Patent application number | Description | Published |
20090098561 | Higher-order cellular information processing devices - The invention provides various signal processing devices for integrating two or more biological signals (e.g., the presence, absence or concentration of specific ligands, etc.) to generate a status output, or a response that modulates one or more biological activities based on the status of the biological signals. The various described signal processing/integration mechanisms may be combined with one another to provide the device with more flexibility in integrating high-order cellular information. The signal processing devices of the invention have many uses in various biological systems, including gene expression control or ligand-concentration sensing. | 04-16-2009 |
20120165387 | General composition framework for ligand-controlled RNA regulatory systems - The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing. | 06-28-2012 |
20130102651 | GENERAL COMPOSITION FRAMEWORK FOR LIGAND-CONTROLLED RNA REGULATORY SYSTEMS - The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing. | 04-25-2013 |
Patent application number | Description | Published |
20110202275 | DETERMINING FLUID PRESSURE - A wellbore fluid pressure measurement system includes a densometer adapted to measure a fluid density of a fluid flowing in a tubing system; and a monitoring unit communicably coupled to the densometer. The monitoring unit is adapted to receive a plurality of values representative of the fluid density from the densometer and includes a memory adapted to store the plurality of values representative of the fluid density; and one or more processors operable to execute a fluid pressure measurement module. The module is operable when executed to determine a fluid pressure of the fluid based on at least a portion of the values representative of the fluid density. | 08-18-2011 |
20130240063 | PARTICULATE-TOLERANT VALVE COMPRISING ONE OR MORE RECESSES CAPABLE OF CONTAINING THE PARTICULATE - According to an embodiment, a valve comprises: a valve member, wherein the valve member is made from a non-deformable material; a seat, wherein the seat: (A) is made from a non-deformable material; and (B) is positioned adjacent to the valve member; a seal, wherein the seal is created by the interaction between at least a portion of the seat and at least a portion of the valve member and a sealant; and at least one recess, wherein the at least one recess: (A) is located on the inside of the seat or the outside of the valve member; and (B) is capable of containing at least one particulate, wherein the valve is capable of being opened or closed via relative movement of the valve member and the seat. | 09-19-2013 |
20140149043 | Determining Fluid Pressure - A wellbore fluid pressure measurement system includes a densometer adapted to measure a fluid density of a fluid flowing in a tubing system; and a monitoring unit communicably coupled to the densometer. The monitoring unit is adapted to receive a plurality of values representative of the fluid density from the densometer and includes a memory adapted to store the plurality of values representative of the fluid density; and one or more processors operable to execute a fluid pressure measurement module. The module is operable when executed to determine a fluid pressure of the fluid based on at least a portion of the values representative of the fluid density. | 05-29-2014 |
20140151062 | Wellhead Flowback Control System and Method - A wellbore servicing system disposed at a wellbore, the wellbore servicing system comprising at least one wellbore servicing equipment component, wherein a flow path extends from the wellbore servicing system component into the wellbore, and a flow-back control system, wherein the flow-back control system is disposed along the flow path, and wherein the flow-back control system is configured to allow fluid communication via the flow path in a first direction at not less than a first rate and to allow fluid communication via the flow path in a second direction at not more than a second rate, wherein the first rate is greater than the second rate. | 06-05-2014 |
20140151065 | Fast Pressure Protection System and Method - A wellbore servicing system, the system comprising at least one wellbore servicing equipment component, wherein a flow path extends from the wellbore servicing system component into a wellbore penetrating a subterranean formation, and a pressure control system in fluid communication with the flow path, wherein the pressure control system comprises a relief path configured to communicate fluid through the pressure control system, a pressure control device configured to permit fluid communication between the flow path and the relief path upon experiencing a pressure and/or a differential pressure of at least a predetermined pressure threshold, and a first valve disposed within the relief path, wherein the first valve is configured to actuate from an open configuration to a closed configuration. | 06-05-2014 |
20140166267 | Suction Pressure Monitoring System - A wellbore servicing system comprising a pump, a fluid supply flow path configured to supply fluid to the pump, and a suction pressure monitoring system comprising a transducer in pressure communication with the fluid supply flow path, and an electronic circuit in electrical communication with the transducer and a monitoring system, wherein the electronic circuit is configured to generate a lower pressure envelope signal, wherein the lower pressure envelope signal is representative of a low pressure within the fluid supply flow path over a predetermined duration of time. | 06-19-2014 |
20140166268 | Discharge Pressure Monitoring System - A pressure monitoring method comprising providing wellbore servicing equipment comprising a pump, a discharge flow path configured to discharge fluid from the pump, a discharge pressure monitoring system comprising a transducer in pressure communication with the discharge flow path, and an electronic circuit in electrical communication with the transducer and a monitoring system, collecting an electrical signal indicative of the pressure within the discharge flow path, processing the electrical signal to generate an upper pressure envelope signal, wherein the upper pressure envelope signal is representative of a high pressure within the discharge flow path over a predetermined duration of time, and comparing the upper pressure envelope signal to a predetermined upper threshold. | 06-19-2014 |
Patent application number | Description | Published |
