Ralf Hoffmann
Ralf Hoffmann, Bruggen DE
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20090028408 | RADIATION THERAPY FLANNING PROCEDURE - An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in-vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer | 01-29-2009 |
20100298153 | METHODS FOR ANALYSING PROTEIN SAMPLES BASED ON THE IDENTIFICATION OF C-TERMINAL PEPTIDES - The present invention relates to a method for identifying proteins in one or more samples based on the isolation and analysis of their C-terminal peptides. The isolated peptides are purified and analysed by Mass spectroscopy. Identification of the parent protein is based on the mass of the C-terminal peptide in combination with additional physicochemical parameters. The present invention further relates to an annotated database of C-terminal peptides of in silico cleaved proteins comprising the masses of C-terminal peptides and one or more physicochemical properties thereof. | 11-25-2010 |
Ralf Hoffmann, Grossposna DE
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20100222268 | ANTIBIOTIC PEPTIDES - This invention concerns novel antibiotic peptide and peptide derivates, especially for use in medicine. Further, the invention relates to compositions and methods for killing microbes, like bacteria or fungus, and methods to treat microbial infections. The invention further relates to a method for drug screening analysis. The peptides and peptide derivates have the general formula Sub | 09-02-2010 |
20110111388 | METHOD FOR THE SENSITIVE DETECTION OF POLYAMINO ACIDS AND OTHER MACRO-MOLECULES - The invention relates to a method for the detection of an analyte containing polyamino acid. The object of the invention is to detect polyamino acids in a highly sensitive manner. The object is achieved in that an LM is coupled to a protein after chemical activation, and is complexed using a lanthanoid ion. In order to detect polyamino acids, the time resolved fluorescence measurement is utilized after electrophoretic separation. The detection limit is 0.5 pg per spot (bovine serum albumin), wherein the linear region extends across six orders of magnitude. The invention also relates to analytes containing nucleic acid. | 05-12-2011 |
20130130994 | ANTIMICROBIAL PEPTIDES AND PEPTIDE DERIVATIVES DERIVED FROM ONCOPELTUS FASCIATUS - The present invention relates to a antimicrobial peptide or peptide derivative comprising the following sequence: Sub | 05-23-2013 |
20140309161 | Modified antibiotic peptides having variable systemic release - The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all. | 10-16-2014 |
Ralf Hoffmann, Eindhoven NL
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20100030067 | SYSTEM, METHOD, COMPUTER-READABLE MEDIUM AND USE FOR IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE - A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided. | 02-04-2010 |
20100056916 | SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE - A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used “blind sampling” techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer-readable medium is also provided. | 03-04-2010 |
Ralf Hoffmann, Leverkusen DE
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20080206152 | In Vivo Expression Profiling - The present invention relates to in vivo expression profiling using a plurality of specific targeting moieties each labelled with a different compound which allows to identify simultaneously the binding of each targeting moiety to a target. | 08-28-2008 |
20090238767 | TARGETING CONTRAST AGENTS OR TARGETING THERAPEUTIC AGENTS FOR MOLECULAR IMAGING AND THERAPY - This invention discloses a method of synthesizing targeting contrast agents for molecular imaging and targeting diagnosis and therapy, targeting contrast agents and targeting therapeutic agents and their use. | 09-24-2009 |
Ralf Hoffmann, Berlin DE
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20080296843 | Method for Sealing a Housing - A method for sealing a housing includes providing a base plate of the housing with at least one opening; providing an electrical connection that extends through the base plate from an inner side to an outer side of the base plate; and applying a sealing compound into the opening from an outer side of the base plate in order to seal an interface between the base plate and the electrical connection. | 12-04-2008 |
20110120844 | Electrical switch - A switch for switching an electrical load comprises a contact chamber in which a first contact member, a second contact member and a movable contact bridge are arranged. The contact chamber is arranged in a mounting support. The contact chamber comprises a ceramic material and the mounting support comprises a plastics material. | 05-26-2011 |
