FOOTWEAR WITH MULTI-LAYERED SUPPORT ASSEMBLY - An article of footwear including an upper and a sole assembly secured to the upper and including a support assembly having an upper member and a lower member spaced from the upper member. A first layer is positioned beneath and in contact with the upper member and has a wave shaped profile with a plurality of first wave crests and first wave troughs. A second layer is positioned above the lower member and has a wave shaped profile with a plurality of second wave crests and second wave troughs. | 08-21-2014 |
Eric Steven Schindler, Portland, OR US
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20100132221 | Article of Footwear or Other Foot-Receiving Device Having a Fluid-Filled Bladder with Support and Reinforcing Structures - Impact-attenuating elements, e.g., for use in footwear or other foot-receiving device products, may include: (a) a base member, such as a fluid-tight and/or other fluid-filled or fluid-containing enclosure element; (b) a support element integrally and contiguously formed in a surface of the base member; and/or (c) a spring device engaged with the support element. The support element and its corresponding spring device (if any) may include a non-planar surface (e.g., substantially parabolic shaped, cylindrically shaped, etc.) that extends in a direction into the base member and toward its opposite surface. The support element and its corresponding spring device (if any) also may include reinforcing structure(s), such as raised ribs extending along a surface of the support element and/or spring device. | 06-03-2010 |
Grant Schindler, Atlanta, GA US
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20080301133 | LOCATION RECOGNITION USING INFORMATIVE FEATURE VOCABULARY TREES - A location recognition technique that involves using a query image to identify a depicted location is presented. In addition to the query image, there is also a pre-constructed database of features which are associated with images of known locations. The technique matches features derived from the query image to the database features using a specialized vocabulary tree, which is referred to as an informative feature vocabulary tree. The informative feature vocabulary tree is specialized because it was generated using just those database features that have been deemed informative of known locations. The aforementioned matching features are used to identify a known location image that matches the query image. The location associated with that known location image is then deemed to be the location depicted in the query image. | 12-04-2008 |
Heather Thomson Schindler, New York, NY US
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20140051332 | MULTI-FABRIC GARMENT - A multi-fabric garment for slenderizing the midsection of a user includes a non-compressive upper section, a slenderizing compressive middle section, and a noncompressive lower section. The slenderizing middle section can include both compressive and noncompressive materials. | 02-20-2014 |
Jacob Harrison Schindler, Lake Park, GA US
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20120252671 | Herbicide method and apparatus - Apparatus and method for boring into the earth near a Kudzu vine root system to apply herbicidal helium gas to the roots and eradicate the Kudzu vine. The technique uses a perforated tube with a drill bit that protrudes from one end of the tube to bore into the earth near the vine roots. Boring is stopped when all of the tube perforations are below the earth's surface. About 0.5 cubic meters of helium gas are applied to flow through the tube enabling the helium gas to flow out through the tube perforations and attack the Kudzu vine through the vine's root system. | 10-04-2012 |
James R. Schindler, Lynnwood, WA US
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20100028123 | SUPERCONDUCTING CRAWLER SYSTEM FOR A PRODUCTION LINE - A method of operating a production line comprises the steps of supporting equipment in the production line on a plurality of crawlers comprising at least one rolling track and a structural support for supporting the equipment. A first plurality of lifting magnets coupled to an interior surface of said at least one rolling track is configured to oppose a second plurality of lifting magnets coupled to an exterior surface of said structure support to lift the structural support, such that the structural support floats between and within said at least one rolling track. The magnetic fields experienced by the first and second plurality of lift magnets are adjusted to translate the at least one rolling track, such that the crawlers move along the production line. | 02-04-2010 |
Jiri Schindler, Jamaica Plain, MA US
