Kahnert
Antje Kahnert, Dusseldorf DE
Patent application number | Description | Published |
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20110027268 | ANTI-MESOTHELIN ANTIBODIES AND USES THEREOF - The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. | 02-03-2011 |
20150259433 | ANTI-MESOTHELIN ANTIBODIES AND USES THEREOF - The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. | 09-17-2015 |
Antje Kahnert, Wuppertal DE
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20120189644 | ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR - The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co-administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors. The immunoconjugates comprise antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. | 07-26-2012 |
20130190290 | Substituted phenylimidazopyrazoles and their use - The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumour disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures. | 07-25-2013 |
Christopher A. Kahnert, Euclid, OH US
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20080236999 | Switch assembly having a mechanically actuated override - A method and apparatus for enabling reverse mow condition in a tractor comprises a switch assembly having an ignition switch that is rotatable through a plurality of positions, a housing for supporting the ignition switch, and an actuator movably located in the housing. The enabling of a reverse mow condition is achieved by displacing the actuator from a rest position to two separate and distinct positions. | 10-02-2008 |
20100044194 | SWITCH ASSEMBLY HAVING A MECHANICALLY ACTUATED OVERRIDE - A method and apparatus for enabling reverse mow condition in a tractor comprises a switch assembly having an ignition switch that is rotatable through a plurality of positions, a housing for supporting the ignition switch, and an actuator movably located in the housing. The enabling of a reverse mow condition is achieved by displacing the actuator from a rest position to two separate and distinct positions. | 02-25-2010 |
Christopher A. Kahnert, Lorain, OH US
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20150300466 | ANTI-BACKLASH NUT ASSEMBLY - An anti-lash nut assembly for installation on a threaded rod and including a lead nut, a collar, and a spring positioned between the lead nut and the collar. The lead nut has a set of tabs extending radially outward from a rear end of the body. The collar has a set of clearance slots on an inside surface. The set of clearance slots are configured for sliding of the set of tabs through the clearance slots in the rear direction. The collar has a set of ramps on an inside surface. Each of the set of ramps is configured for engagement with each of the set of tabs to prohibit axial movement of the collar in the rear direction. | 10-22-2015 |
Thomas Kahnert, Hemmingen DE
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20100011253 | Circuit Arrangement for monitoring errors during signal transmission - A circuit arrangement, having a circuit and a computer unit is provided, in which the circuit and the computer unit are connected to one another via multiple lines for transmitting a number of signals which are embodied as information signals. The circuit has a multiplexer for combining signals, the multiplexer being connected to the computer unit via an additional line. | 01-14-2010 |