Patent application number | Description | Published |
20080280298 | SATB1: A DETERMINANT OF MORPHOGENESIS AND TUMOR METASTASIS - It is proposed that cancer cells express SATB1, and that SATB1 acts as a determinant for the acquisition of metastatic activity by controlling expression of a specific set of genes that promote metastatic activity. In order for cancer cells to gain the ability to metastasize, SATB1 re-organizes or re-packages genomic sequences in a specific manner to allow a switch in the pattern of gene expression. SATB1 expression was found restricted mainly to aggressive cancer cells where it may regulate the genetic and epigenetic changes that program the steps involved in the metastatic process. The present invention describes reagents and tools to detect the SATB1 protein for use in diagnosis and prognosis of aggressive cancers and therapeutics to inhibit SATB1 protein to deplete its expression in metastatic and aggressive cancers. | 11-13-2008 |
20110230547 | Potential Prognostic Markers and Therapeutic Targets for Neurological Disorders - We recently found that Satb1 is expressed highly by mature neurons in specific regions of the postnatal brain. Satb2, a homolog of Satb1, is expressed at low levels in the postnatal brain. Neurons respond to external stimuli and rapidly and dynamically change their expression. Satb1 has been found to directly regulate a set of genes in the postnatal brain, presumably playing a crucial role as a ‘genome organizer’ for brain function and behaviors. Satb2 may also have a similar function, even though it is expressed at low levels in the postnatal brain. The present invention describes compositions, reagents and tools using wild type and variant SATB1 and SATB2 genes and proteins for use in diagnosis, prognosis and therapeutics in neurological dysfunction and psychiatric disorders. | 09-22-2011 |
20150323536 | SATB1: A DETERMINANT OF MORPHOGENESIS AND TUMOR METASTATIS - It is proposed that cancer cells express SATB1, and that SATB1 acts as a determinant for the acquisition of metastatic activity by controlling expression of a specific set of genes that promote metastatic activity. In order for cancer cells to gain the ability to metastasize, SATB1 re-organizes or re-packages genomic sequences in a specific manner to allow a switch in the pattern of gene expression. SATB1 expression was found restricted mainly to aggressive cancer cells where it may regulate the genetic and epigenetic changes that program the steps involved in the metastatic process. The present invention describes reagents and tools to detect the SATB1 protein for use in diagnosis and prognosis of aggressive cancers and therapeutics to inhibit SATB1 protein to deplete its expression in metastatic and aggressive cancers. | 11-12-2015 |
Patent application number | Description | Published |
20100076248 | Incubator - An incubator according to the present invention will be able to prevent accidents to the incubator itself or other devices, a doctor, a nurse or others causing external force even if the external force is applied to a canopy of a newborn chamber. An optical detector in a control mechanism detects application of external force to the canopy of the newborn chamber, and a signal output section in the control mechanism outputs a signal that renders a driving mechanism for lowering and raising the canopy non-operational when the application of external force is detected. Accordingly, even if external force is applied to the canopy by bump, contact, putting some object or others, the driving mechanism will not continue or start to lower or raise the canopy while the external force is applied to the canopy because the driving mechanism will be rendered non-operational. | 03-25-2010 |
20100109347 | Incubator - In an incubator according to the present invention, physical condition of a newborn is less likely to get out of order though a hand insertion window can easily be opened by operation with, for example, an elbow instead of a hand. A latch in a latch mechanism has a spiral face that extends to at least part of the periphery of a rotation shaft that extends along a side of a newborn chamber. A releasing member in the latch mechanism presses the spiral face of the latch by movement along the side of the newborn chamber and rotates the latch from a holding position to a releasing position for a hand insertion door. In addition, even if the latch in the latch mechanism rotates about the rotation shaft between the holding and releasing positions for the hand insertion door, the releasing member does not rotate. | 05-06-2010 |
20100113864 | Incubator - In an incubator according to the present invention, a single incubator can be used in any state of four types of devices and thus obviates the need for having many types of devices. A canopy is lowered and raised. In addition to that, a left and right treatment door and a foot end treatment door can be located at their highest positions, lowest positions, and intermediate positions. Also, an infrared heater can be lowered and raised independently of the canopy. This makes it possible to switch the incubator among: a state of an open type incubator; a state of a closed type incubator in which the infrared heater is at its highest position such that the infrared heater can heat the canopy and others; a state of a closed type incubator in which the infrared heater is at its lowest position and this incubator is easily conveyable; and a state of a resuscitation treatment device. | 05-06-2010 |
20100206310 | Pressure Controller for Artificial Respirator and Artificial Respirator Using the Same - A pressure controller for an artificial respirator according to this invention includes a control valve facing a gas passage between an inspiratory gas inlet and an inspiratory gas outlet, and an elastic biasing means for elastically biasing the control valve against a valve seat. When an adjustment manipulating member moves backward, even the pivotal motion of the adjustment manipulating member does not operate an adjustment operating member. When the adjustment manipulating member is pulled out, the pivotal motion of the adjustment manipulating member operates the adjustment operating member, thereby adjusting the elastic biasing force of the elastic biasing means. This invention provides a pressure controller for an artificial respirator capable of reliably preventing unnecessary operating of the adjustment operating member although the pivoting operation of the adjustment manipulating member is simple as a whole, and there is no possibility that the adjustment manipulating member and the like are broken. | 08-19-2010 |
