Patent application number | Description | Published |
20090195131 | DRAWER SYSTEM SLIDE ASSEMBLIES AND CLOSURE MECHANISMS - A self-closing drawer slide system includes first and second slide members and a self-closing mechanism which, in turn, includes a housing coupled to the first slide member, a carriage slidably coupled to the housing, and a spring coupled between the housing and the carriage. The carriage has an engagement area that selectively receives a cam/tab extending from the second slide member. As the drawer is pulled open, the carriage disengages from the cam/tab as it rotates and is locked in place. As the drawer returns, the carriage again engages the cam/tab, unlocks, and is pulled toward a drawer-closed position by the spring. The system may also include an intermediate member, with respective sets of three balls disposed between the intermediate and first and second slide members such that respective centers of the balls define corners of an obtuse triangle. The self-closing mechanism may also include a damper. | 08-06-2009 |
20100264793 | ASSISTED-MOTION SYSTEMS AND METHODS - A system for assisting the linear opening and closing movement of a pull-out component relative to a housing includes a first bracket coupled to a slide member of the housing, a second bracket coupled to the pull-out component, and a strut that, at one end, is pivotally coupled to the first bracket and, at a second end, is pivotally coupled to the second bracket. The strut includes an elongate hollow member that houses a spring and a cylindrical piston, as well as a rod sub-assembly that translates through one end of the hollow member. The cylindrical piston is situated between, and at its respective ends is coupled to, the spring and the rod sub-assembly. The free end of the spring is held inside the hollow member by a clevis for the first bracket, and the free end of the rod sub-assembly includes a clevis for the second bracket. | 10-21-2010 |
20100264794 | DAMPENED ASSISTED-MOTION SYSTEMS AND METHODS - A system for assisting the linear movement of a pull-out component relative to a housing includes a first bracket coupled to a slide member of the housing, a second bracket coupled to the pull-out component, and a strut that is pivotally coupled to the first and second brackets at its respective ends. The strut includes an outer hollow member that houses a primary spring, a cylindrical piston that translates through one end of the outer hollow member, and a reverse damping mechanism. A free end of the primary spring is held inside the outer hollow member by a clevis for the first bracket, and its opposite end rests on the piston. The piston's free end includes a clevis for the second bracket. An inner hollow member houses a second spring which regulates movement of a damper shaft such that damping occurs when the shaft is pulled out of the damper. | 10-21-2010 |
Patent application number | Description | Published |
20120164618 | MONOTONOUS GAME-LIKE TASK TO PROMOTE EFFORTLESS AUTOMATIC RECOGNITION OF SIGHT WORDS - System and methods are provided to promote effortless automatic recognition of common sight words. A subject performs a game-like task that generates novel non-verbal visual stimuli that triggers visual attention shifts that enhance foveal and parafoveal recognition of non-verbal and verbal stimuli laterally presented in the right or left visual field. The present invention engages a shared motor-perceptual-cognitive neural network involving oculomotor, visuo-motor and selective executive cognitive behaviors on both brain hemispheres. The present invention has applications to a wide range of non-verbal pre-orthographic visual processes and early lexical processes, not only contributing to enabling reading fluency to dyslexics, reluctant and slow readers, but also to beginning readers. The present invention has wide applications in learning disabilities and normative individuals learning to read. | 06-28-2012 |
20150031003 | NEUROPERFORMANCE - A method of promoting fluid intelligence abilities in a subject includes the steps of: selecting one or more serial order of symbols sequences from a predefined library of complete symbols sequences and, from this selection, providing the subject with one or more incomplete serial orders of symbols sequences; prompting the subject to manipulate symbols within the one or more incomplete serial orders of symbols sequences or to discriminate differences or sameness between two or more of the incomplete serial orders of symbols sequences; determining whether the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more further selected incomplete serial orders of symbols sequences; if the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more of the incomplete serial orders of symbols sequences, then displaying the correct manipulations or discriminated differences or sameness with at least one different spatial or time perceptual related attribute, to highlight the correct answer. | 01-29-2015 |
