Spira
Avrum Spira, Newton, MA US
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20090061454 | DIAGNOSTIC AND PROGNOSTIC METHODS FOR LUNG DISORDERS USING GENE EXPRESSION PROFILES FROM NOSE EPITHELIAL CELLS - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer. | 03-05-2009 |
20090186951 | IDENTIFICATION OF NOVEL PATHWAYS FOR DRUG DEVELOPMENT FOR LUNG DISEASE - The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene expression patterns (biomarkers) associated with pathway activation. These biomarkers and pathways may provide prognostic and/or diagnostic indicators in lung disease, e.g., lung cancer. Additionally, these pathways and biomarkers may provide therapeutic targets for the treatment of lung disease, as well as markers for the assessment of treatment efficacy. | 07-23-2009 |
20090311692 | ISOLATION OF NUCLEIC ACID FROM MOUTH EPITHELIAL CELLS - The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk associated with airway pollutants. | 12-17-2009 |
20100055689 | MULTIFACTORIAL METHODS FOR DETECTING LUNG DISORDERS - Described herein are multifactorial methods for detecting, diagnosing or aiding in the diagnosis of lung disorders or disease, e.g., lung cancer. The methods disclosed utilize multiple diagnostic paradigms, for example, to improve diagnostic sensitivity, specificity, negative predictive value and/or positive predictive value over each of the paradigms alone. For example, a clinicogenomic model is disclosed for lung cancer diagnosis which combines clinical factors and gene expression, particularly a sensitive and specific gene expression biomarker. | 03-04-2010 |
20110190150 | ISOLATION OF NUCLEIC ACID FROM MOUTH EPITHELIAL CELLS - The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk associated with airway pollutants. | 08-04-2011 |
20110217717 | DIAGNOSTIC AND PROGNOSTIC METHODS FOR LUNG DISORDERS USING GENE EXPRESSION PROFILES FROM NOSE EPITHELIAL CELLS - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer. | 09-08-2011 |
20120041686 | DIAGNOSTIC FOR LUNG DISORDERS USING CLASS PREDICTION - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, particularly in individuals who are exposed to air pollutants, such as cigarette or cigar smoke, smog, asbestos and the like air contaminants or pollutants. | 02-16-2012 |
20120190567 | DIAGNOSTIC AND PROGNOSTIC METHODS FOR LUNG DISORDERS USING GENE EXPRESSION PROFILES FROM NOSE EPITHELIAL CELLS - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer. | 07-26-2012 |
20120322673 | ISOLATION OF NUCLEIC ACID FROM MOUTH EPITHELIAL CELLS - The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk associated with airway pollutants. | 12-20-2012 |
20130023437 | DIAGNOSTIC FOR LUNG DISORDERS USING CLASS PREDICTION - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, particularly in individuals who are exposed to air pollutants, such as cigarette or cigar smoke, smog, asbestos and the like air contaminants or pollutants. | 01-24-2013 |
20140199411 | THERAPEUTIC AGENT FOR EMPHYSEMA AND COPD - The invention described herein relates to methods of treating emphysema and COPD with a GHK tripeptide. The invention further relates to methods of determining the state of the lungs using biomarkers described herein. | 07-17-2014 |
Avrum Spira, Boston, MA US
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20100035244 | Diagnostic for lung disorders using class prediction - The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, particularly in individuals who are exposed to air pollutants, such as cigarette or cigar smoke, smog, asbestos and the like air contaminants or pollutants. | 02-11-2010 |
Brian Spira, Edmonton CA
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20100285678 | MULTIPURPOSE CABLE CONNECTOR - A cable connector assembly comprising an insulating block defining a plurality of cable receiving channels therein. Each cable receiving channel has an entrance at a periphery of the insulating block. A plurality of ground connectors are coupled to the insulating block and positioned such that a ground connector is located proximate to the entrance of each cable receiving channel. Each ground connector comprises a U-shaped member for engaging a ground braid of a heating cable and a grounding screw for engaging a ground wire of a power cable. A ground linking structure electrically connects the plurality of ground connectors. A plurality of first and second wire connectors are adjustably coupled to the insulating block and positioned such that a first wire connector is selectively extendible into a first side of each cable receiving channel and a second wire connector is positioned to selectively extend into a second side of each cable receiving channel. First and second wire linking structures electrically connect the plurality of first wire connectors and the plurality of second wire connectors, respectively. The first and second wire linking structures may comprise leaf springs. | 11-11-2010 |
