Patent application number | Description | Published |
20100078962 | Systems for Positioning and Linking Motor Vehicles to Reduce Aerodynamic Drag - A system for linking two or more vehicles to achieve reduced aerodynamic drag while the vehicles are travelling on the road is disclosed. The disclosed system not only physically connects the vehicles but also allows the driver of the leading vehicle to monitor and control essential functions of the trailing vehicles. Preferably, the driving mechanisms of the trailing vehicles, such as throttles, brakes, and gears, are fully operational so as not to put excessive burden on the driving mechanisms of the leading vehicle. Methods for linking individual vehicles as well as streamlining the operation of a fleet of vehicles are also disclosed. | 04-01-2010 |
20100082179 | Methods for Linking Motor Vehicles to Reduce Aerodynamic Drag and Improve Fuel Economy - Methods for linking two or more vehicles to achieve reduced aerodynamic drag while the vehicles are travelling on the road are disclosed. The disclosed methods utilize a dynamic linking system that not only physically connects the vehicles but also allows the driver of the leading vehicle to monitor and control essential functions of the trailing vehicles. Preferably, the driving mechanisms of the trailing vehicles, such as throttles, brakes, and gears, are fully operational so as not to put excessive burden on the driving mechanisms of the leading vehicle. Methods for linking individual vehicles as well as streamlining the operation of a fleet of vehicles are also disclosed. | 04-01-2010 |
20110270520 | Methods for Linking Motor Vehicles to Reduce Aerodynamic Drag and Improve Fuel Economy - Methods for linking two or more vehicles to achieve reduced aerodynamic drag while the vehicles are travelling on the road are disclosed. The disclosed methods utilize a dynamic linking system that not only physically connects the vehicles but also allows the driver of the leading vehicle to monitor and control essential functions of the trailing vehicles. Preferably, the driving mechanisms of the trailing vehicles, such as throttles, brakes, and gears, are fully operational so as not to put excessive burden on the driving mechanisms of the leading vehicle. Methods for linking individual vehicles as well as streamlining the operation of a fleet of vehicles are also disclosed. | 11-03-2011 |
Patent application number | Description | Published |
20090264365 | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONE (PTH) ANALOGS - The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs, and methods of preparing and using the PTH analogs. The invention provides novel PTH polypeptide derivatives containing amino acid substitutions at selected positions in the polypeptides. The invention provides derivatives of PTH(1-34), PTH(1-21), PTH(1-20), PTH(1-19), PTH(1-18), PTH(1-17), PTH(1-16), PTH(1-15), PTH(1-14), PTH(1-13), PTH(1-12), PTH(1-11), and PTH(1-10) polypeptides, wherein at least one residue in each polypeptide is a helix, preferably an α-helix, stabilizing residue. The invention also provides methods of making such peptides. Further, the invention encompasses compositions and methods for use in limiting undesired bone loss in a vertebrate at risk of such bone loss, in treating conditions that are characterized by undesired bone loss or by the need for bone growth, e.g., in treating fractures or cartilage disorders and for raising cAMP levels in cells where deemed necessary. | 10-22-2009 |
20100081612 | POLYPEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) - The present invention is related to novel parathyroid hormone polypeptide derivatives, and to pharmaceutical composition containing the polypeptides, as well as synthetic and recombinant methods for producing the polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing the polypeptides of the present invention. The present invention further provides diagnostic and therapeutic methods using the polypeptide derivatives. | 04-01-2010 |
20110009328 | Polypeptide Derivatives of Parathyroid Hormone (PTH) - Novel parathyroid hormone (PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said polypeptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds. | 01-13-2011 |
20110224142 | PARATHYROID HORMONE RECEPTOR ACTIVATION AND STEM AND PROGENITOR CELL EXPANSION - The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells. | 09-15-2011 |
20130288969 | PARATHYROID HORMONE RECEPTOR ACTIVATION AND STEM AND PROGENITOR CELL EXPANSION - The invention relates to methods for manipulating hematopoietic stem or progenitor cells, mesenchymal stem cells, epithelial stem cells, neural stem cells and related products through activation of the PTH/PTHrP receptor in neighboring cells. | 10-31-2013 |
Patent application number | Description | Published |
20100048321 | MOVABLE WEIGHTS FOR A GOLF CLUB HEAD - Embodiments of movable weights, such as weight assemblies and weight screws, for a golf club head are disclosed herein. One embodiment for a weight assembly, for example, comprises a mass element having a first end, a second end and a sidewall extending between the first end and the send end. The sidewall of the mass element defines a first bore extending through the mass element and at least a portion of the sidewall of mass element tapers in a direction from the first end to the second end. This embodiment further includes a retaining element configured to engage the first bore adjacent the first end of the mass element and defining a second bore. The weight assembly further includes an elongate fastener having a first end configured to be received within the second bore of the retaining element and a second end extending through the first bore and beyond the second end of the mass element when the mass element, retaining element and fastener are assembled together. | 02-25-2010 |
20110306439 | GOLF CLUB HEAD AND FACE INSERT - A face insert for golf club head in one embodiment can comprise a substrate comprising a score line groove-free front surface. A cover layer is provided at least on the front surface of the substrate. The cover layer can alternatively overlay at least a portion of the peripheral edge of the substrate. The cover layer comprises a ball-striking surface spaced by the cover layer from the substrate. Plural elongated score line grooves can extend into the polymer layer from the ball-striking surface. In addition, visible markings are interposed between the cover layer and the front surface of the substrate, the visible markings being visible through the cover layer. In one form the visible markings comprise elongated score line markings and target markings in a central portion of the substrate. The visible markings can be screen-printed markings, which are then protected by the cover layer from wear. The cover layer can be molded and can be a polymer layer. The score line grooves can be formed, for example, by molding during molding of the polymer layer. | 12-15-2011 |