20150031009 | NEUROPERFORMANCE - A method of promoting fluid intelligence abilities in a subject includes: selecting one or more serial order of symbols sequences from a predefined library of complete symbols sequences and providing the subject with one or more incomplete serial orders of symbols sequences; prompting the subject to manipulate symbols within the incomplete serial orders of symbols sequences or to discriminate differences or sameness between two or more of the incomplete serial orders of symbols sequences; determining whether the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more incomplete serial orders of symbols sequences; if the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more of the incomplete serial orders of symbols sequences, then displaying the correct manipulations or discriminated selection with at least one different spatial or time perceptual related attribute, to highlight the correct answer. | 01-29-2015 |
20150031010 | IMPROVING NEUROPERFORMANCE - A method of promoting fluid intelligence abilities in a subject includes: selecting one or more serial order of symbols sequences from a predefined library of complete symbols sequences and providing the subject with one or more incomplete serial orders of symbols sequences; prompting the subject to manipulate symbols within the incomplete serial orders of symbols sequences or to discriminate differences or sameness between two or more of the incomplete serial orders of symbols sequences; determining whether the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more incomplete serial orders of symbols sequences; if the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more of the incomplete serial orders of symbols sequences, then displaying the correct manipulations or discriminated selection with at least one different spatial or time perceptual related attribute, to highlight the correct answer. | 01-29-2015 |
20150086950 | IMPROVING NEUROPERFORMANCE - A method of promoting fluid intelligence abilities in a subject includes: selecting one or more serial order of symbols sequences from a predefined library of complete symbols sequences and providing the subject with one or more incomplete serial orders of symbols sequences; prompting the subject to manipulate symbols within the incomplete serial orders of symbols sequences or to discriminate differences or sameness between two or more of the incomplete serial orders of symbols sequences; determining whether the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more incomplete serial orders of symbols sequences; if the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more of the incomplete serial orders of symbols sequences, then displaying the correct manipulations or discriminated selection with at least one different spatial or time perceptual related attribute, to highlight the correct answer. | 03-26-2015 |
20150294577 | NEUROPERFORMANCE - Methods of promoting searching, pattern recognition and sensory motor selection in a subject including the steps of: selecting a first number of open-bigram terms as target terms and a second number of open-bigram terms as distractor terms, both from any class and all having the same spatial and time perceptual related attributes, arranging the open-bigrams terms in a matrix format in a number of arrays, selecting one or more sectors in the matrix where the target terms replace an equal number of distractor terms; providing the subject with the arranged matrix along with a ruler displaying a predefined alphabetic letters sequence; prompting the subject to search, recognize, and select all of the target terms within a first predefined period of time; and displaying correctly identified target terms with a changed spatial or time perceptual related attribute. | 10-15-2015 |
20150294580 | SYSTEM AND METHOD FOR PROMOTING FLUID INTELLEGENCE ABILITIES IN A SUBJECT - A method of promoting fluid intelligence abilities in a subject includes: selecting one or more serial order of symbols sequences from a predefined library of complete symbols sequences and providing the subject with one or more incomplete serial orders of symbols sequences; prompting the subject to manipulate symbols within the incomplete serial orders of symbols sequences or to discriminate differences or sameness between two or more of the incomplete serial orders of symbols sequences; determining whether the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more incomplete serial orders of symbols sequences; if the subject correctly manipulated the symbols or correctly discriminated differences or sameness between the two or more of the incomplete serial orders of symbols sequences, then displaying the correct manipulations or discriminated selection with at least one different spatial or time perceptual related attribute, to highlight the correct answer. | 10-15-2015 |
