Patent application number | Description | Published |
20080318261 | Small Volume in Vitro Analyte Sensor - A sensor designed to determine the concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a redox mediator that acts as an electron transfer agent between the analyte and the electrode. A second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. Various electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can be used to determine the analyte concentration. The sensor can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. | 12-25-2008 |
20090095642 | TRANSITION METAL COMPLEXES WITH PYRIDYL-IMIDAZOLE LIGANDS - Enzyme-based electrochemical sensors comprising transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators and include substituted or unsubstituted pyridyl-imidazole ligands. Transition metal complexes attached to polymeric backbones are also described. | 04-16-2009 |
20100213057 | Self-Powered Analyte Sensor - Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 08-26-2010 |
20100213082 | Self-Powered Analyte Sensor - Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 08-26-2010 |
20130066178 | Lyotropic Liquid Crystal Coated Analyte Monitoring Device and Methods of Use - The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions. | 03-14-2013 |
Patent application number | Description | Published |
20140141487 | Cationic Polymer Based Wired Enzyme Formulations for Use in Analyte Sensors - Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring. | 05-22-2014 |
20140201988 | Analyte Sensors and Methods - A sensor, and methods of making, for determining the concentration of an analyte, such as glucose, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and may include an insertion monitoring trace to determine correct positioning of the sensor in a connector. The sensor is calibration-adjusted, eliminating the need for a user to enter a calibration code or for the meter to read a calibration code. | 07-24-2014 |
20140202853 | Small Volume Test Strips with Large Sample Fill Ports, Supported Test Strips, and Methods of Making and Using Same - The present disclosure provides small volume analyte sensors having large sample fill ports, supported analyte sensors, analyte sensors having supported tip protrusions and methods of making and using same. | 07-24-2014 |
20140303592 | Smart Sensor Ports and Methods of Using Same - The present disclosure provides an orientation-nonspecific sensor port for use in analyte meters designed to detect and quantify analyte levels in a fluid sample along with methods of using the same. The present disclosure also provides compositions and methods for facilitating the correct insertion of a sensor into a corresponding analyte meter. | 10-09-2014 |
20140336486 | Analyte Monitoring: Stabilizer for Subcutaneous Glucose Sensor with Incorporated Antiglycolytic Agent - An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring. | 11-13-2014 |
20140353173 | Small Volume In Vitro Analyte Sensor - A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable. | 12-04-2014 |
20150038410 | Heterocyclic Nitrogen Containing Polymer Coated Analyte Monitoring Device and Methods of Use - The present invention is directed to membranes composed of heterocyclic nitrogen groups, such as vinylpyridine and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes described herein demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions. | 02-05-2015 |
20150090590 | Cationic Polymer Based Wired Enzyme Formulations for Use in Analyte Sensors - Embodiments of the invention include analyte-responsive compositions and electrochemical analyte sensors having a sensing layer that includes an analyte-responsive enzyme and a cationic polymer. Also provided are systems and methods of making the sensors and using the electrochemical analyte sensors in analyte monitoring. | 04-02-2015 |
20150173657 | Analyte Monitoring Device and Methods - Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided. | 06-25-2015 |
20150223740 | Service-Detectable Analyte Sensors and Methods of Using and Making Same - Generally, embodiments of the invention relate to analyte determining devices (e.g., electrochemical analyte monitoring systems) that include an indicator element that provides information relating to service history of the analyte determining devices, including, for example, previous use of the analyte determining devices. Also provided are systems and methods of using the, for example electrochemical, analyte determining devices in analyte monitoring. | 08-13-2015 |
20150226691 | Small Volume Test Strips with Large Sample Fill Ports, Supported Test Strips, and Methods of Making and Using Same - The present disclosure provides small volume analyte sensors having large sample fill ports, supported analyte sensors, analyte sensors having supported tip protrusions and methods of making and using same. | 08-13-2015 |
20150257688 | Reference Electrodes Having an Extended Lifetime for Use in Long Term Amperometric Sensors - The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions. | 09-17-2015 |
