Patent application number | Description | Published |
20090075312 | ASSESSING COLORECTAL CANCER BY MEASURING OSTEOPONTIN AND CARCINOEMBRYONIC ANTIGEN - The present invention relates to a method aiding in the assessment of colorectal cancer (=CRC). It discloses the use of a marker combination comprising osteopontin and carcinoembryonic antigen in the assessment of colorectal cancer. Furthermore, it especially relates to a method for assessing colorectal cancer from a liquid sample, derived from an individual by measuring at least the markers osteopontin and carcinoembryonic antigen in said sample. The marker combination comprising osteopontin and carcinoembryonic antigen can, e.g., be used in the early detection of colorectal cancer or in the surveillance of patients who undergo therapy, e.g., surgery. | 03-19-2009 |
20090263841 | USE OF NNMT AS A MARKER FOR LUNG CANCER - The present invention relates to the assessment of lung cancer. It discloses the use of protein NNMT in the assessment of lung cancer. It also relates to a method for assessing lung cancer by measuring NNMT in vitro in a liquid sample derived from an individual. Measurement of NNMT can, e.g., be used in the early detection or in the follow-up of patients with lung cancer. | 10-22-2009 |
20090286328 | USE OF PROTEIN S100A12 AS A MARKER FOR COLORECTAL CANCER - The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein S100A12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring S100A12 in said sample. Measurement of S100A12 can, e.g., be used in the early detection or diagnosis of colorectal cancer. | 11-19-2009 |
20100240081 | SEPRASE AS A MARKER FOR CANCER - The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different cancer types. Seprase aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., esophagus, head and neck cancer, stomach cancer, bile duct cancer, pancreas cancer, kidney cancer, cervix cancer, ovary cancer, breast cancer, bladder cancer, endometrium cancer or prostate cancer. Furthermore, it especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring seprase in said sample. Measurement of seprase can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery. | 09-23-2010 |
20110097756 | APEX AS A MARKER FOR LUNG CANCER - The present invention relates to the assessment of lung cancer. It discloses the use of protein AP endonuclease (APEX) in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample derived from an individual by measuring APEX in the sample. Measurement of APEX can, e.g., be used in the early detection or in the follow-up of patients with lung cancer. | 04-28-2011 |
20110171676 | ASC AS A MARKER FOR LUNG CANCER - The present invention relates to the assessment of lung cancer. It discloses the use of protein ASC in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or in the follow-up of patients with lung cancer. | 07-14-2011 |
20110212464 | PACAP AS A MARKER FOR CANCER - The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the proapoptotic caspase adaptor protein (=PACAP) as a universal marker of different types of cancer. PACAP aids in the assessment of pulmonary or lung cancer (LC), particularly of non-small cell lung carcinoma (NSCLC), but also of other specific types of cancer. Such specific types of cancer are e.g. colon, bladder, cervix, ovary, endometrial, head and neck, breast, melanoma, pancreas, kidney, prostate, esophagus, stomach or bile duct cancer. Furthermore, the present invention especially relates to a method for assessing cancer from a liquid sample, derived from an individual by measuring PACAP in said sample. Measurement of PACAP can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery. | 09-01-2011 |
20110212465 | ARMET AS A MARKER FOR CANCER - Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., breast, ovary, cervix, head and neck, endometrium, melanoma, bladder, kidney, pancreas, prostate, esophagus, stomach or bile duct cancer. Further disclosed is a method for assessing cancer from a liquid sample, derived from an individual by measuring ARMET in the sample. Measurement of ARMET can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery. | 09-01-2011 |