20150294581 | NEUROPERFORMANCE - Methods of promoting fluid intelligence abilities in a subject including the steps of: selecting a complete serial order of different open-bigram terms with the same spatial and time perceptual related attributes, providing the subject, from the selected complete serial order, with a randomized open-bigrams sequence having a plurality of repeated open-bigram terms, a plurality of open-bigram terms out of serial order, and a plurality of missing open-bigram terms; prompting the subject to serially sensorially discriminate and sensory motor remove the repeated open-bigram terms; prompting the subject to sensory motor reorganize the out of serial order open-bigram terms; prompting the subject to sensory motor insert the missing open-bigram terms; and displaying the correctly sensory motor inserted open-bigram terms with at least one different spatial or time perceptual related attribute to highlight the correct open-bigram terms answer. | 10-15-2015 |
20150294584 | NEUROPERFORMANCE - Methods of promoting fluid intelligence abilities in a subject including the steps of: selecting one or more serial orders of open-bigram terms from a predefined library of open-bigram sequences, providing the subject with further selected one or more incomplete serial orders of open-bigram terms; prompting the subject to reason in order to sensory motor manipulate open-bigram terms or to reason in order to sensorially discriminate differences or sameness between two or more of incomplete open-bigram sequences; determining whether the subject correctly sensory motor manipulated the open-bigram terms or sensorially discriminated differences or sameness; and displaying the correct sensory motor manipulations or sensorially discriminated differences or sameness with at least one different spatial or time perceptual related attribute to highlight the correct answer. | 10-15-2015 |
20150294585 | NEUROPERFORMANCE - Methods of promoting fluid intelligence abilities in a subject including the steps of: selecting one or more serial orders of open-bigram terms from a predefined library of complete open-bigram sequences, providing the subject with a further selected one or more incomplete serial orders of different open-bigram terms from the selected one or more serial orders; prompting the subject to sensorially discriminate and sensory motor insert one or more missing open-bigram terms in the one or more incomplete serial orders of open-bigram terms to form one or more completed alphabetical serial orders of open-bigram terms; determining whether the subject correctly sensorially discriminated and sensory motor inserted the open-bigram terms; and displaying the correct sensorially discriminated and sensory motor inserted open-bigram terms with at least one different spatial and/or time perceptual related attribute to highlight the correct open-bigram term answers. | 10-15-2015 |
20150294586 | NEUROPERFORMANCE - Methods of promoting fluid reasoning ability in a subject including the steps of: selecting a letters sequence from a predefined library of letters sequences, providing the subject with the letters sequence and a ruler displaying a selected complete open proto-bigram sequence with the same spatial and time perceptual related attributes; asking the subject to reason in order to solve a selected serial order of letters exercise by searching within the letters sequence to judge if any two letters can or cannot form an open proto-bigram term according to predefined instructions; prompting the subject to sensory motor select, with predefined means, two recognized letters that can or cannot form an open proto-bigram term; determining whether the subject correctly sensory motor selected the letters; and displaying the correctly sensory motor selected open proto-bigram terms, with at least one different spatial or time perceptual related attribute to highlight the correct sensory motor selection. | 10-15-2015 |
20150294587 | NEUROPERFORMANCE - Methods of promoting reasoning ability in a subject by performing a local or a non-local compression of a provided letters sequence when removing one or more contiguous letters located in between the two letters of an assigned open proto-bigram recognized by the subject in the provided letters sequence, and by performing an alphabetic expansion of an assigned open proto-bigram term by explicitly actualizing a collective critical space of the assigned open proto-bigram term by inserting the corresponding incomplete alphabetic letters sequence in between the two letters of an assigned open proto-bigram. | 10-15-2015 |
Patent application number | Description | Published |
20080269821 | Method and Apparatus For Affecting The Autonomic Nervous System - A method and apparatus for affecting the autonomic nervous system of a subject using stimuli based on separate analysis of the sympathetic and/or parasympathetic branches of the subject's autonomic nervous system. The present invention also relates to a method and apparatus for affecting the autonomic nervous system, wherein stimuli is applied in coordination with cyclical activities of the subjects body such as respiration or cardiac cycle. | 10-30-2008 |