20090187191 | Systems, Devices and Apparatuses for Bony Fixation and Disk Repair and Replacement and Methods Related Thereto - Disclosed is an apparatus for forming an arcuate channel in one or more segments of a bone, bony structure or adjacent vertebrae of a spine. The apparatus includes, inter alia, a base member which is positioned proximate to the surgical site, a support arm extending proximally from the base member, an arcuate guide member and a drill assembly. The arcuate guide member is slidably mounted to the support arm. The drill assembly is operatively coupled to the support arm and includes a drill bit attached to the distal end of a flexible drive cable. The flexible drive cable extends axially along the support arm and is axially and rotationally movable with respect thereto. The drill bit is operatively coupled to an end of the arcuate guide member such that when the drill assembly is moved distally, the arcuate guide member slides with respect to the support arm and forces the drill bit to traverse an arcuate path. | 07-23-2009 |
20120116411 | SYSTEMS, DEVICES AND APPARATUSES FOR BONY FIXATION AND DISK REPAIR AND REPLACEMENT METHODS RELATED THERETO - The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize a new apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member, which also preferably is arcuate, and avoids the associated problems with prior cage or straight rod and screw systems. Also featured are systems, apparatuses and methods for repairing, replacing or augmenting the nucleus and/or annulus of a disc. | 05-10-2012 |
20130253550 | SELF-ASSEMBLING MAGNETIC ANASTOMOSIS DEVICE HAVING AN EXOSKELETON - The invention is an implantable magnetic anastomosis device having an exoskeleton that directs self-assembly. The design allows the device to be delivered in a linear configuration using a minimally-invasive technique, such as endoscopy or laparoscopy, whereupon the device self-assembles into, e.g., a polygon. A coupled set of polygons define a circumscribed tissue that can be perforated, or the tissue can be allowed to naturally necrose and perforate. The device can be used to create anastomoses in a variety of tissues, such as tissues found in the gastrointestinal, renal/urinary, and reproductive tracts. New procedures for using anastomoses, e.g., surgical bypass are also disclosed. | 09-26-2013 |
20140214040 | SYSTEMS, DEVICES AND APPARATUSES FOR BONY FIXATION AND DISK REPAIR AND REPLACEMENT METHODS RELATED THERETO - The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize a new apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member, which also preferably is arcuate, and avoids the associated problems with prior cage or straight rod and screw systems. Also featured are systems, apparatuses and methods for repairing, replacing or augmenting the nucleus and/or annulus of a disc. | 07-31-2014 |
20140236200 | SELF-ASSEMBLING MAGNETIC ANASTOMOSIS DEVICE HAVING AN EXOSKELETON - The invention is an implantable magnetic anastomosis device having an exoskeleton that directs self-assembly. The design allows the device to be delivered in a linear configuration using a minimally-invasive technique, such as endoscopy or laparoscopy, whereupon the device self-assembles into, e.g., a polygon. A coupled set of polygons define a circumscribed tissue that can be perforated, or the tissue can be allowed to naturally necrose and perforate. The device can be used to create anastomoses in a variety of tissues, such as tissues found in the gastrointestinal, renal/urinary, and reproductive tracts. New procedures for using anastomoses, e.g., surgical bypass are also disclosed. | 08-21-2014 |
20150057688 | SELF-ASSEMBLING MAGNETIC ANASTOMOSIS DEVICE HAVING AN EXOSKELETON - The invention is an implantable magnetic anastomosis device having an exoskeleton that directs self-assembly. The design allows the device to be delivered in a linear configuration using a minimally-invasive technique, such as endoscopy or laparoscopy, whereupon the device self-assembles into, e.g., a polygon. A coupled set of polygons define a circumscribed tissue that can be perforated, or the tissue can be allowed to naturally necrose and perforate. The device can be used to create anastomoses in a variety of tissues, such as tissues found in the gastrointestinal, renal/urinary, and reproductive tracts. New procedures for using anastomoses, e.g., surgical bypass are also disclosed. | 02-26-2015 |
Patent application number | Description | Published |
20100268237 | Systems, Devices and Apparatuses For Bony Fixation and Disk Repair and Replacement Methods Related Thereto - The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize an apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member. Also featured are systems, apparatuses and methods for removably suspending a spacer in the intervertebral space while forming such a channel as well as systems, apparatuses and methods for use of dynamized implant members. | 10-21-2010 |
20140012379 | SYSTEMS, DEVICES AND APPARATUSES FOR BONY FIXATION AND DISK REPAIR AND REPLACEMENT METHODS RELATED THERETO - The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize an apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member. Also featured are systems, apparatuses and methods for removably suspending a spacer in the intervertebral space while forming such a channel as well as systems, apparatuses and methods for use of dynamized implant members. | 01-09-2014 |
20140039504 | Systems, Devices and Apparatuses for Bony Fixation and Disk Repair and Replacement and Methods Related Thereto - Disclosed is an apparatus for forming an arcuate channel in one or more segments of a bone, bony structure or adjacent vertebrae of a spine. The apparatus includes, inter alia, a base member which is positioned proximate to the surgical site, a support arm extending proximally from the base member, an arcuate guide member and a drill assembly. The arcuate guide member is slidably mounted to the support arm. The drill assembly is operatively coupled to the support arm and includes a drill bit attached to the distal end of a flexible drive cable. The flexible drive cable extends axially along the support arm and is axially and rotationally movable with respect thereto. The drill bit is operatively coupled to an end of the arcuate guide member such that when the drill assembly is moved distally, the arcuate guide member slides with respect to the support arm and forces the drill bit to traverse an arcuate path. | 02-06-2014 |
20140358236 | SYSTEMS, DEVICES AND APPARATUSES FOR BONY FIXATION AND DISK REPAIR AND REPLACEMENT METHODS RELATED THERETO - The present invention features new methods, apparatuses and devices for fixing adjacent bone segments, segments of a bony structure and adjacent vertebrate of a spine. The methods, apparatuses and devices utilize an apparatus for forming a channel in a surface of the bone or bony structure segments or adjacent vertebra or a channel submerged within the bone or bony structure segments or adjacent vertebra. In more particular embodiments such apparatuses and methods including forming an arcuate channel and which channel can receive therein a curved rod or implant member. Also featured are systems, apparatuses and methods for removably suspending a spacer in the intervertebral space while forming such a channel as well as systems, apparatuses and methods for use of dynamized implant members. | 12-04-2014 |