20110275100 | SERPIN B 13 AS A MARKER FOR SQUAMOUS CELL CARCINOMA OF THE LUNG - Disclosed is a method aiding in the assessment of squamous cell carcinoma (SCC). It involves the use of the protein serpin B13 as a marker of SCC. Furthermore, the disclosure relates to a method for assessing lung cancer in a tissue sample derived from a patient having non-small cell lung carcinoma (NSCLC) and for differentiating SCC from adenocarcinoma or large cell carcinoma of the lung. | 11-10-2011 |
20120028835 | SECERNIN-1 AS A MARKER FOR CANCER - Disclosed is a method aiding in the assessment of cancer. It involves the use of the secernin-1 protein (SCRN1) as a universal marker of different cancer types. More specifically disclosed is a method for assessing cancer from a liquid sample derived from an individual by measuring SCRN1 in the sample. Measurement of SCRN1 can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery. | 02-02-2012 |
20120196303 | CYBP AS A MARKER FOR LUNG CANCER - The present invention relates to the assessment of lung cancer. It discloses the use of protein CYBP in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring CYBP in said sample. Measurement of CYBP can, e.g., be used in the early detection or in the follow-up of patients with lung cancer. | 08-02-2012 |
20130288266 | DETECTION OF A POSTTRANSLATIONALLY MODIFIED POLYPEPTIDE BY A BI-VALENT BINDING AGENT - A bi-valent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bi-valent binding agent, and for use of the disclosed bi-valent binding agent in histological staining procedures. | 10-31-2013 |
20130288267 | DETECTION OF A POLYPEPTIDE DIMER BY A BIVALENT BINDING AGENT - A bivalent binding agent, capable of binding a polypeptide dimer, consisting of two monovalent binders linked to each other via a linker, the first monovalent binder binds an epitope of a first target polypeptide comprised in said dimer and the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer. Each monovalent binder has a Kdiss in the range of 5×10 | 10-31-2013 |
20130344094 | POLYPEPTIDE-POLYNUCLEOTIDE-COMPLEX AND ITS USE IN TARGETED EFFECTOR MOIETY DELIVERY - Herein is reported a polypeptide-polynucleotide-complex as therapeutic agent and its use as tool for the targeted delivery of an effector moiety. The polynucleotide part of the complex is essentially resistant to proteolytic and enzymatic degradation in vivo. Additionally the polypeptide part specifically binds to a compound or structure such as a tissue or organ, a process or a disease. Thus, one aspect as reported herein is a polypeptide-polynucleotide-complex comprising a) a polypeptide specifically binding to a target and conjugated to a first member of a binding pair, b) a polynucleotide linker conjugated at its first terminus to the second member of the binding pair, and c) an effector moiety conjugated to a polynucleotide that is complementary to at least a part of the polynucleotide linker. | 12-26-2013 |
20140219998 | ARMET AS A MARKER FOR CANCER - Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small cell lung carcinoma (NSCLC) or colorectal cancer (CRC), but also likely of other specific types of cancer. Such specific cancer types are, e.g., breast, ovary, cervix, head and neck, endometrium, melanoma, bladder, kidney, pancreas, prostate, esophagus, stomach or bile duct cancer. Further disclosed is a method for assessing cancer from a liquid sample, derived from an individual by measuring ARMET in the sample. Measurement of ARMET can, e.g., be used in the early detection of cancer or in the surveillance of patients who undergo surgery. | 08-07-2014 |
20150072355 | FLAP ENDONUCLEASE-1 AS A MARKER FOR CANCER - Methods aiding in the assessment of cancer comprising use of the Flap endonuclease-1 protein (=FEN1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring FEN1 in the sample are disclosed. Measurement of FEN1 is useful for the early detection of cancer or in the monitoring of patients who undergo surgery for tumor removal. | 03-12-2015 |
Patent application number | Description | Published |
