Patent application number | Description | Published |
20120263382 | OPTIMIZED ORTHONORMAL SYSTEM AND METHOD FOR REDUCING DIMENSIONALITY OF HYPERSPECTRAL IMAGES - A method for reducing dimensionality of hyperspectral images includes receiving a hyperspectral image having a plurality of pixels. The method may further include establishing an orthonormal basis vector set comprising a plurality of mutually orthogonal normalized members. Each of the mutually orthogonal normalized members may be associated with one of the plurality of pixels of the hyperspectral image. The method may further include decomposing the hyperspectral image into a reduced dimensionality image, utilizing calculations performed while establishing said orthonormal basis vector set. A system configured to perform the method may also be provided. | 10-18-2012 |
20130044963 | MULTIPLY ADAPTIVE SPATIAL SPECTRAL EXPLOITATION - A method of filtering hyperspectral image data associated with a hyperspectral image to produce a detection image data having a plurality of pixels, where the detection image data is associated with the degree to which a target may be present in a pixel. The method also includes adaptively processing the detection image data to determine a background variation in the plurality of pixels. The method additionally includes establishing a plurality of spatial filters for the detection image data, where each of the plurality of spatial filters are associated with energy being received at different locations on each of the plurality of pixels, and where the outputs of the plurality of spatial filters are weighted by the variation in background. The method further includes applying each of the plurality of spatial filers to the detection image data, such that each of the plurality of pixels are associated with a selected one of the plurality of spatial filters. | 02-21-2013 |
20130129256 | SPECTRAL IMAGE DIMENSIONALITY REDUCTION SYSTEM AND METHOD - Methods for reducing dimensionality of hyperspectral image data having a number of spatial pixels, each associated with a number of spectral dimensions, include receiving sets of coefficients associated with each pixel of the hyperspectral image data, a set of basis vectors utilized to generate the sets of coefficients, and either a maximum error value or a maximum data size. The methods also include calculating, using a processor, a first set of errors for each pixel associated with the set of basis vectors, and one or more additional sets of errors for each pixel associated with one or more subsets of the set of basis vectors. Utilizing such errors calculations, an optimum size of the set of basis vectors may be ascertained, allowing for either a minimum amount of error within the maximum data size, or a minimum data size within the maximum error value. | 05-23-2013 |
20130216144 | METHOD AND APPARATUS FOR IMAGE PROCESSING - In accordance with various aspects of the disclosure, a system, a method, and computer readable medium having instructions for processing images is disclosed. For example, the method includes receiving, at an image processor, a set of images corresponding to a scene changing with time, decomposing, at the image processor, the set of images to detect static objects, leaner objects, and mover objects in the scene, the mover objects being objects that change spatial orientation in the scene with time, and compressing, using the image processor, the mover objects in the scene separately at a rate different from that of the static objects and the leaner objects for storage and/or transmission. | 08-22-2013 |
20130223752 | BASIS VECTOR SPECTRAL IMAGE COMPRESSION - Computer implemented methods for compressing 3D hyperspectral image data having a plurality of spatial pixels associated with a hyperspectral image, and a number of spectral dimensions associated with each spatial pixel, include receiving, using a processor, the 3D hyperspectral image data, a set of basis vectors associated therewith, and either a maximum error amount or a maximum data size. The methods also include partitioning the 3D hyperspectral image data into a plurality of 2D images, each associated with one of the number of spectral dimensions, and an associated one of the set of basis vectors. The methods additionally include ranking the set of basis vectors if not already ranked. The methods may further include iteratively applying lossy compression to the 2D images, in an order determined by the ranking. Other embodiments and features are also disclosed. | 08-29-2013 |
20140037209 | SYSTEM AND METHOD FOR REDUCED INCREMENTAL SPECTRAL CLUSTERING - A method of clustering and reducing hyperspectral image data having a plurality of spatial pixels, and a plurality of spectral dimensions associated with each spatial pixel, includes computing an initial basis vector associated with the hyperspectral image data, unmixing the initial basis vector with the hyperspectral image data to generate an initial set of coefficients and an associated set of residual vectors, generating a set of clusters based on the initial set of coefficients, and iteratively computing one or more additional basis vectors and updating the set of clusters. The iterative computing includes calculating a subsequent basis vector based on a residual vector associated with a prior unmixing, unmixing the subsequent basis vector with a prior set of residual vectors to generate additional coefficients associated with each pixel, and iteratively computing cluster centers and content including an additional dimension associated with the subsequent basis vector. | 02-06-2014 |
