Patent application number | Description | Published |
20080241143 | Inhibition of leukocyte adhesion - This invention relates to the inhibition of intercellular adhesion mediated by L-selectin by administering a newly identified L-selectin ligand, CD34. More particularly, the invention concerns a method for inhibiting leukocyte adhesion to endothelial cells by administering an effective amount of an isolated, purified CD34 polypeptide or an antibody capable of binding native CD34. | 10-02-2008 |
20120328632 | INHIBITION OF LEUKOCYTE ADHESION - This invention relates to the inhibition of intercellular adhesion mediated by L-selectin by administering a newly identified L-selectin ligand, CD34. More particularly, the invention concerns a method for inhibiting leukocyte adhesion to endothelial cells by administering an effective amount of an isolated, purified CD34 polypeptide or an antibody capable of binding native CD34. | 12-27-2012 |
20140057339 | SYSTEMS AND METHODS FOR GENETIC AND BIOLOGICAL ANALYSIS - The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices. | 02-27-2014 |
20140235457 | SYSTEMS AND METHODS FOR GENETIC AND BIOLOGICAL ANALYSIS - The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices. | 08-21-2014 |
Patent application number | Description | Published |
20080311208 | Pharmaceutical Formulations Useful in the Treatment of Insomnia - There is provided a formulation suitable for transmucosal administration comprising a short acting hypnotic drug, which formulation provides a measurable plasma concentration of drug within 10 minutes of administration. The formulation is capable of providing sleep on demand, and preferably comprises particles of drug, for example zolpidem or a pharmaceutically-acceptable salt thereof and a mucoadhesion promoting agent, such as sodium carboxymethylcellulose, which particles of drug and mucoadhesive are presented upon the surface of larger carrier particles. | 12-18-2008 |
20110268796 | PHARMACEUTICAL FORMULATIONS USEFUL IN THE TREATMENT OF INSOMNIA - There is provided a formulation suitable for transmucosal administration comprising a short acting hypnotic drug, which formulation provides a measurable plasma concentration of drug within 10 minutes of administration. The formulation is capable of providing sleep on demand, and preferably comprises particles of drug, for example zolpidem or a pharmaceutically-acceptable salt thereof and a mucoadhesion promoting agent, such as sodium carboxymethylcellulose, which particles of drug and mucoadhesive are presented upon the surface of larger carrier particles. | 11-03-2011 |
20120277261 | PHARMACEUTICAL FORMULATIONS USEFUL IN THE TREATMENT OF INSOMNIA - There is provided a formulation suitable for transmucosal administration comprising a short acting hypnotic drug, which formulation provides a measurable plasma concentration of drug within 10 minutes of administration. The formulation is capable of providing sleep on demand, and preferably comprises particles of drug, for example zolpidem or a pharmaceutically-acceptable salt thereof and a mucoadhesion promoting agent, such as sodium carboxymethylcellulose, which particles of drug and mucoadhesive are presented upon the surface of larger carrier particles. | 11-01-2012 |
20130230589 | PHARMACEUTICAL FORMULATIONS USEFUL IN THE TREATMENT OF INSOMNIA - There is provided a formulation suitable for transmucosal administration comprising a short acting hypnotic drug, which formulation provides a measurable plasma concentration of drug within 10 minutes of administration. The formulation is capable of providing sleep on demand, and preferably comprises particles of drug, for example zolpidem or a pharmaceutically-acceptable salt thereof and a mucoadhesion promoting agent, such as sodium carboxymethylcellulose, which particles of drug and mucoadhesive are presented upon the surface of larger carrier particles. | 09-05-2013 |
20130273119 | TRANSDERMAL DRUG ADMINISTRATION DEVICE - A transdermal drug administration device comprising a drug delivery element ( | 10-17-2013 |
Patent application number | Description | Published |
20090248429 | Managing Consistent Interfaces for Sales Price Business Objects Across Heterogeneous Systems - A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to a sales price information and/or a sales price specification business object. | 10-01-2009 |
20090248473 | Managing Consistent Interfaces for Business Objects Across Heterogeneous Systems - A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to a store and/or a work center business object. | 10-01-2009 |
20090248547 | Managing Consistent Interfaces for Retail Business Objects Across Heterogeneous Systems - A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to a retail allocation and/or a retail event business object. | 10-01-2009 |
Patent application number | Description | Published |