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20100293561 | Methods and apparatus for conversion of content - In one embodiment of the invention, a utility may be installed (e.g., by a system administrator) on a storage system. The utility may read content units on the storage system that are stored in one data format, and convert the content units to a second data format. In one embodiment, in response to a read request for a content unit, a data format in which to return the content unit may be selected and the content unit may be returned in that data format. In another embodiment, mapping information may be created that specifies in which data format a content unit should be returned in response to a request for the content unit. The mapping information may be stored either on the storage system that stores the content unit, the computer requesting access to the content unit, or any other computer or device in the computer system. | 11-18-2010 |
20110179232 | METHOD AND SYSTEM FOR ALLOCATING DATA OBJECTS FOR EFFICIENT READS IN A MASS STORAGE SUBSYSTEM - A system and method for allocating data objects across multiple physical storage devices in a mass storage subsystem first determines a set of physical properties associated with the physical storage devices. The system assigns portions of the mass storage subsystem to a first division or a second division based on the physical properties, such that read operations directed to logically related data stored in the first division can be executed more efficiently than read operations directed to data stored in the second division. During operation, the system stores data objects with a low SLR in the second division, which may be allocated according to any well-known file system. If a write request is for a new data object with a high SLR, the system stores the new data object in a set of neighboring primary data chunks in the first division. For subsequent write requests that modify a stored data object, the system stores the modified data in a spillover data chunk located in proximity to the primary data chunk. | 07-21-2011 |
20120266011 | RELIABILITY BASED DATA ALLOCATION AND RECOVERY IN A STORAGE SYSTEM - A storage system provides highly flexible data layouts that can be tailored based on reliability considerations. The system allocates reliability values to logical containers at an upper logical level of the system based, for example, on objectives established by reliability SLOs. Based on the reliability value, the system identifies a specific parity group from a lower physical storage level of the system for storing data corresponding to the logical container. After selecting a parity group, the system allocates the data to physical storage blocks within the parity group. In embodiments, the system attaches the reliability value information to the parity group and the physical storage units storing the data. In this manner, the underlying physical layer has a semantic understanding of reliability considerations related to the data stored at the logical level. Based on this semantic understanding, the system has the capability to prioritize data operations on the physical storage units according to the reliability values attached to the parity groups. | 10-18-2012 |
20150019493 | SYSTEMS AND METHODS FOR PROVIDING AN EVENTUALLY-CONSISTENT SNAPSHOT OF NODES IN A STORAGE NETWORK - Systems and methods which provide for obtaining snapshots of one or more nodes, while having minimal impact on performance and throughput of the storage network are provided. Embodiments may involve a method of obtaining snapshots of individual node data within a clustered storage network having a plurality of nodes without requiring quiescing of every node. The snapshots may be obtained in a rolling fashion, e.g., moving across the individual nodes of a cluster either sequentially or non-sequentially. In other embodiments snapshots may be obtained in an asynchronous manner. The obtained snapshots then collectively define an eventually consistent view of the entire system. Such a view may be utilized to provide for mirroring functionality, e.g. to provide for DR and/or HA capabilities. | 01-15-2015 |
20150081636 | SYSTEMS AND METHODS FOR PROVIDING SNAPSHOTS OF APPLICATIONS TO REMOTE LOCATIONS WITH MINIMAL PERFORMANCE IMPACT - Systems and methods herein obtain snapshots of one or more applications, while having minimal impact on performance of the applications. Embodiments may involve obtaining snapshots of modified application data within a node without disturbing the operations of the application. Systems may be configured to leverage the fast characteristics of local storage devices while utilizing the advantages provided by the remote storage of data. One or more applications may be preconfigured to record data modifications in one or more associated application state storages located on local memory. Further, one or more systems may operate in the background to identify modifications made to the associated application state storages and to determine an appropriate moment to take one or more snapshots of the stored data and transfer the one or more snapshots to one or more remote locations to be stored. Several factors may be used to determine when an appropriate moment has occurred. | 03-19-2015 |
Joanne Elizabeth Sarah Schindler, Natick, MA US