20080306563 | System and method for cardiovascular treatment or training - The invention provides a system and method for cardiovascular treatment or training of an individual. One or more venous return devices are used to alter the venous return in an individual, and one or more heart rate devices are used to alter the individual's heart rate. A processor activates the venous return devices and the one or more heart rate devices at one or more predetermined levels for one or more predetermined time durations | 12-11-2008 |
20150294588 | Neuroperformance - Methods of promoting fluid intelligence abilities in a subject are described herein. In particular, exemplary exercises are directed at the following: sensorially perceptually discriminating embedded relational open proto-bigrams (ROPB) in predefined alphabetic arrays; inserting missing different or same type ROPBs in predefined alphabetic arrays; sensorially perceptually discriminating and sensory motor selecting embedded same or different type ROPBs in predefined stand-alone alphabetic arrays or in predefined stand-alone alphabetic arrays as part of a sentence or figurative speech type sentence; and sensorially perceptually discriminating and sensory motor selecting embedded ROPBs in selected affixes contained within predefined alphabetic arrays. | 10-15-2015 |
20150294589 | Neuroperformance - Methods of promoting fluid intelligence abilities in a subject are described herein. In particular, exemplary exercises are directed at the serial sensory motor insertion of letters of selected alphabetic arrays, which are words that may or may not contain embedded relational open proto-bigrams (ROPB), into a predefined incomplete alphabetic set array. Correctly sensory motor inserted letters and embedded ROPBs are highlighted for the sensorial perceptual discrimination of the subject in the selected alphabetic set array and the selected alphabetic arrays by displaying the same with at least one changed spatial and/or time perceptual related attribute. | 10-15-2015 |
20150294590 | NEUROPERFORMANCE - Methods of promoting fluid intelligence abilities in a subject are described herein. Exemplary exercises are directed to sensorially perceptually discriminating between orthographic numerical name label value representations and the corresponding symbolic graphical digit value representations in predefined ascending or descending sequential orders. The subject is further required to sensorially perceptually discriminate whether any relational open proto-bigrams (ROPB) are embedded in the selected orthographic numerical name label value representations. Correctly sensory motor selected orthographic numerical name label value representations, including any embedded ROPBs, and corresponding symbolic graphical digit value representations are highlighted by displaying the same with at least one changed spatial and/or time perceptual related attribute. | 10-15-2015 |
20150294591 | NEUROPERFORMANCE - Methods of promoting fluid intelligence abilities in a subject are described herein. In particular, exemplary exercises are directed at sensorially perceptually searching and discriminating one or more similarities between the serial order of letters in non-word name label groups, belonging to a relational category represented by a preselected relational non-word name label, and one or more word name labels from a group of words. Correctly sensory motor selected word name labels are highlighted to the subject by displaying the same with at least one changed spatial and/or time perceptual related attribute. Embedded relational open proto-bigrams are further highlighted in the correctly selected word name labels by at least one additional changed spatial and/or time perceptual related attribute. | 10-15-2015 |
Patent application number | Description | Published |
20080230603 | MEDIA ENABLED SHOPPING SYSTEM USER INTERFACE - A media enhanced shopping cart system comprises a shopping cart comprising a frame, a basket, a handle, a base tray, a plurality of wheels, a read component for performing a proximity scan of the shopping cart, a locationing component for determining a location of the shopping cart within a store based on the scan, and a display component for displaying at least one advertisement for a product based on the location of the shopping cart within the store, wherein the locationing component is further operable to determine a location of the product within the store relative to the shopping cart based on the scan, and wherein the display component is further operable to display an indication of the location of the advertised product relative to the location of the shopping cart. | 09-25-2008 |