20140105485 | BASIS VECTOR SPECTRAL IMAGE COMPRESSION - Computer implemented methods for compressing 3D hyperspectral image data having a plurality of spatial pixels associated with a hyperspectral image, and a number of spectral dimensions associated with each spatial pixel, include receiving, using a processor, the 3D hyperspectral image data, a set of basis vectors associated therewith, and either a maximum error amount or a maximum data size. The methods also include partitioning the 3D hyperspectral image data into a plurality of 2D images, each associated with one of the number of spectral dimensions, and an associated one of the set of basis vectors. The methods additionally include ranking the set of basis vectors if not already ranked. The methods may further include iteratively applying lossy compression to the 2D images, in an order determined by the ranking. Other embodiments and features are also disclosed. | 04-17-2014 |
20140126836 | CORRECTION OF VARIABLE OFFSETS RELYING UPON SCENE - In accordance with various aspects of the disclosure, a method, system, and computer readable media having instructions for processing images is disclosed. For example, the method includes determining a suspicious pixel suspected of causing an artifact in a measurement as a function of a statistical analysis of a collection of samples representing residual error values associated with a subject focal plane pixel measuring one waveband at different times. Based on the determination of the suspicious pixel, a pattern of residual error values is identified that is indicative of the artifact caused by the suspicious pixel. A correcting time-dependent offset determined that is substantially reciprocal to the identified pattern of residual error values. The correcting time-dependent offset is applied to the measurement to correct for artifact in the measurement. | 05-08-2014 |
20140241633 | RAPID DETECTION - In accordance with various aspects of the disclosure, a detecting engine for detecting targets/materials in hyperspectral scenes is disclosed. The detecting engine combines data partitioning and dimensionality reduction to reduce the number of computations needed to identify in which pixels in a hyperspectral scene a given material is present. Computation reduction (in some instances, by two fold) greatly impacts the speed of and power consumed by the detecting engine making the engine suitable for hyperspectral imaging of large scenes, processing using many filters per pixel, or missions requiring testing large numbers of reference spectra to see which are present in a scene. | 08-28-2014 |
20150036877 | SPARSE REDUCED (SPARE) FILTER - The disclosure provides a filtering engine for selecting sparse filter components used to detect a material of interest (or specific target) in a hyperspectral imaging scene and applying the sparse filter to a plurality of pixels in the scene. The filtering engine transforms a spectral reference representing the material of interest to principal components space using the eigenvectors of the scene. It then ranks sparse filter components based on each transformed component of the spectral reference. The filtering engine selects sparse filter components based on their ranks. The filtering engine performs the subset selection quickly because the computations are minimized; it processes only the spectral reference vector and covariance matrix of the scene to do the subset selection rather than process a plurality of pixels in the scene, as is typically done. The spectral filter scores for the plurality of pixels are calculated efficiently using the sparse filter. | 02-05-2015 |
Patent application number | Description | Published |
20090059970 | Mode Hopping Swept Frequency Laser for FD OCT and Method of Operation - A frequency swept laser source that generates an optical signal that is tuned over a spectral scan band at single discrete wavelengths associated with longitudinal modes of the swept laser source. Laser hopping over discrete single cavity modes allows long laser coherence length even under dynamic very high speed tuning conditions. A ramp drive to the laser is used to linearize laser frequency tuning. A beam splitter is used to divide the optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample. A detector system detects the optical signal from the reference arm and the sample arm for generating depth profiles and images of the sample. | 03-05-2009 |
20090059971 | Linearized Swept Laser Source for Optical Coherence Analysis System - A frequency swept laser source that generates an optical signal that is tuned over a spectral scan band at single discrete wavelengths associated with longitudinal modes of the swept laser source. Laser hopping over discrete single cavity modes allows long laser coherence length even under dynamic very high speed tuning conditions. A ramp drive to the laser is used to linearize laser frequency tuning. A beam splitter is used to divide the optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample. A detector system detects the optical signal from the reference arm and the sample arm for generating depth profiles and images of the sample. | 03-05-2009 |