20150313520 | Analyte Sensors Having Temperature Independent Membranes - Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring. | 11-05-2015 |
20150323487 | Heterocyclic Nitrogen Containing Polymer Coated Analyte Monitoring Device and Methods of Use - The present invention is directed to membranes composed of heterocyclic nitrogen groups, such as vinylpyridine and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes described herein demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions. | 11-12-2015 |
20150374271 | ANALYTE MONITORING SYSTEM AND METHOD - Devices and methods for monitoring an analyte are provided. Embodiments include continuous analyte sensors having a high degree of accuracy. | 12-31-2015 |
20160045147 | Temperature Insensitive In Vivo Analyte Devices, Methods and Systems - Disclosed herein are membrane structures for use in analyte sensors, where the membrane structures exhibit low temperature sensitivity. | 02-18-2016 |
20160058351 | Lyotropic Liquid Crystal Coated Analyte Monitoring Device and Methods of Use - The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions. | 03-03-2016 |
Patent application number | Description | Published |
20130317332 | Method and System for Providing Continuous Calibration of Implantable Analyte Sensors - Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed. | 11-28-2013 |
20140046161 | Method and Apparatus for Providing Data Processing and Control in a Medical Communication System - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 02-13-2014 |
20140088908 | Method and Apparatus for Providing Data Processing and Control in a Medical Communication System - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 03-27-2014 |
20140171771 | DERMAL LAYER ANALYTE SENSING DEVICES AND METHODS - Provided are dermal sensors and dermal sensor applicator sets to insert at least a portion of a dermal sensor into a dermal layer of a subject, as well as methods of making and using the same. | 06-19-2014 |
20140207400 | Method and Apparatus for Providing Data Processing and Control in a Medical Communication System - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 07-24-2014 |
20140213868 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same. | 07-31-2014 |
20140275907 | IN VIVO GLUCOSE SENSING IN AN INCREASED PERFUSION DERMAL LAYER - Systems, devices, and methods are provided that enable the sensing of an analyte level within, e.g., the dermal layer of the skin of a subject. These systems, devices, and methods can utilize modalities that increase perfusion in an area local to a dermal sensor. | 09-18-2014 |
20140372065 | Method and Apparatus for Providing Analyte Sensor Calibration - Methods and apparatus for providing data processing and control for use in verifying the stability of sensor sensitivity of an analyte sensor. | 12-18-2014 |
20150094553 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same. | 04-02-2015 |
20150094554 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, a multi compatible or universal blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that require calibration code and test strips that do not require calibration code. Also disclosed are methods, systems, devices and kits for providing the same. | 04-02-2015 |
20150119669 | Method of Calibrating an Analyte-Measurement Device, and Associated Methods, Devices and Systems - The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site. | 04-30-2015 |
20150182153 | Self-Powered Analyte Sensor and Devices Using the Same - Systems, devices and methods for monitoring analyte levels using a self-powered analyte sensor and associated sensor electronics are provided. | 07-02-2015 |
20150208960 | Method and Apparatus for Providing Data Processing and Control in Medical Communication System - Methods and apparatus for providing data processing and control for use in a medical communication system are provided. | 07-30-2015 |
20150230739 | Analyte Sensors and Methods of Use - An analyte sensor system including a substrate, a first electrode disposed on a first surface of the substrate, a second electrode disposed on a second surface of the substrate, a third electrode provided in electrical contact with at least one of the first or second electrodes, where at least a portion of the first electrode and the second electrode are subcutaneously positioned in a patient, and where the third electrode is substantially entirely positioned external to the patient, and corresponding methods are provided. | 08-20-2015 |
20150265192 | Method and Apparatus for Detecting False Hypoglycemic Conditions - Embodiments of the present disclosure include detecting a concurrent occurrence of a decrease in monitored analyte level and a corresponding decrease in monitored on-skin temperature, confirming a presence of an impending hypoglycemic condition, and asserting a notification corresponding to the confirmed impending hypoglycemic condition. Devices, methods, systems and kits incorporating the same are also provided. | 09-24-2015 |
20160000360 | Method and System for Providing Continuous Calibration of Implantable Analyte Sensors - Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed. | 01-07-2016 |
