Cole, MA
Andrew James Cole, Lincoln, MA US
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20110137381 | Treatment of neurological disorders via electrical stimulation, and methods related thereto - Disclosed are medical devices for the prevention and/or treatment of neurological disorders via electrical stimulation, and methods related thereto. The devices may also be utilized to detect disorders before the prevention or treatment of a neurological disorder. These devices are minimally or non-invasive. The present medical devices comprise various components, which include electrodes and control electronics. The electrodes are targeting electrodes constructed from ring type structures or virtually connected disc type arrays. The electrodes are located entirely outside the skull. The present medical devices also comprise one or more subsystems, a control system, a battery unit, and wires connecting the one or more subsystems. These devices may also be used for acute seizure control. | 06-09-2011 |
Brian J. Cole, Cotuit, MA US
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20140153405 | COMPUTER TELEPHONY HEADSET WITH PRESENCE INDICATOR - A telephone headset is provided which includes a presence status indicator thereon for signaling to other persons the user's availability and/or willingness to communicate face-to-face. | 06-05-2014 |
Bridget Cole, Quincy, MA US
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20120202793 | RHO KINASE INHIBITORS - The present invention relates to inhibitors of ROCK1 and ROCK2, which may be selective for ROCK2, and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and/or ROCK2. Also provided are treatments combining inhibitors of ROCK1 and/or ROCK2 with statins. | 08-09-2012 |
Bridget M. Cole, Quincy, MA US
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20140274933 | PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS - The invention relates to a compound of Formula I and methods of treating CFTR (cystic fibrosis transmembrane conductance regulator) mediated diseases, in particular cystic fibrosis, comprising the step of administering a therapeutically effective amount of a compound of Formula I to a patient in need thereof: | 09-18-2014 |
20140371225 | PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS - The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I to a patient in need thereof: | 12-18-2014 |
20140371238 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS - The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof: | 12-18-2014 |
20140371263 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS - The invention relates to a compound of Formula I and methods of treating CFTR (cystic fibrosis transmembrane conductance regulator) mediated diseases, in particular cystic fibrosis, comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to a patient in need thereof: | 12-18-2014 |
20150299176 | PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS - The invention relates to a compound of Formula I and methods of treating CFTR (cystic fibrosis transmembrane conductance regulator) mediated diseases, in particular cystic fibrosis, comprising the step of administering a therapeutically effective amount of a compound of Formula I to a patient in need thereof: | 10-22-2015 |
Bridget Mccarthy Cole, Quincy, MA US
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20090093463 | NOVEL COMPOUNDS OF SUBSTITUTED AND UNSUBTITUTED ADAMANTYL AMIDES - The present invention relates to compounds with the formula (I) or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of 11-β-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I). | 04-09-2009 |
Bryan Thomas Cole, Allston, MA US
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20150190068 | System and Method for Detecting a Characteristic in an ECG Waveform - An apparatus and method is provided that identifies the presence or absence of a P-wave within a set of ECG data. A computation processor identifies the R-wave and then analyses a section of the waveform within a predetermined time window preceding the detected R-wave peak. The waveform within the window is analysed to identify a candidate P-wave, and in response to identifying the candidate P-wave a first and second feature associated therewith is measured. A composite feature value is calculated from the first and second measures, and compared to a classification threshold value. In an exemplary embodiment, the first feature represents a height between a highest peak of the candidate P-wave and a trough of the Q-wave, and the second feature represents a time between the peak of the candidate P-wave and a peak of the R-wave. | 07-09-2015 |
Christopher Cole, Middleton, MA US
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20090194503 | METHOD FOR ETCHING SILICON-CONTAINING ARC LAYER WITH REDUCED CD BIAS - A method of dry developing a multi-layer mask having a silicon-containing anti-reflective coating (ARC) layer on a substrate is described. The method comprises forming the multi-layer mask on the substrate, wherein the multi-layer mask comprises a lithographic layer overlying the silicon-containing ARC layer. A feature pattern is then formed in the lithographic layer using a lithographic process. Thereafter, the feature pattern is transferred from the lithographic layer to the silicon-containing ARC layer using a dry plasma etching process, wherein the offset in the critical dimension (CD) bias is reduced between nested structures and isolated structures. | 08-06-2009 |
