Pfleger
Brian Pfleger, Madison, WI US
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20120021922 | TRANSLATION-COUPLING SYSTEMS - Disclosed are systems and methods for coupling translation of a target gene to a detectable response gene. A version of the invention includes a translation-coupling cassette. The translation-coupling cassette includes a target gene, a response gene, a response-gene translation control element, and a secondary structure-forming sequence that reversibly forms a secondary structure masking the response-gene translation control element. Masking of the response-gene translation control element inhibits translation of the response gene. Full translation of the target gene results in unfolding of the secondary structure and consequent translation of the response gene. Translation of the target gene is determined by detecting presence of the response-gene protein product. The invention further includes RNA transcripts of the translation-coupling cassettes, vectors comprising the translation-coupling cassettes, hosts comprising the translation-coupling cassettes, methods of using the translation-coupling cassettes, and gene products produced with the translation-coupling cassettes. | 01-26-2012 |
20140030708 | TRANSLATION-COUPLING SYSTEMS - Disclosed are systems and methods for coupling translation of a target gene to a detectable response gene. A version of the invention includes a translation-coupling cassette. The translation-coupling cassette includes a target gene, a response gene, a response-gene translation control element, and a secondary structure-forming sequence that reversibly forms a secondary structure masking the response-gene translation control element. Masking of the response-gene translation control element inhibits translation of the response gene. Full translation of the target gene results in unfolding of the secondary structure and consequent translation of the response gene. Translation of the target gene is determined by detecting presence of the response-gene protein product. The invention further includes RNA transcripts of the translation-coupling cassettes, vectors comprising the translation-coupling cassettes, hosts comprising the translation-coupling cassettes, methods of using the translation-coupling cassettes, and gene products produced with the translation-coupling cassettes. | 01-30-2014 |
20140370594 | BIOLOGICAL CONVERSION OF BIOMASS-DERIVED SUGARS TO VALUE ADDED CHEMICALS - A method of growing a microorganism by culturing the microorganism in a an aqueous solution of carbohydrates containing C6-sugar monomers or C5-sugar monomers, wherein the aqueous solution of carbohydrates is made by reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid catalyst. The reaction yields a product mixture containing water-soluble C6-sugar-containing oligomers, C6-sugar monomers, C5-sugar-containing oligomers, C5-sugar monomers, or any combination thereof. The product mixture is then partitioned or extracted to yield an aqueous layer containing the carbohydrates and a substantially immiscible organic layer containing the lactone. The aqueous layer is used for growing the microorganisms. | 12-18-2014 |
Brian F. Pfleger, Ann Arbor, MI US
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20100055754 | METHODS FOR INCREASING ISOPRENOID AND ISOPRENOID PRECURSOR PRODUCTION BY MODULATING FATTY ACID LEVELS - The present invention provides methods of increasing production of an isoprenoid or an isoprenoid precursor in a host cell, the methods generally involving modulating the level of activity of a fatty acid biosynthetic pathway enzyme in the host cell and/or culturing the host cell in a culture medium comprising a fatty acid or a compound that can be metabolized in a cell or broken down in the medium to yield a fatty acid and/or culturing the host cell in a culture medium having increased osmolarity. | 03-04-2010 |
Brian F. Pfleger, Madison, WI US
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20110165637 | FATTY ACID-PRODUCING HOSTS - Described are hosts for overproducing a fatty acid product such as a fatty acid. The hosts include an exogenous nucleic acid encoding a thioesterase and, optionally, an exogenous nucleic acid encoding an acetyl-CoA carboxylase, wherein an acyl-CoA synthetase in the hosts are functionally deleted. The hosts preferably include the nucleic acid encoding the thioesterase at an intermediate copy number. The hosts are preferably recombinantly stable and growth-competent at 37° C. Methods of producing a fatty acid product comprising culturing such hosts at 37° C. are also described. | 07-07-2011 |
Brian Frederick Pfleger, Madison, WI US
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20140073022 | PRODUCTION OF POLYHYDROXYALKANOATES WITH A DEFINED COMPOSITION FROM AN UNRELATED CARBON SOURCE - Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an R-specific enoyl-CoA hydratase gene, a PHA polymerase gene, a thioesterase gene, and an acyl-CoA-synthetase gene. The cells further have one or more genes functionally deleted. The functionally deleted genes include such genes as an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase, and a 3-ketoacyl-CoA thiolase gene. The recombinant cells are capable of using producing polyhydroxyalkanoates with a high proportion of monomers having the same carbon length from non-lipid substrates, such as carbohydrates. | 03-13-2014 |
Christian Pfleger, Reutlingen DE