20080231431 | CART COORDINATOR/DEPLOYMENT MANAGER - A media enhanced shopping cart system comprises a shopping cart comprising a frame, a basket, a handle, a base tray, a plurality of wheels, a read component for performing a proximity scan of the shopping cart, a locationing component for determining a location of the shopping cart within a store based on the scan, and a display component for displaying at least one advertisement for a product based on the location of the shopping cart within the store, wherein the locationing component is further operable to determine a location of the product within the store relative to the shopping cart based on the scan, and wherein the display component is further operable to display an indication of the location of the advertised product relative to the location of the shopping cart. | 09-25-2008 |
20080231432 | CART EXPLORER FOR FLEET MANAGEMENT/MEDIA ENHANCED SHOPPING CART PAGING SYSTEMS/MEDIA ENHANCED SHOPPING DEVICES WITH INTEGRATED COMPASS - A media enhanced shopping cart system comprises a shopping cart comprising a frame, a basket, a handle, a base tray, a plurality of wheels, a read component for performing a proximity scan of the shopping cart, a locationing component for determining a location of the shopping cart within a store based on the scan, and a display component for displaying at least one advertisement for a product based on the location of the shopping cart within the store, wherein the locationing component is further operable to determine a location of the product within the store relative to the shopping cart based on the scan, and wherein the display component is further operable to display an indication of the location of the advertised product relative to the location of the shopping cart. | 09-25-2008 |
20080237339 | INTEGRATION OF CUSTOMER-STORED INFORMATION WITH MEDIA ENABLED SHOPPING SYSTEMS - A media enhanced shopping cart system comprises a shopping cart comprising a frame, a basket, a handle, a base tray, a plurality of wheels, a read component for performing a proximity scan of the shopping cart, a locationing component for determining a location of the shopping cart within a store based on the scan, and a display component for displaying at least one advertisement for a product based on the location of the shopping cart within the store, wherein the locationing component is further operable to determine a location of the product within the store relative to the shopping cart based on the scan, and wherein the display component is further operable to display an indication of the location of the advertised product relative to the location of the shopping cart. | 10-02-2008 |
20080243626 | POS FOCUSED MEDIA ENHANCED SHOPPING SYSTEMS - PRICING AND SHRINKAGE CONTROL - A media enhanced shopping cart system comprises a shopping cart comprising a frame, a basket, a handle, a base tray, a plurality of wheels, a read component for performing a proximity scan of the shopping cart, a locationing component for determining a location of the shopping cart within a store based on the scan, and a display component for displaying at least one advertisement for a product based on the location of the shopping cart within the store, wherein the locationing component is further operable to determine a location of the product within the store relative to the shopping cart based on the scan, and wherein the display component is further operable to display an indication of the location of the advertised product relative to the location of the shopping cart. | 10-02-2008 |
20140108195 | Integration of Customer-Stored Information with Media Enabled Shopping Systems - A media enhanced shopping cart system comprises a shopping cart comprising a frame, a basket, a handle, a base tray, a plurality of wheels, a read component for performing a proximity scan of the shopping cart, a locationing component for determining a location of the shopping cart within a store based on the scan, and a display component for displaying at least one advertisement for a product based on the location of the shopping cart within the store, wherein the locationing component is further operable to determine a location of the product within the store relative to the shopping cart based on the scan, and wherein the display component is further operable to display an indication of the location of the advertised product relative to the location of the shopping cart. | 04-17-2014 |
Patent application number | Description | Published |