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20110097345 | NOVEL DOSING REGIMEN AND METHOD OF TREATMENT - This invention relates to a method of treatment and dosing regimen for treating disease, such as cancer and mammalian tumors, wherein therapy with a cytotoxic drug is suitable, by the administration of an antibody-toxin conjugate, such as a maytansinoid toxin, by infusion at an initial infusion rate of 1 mg/min or lower on a schedule selected from the group consisting of: (1) an amount of at least about 90 mg/m | 04-28-2011 |
John F. Schindler, Chesterfield, MO US
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20120142696 | SUBSTITUTED INDOLE/INDAZOLE-PYRIMIDINYL COMPOUNDS - The present disclosure provides indole/indazole-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): | 06-07-2012 |
20120142708 | SUBSTITUTED PYRIDINE UREA COMPOUNDS - The present disclosure provides pyridine urea compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): | 06-07-2012 |
20120142709 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS - The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): | 06-07-2012 |
20130274272 | METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS - The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): | 10-17-2013 |
20140171449 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS - The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): | 06-19-2014 |
20140171450 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS - The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): | 06-19-2014 |
Jon Schindler, Glenview, IL US
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20080234005 | METHOD AND APPARATUS FOR SELECTIVE ACCESS OF DISPLAY DATA SEQUENCING IN MOBILE COMPUTING DEVICES - A method and apparatus for selective control of display data sequencing in a mobile computing device is disclosed. The method may include storing a plurality of display data sequencing instruction sets in a memory of the mobile computing device, each of the display data sequencing instruction sets being usable for transferring data in accordance with a different sequencing of display data than other ones of the display data sequencing instruction sets, receiving an indication of a particular type of display data sequencing to be used, selecting one of the display data sequencing instruction sets based on the received indication of the particular type of display data sequencing to be used, transferring data for display based on the selected one of the display data sequencing instruction sets, and controlling the transfer of data to the display device in order to synchronize the data transfer with the data and timing requirements of the display device. | 09-25-2008 |
Jon L. Schindler, Glenview, IL US
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20090102868 | METHOD AND APPARATUS FOR DYNAMICALLY ADJUSTING RESOLUTION OF DISPLAY DEVICE IN MOBILE COMPUTING DEVICES - A method and apparatus for dynamically selecting one of plurality of resolutions for display in a mobile computing device is disclosed. The method may include determining at least one of a media type of the visual media file and an image height and an image width of the visual media file, determining whether an energy level of the mobile computing device is a normal energy level or a low energy level, selecting a first one of the plurality of resolutions as the display resolution for display of the visual content file, the first one of the plurality of display resolutions being selected based on the determined at least one of the media type of the visual media file and the image height and the image width of the visual media file, if the energy level is determined to be the normal energy level, and selecting a second one of the plurality of resolutions as the display resolution for display of the visual content file, if the energy level is determined to be the low energy level, wherein the first one of the plurality of resolutions is a higher resolution than the second one of the plurality of resolutions. | 04-23-2009 |
20120254347 | PROVIDING SUPPLEMENTAL CONTENT ASSOCIATED WITH AN INFORMATION DEVICE - A system and method for providing supplemental content associated with an information device includes a user device detecting ( | 10-04-2012 |
Jordan Schindler, Tucson, AZ US
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20140271863 | HOT WASHABLE POLY-N-ISOPROPYLACRYLAMIDE HYDROGEL DELIVERY SYSTEMS - The present disclosure is in the field of controlled release delivery of actives (e.g., drug-delivery, cosmeceutics, alternative medicine) though from an unusual and novel delivery vehicle: personal clothing. Means are disclosed for producing controlled-release systems well-suited not only for affixation to fabrics—e.g., clothing, bedding—but also for maintenance of active throughout washing cycles including hot-wash laundry cycles. Some embodiments comprise a material comprising a unique combination of the thermoresponsive polymer poly-N-isopropylacrylamide, crosslinked and water-swollen in the form of a hydrogel, with embedded thin platelet-shaped solid crystals, drug-solubilizing microparticles, and a drug or other active that is released at ambient or body temperature, but only slowly in warm or hot water. Also disclosed are particles comprising solid dispersions of active compounds dispersed in nested or layered arrangements of at least two distinct polymers, in a fiber- or rod-shaped configurations, satisfying certain mathematical criteria. | 09-18-2014 |