20110240603 | CONTACT BRIDGE WITH BLOW MAGNETS - The present invention relates to contactors for unidirectional DC operation with permanent magnetic arc extinguishing. In addition to the blow magnets, the contactors are equipped with compensatory permanent magnets for compensating the magnetic field in the vicinity of the contact bridge in order to prevent contact levitation, i.e., an uncontrolled opening of the contacts that is due to a magnetic force generated by a strong current flowing through the contact bridge. To this end, the compensatory permanent magnets are arranged in the vicinity of the contact bridge and polarized in the opposite direction of the blow magnets. The magnetic field of the compensatory magnets and the current flowing through the contact bridge are generating a magnetic force that acts on the contact bridge and tends to keep the electrical contacts closed. | 10-06-2011 |
20130002380 | ELECTRIC CONTACT ELEMENT AND METHOD FOR PRODUCING AN ELECTRIC CONTACT ELEMENT - The present invention relates to a method for producing an electric contact element from a semifinished product and to the electric contact element and the corresponding semifinished product. The method for producing an electric contact element ( | 01-03-2013 |
20150042423 | Relay Having Two Switches That Can Be Actuated In Opposite Directions - An electromechanical relay is provided, comprising a magnetic system and a pivotable armature. A diagnostic switch is arranged on one side of the relay, and the set of contacts of the diagnostic switch is driven by the adjacent leg of the armature. A load switch is arranged on the bottom side of the relay and is driven by the second leg of the armature via an insulating coupling member. | 02-12-2015 |
20150048909 | Polarized Electromagnetic Relay and Method for Production Thereof - A polarized relay comprising an electromagnet, a two-pole or three-pole permanent magnet, an armature, and switches, which are mounted in and on a shelf-like support component. | 02-19-2015 |
20150061809 | Coil Assembly - A coil assembly is provided, comprising a coil former, a coil, and a connection block which is pivotally joined to the coil former. The coil is wound while the connection block is pivoted away, the winding wire ends are soldered to the terminal pins, and the connection block is pivoted close to the coil. | 03-05-2015 |
Ralf Hoffmann, Grosspoesna DE
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20120021975 | ANTIBIOTIC PEPTIDES - The invention relates to a peptide or peptide derivative having the general formula: Sub | 01-26-2012 |
Ralf Hoffmann, Wesel DE
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20130018121 | COMPOSITION COMPRISING STABLE POLYOL MIXTURES - Single-phase, liquid compositions, comprising at least two isocyanate-reactive polyol components that are incompatible with each other and, as a mediator additive, at least one copolymer that prevents or delays the separation of the polyol components and that is composed of certain structural units, of which certain structural units have no acidic functional groups and certain structural units have at least one acidic functional group and said structural units are optionally reacted at least partially with at least one preferably organic compound having at least one basic group to produce salt, and to the use thereof to produce polyurethanes or corresponding polyurethane items. | 01-17-2013 |
Ralf Hoffmann, Werle DE
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20140367055 | CONNECTING MEANS COMPRISING A HATCH AND A BELLOWS - A connecting means provides a connecting passage between a first compartment of a vehicle and a storage means located in a second compartment of the vehicle. The first and the second compartment are separated by a wall. A catering system for a vehicle includes the connecting means. A method provides a sealed connecting passage between a first compartment of a vehicle and a storage means located in second compartment of a vehicle. The connecting means includes a frame, a hatch arrangement for selectively closing and opening a frame aperture with a hatch cover and a bellows arrangement including a flexible bellows. The flexible bellows can be extended from the frame to a storage means located in the second compartment of the vehicle. A continuous passage defined by the flexible bellows and the frame provides a sealed connecting passage between the first compartment and the storage means. | 12-18-2014 |
20140370720 | SELF-ALIGNING CONNECTOR FOR DATA AND/OR POWER TRANSMISSION - A self-aligning connector for data and/or power transmission includes a base plate, a plurality of data and/or power contact elements arranged on the base plate, first and second positioning means attached to the base plate, a mounting means and a frame assembly connecting the base plate to the mounting means and comprising a plurality of frames. Each frame is directly connected to exactly two elements selected from a group consisting of the plurality of frames, the mounting means and the base plate. Each frame is tiltable at least about one axis and/or displaceable in at least one direction with respect to each element it is directly connected to. A connector assembly includes a first self-aligning connector and a second connector. A vehicle includes a first compartment and a second compartment separated by a wall, a bellows assembly and the connector assembly. | 12-18-2014 |