Patent application number | Description | Published |
20090259118 | Shallow Implantable Analyte Sensor with Rapid Physiological Response - Methods and devices to detect analyte in body fluid are provided. Embodiments include analyte sensors designed so that at least a portion of the sensor is positionable beneath a skin surface in the dermal layer. | 10-15-2009 |
20100094110 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same. | 04-15-2010 |
20100094111 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, a multi compatible or universal blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that require calibration code and test strips that do not require calibration code. Also disclosed are methods, systems, devices and kits for providing the same. | 04-15-2010 |
20100094112 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, an auto turn on blood glucose monitoring unit including a calibration unit integrated with one or more components of an analyte monitoring system is provided. Also disclosed are methods, systems, devices and kits for providing the same. | 04-15-2010 |
20100331646 | Health Management Devices and Methods - Methods and devices to detect analyte in body fluid are provided. Embodiments include analyte sensors designed so that at least a portion of the sensor is positionable beneath a skin surface during analyte monitoring. | 12-30-2010 |
20110105873 | Method and Apparatus for Detecting False Hypoglycemic Conditions - Embodiments of the present disclosure include detecting a concurrent occurrence of a decrease in monitored analyte level and a corresponding decrease in monitored on-skin temperature, confirming a presence of an impending hypoglycemic condition, and asserting a notification corresponding to the confirmed impending hypoglycemic condition. Devices, methods, systems and kits incorporating the same are also provided. | 05-05-2011 |
20110213225 | Medical devices and methods - Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user. | 09-01-2011 |
20120088995 | Analyte Monitoring Devices and Methods - Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided. | 04-12-2012 |
20120265031 | Method and Apparatus for Detecting False Hypoglycemic Conditions - Embodiments of the present disclosure include detecting a concurrent occurrence of a decrease in monitored analyte level and a corresponding decrease in monitored on-skin temperature, confirming a presence of an impending hypoglycemic condition, and asserting a notification corresponding to the confirmed impending hypoglycemic condition. Devices, methods, systems and kits incorporating the same are also provided. | 10-18-2012 |
20130116525 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, a multi compatible or universal blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that require calibration code and test strips that do not require calibration code. Also disclosed are methods, systems, devices and kits for providing the same. | 05-09-2013 |
20130281809 | Analyte Monitoring Device and Methods of Use - In aspects of the present disclosure, an auto turn on blood glucose monitoring unit including a calibration unit integrated with one or more components of an analyte monitoring system is provided. Also disclosed are methods, systems, devices and kits for providing the same. | 10-24-2013 |
Patent application number | Description | Published |
20120095878 | INTEGRATED APPLICATION STORE FOR A USER DEVICE - Methods, systems and machine readable tangible storage media that integrate an application store in a user device. In one embodiment, a selected document that cannot be used as selected triggers a request to an application store server to determine an availability of applications to use the document as selected. The user device enhances the display of the document selection interface to allow the user to display an application store interface to purchase the application. The purchased application is downloaded and installed on the user device, and the user is optionally apprised of the progress of the purchase with an animated icon representing the application “flying” from the application store interface and “landing” in a dock area within the display on the user device when ready for subsequent launch. Other embodiments are also described. | 04-19-2012 |
20120096386 | USER INTERFACE FOR APPLICATION TRANSFERS - Methods, systems and machine readable tangible storage media that provide a user interface to an application store. In one embodiment, an icon representing an application being transferred to a user device appears to fly across the display area during the download and installation of the application before landing on a dock or other program control area from which the application can subsequently be launched. The user device synchronizes the flight of the icon with the progress of the download and installation by tracking the progress in communication with the server from which the application was transferred. The appearance of flight can be both vertical and horizontal and the icon bounces after the download and installation is complete conveying to the user that the application is ready to launch. The appearances of the locations from which the icon begins and ends its journey are changed to enhance the simulation of flight. Other embodiments are also described. | 04-19-2012 |
