Patent application number | Description | Published |
20100034799 | ANTI-COCAINE COMPOSITIONS AND TREATMENT - Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides. | 02-11-2010 |
20100204258 | METHODS AND COMPOSITIONS FOR MODULATING INSULIN SECRETION AND GLUCOSE METABOLISM - The present invention relates to methods and compositions for treating or ameliorating the effects of diabetes. In addition, the present invention relates to methods and compositions for treating or preventing hyperglycemia, as well as modulating monoamine levels, islet β-cell insulin secretion, insulin and/or glucagon levels in a patient. In certain preferred embodiments, such methods include administering to a patient an effective amount of a vesicular monoamine transporter type 2 (VMAT2) antagonist, such as tetrabenazine (TBZ), dihydrotetrabenazine (DTBZ), tetrahydroberberine (THB), reserpine, emetine, Compound 6, or enantiomers, optical isomers, diastereomers, N-oxides, crystalline forms, hydrates, metabolites or pharmaceutically acceptable salts thereof. | 08-12-2010 |
20110118300 | GLUCOSE METABOLISM MODULATING COMPOUNDS - The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyper-glycemia. | 05-19-2011 |
20110152220 | METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES - The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists. | 06-23-2011 |
20110281899 | METHODS OF PREVENTING AND TREATING LOW BONE MASS DISEASES - The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists. | 11-17-2011 |
20130053343 | COMPOUNDS AND METHODS FOR INHIBITING SEROTONIN SYNTHESIS - Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful of, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis. | 02-28-2013 |
20130136728 | ANTI-COCAINE COMPOSITIONS AND TREATMENT - Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides. | 05-30-2013 |
20140024683 | CHLORIDE CHANNEL AND CHLORIDE TRANSPORTER MODULATORS FOR THERAPY IN SMOOTH MUSCLE DISEASES - The present invention provides, inter alia, methods and pharmaceutical compositions for preventing, treating, or ameliorating the effects of a disease characterized by altered smooth muscle contractility, such as e.g., asthma and chronic obstructive pulmonary disease. | 01-23-2014 |
20140121368 | PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES - The invention provides a process for preparing a 2,3,4,5-tetrahydro[1.4]benzothiazepine of formula: | 05-01-2014 |
Patent application number | Description | Published |
20100060807 | MEANS TO ENGAGE ELECTRONIC DISPLAY PANELS TO CONVENTIONAL PICTURE FRAMES - Various techniques for detachably connecting a commercially-available convention picture frame to an electronic display panel, such as one used in a digital picture frame. The electronic display panel includes a display and a bordering housing surrounding the display and having an opening, that in combination with the opening in the conventional picture frame, allow the display to be visible through the openings. The height, width, and thickness of the bordering housing are configured to allow the electronic display panel to be engaged with multiple commercially-available conventional picture frames. | 03-11-2010 |
20100245263 | DIGITAL PICTURE FRAME HAVING NEAR-TOUCH AND TRUE-TOUCH - A digital picture frame includes a near-touch user interface component that senses when an object is within a predetermined spatial region of the digital picture frame; a true-touch user interface component that senses physical contact with the digital picture frame; and a processor that receives input signals from the near-touch user interface component and the true-touch user interface component and executes device controls based on inputs from both user interface components. | 09-30-2010 |
20110173240 | MEDIA COLLECTION MANAGEMENT - A removable storage device ( | 07-14-2011 |
20120075167 | HEAD-MOUNTED DISPLAY WITH WIRELESS CONTROLLER - A head-mounted display apparatus includes a head-mounted display, the head-mounted display including a viewing area that displays information to a user of the head-mounted display and including a display wireless communication circuit for receiving wireless control signals and a controller including a controller wireless communication circuit, wherein the controller controls the information displayed in the head-mounted display by communicating the wireless control signals to the display wireless communication circuit with the controller wireless communication circuit and wherein the controller is physically separate from the head-mounted display. A distance-monitoring circuit in the controller or the head-mounted display monitors the distance between the controller and the head-mounted display and, when the distance between the controller and the head-mounted display is greater than a pre-determined distance, initiating a range signal to the user. | 03-29-2012 |
20120124517 | IMAGE DISPLAY DEVICE PROVIDING IMPROVED MEDIA SELECTION - A digital image display device for displaying a collection of digital media assets, comprising a display screen; a processor; a network connection for receiving digital media assets provided by a plurality of individuals; an image memory for storing the received digital media assets together with associated metadata; and a user interface. A program memory stores instructions for causing the processor to execute the steps of: displaying identifiers on the display screen for a plurality of individuals who have provided digital media assets; receiving input from a user of the digital image display device identifying a particular individual; selecting digital media assets provided by the identified individual responsive to the metadata; and displaying the selected digital media assets on the display screen. | 05-17-2012 |