20100221705 | IN SITU HYBRIDIZATION DETECTION METHOD - The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are also compatible with immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats. The invention is also compatible with many different types of targets, probes, and detectable labels. | 09-02-2010 |
20110177500 | IMMUNOHISTOCHEMISTRY DETECTION METHOD - The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (IHC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats. The invention is also compatible with many different types of targets, probes, and detectable labels. | 07-21-2011 |
20140315204 | Immunohistochemistry Detection Method - The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are compatible with immunohistochemistry (THC), but also could be used in immunocytochemistry (ICC), in situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats. The invention is also compatible with many different types of targets, probes, and detectable labels. | 10-23-2014 |
Patent application number | Description | Published |
20090202774 | LAMINATED PAPER ARTICLE AND PAPER WEB - An absorbent laminated paper article in the form of a rectangular sheet has first parallel edges in a first direction and second parallel edges in a second direction perpendicular to the first direction and an article area delimited by the edges. The article includes at least two plies adhesively bonded together in a bonding pattern between the plies. The bonding pattern includes bonding elements arranged along a first set of bonding lines extending from one of the first parallel edges to the other of first parallel edges in a first general direction at a first angle to the first direction and along a second set of bonding lines extending from the one of first parallel edges to the other of first parallel edges in a second general direction at a second angle to the first direction, the first set of bonding lines intersecting with the second set and forming an intermeshing network of bonding lines. | 08-13-2009 |
20100270412 | FOLDED PERFORATED WEB - A web, such as a tissue or nonwoven web. Perforation lines in the web define sheets. The web is folded before being rolled or stacked, such that the intersection of the perforation lines and the folding line provides reliable dispensing. The web in roll or stack form, a method for forming the web, and a dispenser adapted for dispensing the web are also described. | 10-28-2010 |
20120241509 | COLLAPSIBLE CARDBOARD BOX - A collapsible cardboard box including, in an erected state, a back wall, an opposing front wall, a first side wall and an opposing second side wall. In its collapsed state, the box includes a first through hole in the front portion and a second through hole in the back portion. In the collapsed state, the box has been unfolded in such a way that the first and second through holes are in line with each other forming a handle for allowing a person to carry the collapsed box by use of the first and second through holes. | 09-27-2012 |
20130198984 | FLUSHABLE MOIST WIPE OR HYGIENE TISSUE - A flushable moist wipe or hygiene tissue includes a hydraulically entangled nonwoven material impregnated with a wetting composition. The nonwoven material contains at least 70%, by fibre weight, pulp fibres and at least 5%, by fibre weight, manmade fibres and/or natural fibres with a length of at least 6 mm. The moist wipe or hygiene tissue includes at least two plies of the hydraulically entangled nonwoven material, each ply having a basis weight between 30 and 50 g/m | 08-08-2013 |
Patent application number | Description | Published |
20090044288 | Transgenic plants with enhanced agrnomic traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting, of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait. | 02-12-2009 |
20100186105 | YIELD AND STRESS TOLERANCE IN TRANSGENIC PLANTS III - Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant. | 07-22-2010 |
20100186106 | YIELD AND STRESS TOLERANCE IN TRANSGENIC PLANTS IV - Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant. | 07-22-2010 |
20100192249 | YIELD AND STRESS TOLERANCE IN TRANSGENIC PLANTS II - Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant. | 07-29-2010 |
Patent application number | Description | Published |
20090306716 | Implant and implant system - In order to improve an implant for the dorsal stabilization of a human or animal spinal column, comprising an attachment device for placing in position against and/or fixing to spinous processes of adjacent vertebrae of the spinal column, such that it can be used for the dynamic dorsal stabilization of the spinal column, it is suggested that the implant comprise at least one spacer element which is associated with the attachment device and designed in such a manner that it alters its external shape and/or its elastic properties as a result of a change in ambient conditions and/or forces acting on it. | 12-10-2009 |