20100063384 | LOCAL INTRA-BODY DELIVERY SYSTEM - A system for delivery of a capsule to a target location within a subject body including a capsule including a locomotion element and a gamma emitting radioactive source, a radiation tracking subsystem capable of locating the gamma emitting radioactive source in three dimensions, and a locomotion control subsystem capable of controlling movement of the capsule by effecting movement of the locomotion element, based, at least partly, on a location of the gamma emitting radioactive source provided by the radiation tracking subsystem. A method of measuring a velocity of flow of a fluid at a target location within a subject body including inserting a capsule including a locomotion element and a gamma emitting radioactive source into the body, using a radiation tracking subsystem to locate the gamma emitting radioactive source in three dimensions, moving the capsule to the target location within the body using a locomotion control subsystem which controls movement of the capsule by effecting movement of the locomotion element, based, at least partly, on location of the gamma emitting radioactive source provided by the radiation tracking subsystem, and measuring the velocity of flow of the fluid at the target location. Related apparatus and methods are also described. | 03-11-2010 |
20110006212 | DETECTING PHOTONS IN THE PRESENCE OF A PULSED RADIATION BEAM - A detector system adapted for monitoring a radiation treatment system comprising a pulsed beam radiation source for treating a body with a given beam intensity and beam configuration, with pulse times and intervals between pulses less than 100 milliseconds, using at least one monitoring radiation source located inside or outside the body, the detector system comprising; a) a detector designed to detect radiation from the monitoring source, and subject to interference radiation from the beam source; and b) control circuitry that creates a data record of radiation received by the detector, to provide information about the body; wherein, when the detector detects radiation in real time during operation of the beam, the data record selectively excludes data for radiation received by the detector during the pulses, as opposed to data for radiation received by the detector between pulses. | 01-13-2011 |
20110105895 | GUIDED SURGERY - System and methods for image guided surgery is provided. The surgical tracking system can include at least one sensor configured to acquire a marker signal associated with a first location of a marker within a body and to output a first signal indicative of the first location, and also further configured to acquire a device signal associated with a second location of a movable imaging device and to output a second signal indicative of the second location. The movable imaging device can be configured to generate a plurality of sequential images. The surgical tracking system can further include at least one processor configured to receive the first signal, the second signal, and the plurality of sequential images, and to generate a plurality of composite images where at least one of the plurality of composite images include a visual indication of the first location on at least one of the plurality of sequential images. | 05-05-2011 |
20110105897 | HYBRID MEDICAL DEVICE LOCALIZATION SYSTEM - A hybrid radioactive and impedance tracking system for tracking a target in a human or animal body, comprising: a) a radioactive tracking subsystem for tracking the target; b) an impedance tracking subsystem for tracking the target; and c) a processor that uses data from the radioactive tracking subsystem in combination with data from the impedance tracking system to estimate a position of the target. | 05-05-2011 |
20110118588 | Combination MRI and Radiotherapy Systems and Methods of Use - A combination MRI and radiotherapy system comprising: a) an MRI system for imaging a patient receiving radiotherapy, comprising a magnetic field source suitable for generating a magnetic field of strength and uniformity useable for imaging, capable of being ramped up to said magnetic field in less than 10 minutes, and ramped down from said magnetic field in less than 10 minutes; b) a radiation source configured for applying radiotherapy; and c) a controller which ramps the magnetic field source down to less than 20% of said magnetic field strength when the radiation source is to be used for radiotherapy, and ramps the magnetic field source up to said magnetic field strength when the MRI system is to be used for imaging. | 05-19-2011 |
Patent application number | Description | Published |
20090068176 | HUMAN NEUTRALIZING ANTIBODIES AGANST HEMOLYTIC UREMIC SYNDROME - Human and humanized monoclonal antibodies which binds specifically to subunit A of Shiga like toxin II have been developed which are effective to prevent or ameliorate one or more symptoms of HUS in a human. Effective dosages for treatment or prevention range from approximately 0.1 to 5.0 mg of antibody/kg of patient weight. The examples demonstrate the preferred dosage ranges based on the pig model, and what is being tested in phase I clinical trials. Antibodies are preferably transfused over a period of two hours, although this will depend on the patient and the disease state at the time of treatment. Preferred dosages for treatment of humans are between 0.1 mg/kg-5.0 mg/kg of 5C120, or an equivalent dosage of another antibody to subunit A of STX2. In the most preferred embodiments, dosages of 0.1 mg/kg, 0.5 mg/kg, or 5.0 mg/kg of 5C12 (low dose, anticipated therapeutic dose based on animal data and high dose) are administered. | 03-12-2009 |
