Patent application number | Description | Published |
20100059671 | METHODS FOR DETECTING DEHYDROEPIANDROSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of underivatized dehydroepiandrosterone (DHEA) in a sample using mass spectrometry. The methods generally involve ionizing DHEA in a sample and detecting and quantifying the amount of the ion to determine the amount of DHEA in the sample. | 03-11-2010 |
20100084546 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 04-08-2010 |
20100155595 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 06-24-2010 |
20110006197 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 01-13-2011 |
20110147583 | METHODS FOR DETECTING DEHYDROEPIANDROSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of underivatized dehydroepiandrosterone (DHEA) in a sample using mass spectrometry. The methods generally involve ionizing DHEA in a sample and detecting and quantifying the amount of the ion to determine the amount of DHEA in the sample. | 06-23-2011 |
20130206981 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 08-15-2013 |
20140014832 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 01-16-2014 |
20140175275 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 06-26-2014 |
20150276768 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 10-01-2015 |
Patent application number | Description | Published |
20120175517 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 07-12-2012 |
20120228487 | MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA - Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection. | 09-13-2012 |
20130228680 | METHODS FOR DETECTING DIHYDROTESTOSTERONE BY MASS SPECTROMETRY - Provided are methods for determining the amount of dihydrotestosterone (DHT) in a sample using mass spectrometry. The methods generally involve ionizing DHT in a sample and detecting and quantifying the amount of the ion to determine the amount of DHT in the sample. | 09-05-2013 |
Patent application number | Description | Published |
20080227959 | REAGENTS FOR DETECTING EFAVIRENZ - The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay methods for determining efavirenz. | 09-18-2008 |
20090246808 | BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY - A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5. | 10-01-2009 |
20110290670 | METHODS FOR ELECTROCHEMICAL ANALYSIS USING MATRIX COMPOSITIONS WITH ALKYLPHENAZINE QUATERNARY SALT AND A NITROSALINE - A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5. | 12-01-2011 |
20120125788 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS - The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations. | 05-24-2012 |
20130213822 | ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS - The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations. | 08-22-2013 |
Patent application number | Description | Published |
20080239672 | Cooling of High Power Density Devices Using Electrically Conducting Fluids - A system to extract heat from a high power density device and dissipate heat at a convenient distance. The system circulates liquid metal in a closed conduit using one or more electromagnetic pumps for carrying away the heat from high power density device and rejecting the heat at a heat sink located at a distance. The system may make use of a thermoelectric generator to power the electromagnetic pumps by utilizing the temperature difference between the inlet and outlet pipes of the heat sink. The system also provides networks of primary and secondary closed conduits having series and parallel arrangements of electromagnetic pumps for dissipating heat from multiple devices at a remotely located heat sink. | 10-02-2008 |
20080314430 | Line-Voltage-Powered Thermoelectric Device - An apparatus, which may be a heater or cooler, includes a thermoelectric device group having at least one thermoelectric device and an electrical subsystem. The electrical subsystem interfaces the thermoelectric device group to an alternating current (AC) line voltage without utilizing a magnetically coupled structure. In some embodiments the electrical subsystem supplies a rectified signal having a voltage approximately equal to the magnitude of the AC line voltage. In some embodiments the AC line voltage is a standard line voltage of about 90 V to about 250 V. | 12-25-2008 |
20110000224 | METAL-CORE THERMOELECTRIC COOLING AND POWER GENERATION DEVICE - In various embodiments of the present invention, a thermoelectric device is provided. The thermoelectric device includes one or more thermoelements provided for transferring heat across the ends of the thermoelectric device. A method for making the thermoelectric device includes forming a metal substrate, and depositing one or more thermoelectric films on the metal substrate. Thereafter, one or more bumps are provided on one of the one or more thermoelectric films. Deposition of the one or more thermoelectric films on the metal substrate and the provision of the one or more bumps on the thermoelectric film result in the formation of a thermoelement. | 01-06-2011 |
20110016886 | METHOD AND APPARATUS FOR SWITCHED THERMOELECTRIC COOLING OF FLUIDS - A method and system for efficiently cooling a fluid is provided. A cooling system includes a first chamber containing a first fluid, and a second chamber connected to the first chamber and containing a second fluid. The cooling system further includes one or more thermoelectric devices for cooling the second fluid in the second chamber, and a first body that acts as a thermal diode. The first body enables unidirectional transfer of heat from the thermoelectric devices to the first fluid. Further, the cooling system can be installed with one or more phase change materials or heat pipes that enhance the cooling efficiency of the cooling system. The thermoelectric devices are switched on for a certain time period, after which they are switched off and on repeatedly in cycles, depending on the temperature of the second fluid. | 01-27-2011 |
20110220164 | ENHANCED METAL-CORE THERMOELECTRIC COOLING AND POWER GENERATION DEVICE - In various embodiments of the present invention, a thermoelectric device is provided. The thermoelectric device includes one or more thermoelements that transfer heat across the ends of the thermoelectric device. A method for creating the thermoelectric device includes forming a metal substrate, and etching one or more surfaces of the metal substrate to form etched portions. The unetched flat portions on the metal substrate are referred to as mesa cores. Thereafter, thermoelectric films are deposited on the one or more surfaces of the metal substrate. The deposition of the thermoelectric films on the mesa cores results in the formation of a thermoelement. | 09-15-2011 |