20100044514 | CONNECTION ARRANGEMENT FOR CONNECTING A FIRST AND SECOND REINFORCING ELEMENT FOR AN AIRCRAFT OR SPACECRAFT, AND A SHELL COMPONENT - A connection arrangement for connecting a first and second reinforcing element of an aircraft or spacecraft, the reinforcing elements each have profiled cross-sections comprising at least one foot portion and at least one web portion. They are spaced from one another at their end connection faces by a strap element. The connection arrangement comprises at least one foot portion connection element, which can be adjusted and firmly joined on one side to the geometrical shape of the foot portion of the first reinforcing element, on the other side to the geometrical shape of the foot portion of the second reinforcing element and to the interposed strip element, and comprising at least one web coupling element, which can be adjusted and firmly joined on one side to the geometrical shape of the web portion of the first reinforcing element, and on the other side to the strap element. A shell component of an aircraft or spacecraft comprises at least two shell elements connected to a strap element at a transverse seam, which shell elements each comprise at least a first and second reinforcing element which, in turn, are connected to a connection arrangement. | 02-25-2010 |
20100272954 | Method for Coupling Stiffening Profile Elements and Structural Component - This invention provides a coupling method for coupling a first and a second stiffening profile element for an outer skin of an aircraft or space craft. In a first step the stiffening profile elements are arranged on the outer skin in such a manner that the stiffening profile elements oppose each other with their respective front sides and enclose within themselves a cavity. Furthermore, a fixing hole is formed through a wall of at least one of the stiffening profile elements in the cavity inside a coupling zone of the stiffening profile element. An access opening is formed through the wall in the cavity along the coupling zone. A coupling strap, which couples the stiffening profile elements together, is fastened to the coupling zone by means of a fastening element guided through the fixing hole. | 10-28-2010 |
20100320322 | TRANSVERSE BUTT CONNECTION BETWEEN TWO FUSELAGE SECTIONS - The invention relates to a transverse butt connection ( | 12-23-2010 |
20110001010 | ARRANGEMENT OF TWO FUSELAGE SECTIONS OF AN AIRCRAFT AND A CONNECTING STRUCTURE FOR CONNECTING FUSELAGE SKINS - A coupling element for connecting stringers in the process of joining two fuselage sections by means of at least one transverse splicing plate, wherein in each case the fuselage sections on the inside comprise a multitude of stringers arranged on fuselage skins, as well as annular frame elements, wherein the coupling element comprises a base flange and a frame element flange, and by way of the coupling element in each case a connection between the opposing stringers, the annular frame element and the fuselage skins or the transverse splicing plate takes place so that the coupling element beyond a connection of the stringer base also supports the connection of stringers on the flank side. | 01-06-2011 |
20110011980 | CONNECTING ARRANGEMENT FOR JOINING TWO STIFFENING ELEMENTS HAVING DIFFERENT CROSS-SECTIONAL PROFILES FOR AN AIRCRAFT OR SPACECRAFT, AND SHELL COMPONENT - A connecting arrangement for connecting two reinforcing elements of an aircraft or spacecraft, wherein the reinforcing elements have different cross-sectional profiles with in each case at least one foot portion and at least one comb portion, at least one foot portion connecting element which on one side can be adapted to the geometric shape of the foot portion of the first reinforcing element and on the opposite side can be adapted to the geometric shape of the foot portion of the second reinforcing element and can be connected rigidly thereto; and at least one comb portion connecting element which on one side can be adapted to the geometric shape of the comb portion of the first reinforcing element and on the opposite side can be adapted to the geometric shape of the comb portion of the second reinforcing element and can be connected rigidly thereto in each case. | 01-20-2011 |
20110042519 | INTERCONNECTION AND AIRCRAFT OR SPACECRAFT HAVING SUCH AN INTERCONNECTION - The present invention provides an interconnection, in particular in the field of aerospace. The interconnection has a T-stringer, an Ω-stringer and a connecting arrangement. The connecting arrangement connects base sections of the T-stringer and of the Ω-stringer to one another. This provides a coupling of an Ω-stringer to a T-stringer which is comparatively insensitive with respect to tolerances relating to the orientation of the Ω-stringer in relation to the T-stringer. | 02-24-2011 |
