Patent application number | Description | Published |
20100221338 | Coated Tablets Of 6-(5-Chloro-2-Pyridyl)-5-[(4-Methyl-1-Piperazinyl)Carbonyloxy]-7-Oxo-6,7-- Dihydro-5H-Pyrrolo[3,4-b]Pyrazine And Methods For Measuring Effectiveness Of Coating - Coated tablets of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The tablets minimize the perceived bitterness of the medicament. A method for analyzing instantaneous dissolution of sub-microgram quantities of core material is also disclosed. | 09-02-2010 |
20130116332 | FORMULATIONS, SALTS AND POLYMORPHS OF TRANSNORSERTRALINE AND USES THEREOF - Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression. | 05-09-2013 |
20140271858 | COATED TABLETS OF ESZOPICLONE - Coated tablets of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided. The tablets minimize the perceived bitterness of the medicament. A method for analyzing instantaneous dissolution of sub-microgram quantities of core material is also disclosed. | 09-18-2014 |
Patent application number | Description | Published |
20110155171 | Cleaning and Conditioning Cloth - A cleaning and conditioning cloth for an ice skate, including hockey and speed skates, as well as other objects, includes a rectangular body, or a body selected from one of other various shapes such as circle, square, and diamond, of cut-resistant, water-absorbent fabric and an oil impregnated fabric affixed to the approximate center of the cleaning and conditioning cloth body wherein the method includes the steps of holding the cleaning and conditioning cloth in one hand and the ice skate in the other, placing the blade of the ice skate in the middle of the oil impregnated fabric, and moving the ice skate and the cleaning and conditioning cloth relative to each other, so that the blade moves from the cleaning and conditioning cloth body to the oil impregnated fabric. The body and the oil impregnated fabric may be of various sizes. | 06-30-2011 |
20120291802 | MULTI-USE CLEANING AND CONDITIONING CLOTH - A multi-use cloth for cleaning and conditioning metal and non-metal objects includes a two-layer, three-layer or multi-layer structure. Each layer is made of material either capable of retaining an oil, aqueous solution, aqueous suspension or solid or capable of preventing penetration of an oil, aqueous solution, aqueous suspension or solid. In a three-layer or multi-layer cloth, the separation layer is affixed in between two layers having one or both layers embedded with an oil, aqueous solution, or aqueous suspension. In a two-layer cloth, the separation layer is affixed to one side of the layer that is embedded with an oil, aqueous solution or an aqueous suspension. The cloth is folded with the oil, or aqueous solution, or aqueous suspension embedded side on an inner side. A user's hand holds the outside of the cloth and no contamination from oil, aqueous solution, or aqueous suspension or solid occurs. | 11-22-2012 |
Patent application number | Description | Published |
20100140758 | Integrated Circuit with Improved Transmission Line Structure and Electromagnetic Shielding Between Radio Frequency Circuit Paths - An integrated circuit is disclosed having through silicon vias spaced apart one from another and conductors, each coupled to one or more of the through silicon vias, the conductors in aggregate in use forming a segmented conductive plane maintained at a same potential and forming an electromagnetic shield. | 06-10-2010 |
20100327948 | Switching Circuit - A method for controlling a switch based on transistors is disclosed. A switching circuit for switching a signal from an input port to an output port thereof is provided. A shunting circuit for switchably shunting the signal from the input port to ground is also provided. A control signal is generated for biasing a control port of the shunting circuit and an approximately complimentary control signal is generated for biasing of the switching circuit to either shunt a signal received at the input port or to switch the signal to the output port. A further bias signal for biasing a port within the switching circuit along the signal path between the input port and the output port is also provided. | 12-30-2010 |
20110128078 | System and Method of Prebias for Rapid Power Amplifier Response Correction - A system and method are provided for reducing dynamic EVM of an integrated circuit power amplifier (PA) used for RF communication. In a multistage PA, the largest amplification stage is biased with a high amplitude current pulse upon receipt of a Tx enable, before receipt of the RF signal data burst. The high amplitude current pulse causes a large portion of the total ICQ budget of the multistage PA to pass through the largest amplification stage causing the entire integrated circuit to rapidly approach steady-state operating conditions. A smoothing bias current is applied to the largest amplification stage after the pulse decays to compensate for transient bias current levels while standard bias circuitry is still approaching steady-state temperature. | 06-02-2011 |
20110254614 | System and Method of Transistor Switch Biasing in a High Power Semiconductor Switch - A system and method are provided for biasing transistor switches in a semiconductor based high power switch. Off-state Vgsd biasing for the off transistor switches is based upon acceptable levels of spurious harmonic emissions and linearity. | 10-20-2011 |