20090284749 | OCT Combining Probes and Integrated Systems - Optical coherence tomography (OCT) probe and system designs are disclosed that minimize the effects of mechanical movement and strain to the probe to the OCT analysis. It also concerns optical designs that are robust against noise from the OCT laser source. Also integrated OCT system-probes are included that yield compact and robust electro-opto-mechanical systems along with polarization sensitive OCT systems. | 11-19-2009 |
20090290167 | Optical Coherence Tomography Laser with Integrated Clock - A frequency swept laser source for TEFD-OCT imaging includes an integrated clock subsystem on the optical bench with the laser source. The clock subsystem generates frequency clock signals as the optical signal is tuned over the scan band. Preferably the laser source further includes a cavity extender in its optical cavity between a tunable filter and gain medium to increase an optical distance between the tunable filter and the gain medium in order to control the location of laser intensity pattern noise. The laser also include a fiber stub that allows for control over the cavity length while also controlling birefringence in the cavity. | 11-26-2009 |
20110051143 | ASE Swept Source with Self-Tracking Filter for OCT Medical Imaging - An integrated swept wavelength tunable optical source uses a narrowband filtered broadband signal with an optical amplifier and self-tracking filter. This source comprises a micro optical bench, a source for generating broadband light, a tunable Fabry Perot filter, installed on the bench, for spectrally filtering the broadband light from the broadband source to generate a narrowband tunable signal, an amplifier, installed on the bench, for amplifying the tunable signal. The self-tracking arrangement is used where a single tunable filter both generates the narrowband signal and spectrally filters the amplified signal. In some examples, two-stage amplification is provided. The use of a single bench implementation yields a low cost high performance system. For example, polarization control between components is no longer necessary. | 03-03-2011 |
20110051148 | Filtered ASE Swept Source for OCT Medical Imaging - An integrated swept wavelength optical source uses a filtered ASE signal with an optical amplifier and tracking filter. This source comprises a micro optical bench, a source for generating broadband light, a first tunable Fabry Perot filter, installed on the bench, for spectrally filtering the broadband light from the broadband source to generate a narrowband tunable signal, an amplifier, installed on the bench, for amplifying the tunable signal, and a second tunable Fabry Perot filter, installed on the bench, for spectrally filtering the amplified tunable signal from the amplifier. A self-tracking arrangement is also possible where a single tunable filter both generates the narrowband signal and spectrally filters the amplified signal. In some examples, two-stage amplification is provided. The use of a single bench implementation yields a low cost high performance system. For example, polarization control between components is no longer necessary. | 03-03-2011 |
20110080591 | Integrated Dual Swept Source for OCT Medical Imaging - An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal for form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm. | 04-07-2011 |
20110181966 | SOI Lens Structure for Medical Probe - An optical probe for emitting and/or receiving light within a body comprises an optical fiber that transmits and/or receives an optical signal, a silicon optical bench including a fiber groove running longitudinally that holds an optical fiber termination of the optical fiber and a reflecting surface that optically couples an endface of the optical fiber termination to a lateral side of the optical bench. The fiber groove is fabricated using silicon anisotropic etching techniques. Some examples use a housing around the optical bench that is fabricated using LIGA or other electroforming technology. A method for forming lens structure is also described that comprises forming a refractive lens in a first layer of a composite wafer material, such as SOI (silicon on insulator) wafers and forming an optical port through a backside of the composite wafer material along an optical axis of the refractive lens. the refractive lens is preferably formed using grey-scale lithography and dry etching the first layer. | 07-28-2011 |
20110182550 | Silicon Optical Bench OCT Probe for Medical Imaging - An optical probe for emitting and/or receiving light within a body comprises an optical fiber that transmits and/or receives an optical signal, a silicon optical bench including a fiber groove running longitudinally that holds an optical fiber termination of the optical fiber and a reflecting surface that optically couples an endface of the optical fiber termination to a lateral side of the optical bench. The fiber groove is fabricated using silicon anisotropic etching techniques. Some examples use a housing around the optical bench that is fabricated using LIGA or other electroforming technology. A method for forming lens structure is also described that comprises forming a refractive lens in a first layer of a composite wafer material, such as SOI (silicon on insulator) wafers and forming an optical port through a backside of the composite wafer material along an optical axis of the refractive lens. the refractive lens is preferably formed using grey-scale lithography and dry etching the first layer. | 07-28-2011 |