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20130104671 | Arrangement for the Direct Contacting of Contact Mechanism and Associated Connection Unit for a Pressure Measurement Cell | 05-02-2013 |
20130115802 | DEVICE FOR ELECTRICALLY CONTACTING ELECTRONIC UNITS - A device for electrically contacting a first electronic unit with a second electronic unit includes a guiding unit, at least one first contact unit that is guided in the guiding unit, and a second contact unit. The contact units each include at least one contact element, which cooperates with the other as contact partners. The at least one contact element of the first contact unit is embodied as a hollow contact element. The at least one contact element of the second contact unit is embodied as a shaped contact part that comprises an elevated region that tapers in the direction along a vertical axis. The electrical contact of the at least one hollow contact element with the at least one shaped contact part is provided in the form of a plug connection inside the hollow contact element of the first contact unit. | 05-09-2013 |
20130255391 | SENSOR UNIT - A sensor unit has at least one measuring cell and a circuit mount arranged in a protective sleeve. The measuring cell detects a pressure of a hydraulic block. The circuit mount has a printed circuit board, which is positioned perpendicularly relative to the measuring cell. The printed circuit board has an electronic circuit with at least one electronic and/or electrical component. The measuring cell has at least one connection point configured to tap off at least one electrical output signal from the measuring cell. The circuit mount forms an internal interface which taps off the at least one electrical output signal from the measuring cell and applies it to the electronic circuit. An output signal from the electronic circuit can be tapped off by an external interface. The internal interface is formed at a first end and the external interface is formed at a second end of the protective sleeve. | 10-03-2013 |
20150040673 | Support Unit for a Circuit Board in a Sensor Unit and Corresponding Sensor Unit - A support unit for a circuit board in a sensor unit comprises a main body that defines an outer contour and includes a first joining geometry and a second joining geometry. The first joining geometry is configured to at least one of guide and electrically contact external contact elements, and includes contact receiving pockets configured to guide the external contact elements, and at least one reinforcement web that separates two adjacent contact receiving pockets. The second joining geometry is configured to join the support unit to the circuit board. The first joining geometry defines at least in part an external interface via which at least one electrical output signal of the circuit board is tapped. | 02-12-2015 |
20150040676 | Circuit Carrier for a Sensor Unit and Corresponding Sensor Unit - A circuit carrier for a sensor unit comprises a first interface via which at least one electrical output signal is tapped at least at one connection point of a measuring cell, a second interface via which the at least one electrical output signal of the measuring cell is applied via at least one first contact element to a circuit board with an electronic circuit, and a hollow, cylindrical main body. The main body includes an inner joining geometry defined on an inner contour which defines at least in part the first interface, an outer joining geometry which defines at least in part the second interface, and configured to electrically connect to a connection point of the measuring cell in a force-free manner. The outer joining geometry is configured as a receiving pocket with a protruding collar, and includes the at least one first contact element. | 02-12-2015 |
Christoph Pfleger, Wien AU
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20100183205 | METHOD FOR PERCEPTION MEASUREMENT - In a procedure for measuring perception, in particular for measuring the visual attention of an individual, whereby at least the first visual coordinates of a first point of vision ( | 07-22-2010 |
Christoph Pfleger, Karlsruhe DE
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20150205893 | METHOD AND SIMULATION ARRANGEMENT FOR SIMULATING AN AUTOMATED INDUSTRIAL PLANT - A method for simulation of an automated industrial plant simulated in a plant model divided into a plurality of submodels, where the submodels are modeled with a behavior description comprising a calculation algorithm or a mathematical equation, each submodel is connected into the plant model with at least one submodel, where the plant model or the submodels are translated in preparation for the simulation by a translation run into a form which is executable by a computer system, an execution sequence of the submodels is defined, the submodels are expanded by run time models having a calculation time assigned to a respective submodel, where an overall calculation time of the plant model is derived and graphically presented in the granularity of the calculation times of the submodels based on the execution sequence and the expanded submodels to provide a detection and localization of real-time-critical execution paths in the plant model. | 07-23-2015 |
Ernst Pfleger, Wien AT
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20100183205 | METHOD FOR PERCEPTION MEASUREMENT - In a procedure for measuring perception, in particular for measuring the visual attention of an individual, whereby at least the first visual coordinates of a first point of vision ( | 07-22-2010 |