20120238798 | Incubator - A hand insertion door board is attached to the peripheral portion of each hand insertion window formed in an outside portion of a newborn infant container of an incubator. A holding portion is formed on one side portion of the hand insertion door board in the lateral direction. A bracket which pivotally supports a support shaft having a vertical axis is attached to the holding portion. A latch lever is pivotally supported by the support shaft of the bracket. A press lever which releases latching operation of the latch lever is pivotally attached by using the support shaft of the bracket. When the press lever is pressed against the biasing force of a compression coil spring, the press lever presses projecting pieces of the latch lever to make the latch lever pivot about the support shaft to the release position. | 09-20-2012 |
Patent application number | Description | Published |
20130274543 | INFANT INCUBATOR - An infant incubator including: a left-side treatment door, a right-side treatment door, and an end-side treatment door which are rotatably held, and door-locking devices which fixes the left-side and right-side treatment doors on the end-side treatment door; the door-locking devices are formed from: open-close knobs each mounted rotatably on the left-side and right-side treatment doors and each having a hook-shaped distal end, and knob brackets each mounted on side of the end-side treatment doors having a hollow-shape, the infant incubator in which the treatment doors are fixed in a stand state by inserting the open-close knob into the knob bracket. | 10-17-2013 |
20130310634 | INFANT INCUBATOR - An infant incubator including: a bed of an infant; a first supporting-shaft disposed at obliquely above the bed, extends substantially horizontally, and rotatable back and forth at a predetermined extent around an axis; a rotation stay fixed to and rotated with the first supporting-shaft; a second supporting-shaft provided with the rotation stay and parallel to the first supporting-shaft; and a heater disposed at obliquely above the bed, supported to the rotation stay rotatably back and forth at a predetermined extent around the second supporting-shaft, and possible to emit heat ray obliquely to an upper surface of the bed, wherein a position of the heater can be varied between a heating position for emitting the heat ray and a folding position for moving away from above the bed; and at the heating position, an emission angle of the heat ray from the heater is further varied. | 11-21-2013 |
20130310635 | INFANT INCUBATOR - An infant incubator including: an infant chamber in which an infant is placed; an air-supply passage for supplying supply-air to the infant chamber; and a heater equipment for heating the supply-air having a mount base which is mounted in the air-supply passage and a heater which is held to the mount base rotatably, wherein the heater has: a support part provided at a base end of the heater and supported by the mount base rotatably; and a heating part provided at a top end of the heater and heating the supply-air, and the heating part is formed by winding a heating-wire into a coil-shape and disposed so that an axial direction of the coil-shape is orthogonal to a flow direction of the supply-air passing through the air-supply passage. | 11-21-2013 |
20130345494 | INFANT INCUBATOR - An infant incubator including: an infant chamber isolated from external air; a conditioning bath communicating with the infant chamber; an air-conditioning equipment circulating air in the infant chamber through the conditioning bath; a fan provided at the air-conditioning equipment and moving air in the conditioning bath; a heater provided at the air-conditioning equipment and heating the air in the conditioning bath; a humidifier provided at the air-conditioning equipment, removably installed on a constructional member of the conditioning bath, and supplying water-vapor to the air in the conditioning bath; and a channel member for supplying water-vapor removably installed on a water-vapor introduction port penetrating the constructional member of the conditioning bath, and connecting the humidifier and the conditioning bath, in this infant incubator, the channel member for supplying water-vapor closes the water-vapor introduction port when the humidifier is removed, and opens the water-vapor introduction port when the humidifier is installed. | 12-26-2013 |
Patent application number | Description | Published |
20120269568 | Movable Wall Portion Attachment Mechanism of Incubator - According to the present invention, a movable wall portion for forming the outer circumference of an infant accommodation space can pivot forward about a portion of a region including the lower end portion and its vicinity of the movable wall portion from a substantially erect position to the outside of the infant accommodation space. The movable wall portion can move backward from a midway position in forward movement to the final backward moving position by its own weight while abrupt backward movement is suppressed by a damper. The present invention can provide a movable wall portion attachment mechanism of an incubator which does not produce a large sound or a large vibration when closing the movable wall portion, with a small chance that wall portions such as wall portions on the incubator base side, the movable wall portion or the like will be damaged. | 10-25-2012 |