20110236622 | FIBER COMPOSITE COMPONENT FOR ABSORBING ENERGY - In the case of a fiber composite component for energy absorption in the event of a crash for an aircraft or spacecraft, the fiber composite component is formed as a laminate construction made of CFRP layers and at least one integrated metal foil portion which is corrosion-resistant with respect to the CFRP layers. A fuselage structure portion of an aircraft or spacecraft is formed using at least one fiber composite component of this type. An aircraft or spacecraft comprises a fuselage structure portion of this type. | 09-29-2011 |
20110297788 | SHELL COMPONENT FOR AN AIRCRAFT OR SPACECRAFT - The present invention provides a shell component for an aircraft or spacecraft. The shell component comprises a skin panel, a plurality of stringers which are arranged on the skin panel, a former which comprises a fibre composite material and is arranged over the stringers so as to cross said stringers, and a former connection structure which comprises a ductile material and a plurality of foot portions fixed to the skin panel. The foot portions each transition integrally into a shoulder portion fixed to the former over an associated fixing span, the fixing spans associated with the foot portions extending along the former substantially continuously over the stringers. | 12-08-2011 |
20140166811 | METHOD FOR THE PRODUCTION OF A CONNECTING ELEMENT, CONNECTING ELEMENT, AND AIRCRAFT OR SPACECRAFT - A method for producing a connecting element for at least two components of an aircraft structure. A hollow initial profile is formed comprising a wall following a closed path in the initial profile cross-section. The wall has a first, second and third section. Material is removed from the wall in one region of the initial profile, to obtain one opening in the one region, the opening extending at least partially within the first section. A portion of the second section and a portion of the third section form part of the connecting element and are each formed so as to be adapted to at least partially abut against the structure. The one opening is formed such that material initially forming part of the wall in the first section and remaining after the formation of the opening forms a stabilizing section connecting the portions of the second and third sections. | 06-19-2014 |
Patent application number | Description | Published |
20110118504 | THERMAL SALT SPLITTING OF AMMONIUM CARBOXYLATES - The present invention relates to a process for preparing hydroxycarboxylic acids, preferably α- and β-hydroxycarboxylic acids, from ammonium carboxylates of the general formula | 05-19-2011 |
20110189742 | METHOD FOR THE PRODUCTION OF FREE CARBOXYLIC ACIDS - A process for the preparation of free carboxylic acids including: A) preparation of carboxylic acid by a biological cell located in an aqueous medium with addition of an amine of formula (I) | 08-04-2011 |
20110251399 | METHOD FOR PRODUCING ALDEHYDES AND KETONES FROM PRIMARY AND SECONDARY ALCOHOLS - The invention relates to a method for producing aldehydes and ketones from easily accessible primary and secondary alcohols by oxidation with atmospheric oxygen or pure oxygen using a catalyst system which consists of a derivative of a free nitroxyl radical. | 10-13-2011 |
20110257429 | METHOD FOR PRODUCING A FREE ACID FROM THE SALT THEREOF - The invention relates to an improved method for releasing an organic acid, preferably a carbon, sulfone or phosphone acid, particularly an alpha or beta hydroxycarbon acid, from the ammonia salt thereof by releasing and removing ammoniac and simultaneous extraction of the released acid, having an amine as a suitable extraction means from the aqueous phase. This method corresponds to a reactive extraction. The reactive extraction of an organic acid from the aqueous ammonia salt solution thereof can be significantly improved by the use of a strip medium or carrier gas, such as nitrogen, air, water vapor or inert gases such as argon. The released ammoniac is removed from the aqueous solution by the continuous gas flow and can be resupplied into a production process. The free acid can be obtained by a method such as distillation, rectification, crystallization, reextraction, chromatography, adsorption or by a membrane method from the extraction means. | 10-20-2011 |