20120202438 | SYSTEM AND METHOD OF TRANSISTOR SWITCH BIASING IN A HIGH POWER SEMICONDUCTOR SWITCH - A system and method are provided for biasing transistor switches in a semiconductor based high power switch. Off-state Vgsd biasing for the off transistor switches is based upon acceptable levels of spurious harmonic emissions and linearity. | 08-09-2012 |
20130034144 | SYSTEM AND METHOD OF PREBIAS FOR RAPID POWER AMPLIFIER RESPONSE CORRECTION - A system and method are provided for reducing dynamic EVM of an integrated circuit power amplifier (PA) used for RF communication. In a multistage PA, the largest amplification stage is biased with a high amplitude current pulse upon receipt of a Tx enable, before receipt of the RF signal data burst. The high amplitude current pulse causes a large portion of the total ICQ budget of the multistage PA to pass through the largest amplification stage causing the entire integrated circuit to rapidly approach steady-state operating conditions. A smoothing bias current is applied to the largest amplification stage after the pulse decays to compensate for transient bias current levels while standard bias circuitry is still approaching steady-state temperature. | 02-07-2013 |
20130260698 | SWITCHING CIRCUIT - A method for controlling a switch based on transistors is disclosed. A switching circuit for switching a signal from an input port to an output port thereof is provided. A shunting circuit for switchably shunting the signal from the input port to ground is also provided. A control signal is generated for biasing a control port of the shunting circuit and an approximately complimentary control signal is generated for biasing of the switching circuit to either shunt a signal received at the input port or to switch the signal to the output port. A further bias signal for biasing a port within the switching circuit along the signal path between the input port and the output port is also provided. | 10-03-2013 |
Patent application number | Description | Published |
20100117727 | ASYMMETRIC MULTILEVEL OUTPHASING ARCHITECTURE FOR RF AMPLIFIERS - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 05-13-2010 |
20110215866 | ASYMMETRIC MULTILEVEL OUTPHASING ARCHITECTURE FOR RF AMPLIFIERS - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 09-08-2011 |
20120176195 | Asymmetric Multilevel Outphasing Architecture For RF Amplifiers - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 07-12-2012 |
20140125412 | Asymmetric Multilevel Outphasing Architecture For RF Amplifiers - A radio frequency (RF) circuit includes a power supply configured to generate a plurality of voltages, a plurality of power amplifiers, each having an RF output port and a power supply input port, a switch network having a plurality of input ports coupled to the power supply and a plurality of switch network output ports coupled to the power supply input ports of the plurality of power amplifiers, wherein the switch network is configured to output selected ones of the plurality of voltages from the plurality of switch network output ports, at least two of the switch network output port voltages capable of being different ones of the plurality of voltages, and an RF power combiner circuit having a plurality of input ports coupled to RF output ports of the plurality of power amplifiers and an output port at which is provided an output signal of the RF circuit. | 05-08-2014 |
Patent application number | Description | Published |
20110114875 | ELECTROCHEMICALLY ACTIVE MATERIALS AND PRECURSORS THERETO - The invention provides unique methods and compositions useful for preparing high-quality, nano-scale powdery precursor materials that are efficiently converted to electrochemically active materials, for example those useful in rechargeable lithium-ion batteries as electrode materials and various applications. | 05-19-2011 |
20120058039 | HIGH PERFORMANCE CATHODE MATERIAL LiFePO4, ITS PRECURSORS AND METHODS OF MAKING THEREOF - In one aspect of the invention, methods of synthesizing iron phosphate precursors and lithium iron phosphate active material usable for a lithium secondary battery include the steps of first forming fine particle iron phosphate precursors hydrated and anhydrous, then forming electrode active material lithium iron phosphate with said iron phosphate precursors. The unique methods are generally efficient and cost effective, as well as stable and scalable for a high performance electrode active material with high capacity, good discharge profile, high electronic conductivity, as well as long cycle life. | 03-08-2012 |
20140054494 | METHODS OF MAKING LOW COST ELECTRODE ACTIVE COMPOSITE MATERIALS FOR SECONDARY ELECTROCHEMICAL BATTERIES - In one aspect, a method of synthesizing a phosphorous active electrode composite material AMPO | 02-27-2014 |
20150076750 | METHODS OF MAKING LOW COST ELECTRODE ACTIVE MATERIALS FOR SECONDARY BATTERIES FROM ILMENITE - A method of producing electrode active materials includes generating a source material of titanium (Ti) and a source material of iron (Fe) from an ilmenite, and performing a operation to the source material of Fe and the source material of Ti. The operation includes determining a content of Fe or Ti in the source material of Fe or Ti, preparing an intermediate mixture having the source material of Fe or Ti and other required source materials, ball-milling and drying the intermediate mixture, and sintering the intermediate mixture to form the electrode active materials. | 03-19-2015 |
Patent application number | Description | Published |