20130289673 | LED THERAPEUTIC APPARATUS HAVING THERMAL RADIATING FUNCTION - An LED therapeutic apparatus is disclosed, which includes a body portion formed of a light-weight resin material into a rectangular housing; a printed circuit board including a plurality of LEDs having different emission colors mounted linearly in a plurality of rows at required intervals; a thermal radiating plate provided with a plurality of thermal radiating studs formed of a light-weight thermally conductive material; and a transparent plate mounted on an opening surface of the body portion. The thermal radiating plate is mounted in tight contact in the body portion, and the printed circuit board is mounted in tight contact with the heat radiating studs. The heat generated by the LEDs is radiated from the surface of the body portion via the thermal radiating plate from the thermal radiating studs. The LEDs may be maintained to a junction allowable temperature or lower, and the long life span without noise is achieved. | 10-31-2013 |
20130325087 | LIGHT-BEAM THERAPEUTIC APPARATUS - A light-beam therapeutic apparatus used for a therapy for neonatal hyperbilirubinemia is disclosed, which includes an apparatus body portion having a light source; a light guide rod that guides light from the light source, a connecting socket, a cooling fan, an electronic component that performs control required for a therapy, and a control display panel that displays the contents of therapy; a therapeutic portion including a light guide portion including a plurality of bundled optical fibers, and a pad portion formed of the optical fibers spread out adjacently to one another into a flat-panel shape, and the therapeutic portion is formed into a light-receiving plug insertable into a connecting socket of the apparatus body portion, and the optical fibers positioned on the pad portion are subjected to exposing processing and have a protecting surface layer portion formed of a bag member filled with transparent and highly flexible high-molecular gel. | 12-05-2013 |
20140012354 | LIGHT-BEAM THERAPEUTIC APPARATUS - A light-beam therapeutic apparatus ensured patient safety is disclosed, which includes an apparatus body portion having a light source; a light guide rod that guides light from the light source, a connecting socket, a cooling fan, an electronic component that performs control required for a therapy, and a control display panel that displays the contents of therapy; a therapeutic portion including a light guide portion including a plurality of bundled optical fibers, and a pad portion formed of the optical fibers spread out adjacently to one another into a flat-panel shape, wherein the therapeutic portion is formed into a light-receiving plug insertable into a connecting socket of the apparatus body portion, and the light-receiving plug is configured to be kept in a coupled state by an attracting action of a permanent magnet provided on the side of the connecting socket. | 01-09-2014 |
20150335843 | GAS SUPPLY MASK APPARATUS - A gas supply mask apparatus has low possibility that a gas rising in a mask main body will flow out from the upper end and the surrounding vicinity of the mask main body and give discomfort to the eyes of a mask wearer. In this gas supply mask apparatus, an angle formed between a direction in which a gas introduction opening faces and a virtual vertical plane facing right frontways falls within the range of 30° to 60° (preferably, the range of 35° to 55°, and more preferably, the range of 40° to 50°) when the mask main body is viewed right sideways. | 11-26-2015 |
20150335844 | GAS SUPPLY MASK APPARATUS - A gas supply mask apparatus allows a mask wearer to inhale a gas such as oxygen gas such that air in a mask main body does not much mix in the gas approaching substantially lower ends and the vicinities of the nostrils of the mask wearer in the mask main body. In this gas supply mask apparatus, a gas introduction opening for introducing a gas such as oxygen gas and water vapor into the mask main body includes a first gas introduction opening capable of introducing the gas in, e.g., a bundle-like state into the mask main body, and a second gas introduction opening capable of introducing the second gas into the mask main body so as to surround, in a substantially ring-like state, the above-mentioned, first gas in a bundle-like state introduced into the mask main body from the first gas introduction opening. | 11-26-2015 |
20150335847 | GAS SUPPLY MASK APPARATUS - A gas supply mask apparatus comprises a mask main body which can be put on a mask wearer relatively simply and relatively reliably by extending a head-worn band such as an elastic bandage relatively simply and relatively reliably over the head of the mask wearer even when there is no head-worn string such as a rubber string at hand. A string attaching short hole and band attaching long hole are formed in each of the left and right end portions of the outer peripheral portion of the mask main body. | 11-26-2015 |
Patent application number | Description | Published |
20090229954 | SPECIMEN TRANSPORT SYSTEM - An object of the present invention is to provide a specimen transport system that can easily be installed without requiring much time and regardless of various transport distances and also is inexpensive. In the present invention, the distance between apparatuses, which had been difficult to be met by a specimen transport line when a specimen transport system is built, can easily be met by providing a structure in which a conveyor belt is formed in an endless loop and the shape of the loop of the conveyor belt is changed according to the length of a rack transport surface (rack transport surface length), and flexibility for apparatus and system installation and space efficiency can be enhanced, enabling substantial reduction of time and costs in building a specimen transport system. | 09-17-2009 |
20120282139 | BLOOD COAGULATION ANALYZER - A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit. | 11-08-2012 |
20120315190 | AUTOMATIC ANALYSIS DEVICE - There is provided a data processing method that reduces influences of air bubbles and dirt while maintaining changes in light amounts. Two scattering light photoreceivers are disposed in the forward direction. A photoreceiver | 12-13-2012 |
20130277542 | MASS ANALYZING APPARATUS, ANALYZING METHOD AND CALIBRATION SAMPLE - The mass analyzing apparatus of the present invention can achieve the speed-up and simplification of the formation of a calibration curve for quantifying an analysis object in a mass analyzing apparatus. The mass analyzing apparatus is provided with: a sample storage-dilution unit | 10-24-2013 |