David John Cole, Medway, MA US
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20110292319 | DUAL MODE ELECTRO-OPTIC DISPLAYS - A display comprises, in this order: a layer ( | 12-01-2011 |
20120293858 | ELECTRO-OPTIC DISPLAYS - A wavelength selective reflection display ( | 11-22-2012 |
Devin Jacqueline Cole, Northborough, MA US
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20110114682 | DJC Existence Lifestyle Holster Accessories - The idea for DJC Existence Lifestyle Hosters is attainable, sustainable glamour. Every woman wants to be a part of the dream-like world of fashion and wishes she could step out of the house and look as stunning as the celebrities she sees in tabloids. By adding a holster from DJC Existence to a tank top and jeans, she can upgrade her look to high fashion. What makes DJC Existence Lifestyle Holster Accessories different from any other bag on the market is that you don't hold them, they hold you. They are streamlined, functional, and designed to compliment a woman's shape. The modern woman is always on the move and now she has an accessory that will easily move with her. She can wear them when she is going to run errands or she can wear them when she is at a club and dance all night with all her valuables secure. | 05-19-2011 |
Geoff Cole, Needham, MA US
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20100168205 | Methods and Compositions for Prevention or Treatment of RSV Infection Using Modified Duplex RNA Molecules - Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides. | 07-01-2010 |
20140323541 | Methods And Compositions For Prevention Or Treatment Of RSV Infection Using Modified Duplex RNA Molecules - Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides. | 10-30-2014 |
20150337311 | Methods And Compositions For Prevention Or Treatment Of RSV Infection Using Modified Duplex RNA Molecules - Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides. | 11-26-2015 |
Geoffrey Cole, Malden, MA US
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20100233087 | CYP1B1 NUCLEIC ACIDS AND METHODS OF USE - The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYP1B1 transcript. The nucleic acids of the invention lack translational repressor elements and thus provide for a system of enhanced translation of the CYP1B1 polypeptide or portions thereof. Also disclosed are methods of administering nucleic acids to a mammal and use in the treatment of proliferative disorders or cancer. | 09-16-2010 |
20120201843 | CYP1B1 NUCLEIC ACIDS AND METHODS OF USE - The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the untranslated region (UTR) of naturally occurring forms of the CYP1B1 transcript. The nucleic acids of the invention lack translational repressor elements and thus provide for a system of enhanced translation of the CYP1B1 polypeptide or portions thereof. Also disclosed are methods of administering nucleic acids to a mammal and use in the treatment of proliferative disorders or cancer. | 08-09-2012 |
Gregory A. Cole, Worcester, MA US
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20110077504 | SYSTEM AND METHOD FOR ROBOTIC SURGICAL INTERVENTION - A system and method for image guided assisted medical procedures. The system and method may utilize MRI real time guidance during the above procedures. | 03-31-2011 |
James Daniel Cole, Wayland, MA US
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20110054488 | SYSTEMS AND METHODS FOR PREVENTING INTRAVASATION DURING INTRAUTERINE PROCEDURES - Systems, methods, apparatus and devices for performing improved gynecologic and urologic procedures are disclosed. Patient benefit is achieved through improved outcomes, reduced pain, especially peri-procedural pain, and reduced recovery times. The various embodiments enable procedures to be performed outside the hospital setting, such as in a doctor's office or clinic. Distension is achieved mechanically, rather than with liquid distension media, thereby eliminating the risk of intravasation. | 03-03-2011 |
Jeff Cole, Cambridge, MA US
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20090125333 | PERSONALIZED MANAGEMENT AND COMPARISON OF MEDICAL CONDITION AND OUTCOME BASED ON PROFILES OF COMMUNITY PATIENTS - The invention can be directed toward a method for personalized management and comparison of medical condition and outcome based on patient profiles of a community of patients. The method can include the steps of providing a database of patient profiles, providing a user interface for inputting a query of the database from a user, generating a query result including one or more matching patient profiles from the database, and displaying the query result as a correlation medical condition parameters of the user with a medical outcome. | 05-14-2009 |