20130019233 | SYSTEM AND METHOD FOR LINKING PRE-INSTALLED SOFTWARE TO A USER ACCOUNT ON AN ONLINE STOREAANM Pardehpoosh; Pedraum R.AACI Palo AltoAAST CAAACO USAAGP Pardehpoosh; Pedraum R. Palo Alto CA USAANM Federighi; Craig M.AACI Los Altos HillsAAST CAAACO USAAGP Federighi; Craig M. Los Altos Hills CA USAANM Feldman; Daniel I.AACI San FranciscoAAST CAAACO USAAGP Feldman; Daniel I. San Francisco CA USAANM Quirk; Gregory T.AACI Maple GlenAAST PAAACO USAAGP Quirk; Gregory T. Maple Glen PA USAANM Matthew; Jack R.AACI San FranciscoAAST CAAACO USAAGP Matthew; Jack R. San Francisco CA USAANM Lee-Kang; JackieAACI SunnyvaleAAST CAAACO USAAGP Lee-Kang; Jackie Sunnyvale CA USAANM Ciudad; Jean-PierreAACI San FranciscoAAST CAAACO USAAGP Ciudad; Jean-Pierre San Francisco CA USAANM Gromek; Monika E.AACI OaklandAAST CAAACO USAAGP Gromek; Monika E. Oakland CA USAANM Burkholder; Thomas K.AACI VancouverAACO CAAAGP Burkholder; Thomas K. Vancouver CAAANM Pu; Daniel EmilAACI San FranciscoAAST CAAACO USAAGP Pu; Daniel Emil San Francisco CA USAANM Gharabally; SamAACI San FranciscoAAST CAAACO USAAGP Gharabally; Sam San Francisco CA USAANM Verosub; Ellis MarshallAACI San CarlosAAST CAAACO USAAGP Verosub; Ellis Marshall San Carlos CA USAANM Hwang; Yoon SubAACI AlamedaAAST CAAACO USAAGP Hwang; Yoon Sub Alameda CA US - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for associating an application that was pre-installed on a computer with a user account on an online store. A system configured to practice the method presents an application available for download, receives a request to download the application to a computing device, determines that the application is a pre-installed application, presents an authorization prompt configured to request user authorization to link the application with a user account, receives the user authorization, generates a unique hardware identifier associated with the computing device, determines that the application is linkable based upon the unique hardware identifier, and links the adoptable application with the user account when the adoptable application is linkable. | 01-17-2013 |
20130019234 | SYSTEM AND METHOD FOR LINKING PRE-INSTALLED SOFTWARE TO A USER ACCOUNT ON AN ONLINE STORE - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for associating an application that was pre-installed on a computer with a user account on an online store. A system configured to practice the method presents an application available for download, receives a request to download the application to a computing device, determines that the application is a pre-installed application, presents an authorization prompt configured to request user authorization to link the application with a user account, receives the user authorization, generates a unique hardware identifier associated with the computing device, determines that the application is linkable based upon the unique hardware identifier, and links the adoptable application with the user account when the adoptable application is linkable. | 01-17-2013 |
20130019237 | SYSTEM AND METHOD FOR LINKING PRE-INSTALLED SOFTWARE TO A USER ACCOUNT ON AN ONLINE STORE - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for associating an application for installation on a computer with a user account on an online store. A system configured to practice the method presents an application available for download, receives from a client device a software adoption request including an identifier associated with a user account and a proof of entitlement associated with a software package or the user account, verifies the proof of entitlement by comparing the proof of entitlement to a database, and if the proof of entitlement is verified, adopts the software package as part of the user account. | 01-17-2013 |
20140012714 | METHOD, MEDIUM AND SYSTEM FOR AN INTEGRATED APPLICATION STORE FOR A USER DEVICE - Methods, systems and machine readable tangible storage media that integrate an application store in a user device. In one embodiment, a selected document that cannot be used as selected triggers a request to an application store server to determine an availability of applications to use the document as selected. The user device enhances the display of the document selection interface to allow the user to display an application store interface to purchase the application. The purchased application is downloaded and installed on the user device, and the user is optionally apprised of the progress of the purchase with an animated icon representing the application “flying” from the application store interface and “landing” in a dock area within the display on the user device when ready for subsequent launch. Other embodiments are also described. | 01-09-2014 |