20120265302 | SURGICAL PROCEDURE FOR EXPANDING A VERTEBRAL CANAL - To provide a method with which expansion of the vertebral canal of vertebrae is possible with less stress for the patient than with the surgical methods used to date, it is proposed that herein the vertebral arch be split and an incision gap thereby be formed, and the incision gap bounded by opposed incision surfaces be expanded to a prescribed gap width and the bone substance of the resulting vertebral arch sections thereby be elastically/plastically deformed. | 10-18-2012 |
20130253585 | SURGICAL FIXATION SYSTEM, SPACER ELEMENT FOR A SURGICAL FIXATION SYSTEM, USE OF AN IMPLANT AND METHOD FOR STABILIZING SPINOUS PROCESSES - A surgical fixation system for stabilizing spinous processes of adjacent vertebral bodies relative to one another comprising at least one first fixing element and at least one second fixing element, which can be transferred relative to one another from an insertion position into an implantation position, wherein the fixing elements in the implantation position have a smaller spacing from one another than in the insertion position and in which implantation position the fixing elements are engageable laterally from different sides with at least one of the spinous processes in each case, and comprising a securing device for securing the fixing elements relative to one another in the implantation position and comprising at least one spacer element, which can be fixed by the fixing elements in the implantation position thereof in the intervertebral space between the spinous processes. | 09-26-2013 |
20140142699 | SURGICAL IMPLANT FOR WIDENING A VERTEBRAL CANAL - An implant is provided which allows for widening of the vertebral canal of vertebrae with less stress on the patient than in heretofore customary surgical procedures, wherein the vertebral arch of a vertebra is cut through, forming an incision gap, or is partially removed and the implant is inserted in the incision gap, wherein the incision gap is bounded by incision faces opposed to each other and the implant comprises an implant body having two contact faces which in the inserted state in the incision gap contact the incision faces of the vertebral arch. | 05-22-2014 |
20150032159 | SYSTEM FOR ANCHORING A PEDICLE SCREW, ASSOCIATED KIT, SPACER AND PEDICLE AUGMENTATION - A system for anchoring a pedicle screw in a patient's vertebra uses a pedicle screw having a threaded portion sinkable in the vertebral arch. The space between the threaded portion and cortical edge layer of the pedicle is at least partially filled by a spacer that enables an all-round support of the threaded portion at the cortical edge layer. A kit includes a pedicle screw and a spacer which at least partially fills the space between the threaded portion and cortical edge layer of the pedicle. A spacer has an essentially oval cross-section for form-locking fit in a corresponding axial recess sunk in the pedicle and having an axial through-hole to accommodate the threaded portion of a pedicle screw, as well as a spacer in the form of an essentially cylindrical pedicle augmentation in the form of a bone screw or a bone bracket. | 01-29-2015 |
Patent application number | Description | Published |
20100081277 | METHOD FOR PASSIVATING EXPOSED COPPER SURFACES IN A METALLIZATION LAYER OF A SEMICONDUCTOR DEVICE - When forming sophisticated metallization systems, surface integrity of an exposed metal surface, such as a copper-containing surface, may be enhanced by exposing the surface to a vapor of a passivation agent. Due to the corresponding interaction with the metal surface, enhanced integrity may be accomplished, while at the same time damage of exposed dielectric surface portions may be significantly reduced compared to conventional aggressive wet chemical cleaning processes that are typically used in conventional patterning regimes. | 04-01-2010 |
20100301494 | RE-ESTABLISHING A HYDROPHOBIC SURFACE OF SENSITIVE LOW-K DIELECTRICS IN MICROSTRUCTURE DEVICES - Silicon oxide based low-k dielectric materials may be provided with a hydrophobic low-k surface area, even after exposure to a reactive process ambient, by performing a surface treatment on the basis of hexamethylcyclotrisilazane and/or octamethylcyclotetrasilazane. In addition to the surface treatment, a polymerization may be initiated on the basis of a hydrophobic surface nature of the silicon-based dielectric material, thereby increasing the chemical stability during the further processing. | 12-02-2010 |
20120315755 | COPPER INTERCONNECT WITH METAL HARDMASK REMOVAL - A passivation layer is formed on inlaid Cu for protection against oxidation and removal during subsequent removal of an overlying metal hardmask. Embodiments include treating an exposed upper surface of inlaid Cu with hydrofluoric acid and a copper complexing agent, such as benzene triazole, to form a passivation monolayer of a copper complex, etching to remove the metal hardmask, removing the passivation layer by heating to at least 300° C., and forming a barrier layer on the exposed upper surface of the inlaid Cu. | 12-13-2012 |
Patent application number | Description | Published |