20150324530 | PERSONALIZED MANAGEMENT AND COMPARISON OF MEDICAL CONDITION AND OUTCOME BASED ON PROFILES OF COMMUNITY PATIENTS - The invention can be directed toward a method for personalized management and comparison of medical condition and outcome based on patient profiles of a community of patients. The method can include the steps of providing a database of patient profiles, providing a user interface for inputting a query of the database from a user, generating a query result including one or more matching patient profiles from the database, and displaying the query result as a correlation medical condition parameters of the user with a medical outcome. | 11-12-2015 |
Jonathan T. Cole, Sudbury, MA US
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20080236254 | DYNAMIC RECIPROCATING-BOB RHEOMETRY - A sensor for making rheological measurements takes the form of a ferromagnetic bob alternately driven through a sample fluid in opposite directions by magnetic force from two alternately driven coils. The bob's position affects the mutual inductance between the coils, so it can be inferred by sensing the signal that current flowing in one coil induces in the other, and rheological properties are determined from the relationships among the bob's motion, the coil current, and the sensor geometry. Some such measurements' accuracies are enhanced by computing bob acceleration and suppressing inertial effects thereby detected. | 10-02-2008 |
Kenneth J. Cole, Somerville, MA US
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20150336790 | Fabrication of Tungsten MEMS Structures - Thick (i.e., greater than two microns), fine-grained, low-stress tungsten MEMS structures are fabricated at low temperatures, particularly for so-called “MEMS last” fabrication processes (e.g., when MEMS structures are fabricated after electronic circuitry is fabricated). Means for very accurately etching structural details from the deposited tungsten layer and for strongly and stably anchoring the tungsten layer to an underlying substrate are disclosed. Also, means for removing a sacrificial layer underlying the mobile tungsten layer without damaging the tungsten or allowing it to be drawn down and stuck by surface tension is disclosed. | 11-26-2015 |
Matthew D. Cole, Boston, MA US
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20140297117 | DISTRIBUTED ACTIVE SUSPENSION CONTROL SYSTEM - A distributed active suspension control system is provided. The control system is based on a distributed, processor-based controller that is coupled to an electronic suspension actuator. The controller processes sensor data at the distributed node, making processing decisions for the wheel actuator it is associated with. Concurrently, multiple distributed controllers on a common network communicate such that vehicle-level control (such as roll mitigation) may be achieved. Local processing at the distributed controller has the advantage of reducing latency and response time to localized sensing and events, while also reducing the processing load and cost requirements of a central node. The topology of the distributed active suspension controller contained herein has been designed to respond to fault modes with fault-safe mechanisms that prevent node-level failure from propagating to system-level fault. Systems, algorithms, and methods for accomplishing this distributed and fault-safe processing are disclosed. | 10-02-2014 |
20150224845 | ACTIVE VEHICLE SUSPENSION SYSTEM - A method of on-demand energy delivery to an active suspension system comprising an actuator body, hydraulic pump, electric motor, plurality of sensors, energy storage facility, and controller is provided. The method comprises disposing an active suspension system in a vehicle between a wheel mount and a vehicle body, detecting a wheel event requiring control of the active suspension; and sourcing energy from the energy storage facility and delivering it to the electric motor in response to the wheel event. | 08-13-2015 |
Paul Cole, Gloucester, MA US
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20110022242 | METHODS AND SYSTEMS FOR MANAGING ENERGY USAGE IN BUILDINGS - A method and system for managing energy usage in a building is provided. The method includes collecting data on energy consumption in the building on a generally continuous basis for at least a given time period. Information relating to the energy consumption is displayed to a user on one or more devices. The information includes (a) the data collected on energy consumption to be displayed in real-time on the one or more devices, (b) a comparison of the data collected on energy consumption in the building to energy consumption data of a cohort or group of cohorts, (c) recommendations for reducing energy consumption in the building based on the data collected on energy consumption, and (d) progress report data comparing the data collected on energy consumption to a desired consumption level. | 01-27-2011 |
20140278264 | PERSONALIZATION OF RECOMMENDATIONS BASED ON BUILDING MODEL AND BEHAVIORAL SCIENCE - The technology disclosed herein provides accurate, targeted, building improvement content in a way that resonates with the user by considering the user's whole ecosystem. The technology uses details of the user's home, neighborhood, family, environmental and historical factors, goals, economic situation, and motivations and preferences to tailor content to a user's personal situation. A server or other computing device may accomplish this by receiving data from the client, a third party, or data local to the server; building modeling constructs based on these data sets such as a physics-based model of the building and a behavioral model of the user; operating these models relative to possible discrete building improvement content units; and using the results to determine personalized building improvement content for the user such as, for example, a webpage. | 09-18-2014 |