20100087429 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 04-08-2010 |
20120165334 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors - The present invention provides compounds that are kinase inhibitors, specifically PIK kinase inhibitors, more specifically, mTOR inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PIK kinase inhibitors, more specifically, mTOR such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. | 06-28-2012 |
20120190666 | Heteroaryl Compounds as PIKK Inhibitors - The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3Kα kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3Kα, such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. | 07-26-2012 |
20140371201 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS - The present invention provides compounds of Formula I, | 12-18-2014 |
20150045368 | OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF - Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein. | 02-12-2015 |
Patent application number | Description | Published |
20090062886 | SYSTEMS AND METHODS FOR DELIVERING ELECTRICAL ENERGY IN THE BODY - Small implantable magnetostrictive-electroactive (ME) device for delivering electrical energy to surrounding tissue. The wireless ME device is activated by a changing magnetic field from an externally applied alternating magnetic field source. The ME device provides a means for stimulating a nerve, tissue or internal organ with direct electrical current, such as relatively low-level direct current for temporary or as needed therapy. The field source (e.g. small coil antenna) may be a hand-held device or affixed to the wearer's skin, clothing or accessories. The ME implant may be configured as pellets which are small enough to be implanted through a surgical needle. In one embodiment, the wireless energy transmission system can be used for stimulating bone growth. | 03-05-2009 |
20100015918 | WIRELESS TRANSFER OF INFORMATION USING MAGNETO-ELECTRIC DEVICES - Apparatus and method for wireless near-field magnetic communication (NFMC) of information (e.g., voice or data) over modest distances (centimeters to a few kilometers). The transmission can proceed from an inductive coil transmitter to a magneto-electric (ME) receiving device, or between two ME devices. Electrical power may also be transmitted from and/or received using the same device. In one case, power and data are transmitted from an induction coil to a distant ME device that collects power and transmits data back to the power-transmission coil. In another case, the wireless transfer of data can be carried out between two ME devices. ME devices can be engineered to transmit or receive data and to receive electric power over a variety of frequencies by changing their dimensions, their material makeup and configuration, electrode configurations, and/or their resonance modes (longitudinal, transversal, bending, shear etc). Data rates up to and above several kilo-bits/s are possible using these methods with no limits on the frequency and duration of the communication. | 01-21-2010 |
20140028109 | WIRELESS POWER TRANSFER SYSTEM FOR FREELY-MOVING ANIMAL EXPERIMENTS - Disclosed herein are systems and methods for wirelessly transmitting power to receivers that are freely mobile, such as power receivers for sensors attached to animal experiments. An example transmitter includes a resonator including a generator and transmitter coil, an initial drive signal generator that removes the generator from an ‘off’ state thereby causing the transmitter coil to create an alternating magnetic field that oscillates within a threshold of a resonant frequency of the generator, a phase detector that receives a signal from a receiver coil receiving power via the magnetic field, and a transition module that switches from the initial drive signal to a drive signal generated based on output from the phase detector. An example wireless power receiver has three turns of wire, one on each axis, around a ferrite plate, the outputs of which are connected in parallel to produce a combined output power signal. | 01-30-2014 |
Patent application number | Description | Published |
20100055758 | Magnetic Device for Isolation of Cells and Biomolecules in a Microfluidic Environment - The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the surface of the magnetic particles may then be used to bind particles, e.g., cells, or molecules of interest from complex samples, and the bound species may then be selectively released for downstream collection or further analysis. | 03-04-2010 |
20140190903 | SYSTEM AND METHOD FOR PARTICLE FILTRATION - Embodiments of the present disclosure feature a filtration system comprising a filtration module for particle filtration and methods of using the device for the isolation of particles (e.g., viable cells). Advantageously, embodiments of the device provide for the high throughput filtration of large volumes of sample while preserving cell viability and providing high yields. | 07-10-2014 |
20140315303 | METHOD AND DEVICE FOR SAMPLE PROCESSING - In accordance with an aspect of the present disclosure there is provided an apparatus for the processing of biological sample. The apparatus comprises a first sheet of material, a second sheet of material bonded to the first sheet of material, and a plurality of chambers defined between the first sheet of material and the second sheet of material, the plurality of chambers including a sample dissociation chamber including an inlet and an outlet; a waste collection chamber including an inlet in fluid communication with the outlet of the sample dissociation chamber, and a cell refinement chamber including an inlet in fluid communication with the sample dissociation chamber and an outlet. | 10-23-2014 |