Katie M. Schindler, Fort Wayne, IN US
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20130150979 | ANTIMICROBIAL METHACRYLATE CEMENTS - Bone cement compositions and methods of making two-part bone cements. The methods comprise transferring premixed powder and a liquid component into a receptacle, and mixing the powder component and the liquid component to form a cement composition. The premixed powder component comprises an acrylic polymer and a radical initiator. The bone cement is loaded with from about 5% to about 6% gentamicin by weight of the powder component, and from about 4% to about 5% vancomycin by weight of the powder component. The methods include filling a mold cavity with the bone cement composition to form a temporary spacer implant. The bone cement compositions provide a viscosity profile sufficient for the bone cement composition to flow within the mold cavity for an elapsed working time period of greater than about 6 minutes from the start of mixing at approximately 23° C. | 06-13-2013 |
20140017391 | DEVICE FOR COATING INTRAMEDULLARY RODS WITH CEMENT - A mold for forming a coated intramedullary (IM) nail can include a tubular member having an insertion end and an opposite end. The tubular member can comprise a sidewall extending along a longitudinal axis between an outer surface and an inner surface. The sidewall can define at least one threaded inlet port therealong. The tubular member can be configured to receive the IM nail therein. The tubular member can be further configured to locate a flowable material against the IM nail within the inner surface. | 01-16-2014 |
Kevin Schindler, Red Lake Falls, MN US
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20080264196 | ADJUSTABLE STEERING ASSEMBLY - A vehicle, such as an all-terrain or utility-terrain vehicle, includes a telescoping, adjustable, steering assembly. The steering assembly includes a steering device that is coupled to the steering assembly, which can be adjusted to increase or decrease the height of the steering device. The steering assembly may include a detent member, a steering post, a yoke, a collar, and a biasing member. The steering post includes axially spaced arcuate grooves where a detent member is seated and held in place with a collar. The collar includes a tapered internal surface for applying lateral pressure to the detent member to lock the yoke in place relative to the steering post. Without the use of tools, the collar may be moved to release the lateral pressure on the detent member, which in turn permits the yoke to be moved relative to the steering post—resulting in adjustment of the steering device. | 10-30-2008 |
20120247260 | ADJUSTABLE STEERING ASSEMBLY - A vehicle, such as an all-terrain or utility-terrain vehicle, includes a telescoping, adjustable, steering assembly. The steering assembly includes a steering device that is coupled to the steering assembly, which can be adjusted to increase or decrease the height of the steering device. The steering assembly may include a detent member, a steering post, a yoke, a collar, and a biasing member. The steering post includes axially spaced arcuate grooves where a detent member is seated and held in place with a collar. The collar includes a tapered internal surface for applying lateral pressure to the detent member to lock the yoke in place relative to the steering post. Without the use of tools, the collar may be moved to release the lateral pressure on the detent member, which in turn permits the yoke to be moved relative to the steering post—resulting in adjustment of the steering device. | 10-04-2012 |
Mark Byron Schindler, Cambridge, MA US
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20090204938 | SYSTEM AND METHOD FOR SYSTEMATICALLY ARRANGING A SET OF DISPLAY ELEMENTS IN ASSEMBLAGES TO MEANINGFULLY REPRESENT DATA - A system, method and computer program for creating a software application specification, including arranging graphical elements to form assemblages including information displays of the graphical elements. The assemblages are classified along a layout type dimension, and a relationship metaphor dimension, are specified by attributes of a situation being studied, and are respectively associated so as to describe a behavior of the graphical elements, a software application specification is generated based thereon. Further embodiments display graphical elements, corresponding to a feature set based on a matrix, a list, a collection, a curve, a timeflow, a sequence flow, a relationship, a map, a stack or a control and a feature set based on a situation of interest, a goal, a plan, a comparison, an evaluation, a conceptual aid, a qualifier, an action, an alert or an alarm, in a consistent manner to represent information in a form useful for decision-making or problem-solving. | 08-13-2009 |
Melvin Schindler, Piscataway, NJ US