20110269977 | METHOD FOR PRODUCING 2,6-DIOXABICYCLO-(3.3.0)-OCTANE-4,8-DIONE - The invention relates to a method for producing 2,6-dioxabicyclo-(3.3.0)-octane-4,8-dione (I), comprising the oxidation of dianhydrohexitols (II-IV), or of corresponding hydroxy ketones, with an oxygen-containing gas in the presence of a catalyst composition, the reaction proceeding without the addition of halogen sources. | 11-03-2011 |
20120034665 | ENZYMATIC METHOD FOR PRODUCING ALDEHYDES - The invention relates to methods for producing aldehydes and the oxidation and reduction products thereof. | 02-09-2012 |
20120315366 | SWEETENER AND METHOD OF PRODUCTION THEREOF - The invention relates to a sweetener and to a method for the production thereof. | 12-13-2012 |
20130165672 | PROCESS FOR THE DIRECT AMINATION OF SECONDARY ALCOHOLS WITH AMMONIA TO GIVE PRIMARY AMINES - The invention relates to a process for preparing primary amines which comprises the process steps
| 06-27-2013 |
20130245276 | PROCESS FOR HOMOGENEOUSLY CATALYZED, HIGHLY SELECTIVE DIRECT AMINATION OF PRIMARY ALCOHOLS WITH AMMONIA TO PRIMARY AMINES WITH A HIGH VOLUME RATIO OF LIQUID PHASE TO GAS PHASE AND/OR HIGH PRESSURES - The present invention relates to a process for preparing primary amines comprising the process steps
| 09-19-2013 |
20130331580 | PROCESS FOR THE DIRECT AMINATION OF ALCOHOLS USING AMMONIA TO FORM PRIMARY AMINES BY MEANS OF A XANTPHOS CATALYST SYSTEM - The present invention relates to a chemocatalytic liquid-phase process for the direct one-stage amination of alcohols to primary amines by means of ammonia in high yields using a catalyst system containing at least one transition metal compound and a xantphos ligand. | 12-12-2013 |
20140039210 | LIQUID CATION EXCHANGER - The invention relates to a method for removing an organic compound having one or more positive charges from an aqueous solution. Said method consists of the following steps a) the aqueous solution containing the organic compound, and a hydrophobic organic solution which contains a hydrophobic liquid cation exchanger having one or more negative charges and a negative total charge, are provided, b) the aqueous solution and the organic solution are brought into contact with each other and c) the organic solution is separated from the aqueous solution. | 02-06-2014 |
20140039223 | CONTINUOUSLY OPERABLE METHOD FOR PRODUCING CARBONYL COMPOUNDS BY MEANS OF A CATALYST CONTAINING A NITROXYL RADICAL - The invention relates to a method for the oxidation of a primary or secondary alcohol, preferably to form an aldehyde or ketone, comprising the following steps: a) providing a catalyst composition comprising at least one compound containing a nitroxyl radical, at least one NO source, at least one carbon or mineral acid or an anhydride of a carbon or mineral acid; b) producing a reaction mixture by adding at least one primary or secondary alcohol and a gas comprising oxygen and optionally one or more than one solvent to the catalyst composition from step a) or step e); c) incubating the reaction mixture from step b) at a temperature of between 0 and 100° C. or at the boiling point of the solvent; d) simultaneously with or subsequent to step c): crystallizing the reaction product; and e) recovering the catalyst composition by removing the crystallized reaction product from the reaction mixture obtained in step d). | 02-06-2014 |
20140054224 | LIQUID CATION EXCHANGER - The present application relates to a process for removing an organic compound having one or more positive charges from an aqueous solution, comprising the steps a) provision of the aqueous solution comprising the organic compound and of a hydrophobic organic solution which comprises a liquid cation exchanger, where the liquid cation exchanger is hydrophobic, and where the liquid cation exchanger has one or more negative charges and an overall negative charge, b) contacting the aqueous solution and the organic solution, and c) separating off the organic solution from the aqueous solution. | 02-27-2014 |