Patent application number | Description | Published |
20080234622 | Methods and Systems for Preparing Blood Products - The present invention is related to pre-connected disposable sets including a pre-connected bag containing a photosensitizer for use in a blood separation and pathogen inactivation procedure. | 09-25-2008 |
20080299538 | Pathogen Inactivation of Whole Blood - This invention is directed toward a method of pathogen inactivating whole blood. The steps include collecting whole blood from a donor into a bag; illuminating the whole blood with light at a sufficient energy so that an alloxazine photosensitizer present in the whole blood may be photolyzed to inactivate any pathogens which may be present in the whole blood; and storing the pathogen inactivated whole blood. The invention also includes a method of separating the pathogen inactivated whole blood into components. | 12-04-2008 |
20090010806 | Apparatus for Photo Reduction of Contaminants in Blood and Blood Products with Calibration Means - An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. A control circuit uses the measurements to control the delivery of an effective dose of illumination to blood or blood products in a bag or container. One or more light integrating optical chambers in the radiometer allow a single light sensor to sense light across an entire field. Thermistors in the irradiating apparatus or the radiometer or both sense the temperature of photo sensors. The control circuit compensates for temperature-dependant variations in the output of the photo sensors. | 01-08-2009 |
20090317296 | Clamp Assembly for Displacing Fluid from Portions of Fluid Containers - Clamps and methods are disclosed for clamping portions of fluid containers and displacing fluid from portions of fluid containers. In one embodiment, a clamp has a first jaw having a photopermeable main body portion and a second jaw. The first and second jaws are operatively associated so that at least one jaw, or both jaws, may be moved between clamped and released positions. The clamp is sized to receive a portion of a fluid container and displace fluid in the fluid container from a clamped region of the fluid container when the first and/or second jaw(s) are in the clamped position. The photopermeable main body portion(s) of the first and/or second jaw(s) allow some light to reach the clamped region of the fluid container during photoradiation to inactivate pathogens in the fluid. Various clamp embodiments and assemblies having lock members and interlocks are also disclosed herein. | 12-24-2009 |
20100189597 | Methods and Systems for Preparing Blood Products - The present invention is related to pre-connected disposable sets including a pre-connected bag containing a photosensitizer for use in a blood separation and pathogen inactivation procedure. | 07-29-2010 |
20100282980 | Stable Calibration Means for Apparatus for Photo Reduction of Contaminants in Blood - An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. The light chambers have an aluminum reflecting surface prepared by machining, grit blasting, polishing and plasma treatment including plasma cleaning and oxidation. | 11-11-2010 |
20110019182 | Apparatus for Photo Reduction of Contaminants in Blood and Blood Products with Calibration Means - An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. A control circuit uses the measurements to control the delivery of an effective dose of illumination to blood or blood products in a bag or container. One or more light integrating optical chambers in the radiometer allow a single light sensor to sense light across an entire field. Thermistors in the irradiating apparatus or the radiometer or both sense the temperature of photo sensors. The control circuit compensates for temperature-dependant variations in the output of the photo sensors. | 01-27-2011 |
20110220290 | Heat Weld Tubing Connectors - The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same. | 09-15-2011 |
20120015795 | CENTRIFUGE FOR PROCESSING BLOOD AND BLOOD COMPONENTS - The present invention relates generally to the field of extracorporeal blood processing methods and apparatus which are particularly useful in blood component collection, and more specifically, the present invention relates to methods and apparatus for centrifugally separating buffy coat that reduce the surface available for separated buffy coat components to sediment on by varying the radius of the product collection bag. | 01-19-2012 |
20130177476 | Slidable Clamp for Port Isolation - Embodiments described herein generally relate to an apparatus and methods for preventing the recontamination of a pathogen-reduced fluid by pathogens trapped in one or more ports of an inactivation fluid container. Through the use of a slidable clamp positioned in an area of the container immediately adjacent to a port to be isolated, the port may be sealed to prevent any liquid product from entering the port and associated tubing when liquid product is added to the container. The slidable clamp includes a slot, in which the distal end of the slot has a larger width than the proximal end of the slot. The width of the slot at the narrowest, most proximal portion allows for a fluid-tight seal to be created when the slidable clamp is slid into the closed position with respect to the port to be isolated. | 07-11-2013 |
20130264288 | System and Method For Collecting And Treating Plasma Protein Fractions - Method and apparatus for separating plasma from blood in a separation vessel, separating the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma, and adding photosensitizer to the desired plasma proteins for viral inactivation treatment of such proteins. | 10-10-2013 |
Patent application number | Description | Published |
20120010421 | PROCESS FOR SYNTHESIZING BRIDGED CYCLOPENTADIENYL-INDENYL METALLOCENES - The present invention provides methods of making bridged cyclopentadienyl-indenyl metallocene compounds. Generally, these methods can be conducted without the use of a fine purification process such as distillation, chromatography, and crystallization. | 01-12-2012 |
20120232235 | CATALYST COMPOSITIONS CONTAINING TRANSITION METAL COMPLEXES WITH THIOLATE LIGANDS - The present invention discloses catalyst compositions employing transition metal complexes with a thiolate ligand. Methods for making these transition metal complexes and for using such compounds in catalyst compositions for the polymerization of olefins also are provided. | 09-13-2012 |