20140047331 | DETECTING AND TRANSMITTING A REDEEMABLE DOCUMENT - Disclosed herein are systems, methods, and non-transitory computer-readable storage media for detecting documents within content received by a computing device. A computing device can receive content through an application. The received content is scanned to determine if it includes a file type indicating that it includes a redeemable document. A notification is presented to the user when a document has been detected within the content including a button enabling rendering of the document on the computing device. The rendered document can include a button to transmit the document to secondary computing devices associated with the user. A user profile associated with the user can include data indicating secondary computing devices associated with the user. The user profile can be accessed to retrieve the data and, if the button is selected, the document can be transmitted to the secondary computing devices from which the user can render the document. | 02-13-2014 |
20140150115 | ASSIGNING ELECTRONICALLY PURCHASED ITEMS OF CONTENT TO USERS - The described embodiments include a content provider device that can assign items of content (applications, digitally-rendered music, books, videos, etc.) to users upon receiving assignment messages from administrative devices. The items of content can be electronically transferred to the user's devices to be used by users. The content provider device can also revoke assignments of items of content from users upon receiving revocation messages from administrative devices. The revocation generally causes the loss of one or more rights to the item of content for the user. For example, the content provider device can stop providing services for the item of content and/or can cause the item of content to be deleted from a corresponding user's device. | 05-29-2014 |
20140282476 | Providing Customized Notifications for Security Software Updates - A method of providing customized software update notifications for a device is described. The method receives information for a set of available system software updates from an update server. The set of available system software updates includes a set of security updates. Each security update includes a set of metadata. The method also receives information for a set of available application software updates. The method determines the total number of available application and system software updates. The method generates a customized update notification string based on the received metadata and the total number of available software updates. The method displays the generated customized update notification string. | 09-18-2014 |
20140282480 | Providing A Unified Update Center for Security Software Updates and Application Software Updates - A graphical user interface (GUI) for a unified software update display center is provided. The GUI includes a first display area for displaying a set of available security system software updates. The GUI includes a second display area for displaying a set of available non-security system software updates. The GUI includes a third display area for displaying a set of available application software updates. The GUI includes a single selection tool for installing all available security updates without installing any updates displayed in the second and third display areas. The GUI includes individual selection tools for installing individual updates displayed in the second and third display areas. The GUI includes a selection tool to receive further updates from a system update server and an application update server. The critical security updates are displayed with different display attributes or in different sections to distinguish them from other types of updates. | 09-18-2014 |
Patent application number | Description | Published |
20080319497 | Architectures for an Implantable Medical Device System - An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC. | 12-25-2008 |
20100331916 | METHOD AND DEVICE FOR ACQUIRING PHYSIOLOGICAL DATA DURING TISSUE STIMULATION PROCEDURE - A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses. | 12-30-2010 |
20110015705 | Architectures for an Implantable Medical Device System - An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC. | 01-20-2011 |
20110112610 | Minimizing Interference Between Charging and Telemetry Coils in an Implantable Medical Device - An improved implantable pulse generator (IPG) containing improved telemetry circuitry is disclosed. The IPG includes charging and telemetry coils within the IPG case, which increases their mutual inductance and potential to interfere with each other; particularly problematic is interference to the telemetry coil caused by the charging coil. To combat this, improved telemetry circuitry includes decoupling circuitry for decoupling the charging coil during periods of telemetry between the IPG and an external controller. Such decoupling circuitry can comprise use of pre-existing LSK circuitry during telemetry, or new discrete circuitry dedicated to decoupling. The decoupling circuitry is designed to prevent or at least reduce induced current flowing through the charging coil during data telemetry. The decoupling circuitry can be controlled by the microcontroller in the IPG, or can automatically decouple the charging coil at appropriate times to mitigate an induced current without instruction from the microcontroller. | 05-12-2011 |