20120127196 | DIGITAL IMAGE DISPLAY DEVICE WITH AUTOMATICALLY ADJUSTED IMAGE DISPLAY DURATIONS - A digital image display device for displaying a collection of digital images, comprising: a display screen; a processor; a real-time clock; an image memory for storing a plurality of digital images; and a processor-accessible program memory. The program memory stores executable instructions for causing the processor to execute the steps of: initiating a sequential display of a sequence of digital images on the display screen at an initial time, the sequence of digital images including at least a subset of the stored digital images, each digital image being displayed for an image display duration, the image display duration being set to an initial image display duration at the initial time; and modifying the image display duration during the display of the sequence of digital images. | 05-24-2012 |
20120130834 | METHOD FOR REMOTELY CONFIGURING A DIGITAL IMAGE DISPLAY DEVICE - A method for providing specified digital image content to a digital image display device, the digital image display device being adapted to receive digital image content from a network, comprising: providing a unique device identifier for the digital image display device, the unique device identifier to be made available to a purchaser of the image display device without requiring the purchaser to have physical access to the digital image display device; enabling a content supplier to specify digital image content to be transferred over the network to the digital image display device associated with the unique device identifier; detecting when the digital image display device is connected to the network by receiving at a network server connected to the network an indication of the unique device identifier from the digital image display device; and transferring the specified digital image content to the detected digital image display device over the network. | 05-24-2012 |
20120130845 | DIGITAL IMAGE DISPLAY DEVICE WITH REMOTELY DISABLEABLE USER INTERFACE - A digital image display device for displaying a collection of digital images, comprising: a display screen; a processor; a user interface including one or more user interface elements for enabling a user to control the behavior of the digital image display device; a network interface for communicating with a network; an image memory for storing digital images; and a processor-accessible program memory. The program memory stores executable instructions for causing the processor to execute the steps of: receiving user interface control information from a network server via the network interface; disabling at least a portion of the user interface elements responsive to the received user interface control information to selectively disabled at least a portion of the user interface elements of the digital image display device; and displaying stored digital images on the display screen. | 05-24-2012 |
20120131359 | DIGITAL IMAGE DISPLAY DEVICE WITH REDUCED POWER MODE - A digital image display device for displaying a collection of digital images, comprising: a display screen; a processor; a power control circuit for enabling an active display mode for displaying digital images on the display screen and a reduced power mode wherein the display screen does not display digital images; a network interface for communicating with a network; an image memory for storing digital images; and a processor-accessible program memory. The program memory stores executable instructions for causing the processor to execute the steps of: receiving one or more digital images from a network server using the network interface; storing the received digital images in the image memory; if the power control circuit is in the reduced power mode when the digital images are received setting it to operate in the active display mode; and displaying the stored received digital images on the display screen. | 05-24-2012 |
20120131465 | DIGITAL IMAGE DISPLAY DEVICE WITH REMOTE VIEWING INTERFACE - A method for remotely viewing digital images provided to a digital image display device, the digital image display device including an image memory for storing a plurality of digital images, a display screen, and a network interface for communicating with a network, the method comprising: providing a remote viewing interface for the digital image display device, the remote viewing interface being accessible over the network from a location remote from the digital image display device; displaying one of the plurality of stored digital images on the display screen; and simultaneously displaying, on the remote viewing interface, information indicating which of the plurality of stored digital images is currently displayed on the display screen. | 05-24-2012 |
20120150870 | IMAGE DISPLAY DEVICE CONTROLLED RESPONSIVE TO SHARING BREADTH - A digital image display device for displaying a collection of digital media assets, comprising: a display screen; a processor; a network connection for communicating with a network; an image memory; and a processor-accessible program memory. The processor-accessible memory stores executable instructions for causing the processor to execute the steps of: receiving a plurality of digital media assets using one or more different origins; determining an importance value for each of the received digital media assets responsive to an associated sharing breadth; and performing an operation using at least one of the received digital media assets responsive to the determined importance value. | 06-14-2012 |
20130208109 | WIRELESS SECURITY CAMERA SYSTEM - A security camera system, comprising wireless communication components for communicating over first and second wireless communications, and a digital camera system. A data processing system implements a method for providing digital images to an image receiving system. The method includes: establishing a first wireless connection between the security camera system and an external electronic device using the first wireless communication system. Configuration information pertaining to the second wireless communication system is transmitted from the security camera system to the external electronic device using the first wireless connection. Instructions for configuring the security camera system to communicate using the second wireless communication system are transmitted by the external electronic device to the security camera system over the first wireless connection. Captured digital images are then transmitted to the image receiving system over the second wireless communication system. | 08-15-2013 |