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20120169718 | THREE DIMENSIONAL DISPLAY STRUCTURE - A three dimensional display system presents a physical three dimensional representation of a two dimensional image. The display system includes multiple display portions where each portion subsumes at least a portion of the two dimensional image. The display portions are arranged in a nested stacked and spaced arrangement, such that the portions of the two dimensional image depicted on the display portions are congruent. | 07-05-2012 |
Melvin S. Schindler, Piscataway, NJ US
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20090221047 | WEB COMPRISING FINE FIBER AND BIOACTIVE PARTICULATE AND USES THEREOF - The assemblies of the invention can comprise a fine fiber layer forming a multilamellar web or matrix, having dispersed within the fine fiber layer a bioactive particulate material, including cells, enzymes or microorganisms. Fluid that flows through the assemblies of the invention can have any material dispersed or dissolved in the fluid react with, be absorbed by, or adsorbed onto, the bioactive particulate within the nanofiber layer. The assemblies of the invention can be used to treat or purify fluid streams. The assemblies of the invention can be used in conjunction with a bioreactor system, a bioartificial organ, or a culture container. | 09-03-2009 |
20100297768 | NANOFIBRILLAR STRUCTURE AND APPLICATIONS INCLUDING CELL AND TISSUE CULTURE - A nanofibrillar structure for cell culture and tissue engineering is disclosed. The nanofibrillar structure can be used in a variety of applications including methods for proliferating and/or differentiating cells and manufacturing a tissue. Also disclosed is an improved nanofiber comprising a lipid, lipophilic molecule, or chemically modified surface. The nanofibers can be used in a variety of applications including the formation of nanofibrillar structures for cell culture and tissue engineering. | 11-25-2010 |
Michael J. Schindler, Seattle, WA US
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20120135826 | BAT HAVING VARIABLE PROPERTIES RELATIVE TO A SWING AXIS - A bat having different stiffnesses in different planes relative to a longitudinal axis (i.e., swing axis) of the bat. More specifically, the bat includes a greater stiffness in a vertical plane as compared to relatively more flexible stiffness in a swing plane. This differential stiffness may be accomplished with an intermediate material located within an internal space defined where a handle affixes to a barrel of the bat or alternatively with a transitional member structurally arranged between the handle and the barrel of the bat. The transitional member may provide for vibration and/or shock dampening to minimize or eliminate the “sting” typically associated with monolithic, metallic bats. Additionally, the handle may include a shape that tends to naturally align the vertical and swing planes of the bat when the handle is gripped by a player. | 05-31-2012 |
Robert Schindler, Euclid, OH US
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20120105136 | FUSE LINK SYSTEM FOR DISPOSABLE COMPONENT - A fuse system for use with a disposable component of a device may include a disposable component having at least a first lockout circuit and a second lockout circuit. The first lockout circuit may include a first fuse link, and the second lockout circuit may include a second fuse link. The fuse system may include a computing device in communication with the first lockout circuit and the second lockout circuit, and a computer-readable storage medium in communication with the computing device. The computer-readable storage medium may include one or more programming instructions for deactivating the first fuse link at a first time, and deactivating the second fuse link at a second time. | 05-03-2012 |
20120106016 | Fuse Link System For A Hyperthermia Apparatus - A fuse system for a hyperthermia apparatus may include a disposable reservoir cartridge configured to be used with a hyperthermia apparatus. The disposable reservoir cartridge may include at least a first lockout circuit and a second lockout circuit. The first lockout circuit may include a first fuse link, and the second lockout circuit may include a second fuse link. The fuse system may include a computing device in communication with the first lockout circuit and the second lockout circuit, and a computer-readable storage medium in communication with the computing device. The computer-readable storage medium may include one or more programming instructions for deactivating the first fuse link at a first time, and deactivating the second fuse link at a second time. | 05-03-2012 |
Robert J. Schindler, Euclid, OH US
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20080234619 | Portable Hyperthermia Apparatus - An apparatus for implementing hyperthermia may include a reservoir cartridge having an inlet and an outlet, a disposable outflow tube having a reservoir cartridge end connected to the reservoir cartridge at the outlet and an outflow catheter end connected to an outflow catheter, a disposable inflow tube having a reservoir cartridge end connected to the reservoir cartridge at the inlet and an inflow catheter end connected to an inflow catheter, a pump connected to the outflow tube, an integrated computer in communication with at least one disposable temperature sensor and at least one pressure sensor, a thermoelectric heater, proximate to the reservoir cartridge and a housing that contains the reservoir cartridge, the heater and the integrated computer. | 09-25-2008 |