20110118797 | Multi-Electrode Implantable Stimulator Device with a Single Current Path Decoupling Capacitor - Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device. | 05-19-2011 |
20120092031 | Sample and Hold Circuitry for Monitoring Voltages in an Implantable Neurostimulator - Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing. | 04-19-2012 |
20120095519 | Monitoring Electrode Voltages in an Implantable Medical Device System Having Daisy-Chained Electrode-Driver Integrated Circuits - Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation. | 04-19-2012 |
20120095529 | Architectures for an Implantable Medical Device System Having Daisy-Chained Electrode-Driver Integrated Circuits - Architectures for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. A parallel bus operating in accordance with a communication protocol couples the ICs, and certain functional blocks not needed in the slave are disabled. Stimulation parameters are loaded via the bus into each IC, and a stimulation enable command is issued on the bus to ensure simultaneous stimulation from the electrodes on both ICs. Clocking strategies are also disclosed to allow clocking of the master and slave ICs to be independently controlled, and to ensure that relevant internal and bus clocks used in the system are synchronized. | 04-19-2012 |
20130023943 | Battery Management for an Implantable Medical Device - Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes. | 01-24-2013 |
20130103115 | Communication and Charging Circuitry for a Single-Coil Implantable Medical Device - Communication and charging circuitry for an implantable medical device is described having a single coil for receiving charging energy and for data telemetry. The circuitry removes from the AC side of the circuit a tuning capacitor and switch traditionally used to tune the tank circuitry to different frequencies for telemetry and charging. As such, the tank circuitry is simplified and contains no switchable components. A switch is serially connected to the storage capacitor on the DC side of the circuit. During telemetry, the switch is opened, thus disconnecting the storage capacitor from the tank circuit, and alleviating concerns that this capacitor will couple to the tank circuit and interfere with telemetry operations. During charging, the switch is closed, which allows the storage capacitor to couple to the tank circuitry through the rectifier during some portions of the tank circuitry's resonance. | 04-25-2013 |
20130110203 | Managing a Multi-function Coil in an Implantable Medical Device Using an Optical Switch | 05-02-2013 |
20130131742 | Multi-Electrode Implantable Stimulator Device with a Single Current Path Decoupling Capacitor - Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device. | 05-23-2013 |
20130184794 | Architectures for an Implantable Stimulator Device Having a Plurality of Electrode Driver Integrated Circuits with Shorted Electrode Outputs - Disclosed is a new architecture for an IPG having a master and slave electrode driver integrated circuits. The electrode outputs on the integrated circuits are wired together. Each integrated circuit can be programmed to provide pulses with different frequencies. Active timing channels in each of the master and slave integrated circuits are programmed to provide the desired pulses, while shadow timing channels in the master and slave are programmed with the timing data from the active timing channels in the other integrated circuit so that each chip knows when the other is providing a pulse, so that each chip can disable its recovery circuitry so as not to defeat those pulses. In the event of pulse overlap at a given electrode, the currents provided by each chip will add at the affected electrode. Compliance voltage generation is dictated by an algorithm to find an optimal compliance voltage even during periods when pulses are overlapping. | 07-18-2013 |
20130245723 | NEUROSTIMULATION SYSTEM FOR PREVENTING MAGNETICALLY INDUCED CURRENTS IN ELECTRONIC CIRCUITRY - A neurostimulation device capable of being placed between an active stimulation state and an inactive stimulation state and method of using same. The neurostimulation device comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of stimulation electrodes, a first solid-state switching device coupled to a first one of the electrical terminals, a variable power source coupled to the first switching device, and a controller configured for, when the neurostimulation device is in the inactive stimulation state, prompting the variable power source to selectively output a relatively low voltage to place the first switching device into a first open state and a relatively high voltage to place the first switching device into a second open state. | 09-19-2013 |