Karl Pfleger, San Francisco, CA US
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20110184930 | Methods and Systems for Adjusting a Scoring Measure Based on Query Breadth - Methods and systems for adjusting a scoring measure of a search result based at least in part on the breadth of a previously-executed search query associated with the search result are described. In one described system, a search engine determines a popularity measure for a search result, and then adjusts the popularity measure based at least in part on a query breadth measure of a previously-executed search query associated with the search result. The search engine may use a variety of query breadth measures. For example, the search engine may use the quantity of results returned by the search query, the length of the query, the IR score drop-off, or some other measure of breadth. | 07-28-2011 |
Karl Pfleger, Mountain View, CA US
Patent application number | Description | Published |
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20110022605 | DOCUMENT SCORING BASED ON LINK-BASED CRITERIA - A method may include receiving a document and an initial score for the document; determining that there has been a decrease in a rate or quantity of new links that point to the document over time; classifying the document as stale in response to the determining; decreasing the initial score for the document, resulting in an updated score; and ranking the document with regard to at least one other document based, at least in part, on the score. | 01-27-2011 |
20110029542 | DOCUMENT SCORING BASED ON DOCUMENT INCEPTION DATE - A system may determine a document inception date associated with a document, generate a score for the document based, at least in part, on the document inception date, and rank the document with regard to at least one other document based, at least in part, on the score. | 02-03-2011 |
20110258185 | DOCUMENT SCORING BASED ON DOCUMENT CONTENT UPDATE - A system may determine a measure of how a content of a document changes over time, generate a score for the document based, at least in part, on the measure of how the content of the document changes over time, and rank the document with regard to at least one other document based, at least in part, on the score. | 10-20-2011 |
20110264671 | DOCUMENT SCORING BASED ON DOCUMENT CONTENT UPDATE - A system may determine a measure of how a content of a document changes over time, generate a score for the document based, at least in part, on the measure of how the content of the document changes over time, and rank the document with regard to at least one other document based, at least in part, on the score. | 10-27-2011 |
20110270863 | QUERY REWRITING WITH ENTITY DETECTION - A system determines whether a received search query includes an entity name, determines whether to rewrite the received search query based on information relating to prior searches involving the entity name, and rewrites the received search query when it is determined that the received search query should be rewritten. The system further determines whether to provide a suggestion of rewriting the received search query, as a rewriting suggestion, based on information relating to prior searches involving the entity name when it is determined that the received search query should not be rewritten. The system also generates the rewriting suggestion when it is determined that the rewriting suggestion should be provided. The system performs a search based on one of the received search query and the rewritten search query to obtain search results, presents the search results, and presents the rewriting suggestion when it is determined that the rewriting suggestion should be provided. | 11-03-2011 |
20120005199 | DOCUMENT SCORING BASED ON DOCUMENT CONTENT UPDATE - A system may determine a measure of how a content of a document changes over time, generate a score for the document based, at least in part, on the measure of how the content of the document changes over time, and rank the document with regard to at least one other document based, at least in part, on the score. | 01-05-2012 |
20120016870 | DOCUMENT SCORING BASED ON QUERY ANALYSIS - A system may determine an extent to which a document is selected when the document is included in a set of search results, generate a score for the document based, at least in part, on the extent to which the document is selected when the document is included in a set of search results; and rank the document with regard to at least one other document based, at least in part, on the score. | 01-19-2012 |
20120016871 | DOCUMENT SCORING BASED ON QUERY ANALYSIS - A system may determine an extent to which a document is selected when the document is included in a set of search results, generate a score for the document based, at least in part, on the extent to which the document is selected when the document is included in a set of search results; and rank the document with regard to at least one other document based, at least in part, on the score. | 01-19-2012 |
20120016874 | DOCUMENT SCORING BASED ON QUERY ANALYSIS - A system may determine an extent to which a document is selected when the document is included in a set of search results, generate a score for the document based, at least in part, on the extent to which the document is selected when the document is included in a set of search results; and rank the document with regard to at least one other document based, at least in part, on the score. | 01-19-2012 |