20100010113 | RADIATION-CURABLE COMPOUNDS - The invention relates to radiation-curable compounds, to processes for preparing them, to their use, and to coating compositions comprising them and featuring high scratch resistance. | 01-14-2010 |
20100098950 | RADIATION-CURABLE COMPOUNDS - The invention relates to radiation-curable compounds, to processes for preparing them, to their use, and to coating compositions comprising them and featuring high scratch resistance. | 04-22-2010 |
20120136111 | RADIATION-CURABLE, WATER-DISPERSIBLE POLYURETHANES AND POLYURETHANE DISPERSIONS - The present invention relates to dispersible polyurethanes and polyurethane dispersions curable with UV radiation, to a process for preparing them, and to their use. | 05-31-2012 |
20120321900 | RADIATION-CURABLE AQUEOUS POLYURETHANE DISPERSIONS - The present invention relates to polyurethane dispersions that are curable with UV radiation, to a process for preparing them, and to the use thereof. | 12-20-2012 |
20130245196 | RADIATION-CURABLE AQUEOUS DISPERSIONS - The invention relates to radiation-curable aqueous dispersions having mercapto groups, to processes for preparing them, and to their use. | 09-19-2013 |
Patent application number | Description | Published |
20080306578 | Attachment of Tubing in a Cardiac Lead - In a method for fixing tubing of a cardiac lead to a termination element, such as an electrode or a pin connector and in a cardiac lead formed according to such a method, an exterior of the termination element is provided with a thermoplastic fixation element, and thermoplastic tubing is provided with an end portion that coaxially surrounds a portion of the fixation element. A section of the end portion of the thermoplastic tubing is fused to the thermoplastic fixation element, so that the thermoplastic tubing is fixed to the termination element. | 12-11-2008 |
20100114279 | MEDICAL IMPLANTABLE LEAD - A medical implantable lead has a proximal end and a distal end, and a flexible flat elongate body. The elongate body includes a layer of strip conductors extending along the length of the flat elongate body, a top insulating layer, and a bottom insulating layer. The layer of strip conductors is sealingly enclosed between the top and bottom insulating layers, and at least a major portion of the flat elongate body is twisted into an elongate helical portion having a central cavity extending longitudinally of the helical portion. | 05-06-2010 |
20130156933 | METHOD FOR MANUFACTURING AN ACTIVE FIXATION ELECTRODE - The present invention relates to methods for manufacturing active fixation helices for the stimulation and/or sensing of organs. A first embodiment of a method in accordance with the present invention for making a helix comprises a first step of producing an elongated helix precursor body comprising one or more electrical conductors surrounded by an insulating material. This helix precursor body is then shaped into a helix, material removed in predetermined places in order to expose the areas of the conductors which will be used as electrodes in the final product. The body is coated with an electrically conducting biocompatible coating which is subsequently partly removed in continuous loops from around the electrodes in order to electrically insulate them from each other and to ensure that the electrically active areas of the electrodes are of the correct dimensions. | 06-20-2013 |
Patent application number | Description | Published |
20090048433 | Scalable Process for Protein Purification - The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations. | 02-19-2009 |
20110306113 | Scalable Process for Protein Purification - The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations. | 12-15-2011 |
20120214976 | Scalable Process for Protein Purification - The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations. | 08-23-2012 |
20140081008 | Scalable Process for Protein Purification - The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations. | 03-20-2014 |
Patent application number | Description | Published |
20110150758 | TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING - At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method. | 06-23-2011 |
20110229414 | Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients - A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition site for at least one tumor-specific protease, wherein a hyperpolarization site is located at the N and/or C terminus of the substrate, and wherein the linker is configured such that the hydrophobic ends of the substrate interact and form a central core by means of noncovalent interactions with the lipophilic residues, and the contrast agent together with a parahydrogen metal template for use in an imaging method for diagnosing a tumor. At least one embodiment of the invention further relates to a method for imaging a tumor tissue, wherein the above-described contrast agent accumulated in a tumor tissue is imaged using a suitable imaging method after hyperpolarization by way of contact with a parahydrogen metal template, and also to a method for imaging a tumor tissue in a patient, wherein a) a contrast agent as described above is administered to a patient, b) a parahydrogen metal template is administered to the patient, and c) the presence of a tumor is depicted using an imaging method. | 09-22-2011 |