20120026505 | Swept Frequency Laser for FD OCT with Intracavity Element and Method of Operation - A frequency swept laser source that generates an optical signal that is tuned over a spectral scan band at single discrete wavelengths associated with longitudinal modes of the swept laser source. Laser hopping over discrete single cavity modes allows long laser coherence length even under dynamic very high speed tuning conditions. A ramp drive to the laser is used to linearize laser frequency tuning. A beam splitter is used to divide the optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample. A detector system detects the optical signal from the reference arm and the sample arm for generating depth profiles and images of the sample. | 02-02-2012 |
20120162659 | Integrated Dual Swept Source for OCT Medical Imaging - An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal for form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm. In embodiments, the swept sources are tunable lasers that have shared laser cavities. | 06-28-2012 |
20120162662 | Actively Mode Locked Laser Swept Source for OCT Medical Imaging - An optical coherence analysis system uses a laser swept source that is constrained to operate in a mode locked condition. This is accomplished by synchronously changing the laser cavity's gain and/or phase based on the round trip travel time of light in the cavity. This improves high speed tuning by taking advantage of frequency shifting mechanisms within the cavity and avoids chaotic laser behavior. | 06-28-2012 |
20120168650 | Integrated OCT Detector System with Transimpedance Amplifier - An optical detector system comprises a hermetic optoelectronic package, an optical bench installed within the optoelectronic package, a balanced detector system installed on the optical bench. The balanced detector system includes at least two optical detectors that receive interference signals. An electronic amplifier system installed within the optoelectronic package amplifies an output of at least two optical detectors. Also disclosed is an integrated optical coherence tomography system. Embodiments are provided in which the amplifiers, typically transimpedance amplifiers, are closely integrated with the optical detectors that detect the interference signals from the interferometer. Further embodiments are provided in which the interferometer but also preferably its detectors are integrated together on a common optical bench. Systems that have little or no optical fiber can thus be implemented. | 07-05-2012 |
20120170046 | Integrated Optical Coherence Tomography System - An optical detector system comprises a hermetic optoelectronic package, an optical bench installed within the optoelectronic package, a balanced detector system installed on the optical bench. The balanced detector system includes at least two optical detectors that receive interference signals. An electronic amplifier system installed within the optoelectronic package amplifies an output of at least two optical detectors. Also disclosed is an integrated optical coherence tomography system. Embodiments are provided in which the amplifiers, typically transimpedance amplifiers, are closely integrated with the optical detectors that detect the interference signals from the interferometer. Further embodiments are provided in which the interferometer but also preferably its detectors are integrated together on a common optical bench. Systems that have little or no optical fiber can thus be implemented. | 07-05-2012 |
20120199745 | Widely-Tunable Semiconductor Source Integrated in Windowed Hermetic Package - A near infrared (NIR) semiconductor laser system is shown for gas sensing. An embodiment is centered on the use of a system with a much wider tunable laser, which today has a scan band of more than 150 nanometers (nm) to as much as 250 nm or more. In some cases the scan band is about 400 nm or more. This is achieved in the current embodiment through the use of a widely tunable microelectromechanical system (MEMS) based Fabry-Perot filter as an integral part of the laser cavity. Using this technology, these systems are capable of capturing a variety of gases in the any of the well-known spectroscopic scan bands, such as the OH, NH or CH. For example, a single laser with a 250 nm scan band window between 1550-1800 nm can capture ten or as many as twenty hydrocarbon-based gases simultaneously. | 08-09-2012 |
20120257210 | Method and System for Avoiding Package Induced Failure in Swept Semiconductor Source - Dry oxygen, dry air, or other gases such as ozone are hermetically sealed within the package of the external cavity laser or ASE swept source to avoid packaging-induced failure or PIF. PIF due to hydrocarbon breakdown at optical interfaces with high power densities is believed to occur at the SLED and/or SOA facets as well as the tunable Fabry-Perot reflector/filter elements and/or output fiber. Because the laser is an external cavity tunable laser and the configuration of the ASE swept sources, the power output can be low while the internal power at surfaces can be high leading to PIF at output powers much lower than the 50 mW. | 10-11-2012 |
20120300215 | OCT Combining Probes and Integrated Systems - Optical coherence tomography (OCT) probe and system designs are disclosed that minimize the effects of mechanical movement and strain to the probe to the OCT analysis. It also concerns optical designs that are robust against noise from the OCT laser source. Also integrated OCT system-probes are included that yield compact and robust electro-opto-mechanical systems along with polarization sensitive OCT systems. | 11-29-2012 |