20120016889 | DOCUMENT SCORING BASED ON QUERY ANALYSIS - A system may determine an extent to which a document is selected when the document is included in a set of search results, generate a score for the document based, at least in part, on the extent to which the document is selected when the document is included in a set of search results; and rank the document with regard to at least one other document based, at least in part, on the score. | 01-19-2012 |
20120023098 | DOCUMENT SCORING BASED ON QUERY ANALYSIS - A system may determine an extent to which a document is selected when the document is included in a set of search results, generate a score for the document based, at least in part, on the extent to which the document is selected when the document is included in a set of search results; and rank the document with regard to at least one other document based, at least in part, on the score. | 01-26-2012 |
20120209838 | DOCUMENT SCORING BASED ON QUERY ANALYSIS - A system may determine an extent to which a document is selected when the document is included in a set of search results, generate a score for the document based, at least in part, on the extent to which the document is selected when the document is included in a set of search results; and rank the document with regard to at least one other document based, at least in part, on the score. | 08-16-2012 |
20130339381 | QUERY REWRITING WITH ENTITY DETECTION - A system determines whether a received search query includes an entity name, determines whether to rewrite the received search query based on information relating to prior searches involving the entity name, and rewrites the received search query when it is determined that the received search query should be rewritten. The system further determines whether to provide a suggestion of rewriting the received search query, as a rewriting suggestion, based on information relating to prior searches involving the entity name when it is determined that the received search query should not be rewritten. The system also generates the rewriting suggestion when it is determined that the rewriting suggestion should be provided. The system performs a search based on one of the received search query and the rewritten search query to obtain search results, presents the search results, and presents the rewriting suggestion when it is determined that the rewriting suggestion should be provided. | 12-19-2013 |
Karl Pfleger, Moutain View, CA US
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20120016888 | DOCUMENT SCORING BASED ON QUERY ANALYSIS - A system may determine an extent to which a document is selected when the document is included in a set of search results, generate a score for the document based, at least in part, on the extent to which the document is selected when the document is included in a set of search results; and rank the document with regard to at least one other document based, at least in part, on the score. | 01-19-2012 |
Karl Robert Pfleger, San Francisco, CA US
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20100138291 | Adjusting Bids Based on Predicted Performance - A predicted performance metric of a candidate advertisement in an advertising slot can be received and compared to a baseline predicted performance metric for the candidate advertisement. A target bid associated with the candidate advertisement can be adjusted based upon the comparison, and the adjusted bid can be submitted to an auction for the advertising slot. | 06-03-2010 |
Kevin D. Pfleger, Nedlands AU
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20130065253 | DETECTION SYSTEM AND USES THEREFOR - A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents. | 03-14-2013 |
Kevin D. G. Pfleger, Nedlands AU
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20130289084 | COMBINATION THERAPY - The invention relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof, and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof; and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof which inhibits a component of the chemokine receptor pathway other than the chemokine receptor. Oral sustained release pharmaceutical compositions comprising the pharmaceutical composition, as well as injectable sustained release pharmaceutical compositions comprising the pharmaceutical composition are described. The invention further relates to tablets, capsules, injectable suspensions, and compositions for pulmonary or nasal delivery comprising the pharmaceutical composition. Also described are: methods for assessing the efficacy of the pharmaceutical composition; methods for assessing the inhibition or partial inhibition activity of the pharmaceutical composition; methods for the treatment, amelioration or prevention of a condition or disease comprising administering to a subject a therapeutically effective amount of the pharmaceutical composition; and the use of the pharmaceutical composition for the manufacture of a dosage form for the treatment of a disease. | 10-31-2013 |
Kevin Donald George Pfleger, Nedlands AU
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20100021457 | DETECTION SYSTEM AND USES THEREFOR - A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group; iv) a modulator; and v) a detector; wherein proximity of the first and second reporter components generates a signal capable of detection by the detector; and wherein the modulator modulates the association of the second interacting group with the third interacting group; such that monitoring the signal generated by proximity of the first and second reporter components by the detector constitutes monitoring the association of the first and third agents. | 01-28-2010 |