20120192574 | Heat Pipes And Thermoelectric Cooling Devices - In various embodiments of the present invention, a thermoelectric cooling device with a thermoelectric device, heat pipe and a heat sink is provided. The thermoelectric device is connected to a chamber through a metal standoff. The chamber contains a fluid that needs to be cooled. The metal standoff has a shape, e.g. a bevel shape, to minimize heat leakage into the fluid. The heat pipes are preferably connected to the thermoelectric device with a Thermal Interface Material (TIM). In one embodiment, the heat pipes are attached to the thermoelectric device through screws which have an insulating standoff so as to minimize heat leakage into the fluid. In another embodiment of the present invention, two stage thermoelectric cooling devices with multiple heat pipes and common heat sink are provided to cool the fluid. | 08-02-2012 |
20130291564 | THERMOELECTRIC COOLING SYSTEMS - The present disclosure provides a thermoelectric cooling system with improved performance. The thermoelectric cooling system comprises a thermoelectric cooling unit. The thermoelectric cooling unit comprises a thermoelectric device, heat pipes, condenser fins, a cold sink and a cold fan. The thermoelectric cooling unit can be easily assembled with a chamber which contains a fluid to be cooled. The thermoelectric cooling system comprises screws to attach the thermoelectric cooling unit to the chamber, and sealant rings to prevent heat leakage in the thermoelectric cooling system. Further, the present disclosure provides a thermoelectric cooling system with a freezer part and a refrigerator part. The freezer part encloses the cold sink and the cold fan. The freezer part is cooled by the thermoelectric device, and the refrigerator part is cooled by walls of the freezer part. Further, the present disclosure provides a thermoelectric cooling system for use as a wine cooler. | 11-07-2013 |
20140251403 | THERMOELECTRIC ENERGY CONVERTERS AND MANUFACTURING METHOD THEREOF - The present disclosure provides a thermoelement with improved figure of merit for use in thermoelectric devices and a method of manufacturing the thermoelement. The thermoelement comprises metal layers, high power factor electrodes, a thermoelectric layer and a phonon blocking layer. The thickness of the thermoelectric layer is less than a thermalization length to achieve decoupling of phonons and electrons in the thermoelement. The phonon blocking layer reduces phonon conduction without significantly influencing electronic conduction. In an embodiment, the high power factor electrodes are made of materials with high Seebeck coefficient and high thermoelectric power factor that reduce thermal losses at interfaces of the thermoelement. The metal layers form outermost layers of the thermoelement and geometrically shaped to reduce heat flux in the thermoelement. | 09-11-2014 |
20140318152 | METHOD AND APPARATUS FOR THERMOELECTRIC COOLING OF FLUIDS - The present disclosure provides a method and a thermoelectric cooling apparatus for cooling a fluid. The thermoelectric cooling apparatus comprises one or more of thermoelectric devices, a hot sink, a cold sink, and a heat rejection apparatus which comprises condenser fins and a fan to attain a high figure of merit. The heat from the fluid is transferred to the hot sink and/or one or more heat pipes by the one or more thermoelectric devices. The heat from the one or more heat pipes is dissipated to the ambient through condenser fins and the fan. | 10-30-2014 |
20140360545 | THERMOELECTRIC ENERGY CONVERTERS WITH REDUCED INTERFACE LOSSES AND MAUNFACTURING METHOD THEREOF - The present invention relates to a thermoelement for use in thermoelectric energy converters for power generation as well as cooling applications. The thermoelement includes a thermoelectric layer with a first side and a second side. Further, the thermoelement includes a first high power factor electrode and a second high power factor electrode. The first high power factor electrode is thermally and electrically attached to the first side of the thermoelectric layer and the second high power factor electrode is thermally and electrically attached to the second side of the thermoelectric layer. Furthermore, the thermoelement includes a plurality of metal layers. The plurality of metal layers are attached to the first high power factor electrode and the second high power factor electrode. In an embodiment of the present invention, a thermoelement comprises a plurality of micro thermoelements that are configured to reduce thermal density at the electrodes. In an embodiment of the present disclosure, the thermoelectric layer is hemispherical in shape, wherein the hemispherical thermoelectric layer is deposited in an etched metal layer. | 12-11-2014 |
20150128614 | THERMOELECTRIC HEAT PUMP - The present disclosure is related to an apparatus for transporting heat using a thermoelectric converter. The apparatus may include a thermoelectric converter, such as a thin-film. The apparatus may include a heating loop in thermal communication with a hot side of the thermoelectric converter and a cooling loop in thermal communication with a cold side of the thermoelectric converter. The thermoelectric converter may include a stack of alternating thermoelement and constricted contact layers. The thermoelectric converter may have a counter-flow fluid loop that moves a fluid against the temperature gradient of the thermoelectric converter. The apparatus may be configured to provide heating or cooling of a fluid, such as air or water. The apparatus may include a thermal storage medium configured as a thermal battery. | 05-14-2015 |
20150155413 | SOLAR THERMOELECTRIC GENERATOR WITH INTEGRATED SELECTIVE WAVELENGTH ABSORBER - The present disclosure is related to an apparatus for generating electric power from selected wavelengths of electromagnetic radiation and a method of manufacture of said apparatus. The apparatus may include a selective wavelength absorber that is thermally coupled to a thermoelectric generator. The selective wavelength absorber may include alternating absorber and dielectric layers configured to absorb and reflect selected wavelengths of electromagnetic radiation. Absorbed electromagnetic radiation may be converted to heat energy for driving the thermoelectric generator. The method may include manufacturing the selective wavelength absorber, including depositing the alternating layers on a substrate that has been formed to receive the electromagnetic radiation at a selected angle or range of angles. | 06-04-2015 |
20150325773 | REPLICATED THERMOELECTRIC DEVICES - A method of creating a replicated thermoelectric device includes preparing a single thermoelectric device for division. The single thermoelectric device including a plurality of thermoelements positioned between a first substrate and a second substrate. The method further includes dividing the single thermoelectric device to form a replicated thermoelectric device such that the cooling power of the replicated thermoelectric cooling device is substantially equal to twice a cooling power of the single thermoelectric device. | 11-12-2015 |