20150071519 | METHOD AND IMAGING APPARATUS TO AUTOMATICALLY DISPLAY AND/OR MEASURE BONE VARIATIONS IN MEDICAL IMAGE DATA - In a method and apparatus to automatically display and/or measure bone variations in medical image data, an image data set of an examination region is acquired and the bone regions in the image data set are automatically segmented in a first segmentation followed by a second segmentation in which bone variation regions in the image data set are automatically segmented on the basis of the results of the first segmentation. The results of the first and/or second segmentations are stored and/or displayed. | 03-12-2015 |
Patent application number | Description | Published |
20090158719 | Emission Treatment System - An emission treatment system and method for remediating the nitrogen oxides (NOx), particulate matter, and gaseous hydrocarbons present in diesel engine exhaust streams are described. The emission treatment system has an oxidation catalyst upstream of a soot filter upstream from a NOx reducing catalyst. | 06-25-2009 |
20090288402 | Emission Treatment Catalysts, Systems and Methods - Zoned diesel oxidation catalysts containing a higher precious metal loading in the inlet zone that the outlet zone and an equal or shorter length inlet zone are described. Emission treatment systems and methods of remediating nitrogen oxides (NOx), particulate matter, and gaseous hydrocarbons using zoned diesel oxidation catalysts are also described. | 11-26-2009 |
20090304564 | NOx Storage Materials and Traps Resistant to Thermal Aging - Nitrogen oxide storage materials and methods of manufacturing nitrogen oxide storage materials are disclosed. The nitrogen oxide storage materials can be used to manufacture catalytic trap disposed in an exhaust passage of an internal combustion engine which is operated periodically between lean and stoichiometric or rich conditions, for abatement of NOx in an exhaust gas stream which is generated by the engine. In one embodiment, the nitrogen oxide storage material comprises alkaline earth material supported on ceria particles having a crystallite size of between about 10 and 20 nm and the alkaline earth oxide having a crystallite size of between about 20-40 nm. | 12-10-2009 |
20110173950 | Emissions Treatment System with Ammonia-Generating and SCR Catalysts - Provided are emissions treatment systems for an exhaust stream having an ammonia-generating component, such as a NOx storage reduction (NSR) catalyst or a lean NOx trap (LNT) catalyst, and an SCR catalyst disposed downstream of the ammonia-generating catalyst. The SCR catalyst can be a molecular sieve having the CHA crystal structure, for example SSZ-13 or SAPO-34, which can be ion-exchanged with copper. The LNT can be layered, having an undercoat washcoat layer comprising a support material, at least one precious metal, and at least one NOx sorbent selected from the group consisting of alkaline earth elements, rare earth elements, and combinations thereof and a top washcoat layer comprising a support material, at least one precious metal, and ceria in particulate form, the top washcoat layer being substantially free of alkaline earth components. The emissions treatment system is advantageously used for the treatment of exhaust streams from diesel engines and lean burn gasoline engines. | 07-21-2011 |
20110305612 | NOX STORAGE CATALYST WITH IMPROVED HYDROCARBON CONVERSION ACTIVITY - Described is a nitrogen oxide storage catalyst comprising:
| 12-15-2011 |
20110305613 | Fe-BEA/Fe-MFI Mixed Zeolite Catalyst And Process For The Treatment Of NOx In Gas Streams - Disclosed is a catalyst, preferably for use in selective catalytic reduction (SCR), said catalyst comprising one or more zeolites of the MFI structure type, and one or more zeolites of the BEA structure type, wherein at least part of the one or more zeolites of the MFI structure type and at least part of the one or more zeolites of the BEA structure type respectively contain iron (Fe). Furthermore, an exhaust gas treatment system is described, comprising said catalyst as well as a process for the treatment of a gas stream comprising NO | 12-15-2011 |
20110305614 | Cu-CHA/Fe-MFI Mixed Zeolite Catalyst And Process For The Treatment Of NOx In Gas Streams - Described is a catalyst, preferably for use in selective catalytic reduction (SCR), said catalyst comprising one or more zeolites of the MFI structure type, and one or more zeolites of the CHA structure type, wherein at least part of the one or more zeolites of the MFI structure type contain iron (Fe), and wherein at least part of the one or more zeolites of the CHA structure type contain copper (Cu). An exhaust gas treatment system is described, comprising said catalyst as well as a process for the treatment of a gas stream comprising NO | 12-15-2011 |
