Patent application number | Description | Published |
20100100582 | SYSTEM AND METHOD FOR SERVER INITIATION BEACON - A method and system for a server-client communication in a network, is provided. The method includes, at a server: (1) requesting a client to establish an initial connection for discovery, including: generating a discovery beacon for requesting the initial connection, and transmitting the discovery beacon in the network; and (2) requesting the discovered client to establish a further connection for updates, including: generating at least one of an update beacon for requesting the further connection and an event for triggering the further connection, and transmitting the at lease one of the update beacon and the event in the network. The method includes, at a client: for discovery, detecting a discovery beacon from a server for establishing an initial connection, and establishing the initial connection, and for updates, detecting at least one of an update beacon from the server for establishing a further connection and an event for establishing the further connection, and establishing the further connection. A server system includes: an invitation unit for generating and transmitting a discovery beacon for discovering a new client in a network, and generating and transmitting at least one of an update beacon and an event for updating the discovered client in the network; and an administration unit for administering the discovered client, including at least one of: assigning the discovered client to a group; and assigning the server to the client to allow the client to respond to the discovery and update beacons from the assigned server. A client system includes: a beacon client for detecting an invitation beacon from a server, the invitation beacon including a discovery beacon for discovery and an update beacon for updates; an event identifier for detecting an event for the updates; a primary connection client for establishing an initial connection in response to the discovery beacon and establishing a further connection in response to at least one of the update beacon and the event. | 04-22-2010 |
20110265078 | METHOD AND SYSTEM FOR DEVICE CONFIGURATION AND CUSTOMIZATION DURING MANUFACTURING PROCESS - A method and a system for customizing a handheld device being produced in manufacturing assembly. The method provides customization via configuration of the device by a server in a communication network. In response to a configuration predefined such via a customer purchase order, assigning, at the server, a group to the at least one handheld device, identifying, at the server, a configuration of components for download to the at least one handheld device, the configuration of components associated with the assigned group, and downloading, for installation at the handheld device, the configuration of components to the at least one handheld device of the assigned group. | 10-27-2011 |
Patent application number | Description | Published |
20100035248 | SURFACE-BASED NUCLEIC ACID ASSAYS EMPLOYING MORPHOLINOS - The sequence determination, detection, and quantification of nucleic acid molecules through sequence-specific binding (hybridization) on a solid support, specifically when Morpholinos are used as the surface-immobilized probe species in surface-based nucleic acid assays, and the assays as disclosed herein. | 02-11-2010 |
20100187133 | CAPACITIVE MORPHOLINO DIAGNOSTICS FOR ANALYSIS OF NUCLEIC ACIDS - Surface hybridization, a reaction in which nucleic acid molecules in solution react with nucleic acid partners immobilized on a surface, is widely practiced in life science research. In these applications the immobilized partner, or “probe”, is typically single-stranded DNA. Because DNA is strongly charged, high salt conditions are required to enable binding between analyte nucleic acids (“targets”) in solution and the DNA probes. High salt, however, compromises prospects for label-free monitoring or control of the hybridization reaction through surface electric fields, as well as stabilizes secondary structure in target species that can interfere with probe-target recognition. In this work, initial steps toward addressing these challenges are taken by introducing Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports can be fabricated with methods similar to those employed with DNA, and are shown to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Interestingly, positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm | 07-29-2010 |
20120211375 | CAPACITIVE MORPHOLINO DIAGNOSTICS FOR ANALYSIS OF NUCLEIC ACIDS - Use of Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports are fabricated with methods similar to those employed with DNA, and are used to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm | 08-23-2012 |
20120295805 | SOLID PHASE METHODS FOR THERMODYNAMIC AND KINETIC QUANTIFICATION OF INTERACTIONS BETWEEN NUCLEIC ACIDS AND SMALL MOLECULES - Methods for analysis of interactions between nucleic acid-binding agents (BAs) and nucleic acids (NAs) by performance of nucleic acid denaturation assays on solid supports. Typically, BA is a small molecule less than 1000 g/gmol in molecular weight. The methods provide quantitative thermodynamic and kinetic analysis of BA-NA interaction; for example, in the form of free energies, enthalpies, and entropies of BA-NA binding in case of thermodynamic analysis, or in the form of rate constants and activation energies of BA-NA binding in the case of kinetic analysis. Examples of BAs of interest include transcription regulators and other NA-recognition molecules such as dyes and drug potentiators, DNA-targeted therapeutic agents including anticancer, antibiotic, antiviral, and antitrypanosomal compounds, carcinogens, and any other molecules whose interaction with DNA may, or is suspected to, lead to a biologically-relevant consequence. BA may bind to NA either through physical interactions or through formation of covalent adducts. | 11-22-2012 |