20120300216 | Integrated Optical Coherence Analysis System - Optical coherence tomography (OCT) probe and system designs are disclosed that minimize the effects of mechanical movement and strain to the probe to the OCT analysis. It also concerns optical designs that are robust against noise from the OCT laser source. Also integrated OCT system-probes are included that yield compact and robust electro-opto-mechanical systems along with polarization sensitive OCT systems. | 11-29-2012 |
20130204111 | Wireless Pressure Wire System with Integrated Power - A sensor wire system with an integrated power source and wireless transmission is provided. A sensor wire includes a distal end that is inserted into a blood vessel of a patient's body. A sensor that is mounted at the distal end of the sensor wire and an electronics unit of the distal end of the sensor wire transmit information generated by the sensor to a receiver unit outside of the patient's body wirelessly. The system further includes a power source, which in one example is mounted to the distal end of the sensor wire, that supplies power to the electronics unit. Preferably the wire body functions as an antenna for the wireless broadcasting. | 08-08-2013 |
20130215432 | Filtered ASE Swept Source for OCT Medical Imaging - An integrated swept wavelength optical source uses a filtered ASE signal with an optical amplifier and tracking filter. This source comprises a micro optical bench, a source for generating broadband light, a first tunable Fabry Perot filter, installed on the bench, for spectrally filtering the broadband light from the broadband source to generate a narrowband tunable signal, an amplifier, installed on the bench, for amplifying the tunable signal, and a second tunable Fabry Perot filter, installed on the bench, for spectrally filtering the amplified tunable signal from the amplifier. A self-tracking arrangement is also possible where a single tunable filter both generates the narrowband signal and spectrally filters the amplified signal. In some examples, two-stage amplification is provided. The use of a single bench implementation yields a low cost high performance system. For example, polarization control between components is no longer necessary. | 08-22-2013 |
20130271772 | Multi-speed OCT swept source with optimized k-clock - An optical coherence tomography system utilizes an optical swept source that frequency scans at least two different sweep rates. In this way, the system can perform large depth scans of the sample and then the same system can perform shorter depth high precision scans, in one specific example. In order to optimally use the analog to digital converter that samples the interference signal, the system further samples the interference signals at different optical frequency sampling intervals depending upon the selected sweep rates of the optical swept source. This allows the system to adapt to different sweep rates in an optimal fashion. | 10-17-2013 |
20130301098 | Mechanically Balanced Optical Membrane Device for Orientation Insensitivity - An optical membrane device comprises a substrate, at least one support block on a surface of the substrate, and at least one plate. A torsion beam supports the plate above the substrate on the support block. The optical membrane device also includes an optical membrane structure supported by the plate above the substrate and at least one electrode on the substrate underneath the plate. In one implementation, the optical membrane device further comprises a tether for coupling the optical membrane structure to the plate. The tether extends between the optical membrane structure and the plate. In another implementation, the substrate of the optical membrane device has an optical port through the substrate directly below the optical membrane structure. The plate is substantially balanced around the torsion beam to minimize a sensitivity to orientation in a gravitational field. | 11-14-2013 |
20130305513 | Silicon Optical Bench OCT Probe for Medical Imaging - An optical probe for emitting and/or receiving light within a body comprises an optical fiber that transmits and/or receives an optical signal, a silicon optical bench including a fiber groove running longitudinally that holds an optical fiber termination of the optical fiber and a reflecting surface that optically couples an endface of the optical fiber termination to a lateral side of the optical bench. The fiber groove is fabricated using silicon anisotropic etching techniques. Some examples use a housing around the optical bench that is fabricated using LIGA or other electroforming technology. A method for forming lens structure is also described that comprises forming a refractive lens in a first layer of a composite wafer material, such as SOI (silicon on insulator) wafers and forming an optical port through a backside of the composite wafer material along an optical axis of the refractive lens. The refractive lens is preferably formed using grey-scale lithography and dry etching the first layer. | 11-21-2013 |