20130345777 | NEUROSTIMULATION SYSTEM FOR ENABLING MAGNETIC FIELD SENSING WITH A SHUT-DOWN HALL SENSOR - An implantable medical device capable of being placed between a first operational mode and a second operational mode. The medical device comprises a magnetic field sensing device configured for outputting a signal in response to sensing a magnetic field. The medical device further comprises a logic circuit configured for continuously asserting the signal during a time period when the neurostimulation device is in the first operational mode, and intermittently asserting the signal during at least one time period when the neurostimulation device is in the second operational mode. The medical device further comprises a delay circuit configured for introducing a time delay into the asserted signal, the time delay being less than the time period, but greater than each of the at least one time period. The medical device further comprises control circuitry configured for performing a function in response to receiving the delayed signal at a first input terminal. | 12-26-2013 |
20140058479 | Minimizing Interference Between Charging and Telemetry Coils in an Implantable Medical Device - An improved implantable pulse generator (IPG) containing improved telemetry circuitry is disclosed. The IPG includes charging and telemetry coils within the IPG case, which increases their mutual inductance and potential to interfere with each other; particularly problematic is interference to the telemetry coil caused by the charging coil. To combat this, improved telemetry circuitry includes decoupling circuitry for decoupling the charging coil during periods of telemetry between the IPG and an external controller. Such decoupling circuitry can comprise use of pre-existing LSK circuitry during telemetry, or new discrete circuitry dedicated to decoupling. The decoupling circuitry is designed to prevent or at least reduce induced current flowing through the charging coil during data telemetry. The decoupling circuitry can be controlled by the microcontroller in the IPG, or can automatically decouple the charging coil at appropriate times to mitigate an induced current without instruction from the microcontroller. | 02-27-2014 |
20140176066 | Communication and Charging Circuitry for a Single-Coil Implantable Medical Device - Communication and charging circuitry for an implantable medical device is described having a single coil for receiving charging energy and for data telemetry. The circuitry removes from the AC side of the circuit a tuning capacitor and switch traditionally used to tune the tank circuitry to different frequencies for telemetry and charging. As such, the tank circuitry is simplified and contains no switchable components. A switch is serially connected to the storage capacitor on the DC side of the circuit. During telemetry, the switch is opened, thus disconnecting the storage capacitor from the tank circuit, and alleviating concerns that this capacitor will couple to the tank circuit and interfere with telemetry operations. During charging, the switch is closed, which allows the storage capacitor to couple to the tank circuitry through the rectifier during some portions of the tank circuitry's resonance. | 06-26-2014 |
20140266375 | Integrated Circuitry for Generating a Clock Signal in an Implantable Medical Device - Timer circuitry completely formable in an integrated circuit (IC) for generating a clock signal in an implantable medical device is disclosed. The timer circuitry can be formed on the same Application Specific Integrated Circuit typically used in the implant, and requires no external components. The timer circuitry comprises modification to a traditional astable timer circuit. A resistance in the disclosed timer circuit can be trimmed to adjust the frequency of the clock signal produced, thus allowing that frequency to be set to a precise value during manufacturing. Precision components are not needed in the RC circuit, which instead are used to set the rough value of the frequency of the clock signal. A regulator produces a power supply for the timer circuitry from a main power supply (Vcc), producing a clock signal with a frequency that is generally independent of temperature and Vcc fluctuations. | 09-18-2014 |
20140277290 | Monitoring Electrode Voltages In An Implantable Medical Device System Having Daisy-Chained Electrode-Driver Integrated Circuits - Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation. | 09-18-2014 |
20150100109 | Implantable Medical Device with One or More Magnetic Field Sensors to Assist with External Charger Alignment - An implantable medical device (IMD) is disclosed having one or more magnetic field sensors for measuring a strength of a magnetic charging field provided by an external charger and used to provide operational power to the IMD, for example, to charge its battery. The measured field strength data, or derivations of such data, are telemetered to the external charger, which further process the received data if necessary and can inform a user whether alignment between the external charger and IMD is sufficient, a misalignment direction, and/or a misalignment distance, so that the user can attempt to improve the alignment of the external charger. The one or more sensors are preferably placed at or equidistantly around a center axis of the IMD's charging coil. However, the sensors may be placed at any number of locations in the IPG, and at different distances from the center axis. | 04-09-2015 |