20120308516 | USE OF METALLOCENE COMPOUNDS FOR CANCER TREATMENT - Metallocene compounds and pharmaceutical compositions containing these metallocene compounds are disclosed and described. Methods of treating cancer employing such metallocene compounds and pharmaceutical compositions also are provided. | 12-06-2012 |
20130059100 | Polymer Compositions Having Improved Barrier Properties - A polymer having a melt index of from about 0.5 g/10 min to about 4.0 g/10 min and a density of equal to or greater than 0.96 g/cc which when formed into a 1-mil film displays a moisture vapor transmission rate ranging from equal to or greater than about 0 to equal to or about 20% greater than X where X=k | 03-07-2013 |
20130059103 | Polymer Compositions Having Improved Barrier Properties - A unimodal polymer having a melt index of from about 0.5 g/10 min to about 4 g/10 min, a density of equal to or greater than about 0.945 g/cc which when formed into a film displays a moisture vapor transmission rate of less than about 0.55 g-mil/100 in | 03-07-2013 |
20130059140 | Multilayer Polymer Films Having Improved Barrier Properties - A multilayer polymer film comprising an outer skin layer, an inner seal layer and at least one core layer disposed between the inner and outer skin layer, wherein the outer skin layers comprises a metallocene-catalyzed ethylene polymer having a density of equal to or greater than about 0.945 g/cc and a melt index equal to or greater than 0.5 g/10 min. A multilayer polymer film comprising a metallocene-catalyzed high-density polyethylene homopolymer skin layer and at least one core layer comprising a high-density polyethylene having a melt index of less than or equal to 2.0 g/10 min. A multilayer polymer film comprising at least a skin layer and a core layer wherein the skin layer comprises a metallocene-catalyzed ethylene polymer provided from a catalyst composition comprising a single metallocene and an activator support. | 03-07-2013 |
20130172497 | CATALYST COMPOSITIONS FOR THE POLYMERIZATION OF OLEFINS - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization of olefins also are provided. | 07-04-2013 |
20130172498 | CATALYST SYSTEMS FOR PRODUCTION OF ALPHA OLEFIN OLIGOMERS AND POLYMERS - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization or oligomerization of alpha olefins also are provided. | 07-04-2013 |
20140094577 | Catalyst Compositions Containing Transition Metal Complexes With Thiolate Ligands - The present invention discloses catalyst compositions employing transition metal complexes with a thiolate ligand. Methods for making these transition metal complexes and for using such compounds in catalyst compositions for the polymerization of olefins also are provided. | 04-03-2014 |
20140121343 | Novel Catalyst Compositions and Methods of Making and Using Same - An imine phenol compound having Structure I: | 05-01-2014 |
20140121344 | Novel Catalyst Compositions and Methods of Making and Using Same - An ethylene polymer having (i) a density defined by equation (1) | 05-01-2014 |
20140213744 | Novel Catalyst Compositions and Methods of Making and Using Same - A catalyst composition comprising (i) a metal salt complex of an imine bis(phenol) compound characterized by Structure 1: | 07-31-2014 |
20140213747 | Novel Polymer Compositions and Methods of Making and Using Same - A polymer reactor-blend comprising at least a first component having a polydispersity index of greater than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer and a second component having a polydispersity index of less than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer wherein a molecular weight distribution of the second component lies within a molecular weight distribution of the first component. | 07-31-2014 |
20140296453 | Catalyst Compositions for the Polymerization of Olefins - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization of olefins also are provided. | 10-02-2014 |
20140296456 | Catalyst Systems for Production of Alpha Olefin Oligomers and Polymers - Catalyst compositions containing N,N-bis[2-hydroxidebenzyl]amine transition metal compounds are disclosed. Methods for making these transition metal compounds and for using such compounds in catalyst compositions for the polymerization or oligomerization of alpha olefins also are provided. | 10-02-2014 |
20140323437 | Use of Metallocene Compounds for Cancer Treatment - Metallocene compounds and pharmaceutical compositions containing these metallocene compounds are disclosed and described. Methods of treating cancer employing such metallocene compounds and pharmaceutical compositions also are provided. | 10-30-2014 |
20150065669 | Higher Density Polyolefins With Improved Stress Crack Resistance - Disclosed herein are polymerization processes for the production of olefin polymers. These polymerization processes can employ a catalyst system containing two or three metallocene components, resulting in ethylene-based copolymers that can have a medium density and improved stress crack resistance. | 03-05-2015 |
20150191554 | Chromium (III) Catalyst Systems With Activator-Supports - Methods for preparing supported chromium catalysts containing a chromium (III) compound and an activator-support are disclosed. These supported chromium catalysts can be used in catalyst compositions for the polymerization of olefins to produce polymers having low levels of long chain branching, and with greater sensitivity to the presence of hydrogen during polymerization. | 07-09-2015 |
20150210786 | Novel Polymer Compositions and Methods of Making and Using Same - A polymer reactor-blend comprising at least a first component having a polydispersity index of greater than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer and a second component having a polydispersity index of less than about 20 and is present in an amount of from about 1 wt. % to about 99 wt. % based on the total weight of the polymer wherein a molecular weight distribution of the second component lies within a molecular weight distribution of the first component. | 07-30-2015 |
20150259455 | Polymers With Improved Toughness and ESCR for Large-Part Blow Molding Applications - Disclosed herein are ethylene-based polymers having a density greater than 0.945 g/cm | 09-17-2015 |