20120023915 | NOx Storage Materials and Traps Resistant to Thermal Aging - Nitrogen oxide storage materials and methods of manufacturing nitrogen oxide storage materials are disclosed. The nitrogen oxide storage materials can be used to manufacture catalytic trap disposed in an exhaust passage of an internal combustion engine which is operated periodically between lean and stoichiometric or rich conditions, for abatement of NOx in an exhaust gas stream which is generated by the engine. In one embodiment, the nitrogen oxide storage material comprises alkaline earth material supported on ceria particles having a crystallite size of between about 10 and 20 nm and the alkaline earth oxide having a crystallite size of between about 20-40 nm. | 02-02-2012 |
20130089483 | Cu-CHA/Fe-BEA Mixed Zeolite Catalyst And Process For The Treatment Of NOx In Gas Streams - The present invention relates to a catalyst, which may be used in selective catalytic reduction (SCR), said catalyst comprising one or more zeolites of the BEA structure type, one or more zeolites of the CHA structure type, and optionally one or more zeolites of the MFI structure type, wherein at least part of the one or more zeolites of the BEA structure type contain iron (Fe), wherein at least part of the one or more zeolites of the CHA structure type contain copper (Cu), and wherein at least part of the optional one or more zeolites of the MFI structure type contain iron (Fe). Furthermore, the present invention concerns an exhaust gas treatment system comprising said catalyst as well as a process for the treatment of a gas stream comprising NO using said catalyst as well. | 04-11-2013 |
20140047819 | Emissions Treatment System with Ammonia-Generating and SCR Catalysts - Provided are emissions treatment systems for an exhaust stream having an ammonia-generating component, such as a NOx storage reduction (NSR) catalyst or a lean NOx trap (LNT) catalyst, and an SCR catalyst disposed downstream of the ammonia-generating catalyst. The SCR catalyst can be a molecular sieve having the CHA crystal structure, for example SSZ-13 or SAPO-34, which can be ion-exchanged with copper. The LNT can be layered, having an undercoat washcoat layer comprising a support material, at least one precious metal, and at least one NOx sorbent selected from the group consisting of alkaline earth elements, rare earth elements, and combinations thereof and a top washcoat layer comprising a support material, at least one precious metal, and ceria in particulate form, the top washcoat layer being substantially free of alkaline earth components. The emissions treatment system is advantageously used for the treatment of exhaust streams from diesel engines and lean burn gasoline engines. | 02-20-2014 |
20140248200 | Emissions Treatment System with Ammonia-Generating and SCR Catalysts - Provided are emissions treatment systems for an exhaust stream having an ammonia-generating component, such as a NOx storage reduction (NSR) catalyst or a lean NOx trap (LNT) catalyst, and an SCR catalyst disposed downstream of the ammonia-generating catalyst. The SCR catalyst can be a molecular sieve having the CHA crystal structure, for example SSZ-13 or SAPO-34, which can be ion-exchanged with copper. The LNT can be layered, having an undercoat washcoat layer comprising a support material, at least one precious metal, and at least one NOx sorbent selected from the group consisting of alkaline earth elements, rare earth elements, and combinations thereof and a top washcoat layer comprising a support material, at least one precious metal, and ceria in particulate form, the top washcoat layer being substantially free of alkaline earth components. The emissions treatment system is advantageously used for the treatment of exhaust streams from diesel engines and lean burn gasoline engines. | 09-04-2014 |
Patent application number | Description | Published |
20100298301 | OXAZOLE TYROSINE KINASE INHIBITORS - The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar | 11-25-2010 |
20130102592 | OXAZOLE TYROSINE KINASE INHIBITORS - The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar | 04-25-2013 |
20140275041 | OXAZOLE TYROSINE KINASE INHIBITORS - The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar | 09-18-2014 |
20150057282 | OXAZOLE TYROSINE KINASE INHIBITORS - The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar | 02-26-2015 |
Patent application number | Description | Published |