Rodney A. Schindler, Waterloo, IA US
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20100076662 | METHOD OF SELECTING ENGINE TORQUE CURVES - A method of operating an internal combustion engine including the steps of detecting, determining, and switching. The detecting step detects a load on the engine. The determining step determines if the load is below a predetermined value. The switching step switches the engine to operate at a selected one of a plurality of torque power curves, dependent upon the determining step. | 03-25-2010 |
Rodney A. Schindler, Bettendorf, IA US
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20090293836 | ENGINE EXHAUST COOLER AND AIR PRE-CLEANER ASPIRATOR - A diffuser for a work machine having an air breathing fuel consuming internal combustion engine with an exhaust aftertreatment device periodically elevating the exhaust temperatures to a high level. The diffuser has a venturi section and the excess contaminants from an intake air pre-cleaner are directed to the throat of the venturi to aspirate and dispose of excess contaminants while cooling the exhaust flow. Additional openings in the divergent section of the diffuser assist in providing significant reductions in exhaust temperatures within a short axial envelope. | 12-03-2009 |
20100299048 | ENGINE FOR AN AGRICULTURAL HARVESTER HAVING ISOCHRONOUS TORQUE CURVE WITH POWER BULGE - A method of operating an IC engine in an agricultural harvester includes the steps of: operating the IC engine in a normal mode with a base torque curve as a function of engine operating speed and engine power output, the base torque curve being generally isochronous at a rated operating speed over a power output range terminating at a rated power output; and operating the IC engine in a boost mode with a boost torque curve when a power boost is required above the rated power output, the boost torque curve having a power output which is above the base torque curve over a predefined range of the operating speed. | 11-25-2010 |
Rodney Allen Schindler, Eldridge, IA US
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20100275587 | Engine Compartment Arrangement For Cleaning Diesel Particulate Filter - An engine compartment arrangement for an agricultural harvester comprises an engine ( | 11-04-2010 |
Terrence R. Schindler, Blair, NE US
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20120153090 | Roof mounted air hose and electrical cord holder - A roof mounted air hose holder is provided which is adapted to be mounted on roofs having different pitches. The air hose holder may also be mounted on a flat roof. In a modified form of the invention, one of the air hose reels of the air hose holder may be replaced by an electrical cord reel. In another embodiment, both of the air hose reels may be replaced by electrical cord reels. | 06-21-2012 |
Viviana Schindler, Boulder, CO US
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20130086814 | SHOE WITH EXCHANGEABLE UPPER - An article of footwear comprising a sole constructed for receiving a foot having a toe section and an ankle section with at least two loops fixedly attached to the toe section; an interchangeable upper, or several interchangeable uppers, having loops for securing the upper to the loops of the sole of the footwear; such uppers and soles attached by specialized clips adapted to facilitate a wide variety of advantages. | 04-11-2013 |
20130340286 | Shoe With Exchangeable Upper - An article of footwear comprising a sole constructed for receiving a foot having a toe section and an ankle section with at least two loops fixedly attached to the toe section; an interchangeable upper, or several interchangeable uppers, having loops for securing the upper to the loops of the sole of the footwear; such uppers and soles attached by specialized clips adapted to facilitate a wide variety of advantages. | 12-26-2013 |
Wayne Robert Schindler, Lisle, IL US
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20100024541 | Multiple Flow Rate Detection System and Method for Consumer Appliance - A supervisory system and method for monitoring multiple flow rate fluid distribution systems and for determining the presence of a failure therein are provided. The system monitors the flow of fluid through the distribution system with a single flow meter, determines the flow rate at which fluid is flowing, and accumulates at that rate a water flow control value. If the accumulated water flow value exceeds a predetermined threshold, further flow of fluid in the system will be disabled. To take account of the multiple flow rates capable through the distribution system, the accumulated water flow value will decremented at the immediately preceding increment rate. | 02-04-2010 |