Patent application number | Description | Published |
20100097821 | LIGHT EMITTING DIODE-BASED LAMP HAVING A VOLUME SCATTERING ELEMENT - A lamp having a candle-like appearance and using one or more light-emitting diodes (LEDs) as its light source is presented. The candle-like appearance arises because light is emitted from only a small volume at or near the center of the bulb. The heat sink and control electronics are located outside the bulb of the lamp. Inside the bulb is a set of secondary optics that guide the light from one or more LEDs to an emission point at a prescribed location in the interior of the bulb. The secondary optics include a light pipe that guides light away from the LED chip, and a volume scattering element that receives the light from the light pipe and scatters it into various directions. The volume scattering element is made from a transparent base material, and includes transparent particles of a predetermined size and refractive index. Because the lamp is typically used in an overhead position, such as in a hanging chandelier, the density of particles in the volume scattering element, the particle size and the particle refractive index are chosen to produce a scattering pattern that directs more light downward (toward the base of the bulb) than upward, while maintaining a reasonable efficiency (fraction of produced light that successfully exits the lamp). Simulation results are presented. | 04-22-2010 |
20120147611 | LIGHT EMITTING DIODE-BASED LAMP HAVING A VOLUME SCATTERING ELEMENT - A lamp having a candle-like appearance and using one or more light-emitting diodes (LEDs) as its light source is presented. The candle-like appearance arises because light is emitted from only a small volume at or near the center of the bulb. The heat sink and control electronics are located outside the bulb of the lamp. Inside the bulb is a set of secondary optics that guide the light from one or more LEDs to an emission point at a prescribed location in the interior of the bulb. The secondary optics include a light pipe that guides light away from the LED chip, and a volume scattering element that receives the light from the light pipe and scatters it into various directions. The volume scattering element is made from a transparent base material, and includes transparent particles of a predetermined size and refractive index. Because the lamp is typically used in an overhead position, such as in a hanging chandelier, the density of particles in the volume scattering element, the particle size and the particle refractive index are chosen to produce a scattering pattern that directs more light downward (toward the base of the bulb) than upward, while maintaining a reasonable efficiency (fraction of produced light that successfully exits the lamp). Simulation results are presented. | 06-14-2012 |
Patent application number | Description | Published |
20090061031 | Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 03-05-2009 |
20110142973 | Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 06-16-2011 |
20140296141 | Compositions and Methods for Treating Obesity, Obesity Related Disorders and for Inhibiting the Infectivity of Human Immunodeficiency Virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 10-02-2014 |
Patent application number | Description | Published |
20100111853 | ANTIBODIES THAT BIND TO IL-12 AND METHODS OF PURIFYING THE SAME - Anti-IL-12 antibodies are disclosed herein, including antigen-binding portions thereof. One or more methods for isolating and purifying anti-IL-12 antibodies from a sample matrix is presented. These isolated anti-IL-12 antibodies can be used in a clinical setting as well as in research and development. Pharmaceutical compositions comprising isolated anti-IL-12 antibodies are also described. | 05-06-2010 |
20100135987 | ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY - Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention. | 06-03-2010 |
20100150864 | ANTIBODIES THAT BIND TO IL-18 AND METHODS OF PURIFYING THE SAME - Anti-IL-18 antibodies are disclosed herein, including antigen-binding portions thereof. One or more methods for isolating and purifying anti-IL-18 antibodies from a sample matrix is presented. These isolated anti-IL-18 antibodies can be used in a clinical setting as well as in research and development. Pharmaceutical compositions comprising isolated anti-IL-18 antibodies are also described. | 06-17-2010 |
Patent application number | Description | Published |
20110216417 | Selective Repositioning and Rotation Wavelength Beam Combining System and Method - A system and method for reconfiguring a plurality of electromagnetic beams to take advantage of various wavelength beam combining techniques. The reconfiguring of beams includes individual rotation and selective repositioning of one or more beams with respect to beam's original input position. | 09-08-2011 |
20110216792 | Scalable Wavelength Beam Combining System and Method - Systems and methods have been provided to increase output power, as well as spatial and/or spectral brightness when utilizing or combining a plurality of laser elements. | 09-08-2011 |