20100072640 | MANUFACTURING A REPLICATION TOOL, SUB-MASTER OR REPLICA - In a process of manufacturing, by replication, a plurality of optical elements each having geometrical surface features, a method of manufacturing an element that includes a plurality of replicated structures is provided. The method comprises the steps of providing an element substrate, of replicating, by embossing, a surface of a tool element, which surface comprises a negative copy of the geometrical surface feature, into replication material disposed at a first place on a surface of the element substrate, of subsequently hardening the replication material, of replicating said surface of the tool element into replication material disposed at a second place on said substrate, of hardening said replication material, the method comprising the further step of subsequently filling a gap between replication material disposed at the first place and replication material disposed at the second place by filler material. | 03-25-2010 |
20110024030 | MANUFACTURING OPTICAL ELEMENTS - A method includes the steps of: providing a substrate; providing a tool having, on a replication side, a plurality of replication sections, each replication section defining a surface structure of one of an optical element(s), the tool further including at least one contact spacer portion, the contact spacer portion protruding, on the replication side, further than an outermost feature of the replication sections; aligning the tool with a feature of the substrate and bringing the tool and a first side of the substrate together, with replication material between the tool and the substrate, the contact spacer portion contacting the first side of the substrate, and thereby causing the spacer portion to adhere to the first side of the substrate, thereby producing a substrate-tool-assembly; dislocating the substrate-tool-assembly to a hardening station; causing the replication material to harden at the hardening station; and separating the tool from the substrate with the hardened replication material adhering to the substrate. | 02-03-2011 |
20110220278 | METHOD OF MANUFACTURING A PLURALITY OF OPTICAL DEVICES - A method wherein firstly a spacer arrangement and a first wafer are brought together with each other with a first portion of curable adhesive between a first side of the spacer arrangement and the first substrate, to produce a partial stack, and then a second wafer is brought together with a second side of the spacer arrangement, with a second portion of curable adhesive between the second side of the spacer arrangement and the second wafer. Then, the first portion of the curable adhesive and the second portion of the curable adhesive are cured simultaneously. | 09-15-2011 |
20140263973 | INTEGRATED MODULE HAVING MULTIPLE LIGHT EMITTERS OR SENSORS FOR TELEVISIONS AND OTHER APPLIANCES - Compact optoelectronic modules are described and can be used in various electronic or other appliances, such as television units. For example, a light emitting device, a first sensor or sensor module such as an infra-red sensor or an infra-red receiver module, and a second sensor or sensor module such as an ambient light sensor or ambient light sensor module, can be integrated into a single compact optoelectronic module. Multiple such optoelectronic modules can be fabricated in a wafer-level process. | 09-18-2014 |
20140291703 | Opto-Electronic Module - An optical proximity sensor module includes a substrate, a light emitter mounted on a first surface of the substrate, the light emitter being operable to emit light at a first wavelength, and a light detector mounted on the first surface of the substrate, the light detector being operable to detect light at the first wavelength. The module includes an optics member disposed substantially parallel to the substrate, and a separation member disposed between the substrate and the optics member. The separation member may surround the light emitter and the light detector, and may include a wall portion that extends from the substrate to the optics member and that separates the light emitter and the light detector from one another. The separation member may be composed, for example, of a non-transparent polymer material containing a pigment, such as carbon black. | 10-02-2014 |
20140347747 | METHOD FOR MANUFACTURING PASSIVE OPTICAL COMPONENTS, AND DEVICES COMPRISING THE SAME - A device comprises at least one optics member (O) comprising at least one transparent portion (t) and at least one blocking portion (b). The at least one transparent portion (t) is made of one or more materials substantially transparent for light of at least a specific spectral range, referred to as transparent materials, and the at least one blocking portion (b) is made of one or more materials substantially non-transparent for light of the specific spectral range, referred to as non-transparent materials. The transparent portion (t) comprises at least one passive optical component (L). The at least one passive optical component (L) comprises a transparent element ( | 11-27-2014 |