Peter Cole, Natick, MA US
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20130332624 | DYNAMIC REDIRECTION OF NETWORK TRAFFIC WITHIN A SYSTEM UNDER TEST - Redirecting network traffic within a system under test (SUT) can include receiving, within a proxy included within the SUT, a request sent from an upstream component that is directed to a downstream component, wherein the upstream component is configured to direct communications through the proxy. Within the proxy, the request can be redirected from the downstream component to a simulation component according to a routing rule within the proxy using a processor. A response can be received, within the proxy, from the simulation component and sent to the upstream component. | 12-12-2013 |
20130332625 | DYNAMIC REDIRECTION OF NETWORK TRAFFIC WITHIN A SYSTEM UNDER TEST - Redirecting network traffic within a system under test (SUT) can include receiving, within a proxy included within the SUT, a request sent from an upstream component that is directed to a downstream component, wherein the upstream component is configured to direct communications through the proxy. Within the proxy, the request can be redirected from the downstream component to a simulation component according to a routing rule within the proxy using a processor. A response can be received, within the proxy, from the simulation component and sent to the upstream component. | 12-12-2013 |
Robert Cole, Hopkinton, MA US
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20120254123 | METHODS AND SYSTEMS FOR SNAPSHOT RECONSTITUTION - A method, computer readable medium, and a system for reconstituting a virtual snapshot of files in a file virtualization system includes forming at a file virtualization device a virtual snapshot that includes a plurality of physical snapshots associated with one or more file storage devices participating in the virtual snapshot, receiving a request for performing an operation on one or more physical snapshots in the plurality of physical snapshots, providing the one or more physical snapshots in response to the request for performing the operation when the one or more physical snapshots exists in the virtual snapshot, and reconstituting the virtual snapshot by including the one or more physical snapshots to form a reconstituted virtual snapshot in response to the request for performing the operation when the one or more physical snapshots do not exist in the virtual snapshot. | 10-04-2012 |
Stephen W. Cole, Cambridge, MA US
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20140188540 | DELIVERING ELECTRONIC MEETING CONTENT - A method, computer program product, and system for delivering electronic meeting content is described. An electronic meeting is associated with a calendar appointment. Content associated with the electronic meeting is identified. A portion of the content is provided to a computing device associated with a user based upon, at least in part, receiving an indication that the user intends to participate in the electronic meeting, wherein the indication is associated with the calendar appointment | 07-03-2014 |
20140189529 | DELIVERING ELECTRONIC MEETING CONTENT - A method, computer program product, and system for delivering electronic meeting content is described. An electronic meeting is associated with a calendar appointment. Content associated with the electronic meeting is identified. A portion of the content is provided to a computing device associated with a user based upon, at least in part, receiving an indication that the user intends to participate in the electronic meeting, wherein the indication is associated with the calendar appointment | 07-03-2014 |
20150066580 | CUSTOMER RELATIONSHIP MANAGEMENT SYSTEM AND METHOD - A method, computer program product, and computer system for sharing, via a first computing device, customer relationship management opportunity data between a customer relationship management application and an instant messaging application, wherein the customer relationship management opportunity data is associated with an opportunity. At least a portion of the customer relationship management opportunity data is provided to an instant messaging application client executed by a second computing device, the instant messaging application client associated with the instant messaging application, wherein at least the portion of the customer relationship management opportunity data is provided for user access at the second computing device via the instant messaging application client. | 03-05-2015 |
Todd W. Cole, Dracut, MA US
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20080274672 | OPHTHALMIC BLOCKING PAD - An ophthalmic blocking pad includes a foam layer, a film layer disposed over and directly contacting the foam layer, and an adhesive layer disposed over the film layer. The film layer has a tensile strength of at least about 25 ksi (172 MPa). | 11-06-2008 |