Loetscher
Hansruedi Loetscher, Mohlin CH
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20100172907 | Anti-Abeta antibodies and their use - The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention. | 07-08-2010 |
20120225478 | ANTI-AMYLOID BETA ANTIBODIES AND THEIR USE - The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention. | 09-06-2012 |
20130136747 | ANTI-AMYLOID BETA ANTIBODIES AND THEIR USE - The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention. | 05-30-2013 |
Hansruedi Loetscher, Moehlin CH
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20090252724 | Antibodies Against Amyloid Beta 4 With Glycosylated in the Variable Region - The present invention relates to a purified antibody molecule preparation being characterized in that at least one antigen binding site comprises a glycosylated asparagine (Asn) in the variable region of the heavy chain (V | 10-08-2009 |
20100306868 | QUADRUPLE TRANSGENIC NON-HUMAN ANIMAL - The present invention relates to a transgenic non-human animal whose genome comprises a) a first transgenic DNA sequence encoding a human APP Swedish or a human APP London protein, wherein said first transgenic DNA sequence is operably linked to a first promoter; b) a second transgenic DNA sequence encoding a human Presenilin 2 protein comprising a N141I substitution, wherein said second transgenic DNA sequence is operably linked to a second promoter; c) a third transgenic DNA sequence encoding a light chain of a antibody directed against the amyloid peptide, wherein said third transgenic DNA sequence is operably linked to a third promoter and; d) a forth transgenic DNA sequence encoding a heavy chain of said antibody, wherein said forth transgenic is operably linked to the third promoter or to a forth promoter, and methods for producing said animal. | 12-02-2010 |
Josef Loetscher, Kaltbach CH
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20100088836 | TOOTHBRUSH - A toothbrush comprises bristle supporting elements in the head region thereof. The bristle supporting elements are arranged in an elastic manner relative to the neck region and in a bendable and twistable manner relative to one another by a foil-type hard film. Preferably, the foil-type hard film externally extends in a flush fashion around a top opening of the bristle supporting element. | 04-15-2010 |
Jost Loetscher, Bueron CH
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20110109149 | METHOD FOR PRODUCING TOOTHBRUSHES BRISTLED IN AN ANCHORLESS MANNER - The tips of pointed bristles are mechanically processed in order to remove any corroded threads or residual threads from the tip. Mechanically processed pointed bristles are fed to a receptacle recess of a tool in bundles, and aligned by means of a pin guided in the receptacle recess. The pointed bristles are pushed through the passage of the bristle carrier plate, and the end section are subsequently melted by means of a heating die in order to attach the pointed bristles to the bristle carrier plate. The mechanical processing of the tips of the bristles enables an error-free further processing of the pointed bristles utilizing the bristling method, particularly the AFT method. | 05-12-2011 |
20130333132 | METHOD FOR PRODUCING TOOTHBRUSHES COVERED WITH BRISTLES IN AN ANCHOR-FREE MANNER - The tips of pointed bristles are mechanically processed in order to remove any corroded threads or residual threads from the tip. Mechanically processed pointed bristles are fed to a receptacle recess of a tool in bundles, and aligned by means of a pin guided in the receptacle recess. The pointed bristles are pushed through the passage of the bristle carrier plate, and the end section are subsequently melted by means of a heating die in order to attach the pointed bristles to the bristle carrier plate. The mechanical processing of the tips of the bristles enables an error-free further processing of the pointed bristles utilizing the bristling method, particularly the AFT method. | 12-19-2013 |
Lucas Hans Loetscher, Fort Collins, CO US
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20120034681 | DIGESTER FOR HIGH SOLIDS WASTE - A digester with separate stages for hydrolysis and methanogenesis is disclosed. The digester includes a leachate bay reactor, which may be configured as modular, multi-bay units. Waste material is added to the leachate bay reactor. A leachate storage tank is fluidically connected to the leachate bay reactor, which facilitates hydrolysis. Leachate from the leachate storage tank is recirculated through the leachate bay reactor. A high rate methanogenic reactor is fluidically connected to the leachate storage tank to cycle the leachate in a fixed film environment for biogas production from solubilized organic matter. The reactor may be operated in an anaerobic digestion mode, or a dual aerobic-anaerobic digestion mode. The reactor may also include a struvite system having a crystallizer unit and a separation unit to reduce ammonium and phosphate accumulation during operation. | 02-09-2012 |
Luke H. Loetscher, Cheyenne, WY US
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20100176067 | Photocatalytic reactor and process for photocatalysis - A coil-shaped reactor and process are provided to degrade or remove contaminants from water. | 07-15-2010 |
Marcel Loetscher, Maennedorf CH
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20100061983 | Method of inhibiting leukocytes with human cxc chemokine receptor 3 antibody - The present invention relates to proteins or polypeptides, referred to herein as isolated and/Or recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Antibodies reactive with CXCR3 receptors can be produced using the proteins or variants thereof or host cells comprising same as immunogen. | 03-11-2010 |
Michel Loetscher, Kappel CH
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20110014329 | DEVICE AND METHOD FOR FOAMING A LIQUID FOODSTUFF, IN PARTICULAR, MILK - A device for foaming a liquid foodstuff, in particular, milk, including a foaming chamber ( | 01-20-2011 |
Philippe Loetscher, Evilard CH
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20130223195 | WRISTWATCH PROVIDED WITH A CLASP - The wristwatch ( | 08-29-2013 |
Pius Loetscher, Rheinfelden CH
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20150216867 | COMPOUNDS FOR USE IN GASTRIC COMPLICATION - The present invention relates to the use of low molecular weight (lmw) compounds, especially lmw compounds with GPR4-affinity, in the treatment of diseases and disorders which includes gastroesophageal reflux disease (GERD), and/or non-erosive reflux disease (NERD) and the like. | 08-06-2015 |