20100234417 | THYROTROPIN RELEASING HORMONE RECEPTOR-OREXIN RECEPTOR HETERO-DIMERS/-OLIGOMERS - A hetero-dimeric or hetero-oligomeric receptor, comprising at least one thyrotropin releasing hormone receptor subunit associated with at least one orexin receptor subunit. | 09-16-2010 |
20120100130 | Novel Receptor Hetero-Dimers/-Oligomers - A hetero-dimeric or hetero-oligomeric receptor, comprising at least one chemokine receptor subunit associated with at least one angiotensin receptor subunit. | 04-26-2012 |
Markus Pfleger, St. Johann/wbg AU
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20090049429 | Method and System for Tracing Individual Transactions at the Granularity Level of Method Calls Throughout Distributed Heterogeneous Applications Without Source Code Modifications - The present invention provides a method and system for tracing and monitoring of distributed transactions spanning multiple threads or processes, running on multiple host systems, connected by a computer network. The correlation of distributed transactions is based on information that uniquely may identify execution paths within a virtual machine, additional to information which uniquely may identify the virtual machine that processes the execution path. The correlation information is transferred from a monitored thread to threads that are activated by the monitored thread and allows to reconstruct parent-child relations between different threads. Participating threads may run in different processes, in different virtual machines or on different host systems. | 02-19-2009 |
Markus Pfleger, St Johann Am Wimberg AT
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20120297371 | Method and System for tracing individual Transactions at the Granularity Level of Method Calls Throughout Distributed Heterogeneous Applications without Source Code Modifications Including the Detection of Outgoing Requests - A monitoring system uses existing tracing data describing individual distributed transactions to determine if a recorded thread communication performed by the monitored transactions is internal to a monitored application or whether the recorded thread communication is an outgoing communication. Thread communications which are sent and received by threads that are monitored by the monitoring system are considered to be internal communications. Thread communications for which only the sending thread is monitored are considered to be outgoing communications. The determination process analyzes client side tracing data of the recorded thread communication and determines whether corresponding server side tracing data is available. If no corresponding server side tracing data is available, the thread communication is considered to be an outgoing communications. Examples of thread communications include HTTP requests, web service calls, and remote method invocations. | 11-22-2012 |
Stefan Pfleger, Alzenau DE
Stefan Pfleger, Amarillo, TX US
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20110265389 | System and Method for Securing a Door Assembly to a Structure - A system and method for sealing a door assembly to a structure is disclosed. Specifically, a sealing system is disclosed, having a press frame, the press frame having a first side and a second side. The first side is capable of connecting to a doorframe, and the second side comprises an indention. The sealing system also comprises a weatherproof material having a first portion within the indention, and a second portion extending outside of the indention. | 11-03-2011 |
20110265402 | System and Method for Attaching a Door Assembly to a Structure - A system and method for attaching a door assembly to a structure is disclosed. Specifically, a doorframe system comprising a press frame and a plurality of press frame brackets is disclosed. The press frame has a first side and a second side, wherein the first side is capable of connecting to a doorframe, and the second side is capable of pressing against a structure frame. Each press frame bracket has a first end and a second end, wherein the first end is connected to the press frame. | 11-03-2011 |
Tobias Pfleger, Friedrichshafen DE
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20080267255 | Temperature Sensor Arrangement in an Automatic Gearbox - A temperature sensor arrangement in an automatic transmission in which the temperature sensor ( | 10-30-2008 |
Tobias Pfleger, Markdorf DE
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20140048355 | DEVICE FOR PROVIDING THE OIL SUPPLY OF A SECONDARY CIRCUIT OF A TRANSMISSION OF A HYBRID DRIVELINE OF A MOTOR VEHICLE, COMPRISING AN AUXILIARY ELECTRICALLY DRIVEN OIL PUMP - A device for ensuring the supply of oil to the secondary circuit of a transmission of a hybrid drive-train of a motor vehicle, having an electrically operated auxiliary oil pump, which comprises a bypass valve that is connected between the outlet of the auxiliary oil pump and the secondary circuit of the hybrid circuit of the transmission, such that the valve opens at a predetermined opening pressure, closes at a predetermined closing pressure which is lower than the minimum system pressure, and, at a predetermined pressure between the opening and closing pressures, the valve permits flow a predetermined volume flow into the secondary circuit. | 02-20-2014 |