Patent application number | Description | Published |
20090040771 | Thin light guiding plate and methods of manufacturing - The present invention provides a composite light guiding plate comprising a light guiding layer comprising an incident face for receiving light from at least one light source, a light guiding output surface that is also generally orthogonal to the incident face, a featured surface, opposite the light-guiding output surface and generally orthogonal to the input face for redirecting light through the light guiding output surface. Further, the featured surface comprises a plurality of rows of linear prismatic structures extended in a length direction that is substantially perpendicular to the incident face and having height and width dimensions of 10 to 200 microns and wherein the length-to-width aspect ratio of the linear prismatic structures is greater than 100:1 the thickness of the light guiding layer is less than 1 mm. Further, the plate is formed from polymeric materials comprising polyesters, amorphous polyesters, polyarylates, polycarbonates, polyamides, polyether-amides, polyamide-imides, polyimides, polyetherimides, cyclic olefin polymers, impact-modified polymethacrylates, polyacrylates, polyacrylonitrile, polystyrenes, polyethers, cellulosics, sulfur-containing polymers and blends or alloys of two or more polymers or copolymers thereof. Additionally, the plate comprises a light extraction layer comprising an input surface having a plurality of protruding light extraction features that have tips that are bonded to the light-guiding output surface of the light guiding layer and provide optical contact between the light guiding and light extraction layers and an illumination output surface for providing light output from the composite illumination plate. Further, the thickness of the light extraction layer is less than 1 mm and wherein one or more channels of air or other gas are sandwiched between the light guiding layer and the light extraction layer. | 02-12-2009 |
20100075069 | Multifunction light redirecting films - The present invention provides a multifunction light redirecting film for a liquid crystal display comprising at least one base thermoplastic polymer optical layer having a top surface with a plurality of optical features. The film further provides at least one co-extrudable surface thermoplastic polymer optical layer adjacent the base thermoplastic polymer optical layer, wherein the at least one co-extrudable surface has a pencil hardness of at least 1 H. | 03-25-2010 |
20110095442 | THIN LIGHT GUIDING PLATE AND METHODS OF MANUFACTURING - The present invention provides a composite light guiding plate comprising a light guiding layer comprising an incident face for receiving light from at least one light source, a light guiding output surface that is also generally orthogonal to the incident face, a featured surface, opposite the light-guiding output surface and generally orthogonal to the input face for redirecting light through the light guiding output surface. Further, the featured surface comprises a plurality of rows of linear prismatic structures extended in a length direction that is substantially perpendicular to the incident face and having height and width dimensions of 10 to 200 microns and wherein the length-to-width aspect ratio of the linear prismatic structures is greater than 100:1 the thickness of the light guiding layer is less than 1 mm. Further, the plate is formed from polymeric materials comprising polyesters, amorphous polyesters, polyarylates, polycarbonates, polyamides, polyether-amides, polyamide-imides, polyimides, polyetherimides, cyclic olefin polymers, impact-modified polymethacrylates, polyacrylates, polyacrylonitrile, polystyrenes, polyethers, cellulosics, sulfur-containing polymers and blends or alloys of two or more polymers or copolymers thereof. Additionally, the plate comprises a light extraction layer comprising an input surface having a plurality of protruding light extraction features that have tips that are bonded to the light-guiding output surface of the light guiding layer and provide optical contact between the light guiding and light extraction layers and an illumination output surface for providing light output from the composite illumination plate. Further, the thickness of the light extraction layer is less than 1 mm and wherein one or more channels of air or other gas are sandwiched between the light guiding layer and the light extraction layer. | 04-28-2011 |
20110242847 | LAMINATED DOUBLE-SIDED LIGHT GUIDE PLATE - The present invention provides a light guide plate having an input surface for receiving light from a light source, a micro-patterned output surface for emitting light, and a micro-patterned bottom surface opposing to the output surface, made in steps comprising: extruding a first resin into the nip between a first pressure roller and a first patterned roller to form a first layer. Extruding a second resin into the nip between a second pressure roller and a second patterned roller to form a second layer. Laminating the first layer and the second layer at their unpatterned surfaces to form an optical sheet comprising a plurality of light guide plate patterns, and cutting and finishing the optical sheet into a plurality of double-sided light guide plates having the specified length and width dimensions. | 10-06-2011 |