20110310921 | Wavelength Beam Combining Laser with Multiple Outputs - A system and method for producing a multi-output laser by reconfiguring and apportioning a plurality of electromagnetic beams produced by various wavelength beam combining techniques. The reconfiguring of beams includes individual rotation and selective repositioning of one or more beams with respect to beam's original input position. | 12-22-2011 |
20120105968 | Compact Interdependent Optical Element Wavelength Beam Combining Laser System and Method - A Compact Interdependent Optical Laser System and Method is designed for use with wavelength beam combining (WBC) systems that utilize both slow-axis and fast-axis WBC. Multiple optical elements having individual and interdependent functionality allow for the system to compact reducing the overall footprint of the system. Additional, configurations incorporating the compact system described herein allow for high-power and brightness scaling. | 05-03-2012 |
20130208361 | OPTICAL CROSS-COUPLING MITIGATION SYSTEM FOR MULTI-WAVELENGTH BEAM COMBINING SYSTEMS - A system and method for increasing efficiency and power output of a multi-wavelength beam combining system through providing a common output coupler to reflect feedback that stabilizes or individually seeds each emitter, and wherein the individual feedback is preserved by mitigating cross-coupling, wherein a multi-wavelength beam comprised of radiation having a plurality of wavelengths, high brightness and power. | 08-15-2013 |
20130287058 | System and Method for Wavelength Beam Combination on a Single Laser Emitter - A system and method for reducing the M | 10-31-2013 |
20140036358 | Scalable Wavelength Beam Combining System and Method - Systems and methods have been provided to scale wavelength beam combining (WBC) systems, which are systems configured to increase output power, as well as spatial and/or spectral brightness when utilizing or combining a plurality of beam emitters. | 02-06-2014 |
20140036375 | Selective Repositioning and Rotation Wavelength Beam Combining System and Method - A system and method for reconfiguring a plurality of electromagnetic beams to take advantage of various wavelength beam combining techniques. The reconfiguring of beams includes individual rotation and selective repositioning of one or more beams with respect to beam's original input position. | 02-06-2014 |
Patent application number | Description | Published |
20100250143 | IDENTIFYING BIOLOGICAL RESPONSE PATHWAYS - A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response. | 09-30-2010 |
20140074408 | IDENTIFYING BIOLOGICAL RESPONSE PATHWAYS - A method for operating a machine for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response, accessing a database containing information characterizing molecular interactions, determining pathways connecting the identified molecules participating in the response, and solving an optimization problem. The pathways comprise nodes, each representing a molecule, and edges, each connecting a pair of nodes and representing an interaction between a respective pair of molecules represented by the pair of nodes. The nodes includes a subset that represent molecules identified as participating in the cellular response. Solving an optimization problem comprises determining a subset of the molecules and interactions having a minimum aggregate cost, associating each participating node with a penalty value, associating each edge with a cost value, forming an objective function based on the penalty and cost values, and identifying the sub-network of nodes and edges that minimizes the objective function. | 03-13-2014 |
Patent application number | Description | Published |
20110077958 | SYSTEMS AND METHODS FOR CLINICAL, OPERATIONAL, AND FINANCIAL BENCHMARKING AND COMPARATIVE ANALYTICS - The clinical analytics platform automates the capture, extraction, and reporting of data required for certain quality measures, provides real-time clinical surveillance, clinical dashboards, tracking lists, and alerts for specific, high-priority conditions, and offers dynamic, ad-hoc quality reporting capabilities. The clinical informatics platform may include a data extraction facility that gathers clinical data from numerous sources, a data mapping facility that identifies and maps key data elements and links data over time, a data normalization facility to normalize the clinical data and, optionally, de-identify the data, a flexible data warehouse for storing raw clinical data or longitudinal patient data, a clinical analytics facility for data mining, analytic model building, patient risk identification, benchmarking, performing quality assurance, and patient tracking, and a graphical user interface for presenting clinical analytics in an actionable format. The clinical informatics platform may enable a method of benchmarking that includes analyzing the healthcare data to obtain a data sample to compare to at least one of a clinical, operational and financial benchmark, and presenting the data sample with the benchmark as a report in a graphical user interface, wherein the report can be customized by at least one of changing at least one criterion. | 03-31-2011 |