20120037419 | CABLE TERMINATION APPARATUS AND RELATED METHODS - In one embodiment, the termination apparatus provides a means for terminating certain elongate heat tracing products that have corrugated metal sheaths as outer covering for those elongate heaters. The heat tracing products may include oval corrugated metal sheaths as outer covering. Terminating other types of cables, including cables which provide electrical power or electromagnetic signals, is also contemplated. | 02-16-2012 |
Daniel Spira, Beaconsfield CA
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20140207429 | METHODS OF DEVELOPING A MATHEMATICAL MODEL OF DYNAMICS OF A VEHICLE FOR USE IN A COMPUTER-CONTROLLED VEHICLE SIMULATOR - A method of developing a mathematical model of dynamics of a vehicle for use in a computer-controlled simulation, comprising: selecting a coefficient of a state-space model mathematically modelling the dynamics of the vehicle, the selected coefficient having a value for a predetermined state of the vehicle; and varying, a parameter of a physically-based computerized model mathematically modelling the dynamics of the vehicle, the parameter related to at least one of physical characteristics of the vehicle and phenomena influencing the dynamics of the vehicle, to improve the accuracy of the physically-based model via computer-implemented numerical optimization, the computer-implemented numerical optimization targeting the coefficient of the state-space model such that the difference between a value predicted by the physically-based model and the value of the coefficient of the state-space model for the predetermined vehicle state is within a predetermined range. | 07-24-2014 |
Jack Spira, Tyreso SE
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20140128462 | LYOPHILIZED PREPARATION OF CYTOTOXIC DIPEPTIDES - The present invention is directed to novel lyophilized pharmaceutical preparations comprising a cytotoxic dipeptides such as melphalan flufenamide and one or more excipient(s) selected from the group comprising a polysorbate; a polyethylene glycol; β-cyclodextrin; ocyclodextrin; hydroxypropyl-β-cyclodextrin; sulfobutylether-β-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; Dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and an amino acid. This preparation may be further formulated and is useful in cancer therapy. | 05-08-2014 |
James Spira, Honolulu, HI US
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20130209977 | Performance Assessment Tool - Embodiments of the invention relate to cognitive performance and/or psychological assessment of a subject. Measurement of behavioral status and cognitive efficiency is based upon batteries of tests that include a combination of cognitive and/or psychological tests. A module is provided with a processing unit in communication with memory to administer the cognitive and/or psychological tests and to compute an assessment. Results of the assessment are conveyed on a visual display of the module. In some cases, additional sensor data may be added to the assessment. | 08-15-2013 |
Joel J. Spira, Coopersburg, PA US
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20080229226 | SYSTEM AND METHOD FOR GRAPHICALLY DISPLAYING ENERGY CONSUMPTION AND SAVINGS - A system for displaying an electronic representation of the consumption of a resource by a device comprises a communication network, a database, and visual display. The database is accessible by an information processor of the network and stores information including a maximum rated amount of the resource consumed by the at least one device and the actual amount of the resource consumed by the at least one device. The visual display provides an electronic representation of the resource, the amount of the resource consumed by the at least one device and the amount of the resource saved as a function of the electronic device information, wherein the visual display presents the electronic representation in a graphical format. The graphical format of the electronic representation is a graph formatted with a range of values and an indicator of an indicated value in the range. The range of values is operable to dynamically change when the consumption of the resource by the at least one device exceeds the maximum rated amount of the resource consumed by the at least one device. | 09-18-2008 |
Micha Spira, Jerusalem IL
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20140171774 | BIOMOLECULAR ELECTRONIC DEVICE AND PROCESS OF USE - Provided is a biological membrane including at least one ring-like polypeptide, where the at least one of the ring-like polypeptide is not a membrane protein, a surface being associated with at least one ring-like polypeptide capable of integration into a cell membrane, an electrode including said surface and electronically and biomedical devices including the electrodes for recording and stimulating cell activity. | 06-19-2014 |