20130321820 | ASE Swept Source with Self-Tracking Filter for OCT Medical Imaging - An integrated swept wavelength tunable optical source uses a narrowband filtered broadband signal with an optical amplifier and self-tracking filter. This source comprises a micro optical bench, a source for generating broadband light, a tunable Fabry Perot filter, installed on the bench, for spectrally filtering the broadband light from the broadband source to generate a narrowband tunable signal, an amplifier, installed on the bench, for amplifying the tunable signal. The self-tracking arrangement is used where a single tunable filter both generates the narrowband signal and spectrally filters the amplified signal. In some examples, two-stage amplification is provided. The use of a single bench implementation yields a low cost high performance system. For example, polarization control between components is no longer necessary. | 12-05-2013 |
20140016135 | Optical Coherence Tomography Laser with Integrated Clock - A frequency swept laser source for TEFD-OCT imaging includes an integrated clock subsystem on the optical bench with the laser source. The clock subsystem generates frequency clock signals as the optical signal is tuned over the scan band. Preferably the laser source further includes a cavity extender in its optical cavity between a tunable filter and gain medium to increase an optical distance between the tunable filter and the gain medium in order to control the location of laser intensity pattern noise. The laser also includes a fiber stub that allows for control over the cavity length while also controlling birefringence in the cavity. | 01-16-2014 |
20140085639 | Laser Swept Source with Controlled Mode Locking for OCT Medical Imaging - An optical coherence analysis system uses a laser swept source that is constrained to operate in a mode locked condition. This is accomplished by synchronously changing the laser cavity's gain and/or phase based on the round trip travel time of light in the cavity. Many high-speed wavelength swept laser sources emit pulses synchronized with the round trip time of the cavity as part of a nonlinear optical frequency red shifting process. Stable pulsation is associated with smooth tuning and low relative intensity noise. Addition of mode-locking methods to this class of lasers can control and stabilize these lasers to a low clock jitter and RIN state, and in specific cases allow long-to-short wavelength tuning in addition to the usual short-to-long (red shifting). The laser may comprise a SOA ( | 03-27-2014 |
20140119397 | Method and System for Avoiding Package Induced Failure in Swept Semiconductor Source - Dry oxygen, dry air, or other gases such as ozone are hermetically sealed within the package of the external cavity laser or ASE swept source to avoid packaging-induced failure or PLF. PIF due to hydrocarbon breakdown at optical interfaces with high power densities is believed to occur at the SLED and/or SOA facets as well as the tunable Fabry-Perot reflector/filter elements and/or output fiber. Because the laser is an external cavity tunable laser and the configuration of the ASE swept sources, the power output can be low while the internal power at surfaces can be high leading to PIF at output powers much lower than the 50 mW. | 05-01-2014 |
20140125986 | OCT system with tunable clock system for flexible data acquisition - An OCT system and particularly its clock system generates a k-clock signal but also generates an optical frequency reference sweep signal that, for example, indicates the start of the sweep or an absolute frequency reference associated with the sweep at least for the purposes of sampling of the interference signal and/or processing of that interference signal into the OCT images. The clock system is also tunable to allow the control or flexibility over the relationship between the scanning of the swept optical signal and the sampling of the interference signal by the data acquisition system. Specifically, the absolute frequencies of the swept optical signal at which the k-clock signals are generated can be adjusted. Also, the absolute frequency of the swept optical signal at which sampling of the interference signal is initiated can also be changed or stabilized. Moreover, optical frequency sampling interval defined by the k-clock signal can be changed under user control or simply stabilized. | 05-08-2014 |
20140125987 | Integrated Optical Coherence Tomography System - An optical detector system comprises a hermetic optoelectronic package, an optical bench installed within the optoelectronic package, a balanced detector system installed on the optical bench. The balanced detector system includes at least two optical detectors that receive interference signals. An electronic amplifier system installed within the optoelectronic package amplifies an output of at least two optical detectors. Also disclosed is an integrated optical coherence tomography system. Embodiments are provided in which the amplifiers, typically transimpedance amplifiers, are closely integrated with the optical detectors that detect the interference signals from the interferometer. Further embodiments are provided in which the interferometer but also preferably its detectors are integrated together on a common optical bench. Systems that have little or no optical fiber can thus be implemented. | 05-08-2014 |
20140152997 | Integrated Dual Swept Source for OCT Medical Imaging - An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal for form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm. In embodiments, the swept sources are tunable lasers that have shared laser cavities. | 06-05-2014 |