20110077972 | SYSTEMS AND METHODS OF CLINICAL TRACKING - The clinical analytics platform automates the capture, extraction, and reporting of data required for certain quality measures, provides real-time clinical surveillance, clinical dashboards, tracking lists, and alerts for specific, high-priority conditions, and offers dynamic, ad-hoc quality reporting capabilities. The clinical informatics platform may include a data extraction facility that gathers clinical data from numerous sources, a data mapping facility that identifies and maps key data elements and links data over time, a data normalization facility to normalize the clinical data and, optionally, de-identify the data, a flexible data warehouse for storing raw clinical data or longitudinal patient data, a clinical analytics facility for data mining, analytic model building, patient risk identification, benchmarking, performing quality assurance, and patient tracking, and a graphical user interface for presenting clinical analytics in an actionable format. The clinical informatics platform may enable a method of clinical tracking that includes analyzing the healthcare data to obtain at least one report, and presenting the report in a graphical user interface, wherein the report can be customized based on a criterion. | 03-31-2011 |
20110077973 | SYSTEMS AND METHODS FOR REAL-TIME DATA INGESTION TO A CLINICAL ANALYTICS PLATFORM - The clinical analytics platform automates the capture, extraction, and reporting of data required for certain quality measures, provides real-time clinical surveillance, clinical dashboards, tracking lists, and alerts for specific, high-priority conditions, and offers dynamic, ad-hoc quality reporting capabilities. The clinical informatics platform may include a data extraction facility that gathers clinical data from numerous sources, a data mapping facility that identifies and maps key data elements and links data over time, a data normalization facility to normalize the clinical data and, optionally, de-identify the data, a flexible data warehouse for storing raw clinical data or longitudinal patient data, a clinical analytics facility for data mining, analytic model building, patient risk identification, benchmarking, performing quality assurance, and patient tracking, and a graphical user interface for presenting clinical analytics in an actionable format. | 03-31-2011 |
Patent application number | Description | Published |
20080197340 | MULTIPLE-WAVELENGTH OPTO-ELECTRONIC DEVICE INCLUDING A SUPERLATTICE - A multiple-wavelength opto-electronic device may include a substrate and a plurality of active optical devices carried by the substrate and operating at different respective wavelengths. Each optical device may include a superlattice comprising a plurality of stacked groups of layers, and each group of layers may include a plurality of stacked semiconductor monolayers defining a base semiconductor portion and at least one non-semiconductor monolayer thereon. | 08-21-2008 |
20080197341 | METHOD FOR MAKING A MULTIPLE-WAVELENGTH OPTO-ELECTRONIC DEVICE INCLUDING A SUPERLATTICE - A method for making a multiple-wavelength opto-electronic device which may include providing a substrates and forming a plurality of active optical devices to be carried by the substrate and operating at different respective wavelengths. Moreover, each optical device may include a superlattice comprising a plurality of stacked groups of layers, and each group of layers may include a plurality of stacked semiconductor monolayers defining a base semiconductor portion and at least one non-semiconductor monolayer thereon. | 08-21-2008 |
20100270535 | ELECTRONIC DEVICE INCLUDING AN ELECTRICALLY POLLED SUPERLATTICE AND RELATED METHODS - A method for making an electronic device may include forming a selectively polable superlattice comprising a plurality of stacked groups of layers. Each group of layers of the selectively polable superlattice may include a plurality of stacked semiconductor monolayers defining a semiconductor base portion and at least one non-semiconductor monolayer thereon. The at least one non-semiconductor monolayer may be constrained within a crystal lattice of adjacent silicon portions, and at least some semiconductor atoms from opposing base semiconductor portions may be chemically bound together through the at least one non-semiconductor monolayer therebetween. The method may further include coupling at least one electrode to the selectively polable superlattice for selective poling thereof. | 10-28-2010 |
20110193063 | MULTIPLE-WAVELENGTH OPTO-ELECTRONIC DEVICE INCLUDING A SUPERLATTICE - A multiple-wavelength opto-electronic device may include a substrate and a plurality of active optical devices carried by the substrate and operating at different respective wavelengths. Each optical device may include a superlattice comprising a plurality of stacked groups of layers, and each group of layers may include a plurality of stacked semiconductor monolayers defining a base semiconductor portion and at least one non-semiconductor monolayer thereon. | 08-11-2011 |
Patent application number | Description | Published |
20100055090 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS - The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 03-04-2010 |
20100130465 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS - The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 05-27-2010 |
20110044940 | Thiazole Carboxamide Derivatives and Their Use to Treat Cancer - The present invention relates to novel Heterocyclic Ether or Thioether Derivatives, compositions comprising the Heterocyclic Ether or Thioether Derivatives, and methods for using the Heterocyclic Ether or Thioether Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase. | 02-24-2011 |