20150226615 | Temperature Sensing Circuitry for an Implantable Medical Device - Temperature sensing circuitry for an Implantable Medical Device (IMD) is disclosed that can be integrated into integrated circuitry in the IMD and draws very little power, thus enabling continuous temperature monitoring without undue battery depletion. Temperature sensor and threshold setting circuitry produces analog voltage signals indicative of a sensed temperature and at least one temperature threshold. Such circuitry employs a Ptat current reference stage and additional stages, which stages contains resistances that are set based on the desired temperature threshold(s) and to set the voltage range of the sensed temperature. These analog voltages are received at temperature threshold detection circuitry, which produces digital signal(s) indicating whether the sensed temperature has passed the temperature threshold(s). The digital signal(s) are then provided to digital circuitry in the IMD, where they can be stored as a function of time for later review, or used to immediately to control IMD operation. | 08-13-2015 |
20150258340 | Multi-Electrode Implantable Stimulator Device with a Single Current Path Decoupling Capacitor - Disclosed herein are circuits and methods for a multi-electrode implantable stimulator device incorporating one decoupling capacitor in the current path established via at least one cathode electrode and at least one anode electrode. In one embodiment, the decoupling capacitor may be hard-wired to a dedicated anode on the device. The cathodes are selectively activatable via stimulation switches. In another embodiment, any of the electrodes on the devices can be selectively activatable as an anode or cathode. In this embodiment, the decoupling capacitor is placed into the current path via selectable anode and cathode stimulation switches. Regardless of the implementation, the techniques allow for the benefits of capacitive decoupling without the need to associate decoupling capacitors with every electrode on the multi-electrode device, which saves space in the body of the device. Although of particular benefit when applied to microstimulators, the disclosed technique can be used with space-saving benefits in any stimulator device. | 09-17-2015 |
20150290456 | Sample and Hold Circuitry for Monitoring Voltages in an Implantable Neurostimulator - Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing. | 10-15-2015 |
20150335901 | Monitoring Electrode Voltages In An Implantable Medical Device System Having Daisy-Chained Electrode-Driver Integrated Circuits - Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation. | 11-26-2015 |
20160082260 | Architectures for an Implantable Medical Device System - An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicates with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG. | 03-24-2016 |
Patent application number | Description | Published |
20110287500 | CYTOSOLIC ISOBUTANOL PATHWAY LOCALIZATION FOR THE PRODUCTION OF ISOBUTANOL - The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and/or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 11-24-2011 |
20110318799 | YEAST ORGANISM PRODUCING ISOBUTANOL AT A HIGH YIELD - There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The method includes cultivating the microorganism in a culture medium containing a feedstock providing the carbon source, until isobutanol is produced. The method includes recovering the isobutanol. In one embodiment, the microorganism is a yeast with a Crabtree-negative phenotype. In another embodiment, the microorganism is a yeast microorganism with a Crabtree-positive phenotype. There is disclosed a microorganism for producing isobutanol. In an embodiment, the microorganism includes an isobutanol producing pathway containing at least one exogenous gene, and is selected to produce a recoverable quantity of isobutanol from a carbon source at a yield of at least 10 percent theoretical. | 12-29-2011 |
20120028323 | YEAST ORGANISM PRODUCING ISOBUTANOL AT A HIGH YIELD - The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 02-02-2012 |
20120028324 | ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS - The present invention is generlly provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention. | 02-02-2012 |
20120058532 | ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS - The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention. | 03-08-2012 |
20120190089 | ENGINEERED MICROOGRANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS - The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention. | 07-26-2012 |
20120288910 | METHODS OF INCREASING DIHYDROXY ACID DEHYDRATASE ACTIVITY TO IMPROVE PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS - The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 11-15-2012 |
20140308721 | Cytosolic Isobutanol Pathway Localization for the Production of Isobutanol - The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and/or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the | 10-16-2014 |