20090136916 | METHODS AND MICROARRAYS FOR DETECTING ENTERIC VIRUSES - The present invention relates to methods, microarrays and kits for detecting one or more human astrovirus serotypes in a sample (e.g., a fecal sample) from an individual. The method includes amplifying nucleic acid molecules of the sample with one or more primers, to thereby obtain an amplified nucleic acid product; contacting the amplified nucleic acid product with one or more serotype specific probes having a nucleic acid sequence that is specific for only one astrovirus serotype in the group of astroviruses being assessed, wherein the nucleic acid sequence includes between about 9 and 25 nucleic acid bases (e.g., SEQ ID NO: 5-24); and detecting the hybridization complex. The presence of hybridization complexes with a serotype specific probe indicates the presence of one or more specific astrovirus serotypes, and the absence of hybridization complexes with a serotype specific probe indicates the absence of the specific astrovirus serotype. Identification of the astrovirus serotypes allows for one to diagnose an individual infected with the serotype. The present invention further includes microarrays having any one of the astrovirus specific probe, or kits having microarrays and reagents for carrying out the assay. | 05-28-2009 |
20100216215 | METHOD AND DEVICE FOR THE CONCENTRATION OF MULTIPLE MICROORGANISMS AND TOXINS FROM LARGE LIQUID TOXINS - A method for the simultaneous concentration of multiple toxins from large volumes of water. The method includes the steps of providing a disposable separation centrifuge bowl, the centrifuge bowl including a positively charged material at it's inner core. A large water sample contaminated with toxins from a group consisting of protozoa, bacteria, bacterial spores, and toxins is delivered to the centrifuge bowl. A centrifugal force is applied to the separation bowl. The water sample is concentrated to remove large particles of the toxins in the bowl due to the centrifugal forces. The concentrated water sample is passes through the positively charged inner core to capture any remaining concentrated targets by electrostatic forces and the concentrated targets are eluted. | 08-26-2010 |
20100278826 | Designer Ubiquitin Ligases For Regulation Of Intracellular Pathogenic Proteins - The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes an antibody fragment that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes; and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention. | 11-04-2010 |
20110065123 | Methods for diagnosis of Clostridium difficile and methods and vectors for recombinant toxin expression - Cell-based methods for rapid real time assay of a presence of | 03-17-2011 |
20110104200 | Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines - Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both with or without an adjuvant. Also included are thermally-stable vaccine compositions using the method described above and kits including the compositions. | 05-05-2011 |
20120276132 | Atoxic recombinant holotoxins of Clostridium difficile as immunogens | 11-01-2012 |
20150151221 | METHOD AND DEVICE FOR THE CONCENTRATION OF MULTIPLE MICROORGANISMS AND TOXINS FROM LARGE LIQUID TOXINS - A method for the simultaneous concentration of multiple toxins from large volumes of water. The method includes the steps of providing a disposable separation centrifuge bowl, the centrifuge bowl including a positively charged material at it's inner core. A large water sample contaminated with toxins from a group consisting of protozoa, bacteria, bacterial spores, and toxins is delivered to the centrifuge bowl. A centrifugal force is applied to the separation bowl. The water sample is concentrated to remove large particles of the toxins in the bowl due to the centrifugal forces. The concentrated water sample is passes through the positively charged inner core to capture any remaining concentrated targets by electrostatic forces and the concentrated targets are eluted. | 06-04-2015 |
20150267187 | Designer Ubiquitin Ligases for Regulation of Intracellular Pathogenic Proteins - The present invention relates to a designer or recombinant ubiquitin ligase molecule that includes an antibody fragment that is specific for a toxin active fragment, wherein the toxin active fragment is an enzymatically active fragment of one or more toxins or toxin serotypes; and an E3-ligase domain that comprises an E3-ligase or polypeptide that facilitates E2-mediated ubiquitination of the toxin active fragment. In an embodiment, the composition further includes a delivery system that allow the designer ubiquitin ligase to enter the cell. The present invention further includes methods for treating an individual intoxicated with a toxin by administering the designer ubiquitin ligase of the present invention. | 09-24-2015 |