20110237575 | INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) - The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below: (I) | 09-29-2011 |
20120328691 | ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase. | 12-27-2012 |
20130096084 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS - The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same. | 04-18-2013 |
20130164259 | 1,4-SUBSTITUTED PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF - The present invention relates to 1,4-Substituted Piperazine Derivatives, compositions comprising one or more 1,4-Substituted Piperazine Derivatives, and methods of using the 1,4-Substituted Piperazine Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. | 06-27-2013 |
Patent application number | Description | Published |
20080230713 | ION SOURCE ARC CHAMBER SEAL - An exemplary ion source for creating a stream of ions has a chamber body that at least partially bounds an ionization region of the arc chamber. The arc chamber body is used with a hot filament arc chamber housing that either directly or indirectly heats a cathode to sufficient temperature to cause electrons to stream through the ionization region of the arc chamber. A seals has a ceramic body having an outer wall that abuts the arc chamber body along a circumferential outer lip. The seal also has one or more radially inner channels bounded by one or more inner walls spaced inwardly from the outer wall. | 09-25-2008 |
20080265866 | METHOD AND SYSTEM FOR ION BEAM PROFILING - One embodiment of the invention relates to an apparatus for profiling an ion beam. The apparatus includes a current measuring device having a measurement region, wherein a cross-sectional area of the ion beam enters the measurement region. The apparatus also includes a controller configured to periodically take beam current measurements of the ion beam and to determine a two dimensional profile of the ion beam by relating the beam current measurements to sub-regions within the current measuring device. Other apparatus and methods are also disclosed. | 10-30-2008 |
20090236547 | EXTRACTION ELECTRODE SYSTEM FOR HIGH CURRENT ION IMPLANTER - A system and method extraction electrode system, comprising an extraction electrode, wherein the extraction electrode, further defines an aperture and forms a portion of the outside wall of the ion source and is configured to extract ions from the ion source, a suppression disk half assembly comprising two suppression electrode plate disk halves that form a variable suppression aperture, a ground disk half assembly comprising two ground electrode plate disk halves that form an variable ground aperture, wherein the suppression disk half assembly is configured between the extraction electrode and the ground disk half assembly, wherein the suppression aperture and the ground aperture variable in the direction perpendicular to the ion beam direction of travel, and wherein the extraction electrode system is used with a pendulum reciprocating drive apparatus. | 09-24-2009 |
20090267001 | LOW CONTAMINATION, LOW ENERGY BEAMLINE ARCHITECTURE FOR HIGH CURRENT ION IMPLANTATION - An ion implantation system comprising an ion source that generates an ion beam along a beam path, a mass analyzer component downstream of the ion source that performs mass analysis and angle correction on the ion beam, a resolving aperture electrode comprising at least one electrode downstream of the mass analyzer component and along the beam path having a size and shape according to a selected mass resolution and a beam envelope, a deflection element downstream of the resolving aperture electrode that changes the path of the ion beam exiting the deflection element, a deceleration electrode downstream of the deflection element that decelerates the ion beam, a support platform within an end station for retaining and positioning a workpiece which is implanted with charged ions, and wherein the end station is mounted approximately eight degrees counterclockwise so that the deflected ion beam is perpendicular to the workpiece. | 10-29-2009 |
20100243879 | High mass resolution low aberration analyzer magnet for ribbon beams and the system for ribbon beam ion implanter - The present invention provides a mass analyzing magnet which can bend a very wide charged particle ribbon beams through angles between 90 to 200 degrees. The shorter dimension of the ribbon beam is aligned with the magnetic field. The magnet can focus the longer dimension of the ribbon beam through a resolving slot inside the magnet for mass or momentum analysis. The magnet pole is shaped to increase the mass resolving power and to provide the focusing force in the direction of the shorter dimension of the ribbon beam. This magnet can achieve high mass resolving power with very small system aberrations for very wide ribbon beam. This feature is of significant value, for example, in the ion implantation industry. The ribbon beam width can be 300 mm, 450 mm and even 1000 mm. Integrated with the present invention, the ion implanter systems can be built to provide mass analyzed ribbon beams for various applications. The system will have much lower cost and much better ribbon beam quality than the ion implanters which are using conventional mass analyzing magnet. | 09-30-2010 |
Patent application number | Description | Published |