20140163392 | Sheath with Optically Interrogatable Sensors - An intravascular sensor system including an array of pressure and/or temperature sensors for detecting pressure and/temperature. In one example, the sensors are interrogated with an optical catheter. In this example, the swept source is able to acquire both image and pressure/temperature data of a patient's vessel or artery. In another example, the intravascular pressure sensor system has a sheath embedded with pressure sensors in the sheath wall. Other examples include the process of making and using the intravascular pressure sensor system. | 06-12-2014 |
20140168658 | Integrated Dual Swept Source for OCT Medical Imaging - An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal to form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm. | 06-19-2014 |
20140176958 | OCT System with Bonded MEMS Tunable Mirror VCSEL Swept Source - A microelectromechanical systems (MEMS)-tunable vertical-cavity surface-emitting laser (VCSEL) in which the MEMS mirror is a bonded to the active region. This allows for a separate electrostatic cavity, that is outside the laser's optical resonant cavity. Moreover, the use of this cavity configuration allows the MEMS mirror to be tuned by pulling the mirror away from the active region. This reduces the risk of snap down. Moreover, since the MEMS mirror is now bonded to the active region, much wider latitude is available in the technologies that are used to fabricate the MEMS mirror. This is preferably deployed as a swept source in an optical coherence tomography (OCT) system. | 06-26-2014 |
20140218741 | OCT Swept Laser with Cavity Length Compensation - An optical coherence tomography system utilizes an optical swept laser that has cavity length compensator that changes an optical length of the laser cavity for different optical frequencies to increase the length of the laser cavity for lower optical frequencies. Specifically, a spectral separation between longitudinal cavity modes of the laser cavity is shortened or alternatively lengthened as a passband of a cavity tuning element sweeps through a scanband of the swept optical signal. In some examples, the compensator is implemented as two gratings. In others, it is implemented as a chirped grating device. | 08-07-2014 |
20140268166 | OCT Medical Imaging System Using Gain Waveguide Array Swept Source - An optical coherence tomography system uses an optical source that comprises a series of gain waveguides that generate light at the frequencies at which the interference signal is to be sampled. In this way, the optical source generates a discretely tuned optical signal. This has the advantage that the tuning can be directly controlled by a controller that is also used to synchronize the sampling of the interference signal. This avoids the need for separate frequency clock synchronization. In embodiments, the gain waveguides are fabricated from one or more semiconductor edge emitting bars. In some implementations, the gain waveguides comprise periodic structures that define the frequency of operation of the waveguide. However in other implementations, the combiner comprises a dispersive element, such as a diffractive grating, that provides frequency specific feedback to each waveguide. | 09-18-2014 |
20150184994 | OCT swept laser with high coherence signal extraction - An optical coherence tomography system utilizes an optical swept laser that has improved coherence length in the swept optical signal. This is accomplished using an intra-cavity element that extracts the tunable optical signal at the optimal location within the laser's resonant cavity. Generally this location is between the intracavity tuning element and the cavity's gain element so that light coming from the tuning element is extracted. In general in lasers, the gain element adds noise and chirp and this degrades the tunable optical signal's coherence length. | 07-02-2015 |
20150265181 | WIRELESS SENSOR WIRE SYSTEM - A sensor wire system is provided. The system includes a sensor wire body configured to be inserted into a blood vessel of a patient, the sensor wire body having a distal portion; a sensor coupled to the distal portion of the sensor wire body and configured to obtain intravascular information associated with the blood vessel; and an electronics unit coupled to the sensor wire body and configured to wirelessly transmit the intravascular information to a receiver unit outside of the patient, wherein the electronics unit is further configured to vary a frequency at which the intravascular information is wirelessly transmitted. Associated devices and methods are also provided. | 09-24-2015 |
Patent application number | Description | Published |
20110152235 | Aminopyrimidine Kinase Inhibitors - Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. | 06-23-2011 |
20120270892 | Aminopyrimidine Kinase Inhibitors - Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. | 10-25-2012 |
20130310342 | Aminopyrimidine Kinase Inhibitors - Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK1, CK1γ1, CK1γ2, CK1γ3, CK2, Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of CK1, CK1γ1, CK1γ2, CK1γ3, CK2, Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway. | 11-21-2013 |
20140080799 | Aminopyrimidine Kinase Inhibitors - Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. | 03-20-2014 |
20150202205 | AMINOPYRIMIDINE KINASE INHIBITORS - Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of CK1, CK1γ1, CK1γ2, CK1γ3, CK2, Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of CK1, CK1γ1, CK1γ2, CK1γ3, CK2, Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, the AKT pathway, and/or the mTOR pathway. | 07-23-2015 |