Patent application number | Description | Published |
20080293672 | Lipid conjugates in the treatment of disease - The invention relates to methods of use for compounds in treating, reducing the incidence, reducing the severity or pathogenesis of an intestinal disease or condition in a subject, including, inter alia, inflammatory bowel disease, Crohn's disease, ulcerative colitis, or a combination thereof. | 11-27-2008 |
20090325876 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES ASSOCIATED WITH VASCULATURE - This invention provides for the use of compounds represented by the structure of the general formula (A): | 12-31-2009 |
20100022473 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES ASSOCIATED WITH VASCULATURE - This invention provides for the use of compounds represented by the structure of the general formula (A): | 01-28-2010 |
20100087397 | USE OF LIPID CONJUGATES IN THE TREATMENT OF CONJUNCTIVITIS - In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof to a subject with conjunctivitis. | 04-08-2010 |
20100317591 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES - This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes the step of administering to a subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition. | 12-16-2010 |
20110130555 | LIPID-POLYMER CONJUGATES, THEIR PREPARATION AND USES THEREOF - This invention provides low molecular weight lipid-GAG and phospholipids-GAG conjugates and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens. | 06-02-2011 |
20110230652 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES - This invention provides compounds represented by the structure of the general formula (A): | 09-22-2011 |
20120071442 | LIPID CONJUGATES IN THE TREATMENT OF CHRONIC RHINOSINUSITIS - This invention provides a method of treating, suppressing, inhibiting, or preventing chronic rhinosinusitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. This invention also provides a method of treating, suppressing, inhibiting, or preventing nasal polyps in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. | 03-22-2012 |
20120083466 | LIPID CONJUGATES IN THE TREATMENT OF ALLERGIC RHINITIS - Provided herein are methods of treating, suppressing, inhibiting, or preventing allergic rhinitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. | 04-05-2012 |
20130203979 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES - This invention provides compounds represented by the structure of the general formula (A): | 08-08-2013 |
20130316973 | USE OF LIPID CONJUGATES IN THE TREATMENT OF CANCER - This invention provides for the use of compounds represented by the structure of the general formula (A): | 11-28-2013 |
20130338058 | USE OF LIPID CONJUGATES IN THE TREATMENT OF CONJUNCTIVITIS - In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof to a subject with conjunctivitis. | 12-19-2013 |
20140005115 | LIPID CONJUGATES IN THE TREATMENT OF BRONCHITIS | 01-02-2014 |
20140100190 | USE OF LIPID CONJUGATES IN CYSTIC FIBROSIS AND APPLICATIONS THEREOF - This invention provides for the use of compounds represented by the structure of the general formula (A): | 04-10-2014 |
20140199241 | LIPOSOMES COMPRISING POLYMER-CONJUGATED LIPIDS AND RELATED USES - The present invention provides liposomes comprising a lipid bilayer and a polymer-conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome. | 07-17-2014 |
20140323434 | LIPID CONJUGATES IN THE TREATMENT OF CHRONIC RFHINOSINUSITIS - This invention provides a method of treating, suppressing, inhibiting, or preventing chronic rhinosinusitis in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. This invention also provides a method of treating, suppressing, inhibiting, or preventing nasal polyps in a subject comprising the step of administering to a subject a compound comprising a lipid or phospholipid moiety bond to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. | 10-30-2014 |
20150025233 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES - This invention provides compounds represented by the structure of the general formula (A): | 01-22-2015 |
20150057244 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASE - This invention provides a method of preventing or treating a dermatologic condition including, inter alia, psoriasis, contact dermatitis, and atopic dermatitis, in a subject, the method includes the step of administering to said subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition. | 02-26-2015 |
20150057245 | USE OF LIPID CONJUGATES IN THE TREATMENT OF INFLAMMATORY DISORDERS - This invention provides for the use of compounds represented by the structure of the general formula (A): | 02-26-2015 |
20150119567 | LIPID-POLYMER CONJUGATES, THEIR PREPARATION AND USES THEREOF - This invention provides low molecular weight lipid-GAG and phospholipids-GAG conjugates and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens. | 04-30-2015 |