20110242848 | PRINTED DOUBLE-SIDED LIGHT GUIDE PLATE - The present invention provides a light guide plate having an input surface for receiving light from a light source, a micro-patterned output surface for emitting light, and a micro-patterned bottom surface opposing to the output surface, made in steps comprising: extruding a resin into the nip between a pressure roller and a patterned roller to form a layer at a patterned roller surface temperature T1 and a nip pressure P1, the layer having an un-patterned surface and a patterned surface, the patterned surface having a pattern transferred from the patterned roller. Printing a discrete pattern on the un-patterned surface of the layer to form an optical sheet comprising a plurality of light guide plate patterns, and cutting and finishing the said optical sheet into a plurality of double-sided light guide plates having the specified length and width dimensions. | 10-06-2011 |
20110242849 | THIN DOUBLE-SIDED LIGHT GUIDE PLATE - The present invention provides a light guide plate having an input surface for receiving light from a light source, a micro-patterned output surface for emitting light, and a micro-patterned bottom surface opposing to the output surface, made in steps comprising: extruding a first resin into the nip between a first pressure roller and a first patterned roller to form a first layer. Extruding a second resin into the nip between a second pressure roller and a second patterned roller and onto the unpatterned surface of the first layer to form a second layer. The second layer having a pattern transferred from the second patterned roller; the combined first and second layers form an optical sheet comprising a plurality of light guide plate patterns and cutting and finishing the optical sheet into a plurality of double-sided light guide plates having the specified length and width dimensions. | 10-06-2011 |
20110242850 | DOUBLE-SIDED LIGHT GUIDE PLATE MANUFACTURED WITH MICRO-PATTERNED CARRIER - The present invention provides a light guide plate having an input surface for receiving light from a light source, a micro-patterned output surface for emitting light, and a micro-patterned bottom surface opposing to the output surface, made in steps comprising: extruding a resin into the nip between a patterned roller and a patterned carrier film at a nip pressure P | 10-06-2011 |
20110242851 | DOUBLE-SIDED LIGHT GUIDE PLATE MANUFACTURED WITH PATTERNED ROLLERS - The present invention provides a light guide plate having an input surface for receiving light from a light source, a micro-patterned output surface for emitting light, and a micro-patterned bottom surface opposing to the output surface. The invention provides extruding a resin into the nip between a first patterned roller and a second patterned roller at a first patterned roller surface temperature T | 10-06-2011 |
20130277870 | METHOD OF MANUFACTURING A NANO-LAYERED LIGHT GUIDE PLATE - The present invention provides a method of manufacturing a nano-layered light guide plate comprising, forming by a coextrusion method a multi-layered molten sheet comprising a plurality of two or more different alternating material layers and casting the coextruded sheet into a nip between a pressure roller and a pattern roller to form a nano-layered sheet having a discrete micro-pattern on at least one principal surface thereof. In addition, the invention further provides cutting and finishing the extruded micro-patterned sheet to form the nano-layered light guide plate, comprising a plurality of two or more different alternating material layers, with each layer having a thickness of less than a quarter wavelength of visible light. | 10-24-2013 |
20130279196 | NANO-LAYERED LIGHT GUIDE PLATE - The present invention provides a nano-layered light guide plate comprising a light input surface for receiving light from at least one light source, a bottom surface comprising a plurality of discrete surface features for extracting the received light and a light output surface for emitting the extracted light, the light guide plate further comprising a plurality of two or more different alternating layers wherein the layers have a thickness less than a quarter wavelength of visible light. | 10-24-2013 |
20140092632 | COMPOSITE LIGHT GUIDE PLATE - The present invention provides a composite light guide plate having a thickness of more than about 1 mm, for use in LCD backlights or in general illumination devices. In the fabrication method of the present invention the extrusion roll molding process is combined with coating and lamination steps to enable a cost effective roll-to-roll or roll-to-sheet manufacture of the thick composite light guide plate wherein one or both principal surfaces of the light guide plate contain a pattern to enable extraction and redirection of light by the light guide plate from a light source or multiple light sources placed at one or multiple edges of the light guide plate. The composite light guide plate comprises a patterned film and a pre-cut sheet joined together by an adhesive layer. In order to attain good light extraction efficiency the adhesive layer and the two constituent layers of the light guide plate must be optically matched such that the refractive indices of any two of the three materials of the composite light guide plate can differ by no more than 0.01. | 04-03-2014 |
20140093650 | METHOD OF MANUFACTURING A COMPOSITE LIGHT GUIDE - The present invention provides an extrusion casting method for making composite light guide plates with a thickness of more than about 1 mm, for use in LCD backlights or in general illumination devices. In the fabrication method of the present invention the extrusion roll molding process is combined with coating and lamination steps to enable a cost effective roll-to-roll or roll-to-sheet manufacture of thick composite light guide plates wherein one or both principal surfaces of the light guide plate contain a pattern to enable extraction and redirection of light by the light guide plate from a light source or multiple light sources placed at one or multiple edges of the light guide plate. The composite light guide plate comprises a patterned film and a pre-cut sheet joined together by an adhesive layer. In order to attain good light extraction efficiency the adhesive layer and the two constituent layers of the light guide plate must be optically matched such that the refractive indices of any two of the three materials of the composite light guide plate can differ by no more than 0.01. | 04-03-2014 |