20120202615 | FAIRWAY WOOD CENTER OF GRAVITY PROJECTION - A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Embodiments include club heads for a fairway wood that at least one of a high moment of inertia, a low center-of-gravity, a thin crown and a high coefficient of restitution. | 08-09-2012 |
20120220387 | FAIRWAY WOOD CENTER OF GRAVITY PROJECTION - A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Embodiments include club heads for a fairway wood that at least one of a high moment of inertia, a low center-of-gravity, a thin crown and a high coefficient of restitution. | 08-30-2012 |
20120289361 | FAIRWAY WOOD CENTER OF GRAVITY PROJECTION - A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Embodiments include club heads for a fairway wood that at least one of a high moment of inertia, a low center-of-gravity, a thin crown and a high coefficient of restitution. | 11-15-2012 |
20130210542 | FAIRWAY WOOD CENTER OF GRAVITY PROJECTION - A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Embodiments include club heads for a fairway wood that at least one of a high moment of inertia, a low center-of-gravity, a thin crown and a high coefficient of restitution. | 08-15-2013 |
20130244807 | FAIRWAY WOOD CENTER OF GRAVITY PROJECTION - A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Embodiments include club heads for a fairway wood that at least one of a high moment of inertia, a low center-of-gravity, a thin crown and a high coefficient of restitution. | 09-19-2013 |
Patent application number | Description | Published |
20140100056 | FAIRWAY WOOD CENTER OF GRAVITY PROJECTION - A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Embodiments include club heads for a fairway wood that at least one of a high moment of inertia, a low center-of-gravity, a thin crown and a high coefficient of restitution. | 04-10-2014 |
20140171216 | GOLF CLUB HEAD AND FACE INSERT - A face insert for golf club head in one embodiment can comprise a substrate comprising a score line groove-free front surface. A cover layer is provided at least on the front surface of the substrate. The cover layer can alternatively overlay at least a portion of the peripheral edge of the substrate. The cover layer comprises a ball-striking surface spaced by the cover layer from the substrate. Plural elongated score line grooves can extend into the polymer layer from the ball-striking surface. In addition, visible markings are interposed between the cover layer and the front surface of the substrate, the visible markings being visible through the cover layer. In one form the visible markings comprise elongated score line markings and target markings in a central portion of the substrate. The visible markings can be screen-printed markings, which are then protected by the cover layer from wear. The cover layer can be molded and can be a polymer layer. The score line grooves can be formed, for example, by molding during molding of the polymer layer. | 06-19-2014 |
20150105177 | FAIRWAY WOOD CENTER OF GRAVITY PROJECTION - A golf club head includes a body defining an interior cavity. The body includes a sole positioned at a bottom portion of the golf club head, a crown positioned at a top portion, and a skirt positioned around a periphery between the sole and crown. The body has a forward portion and a rearward portion. The club head includes a face positioned at the forward portion of the body. The face defines a striking surface having an ideal impact location at a golf club head origin. Embodiments include club heads for a fairway wood that at least one of a high moment of inertia, a low center-of-gravity, a thin crown and a high coefficient of restitution. A sleeve for easily disconnecting a shaft to the club head allows for selective adjustment of the head's loft and lie angle. | 04-16-2015 |
20150231453 | GOLF CLUB - A golf club includes a golf club head having a body defining an interior cavity. The body includes a sole, a crown and a skirt positioned around a periphery between the sole and crown. A face defines a forward portion of the club head and includes a striking surface width and a hosel defining a hosel bore. A channel and a recessed port are positioned in the sole. The channel extends substantially in a heel-to-toe direction. A sleeve is mounted on a tip end of the golf club shaft and is adapted to be inserted into the hosel bore. A fastener has a shaft portion extending through a passage and a head portion located in the recessed port. Selectively attaching the sleeve adjusts at least one of a loft angle and a lie angle of the club head. | 08-20-2015 |
Patent application number | Description | Published |
20140274458 | METHOD AND SYSTEM OF MANUFACTURING A GOLF CLUB, AND A MANUFACTURED GOLF CLUB HEAD - A golf club head for playing golf made by a method including providing a powdered metal; and applying a controlled source of energy to the powdered metal layer by layer to form a golf club head, wherein the golf club head is formed as a one-piece golf head having a hollow or partially hollow section and no welds. | 09-18-2014 |
20140274459 | METHOD AND SYSTEM OF MANUFACTURING A GOLF CLUB, AND A MANUFACTURED GOLF CLUB HEAD - A golf club head for playing golf made by a method including providing a powdered metal, and applying a controlled source of energy to the powdered metal layer by layer to form a golf club head, wherein the golf club head is a hollow golf club head having a supporting lattice formed within the hollow golf club head. | 09-18-2014 |
20140277671 | METHOD AND SYSTEM OF MANUFACTURING A GOLF CLUB, AND A MANUFACTURED GOLF CLUB HEAD - A method of manufacturing a custom golf club, the method including measuring swing dynamics of a user, determine club design parameters based on the measure swing dynamics of the user, generating a computer model representing an custom golf club head based on the determined design parameters, and manufacturing the custom golf club head based on the generated computer model using additive layer manufacturing processes using powder material and a high energy beam. | 09-18-2014 |
Patent application number | Description | Published |
20090311280 | NOVEL TNF RECEPTOR REGULATORY DOMAIN - Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation. | 12-17-2009 |
20100104559 | US CIP-COMPOSITIONS AND METHODS FOR MODULATING RESPONSES MEDIATED OR ASSOCIATED WITH BTLA ACTIVITY - Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation. | 04-29-2010 |