20150034975 | OPTOELECTRONIC MODULES THAT HAVE SHIELDING TO REDUCE LIGHT LEAKAGE OR STRAY LIGHT, AND FABRICATION METHODS FOR SUCH MODULES - Various optoelectronic modules are described that include an optoelectronic device (e.g., a light emitting or light detecting element) and a transparent cover. Non-transparent material is provided on the sidewalls of the transparent cover, which, in some implementations, can help reduce light leakage from the sides of the transparent cover or can help prevent stray light from entering the module. Fabrication techniques for making the modules also are described. | 02-05-2015 |
20150036046 | OPTOELECTRONIC MODULES THAT HAVE SHIELDING TO REDUCE LIGHT LEAKAGE OR STRAY LIGHT, AND FABRICATION METHODS FOR SUCH MODULES - Optoelectronic modules include an optoelectronic device and a transparent cover. A non-transparent material is provided on the sidewalls of the transparent cover, which can help reduce light leakage from the sides of the transparent cover or can help reduce stray light from entering the module. The modules can be fabricated, for example, in wafer-level processes. In some implementations, openings such as trenches are formed in a transparent wafer. The trenches then can be filled with a non-transparent material using, for example, a vacuum injection tool. When a wafer-stack including the trench-filled transparent wafer subsequently is separated into individual modules, the result is that each module can include a transparent cover having sidewalls that are covered by the non-transparent material. | 02-05-2015 |
Patent application number | Description | Published |
20100112717 | Method for Providing a Dried Reagent in a Microfluidic System and Microfluidic System - A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization. | 05-06-2010 |
20110183432 | TEST ELEMENT FOR ANALYZING AN ANALYTE PRESENT IN A SAMPLE OF A BODY FLUID, ANALYSIS SYSTEM AND METHOD FOR CONTROLLING THE MOVEMENT OF A FLUID CONTAINED IN A CHANNEL OF A TEST ELEMENT - Embodiments disclosed herein include an analysis system for the analysis of a body fluid sample for an analyte contained therein, comprising a test element and an evaluation device having a measuring station for measuring a measuring variable on the measuring zone of the test element. Also included is a mounting to hold a test element, the test element having an airflow channel with two expansion sections and a narrow section located between these expansion sections. The expansion sections may have a cross-sectional area that increases in comparison to the narrow section in the direction away therefrom. A connection channel is located between the narrow section and the analysis function channel such that an air exchange connection is formed. The airflow channel is located in such a manner that a partial vacuum, which is generated using an airflow flowing through the airflow channel, acts on the analysis function channel. | 07-28-2011 |
20120301371 | MICROFLUIDIC ELEMENT FOR ANALYZING A LIQUID SAMPLE - A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample. | 11-29-2012 |
20130004964 | METHOD FOR CARRYING OUT REACTIONS IN AN ANALYTICAL DEVICE - Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone. | 01-03-2013 |
20130236376 | Microfluidic Test Carrier for Apportioning a Liquid Quantity Into Subquantities - A microfluidic test carrier having a substrate, covering layer, and capillary structure formed in the substrate is provided. The capillary structure is enclosed by the substrate and covering layer and comprises a receiving chamber, sample chamber and connection channel between the receiving and sample chambers. The receiving chamber has two boundary surfaces and a side wall, wherein one boundary surface forms the bottom and the other forms the cover. The receiving chamber has a surrounding venting channel and dam between the receiving chamber and venting channel. The dam and venting channel form a capillary stop configured as a geometric valve, through which air from the receiving chamber can escape into the venting channel. The connecting channel between the venting channel outflow and sample chamber inflow controls fluid transport from the receiving chamber into the sample chamber. The capillary stop is configured to prevent autonomous fluid transport from the receiving chamber. | 09-12-2013 |
20130243664 | MICROFLUIDIC ELEMENT FOR ANALYSIS OF A SAMPLE LIQUID - A microfluidic element for analysis of a fluid sample having a substrate and a microfluidic transport system having a channel structure enclosed by the substrate and a covering layer. The channel structure comprises a channel with two side walls as well as a chamber that is in fluid communication with the channel. The chamber has a chamber wall with an inlet orifice. The channel comprises a channel section and a valve section adjoining the channel section, wherein the valve section is in fluid communication with the inlet orifice in the chamber wall in such a way that a fluid can flow from the channel through the valve section and into the chamber. The valve section has a fluid transport cross-section, which enlarges in flow direction. The fluid transport cross-section in the valve section is greater than the fluid transport cross-section in the preceding channel section. | 09-19-2013 |