20100089117 | METHOD OF CALIBRATING A WAVELENGTH-MODULATION SPECTROSCOPY APPARATUS - Several methods of calibrating a wavelength-modulation spectroscopy apparatus configured to measure a concentration of an analyte in a sample gas are disclosed. Each of the methods allows for calibration and recalibration using a relatively safe gas regardless of whether the sample gas for which the concentration of the analyte can be determined is a hazardous gas. In one embodiment of the invention, calibration that is sample-gas specific is accomplished by determining a first slope coefficient and calibration function for the sample gas, after which a scaling factor can be determined based on the first slope coefficient and a second slope coefficient for the same or a different sample gas and used in a subsequent calibration (or recalibration) to scale the calibration function. In other embodiments of the invention, calibration that is not sample-gas specific is accomplished to allow for the determination of the analyte concentration in variable gas compositions and constant gas compositions. | 04-15-2010 |
20100091278 | WAVELENGTH-MODULATION SPECTROSCOPY METHOD AND APPARATUS - In one embodiment of the spectroscopy method, the method comprises the steps of modulating the wavelength of a monochromatic radiation at a modulation amplitude and a modulation frequency; determining a first variable representative of an absorbance of an analyte in a sample; and demodulating by phase-sensitive detection the first variable at a harmonic of the modulation frequency to produce a harmonic spectrum of the analyte. In one embodiment of the spectroscopy apparatus, the apparatus comprises a laser diode integrated with a first photodetector configured to detect an intensity of a backward emission from the laser diode and act as a reference detector; a second photodetector configured to detect an intensity of laser radiation exiting a sample; and electronic circuitry coupled to the laser diode and the photodetectors, configured to acquire and process spectra of the sample. In another embodiment, the spectroscopy apparatus comprises a beam splitter configured to split the laser radiation into a first radiation portion and a second radiation portion and a first photodetector configured to detect the intensity of the first radiation portion. | 04-15-2010 |
20110181876 | METHOD OF CALIBRATING A WAVELENGTH-MODULATION SPECTROSCOPY APPARATUS - Several methods of calibrating a wavelength-modulation spectroscopy apparatus configured to measure a concentration of an analyte in a sample gas are disclosed. Each of the methods allows for calibration and recalibration using a relatively safe gas regardless of whether the sample gas for which the concentration of the analyte can be determined is a hazardous gas. In one embodiment of the invention, calibration that is sample-gas specific is accomplished by determining a first slope coefficient and calibration function for the sample gas, after which a scaling factor can be determined based on the first slope coefficient and a second slope coefficient for the same or a different sample gas and used in a subsequent calibration (or recalibration) to scale the calibration function. In other embodiments of the invention, calibration that is not sample-gas specific is accomplished to allow for the determination of the analyte concentration in variable gas compositions and constant gas compositions. | 07-28-2011 |
20110181877 | METHOD OF CALIBRATING A WAVELENGTH-MODULATION SPECTROSCOPY APPARATUS - Several methods of calibrating a wavelength-modulation spectroscopy apparatus configured to measure a concentration of an analyte in a sample gas are disclosed. Each of the methods allows for calibration and recalibration using a relatively safe gas regardless of whether the sample gas for which the concentration of the analyte can be determined is a hazardous gas. In one embodiment of the invention, calibration that is sample-gas specific is, accomplished by determining a first slope coefficient and calibration function for the sample gas, after which a scaling factor can be determined based on the first slope coefficient and a second slope coefficient for the same or a different sample gas and used in a subsequent calibration (or recalibration) to scale the calibration function. In other embodiments of the invention, calibration that is not sample-gas specific is accomplished to allow for the determination of the analyte concentration in variable gas compositions and constant gas compositions. | 07-28-2011 |
Patent application number | Description | Published |
20090275142 | COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY - The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes. | 11-05-2009 |
20100159446 | Detection Assays and Use Thereof - The invention provides compositions and methods for the detection and/or quantification of biological targets (e.g., nucleic acids and proteins) by the nucleic acid-templated creation of one or more reaction products, for example, epitopes, enzyme substrates, enzyme activators, and ligands. The reaction products can be detected and/or quantitated after signal amplification using an amplification system. | 06-24-2010 |
20100159455 | RECEPTOR FAMILY PROFILING - The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics. | 06-24-2010 |
20110059458 | COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY - The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications. | 03-10-2011 |
20130084561 | BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY - The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals. | 04-04-2013 |